BACE inhibitors and their use in the treatment of Alzheimer's Disease BACE (β-site of APP cleaving enzyme) is a critical component in Alzheimer's Disease (AD), and the development of BACE inhibitors shows great potential as a therapy for the disease. BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease covers virtually all aspects of BACE from initial identification, discovery of inhibitors, and challenges in clinical development, while providing a global understanding essential for productive and successful drug discovery. This book details the story of the discovery of BACE and its role in AD and comprehensively discusses: The development of BACE inhibitors as therapeutics for Alzheimer's disease The research that led to the identification of BACE New BACE inhibitors currently being clinically tested ADME (absorption, distribution, metabolism, excretion) and clinical trial design—topics not addressed in current field literature Cutting-edge technology such as high-throughput screening, structure-based drug design, and QSAR in context of BACE inhibitors and Alzheimer's drug discovery Other approaches to BACE inhibition based on interaction with the precursor protein APP By enhancing the reader's understanding of the various aspects of the BACE drug-discovery process, this much-needed reference will serve as a key resource for all scientists involved in Alzheimer's research—and inspire new approaches to treatment of AD.
Tooth plays a major role in the beauty and personality of an individual. Achieving a pleasant smile that contributes much is nothing but the color of the teeth. Attractive teeth have always been the typical patients‟ primary concern. In the past, the dentist was often dismayed by a patient‟s disappointment in a perfect restoration. Today by taking full advantage of new materials and techniques, dentists can often meet or even exceed such expectations. What most people really want, however are teeth that make them look younger, healthier and more attractive. Color of the tooth is of particular importance to the patient because of social and psychological concern. In fact, matching the color of the teeth with the adjacent teeth is one of the major motivations of the patient to seek cosmetic dental treatment
Going through historical and biographical details, Gertrude Stein American Modernist: Writing Painting and the Feminist Other draws parallels between the concerns and methods of modernist painting, and those that preoccupied Gertrude Stein. Using principles of the semiotics of writing and painting, the book develops a general framework for reading some of the major works of Stein, and examines her importance as a writer. "Just as cubist painting evolved through a series of experiments in the analysis of vision and of its depiction in art, Gertrude Stein's work can be seen to pass through a series of experiments in human perception and its representation in writing. This book suggests a framework for a study of the one through the other." "When writers employed the 'stream of consciousness' mode in narration, it was an attempt to give the written equivalent of a character's thought processes. Stein's writing experiments had their primary focus on the writer's perception of reality and ways of rendering it in writing." "With ... the variety of literary forms that she redefined in her attempts to represent as well as re-present reality, and with the number of writers and artists who had their careers overseen by her, Gertrude Stein has reasonable claims to be regarded as a writers' writer.
The first English study of poet K. V. Simon (1883-1944), with sample translations, including of his 12,000-line epic Vedaviharam, and a critical biography. Opening with the story of South Indian poet laureate (or mahakavi) K. V. Simon's heroic life, this book escorts its global reader through the legendary Malabar Coast, transiting into the densely rich Simon verse in translation, and closing with a comparative reading of a rewarding range of texts from Simon and Milton. When Simon's epic Vedaviharam, a verse rendition of The Book of Genesis, appeared in the Malayalam language in 1931, The Guardian hailed the multifaceted Simon as “India's veritable Milton.” Like Milton, Simon was a polymath, poet, hymnodist, composer, religious reformer and an educator. Like Milton, he was a man of immense learning, writing prose and verse with equal brilliance. As a result of his writings – in which he exhorted the Church of his era to seek scriptural literacy rather than uphold uncritical traditions – Simon was catapulted into public life as a reformer, apologist, and a nationally known prophetic figure. In Mahakavi K. V. Simon: The Milton of the East, translations of Simon's works cover a range, from purpose-driven topic studies to interpretive Bible commentaries, poems, and hymns. Scholarship has so far placed Simon's poetical work on par with the bhakti classics of Ezhuthachen, the Father of modern Malayalam, and of Poonthanam, a Hindu metaphysical poet, both household names in India. But in this study, Varghese Mathai shows how Simon distinguishes himself by his contributions to numerous knowledge fields that bridge him to world literature, modern history, colonial studies, religion, apologetics, rhetorical studies, and more.
India is known as the Melting Pot for World Religions, but this assumed a whole new meaning when in our Batch of less than 100 students at IRMA, Anand, Gujarat, I encountered batch mates who represented every major religion in the world. Hence was born, Project Revelation- where we decided to seek out answers to the greatest questions of life as answered by Buddhism, Christianity, Hinduism, Islam, Jainism, Judaism and Sikhism, where each of us would try to let our respective scriptures talk for itself.
