Hyaluronic acid is an essential part of connective, epithelial and neural tissues, and contributes to cell proliferation and migration. It is used as a stimulating agent for collagen synthesis and is a common ingredient in skin-care products, a multi-billion dollar industry, as it is believed to be a key factor in fighting the aging process. Hyaluronic Acid: Production, Properties, Application in Biology and Medicine consists of six chapters discussing the various issues of hyaluronic acid research. In Chapter 1, a historical analysis recounts the discovery and milestones of the research leading to the practical applications of hyaluronan. Chapter 2 is dedicated to biological role of the hyaluronic acid in nature, in particular in the human body. The chapter starts from the phylogenesis of hyaluronic acid, then describes hyaluronan functions in human ontogenesis and especially the role which hyaluronan plays in extracellular matrix of the different tissues. Chapter 3 describes the methods to manufacture and purify hyaluronic acid, including the analytical means for assessing quality of the finished product. Chapter 4 discusses the structure and rheological properties of hyaluronic acid considering effects on conformation and biological properties related to molecular weight. In Chapter 5, the physical and chemical methods for modifying the structure of hyaluronan are discussed including cross-linking using bi-functional reagents, solid-phase modification and effects of the combined action of high pressures and shift deformation. The final chapter focuses on the products derived from hyaluronic acid, including therapeutics composed of modified hyaluronan conjugated to vitamins, amino acids and oligo-peptides. The biological roles and medical applications of this polysaccharide have been extensively studied and this book provides a wealth of scientific data demonstrating the critical role of hyaluronic acid and its promise as a multifaceted bio-macromolecule. Approaching hyaluronic acid from multiple angles, this book links relationships between its biological functions, structure and physical–chemical properties. It will be an invaluable resource to researchers, both industrial and academic, involved in all aspects of hyaluronan-based technologies.
This encyclopedia presents an all-embracing collection of analytical surface classes. It provides concise definitions and description for more than 500 surfaces and categorizes them in 38 classes of analytical surfaces. All classes are cross references to the original literature in an excellent bibliography. The encyclopedia is of particular interest to structural and civil engineers and serves as valuable reference for mathematicians.
The 22nd International Free Electron Laser Conference and 7th FEL User Workshop were held August 13-18, 2000 at Washington Duke Inn and Golf Club in Durham, North Carolina, USA. The conference and the workshop were hosted by Duke University's Free Electron laser (FEL) Laboratory. Following tradition, the FEL prize award was announced at the banquet. The year 2000 FEL prize was awarded to three scientists propelling the limits of high power FELs: Steven Benson, Eisuke Minehara and George Neill. The conference program was comprised of traditional oral sessions on First Lasing, FEL theory, storage ring FELs, linac and high power FELs, long wavelength FELs, SASE FELs, accelerator and FEL physics and technology, and new developments and proposals. Two sessions on accelerator and FEL physics and technology reflected the emphasis on the high quality of accelerators and components for modern FELs. The breadth of the applications was presented in the workshop oral sessions on materials processing, biomedical and surgical applications, physics and chemistry as well as on instrumentation and methods for FEL applications. A special oral session was dedicated to FEL center status reports for users to learn more about the opportunities with FELs. As usual, the oral sessions were supplemented by poster sessions with in-depth discussions and communications. The FEL physicists and FEL users had excellent opportunities to interact throughout the duration of the event, culminating a Joint Sessions. The year 2000 was very successful being marked by lasing with two SASE and one storage ring short-wavelength FELs, and by the first human surgery with the use of FEL, to mention but a few. The International Program Committee