Heart2heart is about the love of God and humanity as manifested throughout human history with particular reference to the famous Sacred Heart encounters. It is written for people of all religions and no religion. It addresses the loneliness of the human heart.
11 Book Synopsis “Only sixty candidates were to be selected from more than fifty thousand boys who had written the qualifying examination. One hundred and twenty candidates who got the highest marks in the examination would be called for interview in Bombay out of which sixty unfortunate boys would have to return home. Two seats were booked for boys from Ceylon – Sri Lanka. Our state of Travancore-Cochin of those days, later named Kerala, had a quota of six cadets.” In 1957, author Augustine Varghese was one of those boys chosen for a career in the Indian Merchant Marine. His life from the time of getting selected on the merchant training ship Dufferin covers his life through the ranks from apprenticeship as officer cadet, to getting Certificates of Competency, passing the final Master (Foreign-Going) Certificate, working on merchant ships as junior officer, senior officer, and finally as master (captain). The ship Dufferin was named in honour of Lord Dufferin, who had been a highly respected viceroy of the British Government to India. After being chosen from those fifty thousand applicants so many years ago, the author says, “It was almost miraculous that I stepped on that ship.” Here then is his exciting story of his life spent at sea.
Heaven on Earth is a unique perspective on the Holy Eucharist. We see here how the promise of our partaking of the divine Life arises in the religious history of humanity and culminates in the humanizing of the divine and the divinizing of the human. We consider the scientific account of the origin and nature of different kinds of life in the Universe. And it is in this context that we come to see that the progressive elevation of matter in the history of the Universe reaches its climax and consummation in the descent of the divine Life - a theophany most evident today in the celebration that was in ancient times described as the Discipline of the Secret.
incarnaTe - How We Know That Jesus is God and Man/Top 10 Reasons seeks to show that Jesus of Nazareth can be understood only as the human locus of the Divine. Today not just skeptics but many theologians have rejected the traditional affirmation that Jesus is God and man. Yet neither group is aware of the infrastructure of hard facts that testifies to the truth of divine incarnation. The insight that Jesus is God incarnate imposes itself on the human mind once it considers the various phenomena explored here. Once the dots are connected, we cannot but see the picture. But we cannot see the picture if we ignore the relevant dots. You have the see the trees to see the forest! All applicable evidence - the world religions, world history, Jewish history, the experience of Christians through the centuries, the Gospel narratives, the practice of the first Christian communities, the logical coherence of saying that a certain Person is both divine and human - must be submitted and studied as one whole.
Scientific Study from the year 2016 in the subject Biology - Botany, Mar Augusthinose College, language: English, abstract: Diabetes is a complex metabolic disorder resulting from either insulin insufficiency or insulin dysfunction. Diabetes mellitus affects most of the people in both developed and developing countries. The treatment of diabetes with synthetic drugs is costly and chances of side effects are high. Phytomedicine has been used since ancient times in various parts of the world where access to modern medicine is limited. Medicinal plants and phytoconstituents play an important role in the management of diabetes mellitus especially in developing countries where resources are meagre. Phytochemicals identified from medicinal plants present an exciting opportunity for the development of new types of therapeutics for diabetes mellitus. Most prevalent among phytochemical groups are the alkaloids, glycosides, polysaccharides, and phenolics such as flavonoids, terpenoids and steroids. This study aims to provide a comparative information about various plants used for antidiabetes treatment in a trial community (Mannans) and their constituents, which have been shown to display potent hypoglycemic activity. The current study was focused on four plants named Tinospora cordifolia, Ensete superbum, Coccinia grandis wild and Apama siliquosa Lam. which is locally known as Amruthu, Kalluvazha, Kattukoval, and Alpam respectively. The plant parts such as seed, leaves, stem and bark were used by the local people. The plant materials prepared as decoction, infusion, aqueous extracts in milk or honey were used for the treatment of diabetes. The plants that are being used by the local people of the study area have been isolated from plants for the treatment of diabetes. The efficacy of these ethnomedicinal plants needs to be subjected to pharmacological validation. it was found that Coccinia grandis was more efficient than the other plants. Some antidiabetic plants may exert their action by stimulating the function or number of beta-cells and thus increasing insulin release. The study highlighted the central role of traditional herbal medicine for the treatment of diabetes in tribal community. Ethnobotanical survey is most useful for scientists, research scholars and scientific companies for further studies on isolation and identification of active compounds that can be formulated into antidiabetic drugs.
This book cites several clinical indications for embolization. Embolization is a safe and effective therapy for intra visceral bleeding, closure of arterio-venous malformations, non-surgical nephrectomy and splenectomy. It is especially useful in patients with several critical co-morbid medical conditions which preclude radical surgeries. It is organ preserving, with limited complications. In the text, the procedural details are described in each clinical situation. The materials used for the procedure are also be described. The procedural pitfalls and complications are detailed in addition to precautions to be taken during the procedure. This will serve as a reference guide for cardiologists and vascular radiologists.
The Book Is An Academic Endeavour On A Variety Of Themes Encompassing History, Society, Religions, Vedas, Upanishads And Epics. It Also Studies The Movements Led By Various Personalities Enjoying Places Of Prominence In Their Respective Fields.Besides The Major Tenets Of Different Religions, The Book Discusses More Than Thirty Philosophies Representing Various Shades Of Thought Classified Into Five Broad Categories: (I) Saddarsanas Or Six Visions, Inspired By The Vedas, Are Independent In Approach And Argument Though Not Isolated From One Another; (Ii) Sramanas (Strivers) Philosophies Emerged In The 6Th Century Bc. Their Proponents Were, By And Large, Empiricists Who Used Experience And Observation As A Source Of Knowledge; (Iii) The Modern Philosophies In Hindusim Emanated From The Movements Of Revival Of This Religion Through Reformist Organisations Like Arya Samaj, Brahmo Samaj, And Theosophical Society, Etc.; (Iv) The Upanishadic Philosophies Mainly Revolve Around The Concepts Of Self The Individual, And Absolute God Almighty; (V) Finally, The Philosophies Of Different Religions Are Based On Faith And Practices Propounded By Their Respective Founders Or Their Successors.This Elaborate Study Is Structured In Two Volumes Each Consisting Of A Number Of Parts That Include Chapters On Different Themes. Volume I Makes A Detailed Discussion On India, Going In-Depth Into The Name, Basic Characteristics, Geography, History, Civilization, Etc. It Effectively Unveils India S Identity As A Nation Along With Its Historical Realities, Socio-Culture Features And Contribution To The World At Large In Spiritual Pursuits. Volume Ii Is A Self-Contained Comparative Study Of Hinduism And Christianity Accentuating The Doctrinal Issues Which Mark The Points Of Accord And Possible Discords In The Cordiality And Mutuality Of These Two Great Religions. Annexures Given In The End Constitute An Integral Part Of This Volume And Will Provide Useful Study-Aids To The Readers.The Book Will Be Useful To Students, Teachers, Religious Preachers, Educationists, And All Those Who Aspire To Enhance Their Knowledge On India S History, Religion And Spiritual Philosophy.
In The Christ Connection noted apologist Varghese (There Is a God, co-written with atheist-turned-Christian philosopher, Antony Flew) offers a comprehensive and compelling formulation of the monumental discovery that Jesus of Nazareth is God and man, Messiah and Savior. The book explores: · The pre-Christian religions – from native peoples to Egyptians and ancient Judaism – pointing the way to the Messiah to come · Jesus as a phenomenon unique in human history · The Christ connection as a rendezvous of the religions · Fifteen grounds that lead us to affirm Jesus as God and man and Savior · The foundations of the doctrine of the Trinity in human experience.
Does God answer prayers? If he does, what is the timing? What prayers does God answer? Does God answer according to our expectation or differently? How important is God's will in answering prayers? This book answers to those questions and explains how important and essential praying daily is to grow and continue our relationship with God. It contains the prayers of many of the biblical men and women and the principles we can learn from them. Also, this book explains the purpose and reasons behind prayer and why it is important in our lives on earth. It explains how prayer helps us move closer to God and spiritually grow and stay in faith with God. This book explains how God was moved by the prayers of his servants and his children in difficult circumstances. It also proves that our God is a prayer-answering God. Also, this book provides information from the prayers of the apostles and church fathers, including St. Paul, St. Augustine, and Martin Luther, the reformer of the church. This book explains the different types of prayers. There is also a chapter on our Lord's Prayer and how he taught us to pray. How can prayer change things, move the hand of God, change a person's life, move mountains blocking the path to success in our lives, and solve life's problems? God's blessings and wonders by prayers are all discussed in this book.
Is death the end? Or, to put it another way, do we survive bodily death? Some shrug their shoulders and declare we simply can’t know. Others just say “No.” And a few, flying their philosophical colors, pretentiously profess to not even understand the question. Curiously, the overwhelming majority of human beings throughout the course of history have taken it for granted that death is not the end, that there is a life after death. This striking and seemingly instinctive belief has been embodied in the religious traditions and philosophical reflections of most cultures. There is Life After Death is the first of its kind in that it assembles and analyzes a comprehensive range of data on life after death and then provides a framework to understand the data. No previous book has given a concrete structure of the afterlife that is based on the accounts of “eye”-witnesses, as well as on data from diverse sources. Above all, the book provides exciting and compelling answers to the urgent question: what lies on the other side?
Who is she? Sheeba Varghese. What's her secret? That ultimately all success flows from greater self-awareness. Under the categories of self-awareness, focus, and strategy, Sheeba deals with such topics as: Living with conviction Values at work Personal leadership Success is not for sissies What coaching can do for you
This work is a fresh, unusually lucid approach to Christian theology and interfaith dialogue fromÊIndia.ÊIts basic aim is to examine the Christian consciousness of God's work in history--redemption history within the entire Êhistory of the world.ÊIt uses Christian Faith by Friedrich Schleiermacher (1768-1834) as its main text, so as to view this theme in a reversed order from the way it is presented there. This approach, which centers on God's new creation in Christ, leads to an incisive understanding of Christianity's relation to other modes of faith.ÊThroughout, Dr. Kunnuthara compares the thought of another Indian Christian leader steeped in Hindu thought, Pandippedi Chenchiah (1886-1959), to enable renewed interfaith dialogue across a wide spectrum.
The first English study of poet K. V. Simon (1883-1944), with sample translations, including of his 12,000-line epic Vedaviharam, and a critical biography. Opening with the story of South Indian poet laureate (or mahakavi) K. V. Simon's heroic life, this book escorts its global reader through the legendary Malabar Coast, transiting into the densely rich Simon verse in translation, and closing with a comparative reading of a rewarding range of texts from Simon and Milton. When Simon's epic Vedaviharam, a verse rendition of The Book of Genesis, appeared in the Malayalam language in 1931, The Guardian hailed the multifaceted Simon as “India's veritable Milton.” Like Milton, Simon was a polymath, poet, hymnodist, composer, religious reformer and an educator. Like Milton, he was a man of immense learning, writing prose and verse with equal brilliance. As a result of his writings – in which he exhorted the Church of his era to seek scriptural literacy rather than uphold uncritical traditions – Simon was catapulted into public life as a reformer, apologist, and a nationally known prophetic figure. In Mahakavi K. V. Simon: The Milton of the East, translations of Simon's works cover a range, from purpose-driven topic studies to interpretive Bible commentaries, poems, and hymns. Scholarship has so far placed Simon's poetical work on par with the bhakti classics of Ezhuthachen, the Father of modern Malayalam, and of Poonthanam, a Hindu metaphysical poet, both household names in India. But in this study, Varghese Mathai shows how Simon distinguishes himself by his contributions to numerous knowledge fields that bridge him to world literature, modern history, colonial studies, religion, apologetics, rhetorical studies, and more.
This book is a concise study of The Bible from beginning till end. The approach of the author is not confining to normal Christian theologians or conforming to blind religious attitudes. It is a deliberate attempt to revive Christianity to the right track, lining all conventional vices that got into it in due course through many denominations. A special attempt was taken without hesitation to criticize all relevant in the process of purifying the gold to attain its carat. It is a new experience for all studious Christians and scholars with a deep study purpose. It is undoubtedly a good book to read in one stretch as it instigates eagerness to know the truth in simple language. Jesus wanted to bring all mankind under one roof before His second arrival. Henceforth the aim and call of the book are for universally united Christianity. Then only the church will become the body of Christ. It will move the stagnant Christianity forward with hope, in the turbulent world. The title is relevant and invites all to read to quench doubts and find the right way to God.
Solve your Go problems using a problem-solution approach. Each recipe is a self-contained answer to a practical programming problem in Go. Go Recipes contains recipes that deal with the fundamentals of Go, allowing you to build simple, reliable, and efficient software. Other topics include working with data using modern NoSQL databases such as MongoDB and RethinkDB. The book provides in-depth guidance for building highly scalable backend APIs in Go for your mobile client applications and web client applications. All this means that you’ll be able to write programs that get the most out of multicore and networked machines, using Go’s novel type system that enables flexible and modular program construction. You'll see how to test your Go applications so they are ready for deployment, as well as learning how to write HTTP servers to offer you maximum flexibility when dealing with remote clients. What You'll Learn Work with the core fundamentals of Go Persist data into NoSQL databases Build scalable backend APIs Test your Go applications Create HTTP web servers in Go Who This Book Is For Experienced programmers who have some or no prior experience with Go.
Thank you for visiting our website. Would you like to provide feedback on how we could improve your experience?
This site does not use any third party cookies with one exception — it uses cookies from Google to deliver its services and to analyze traffic.Learn More.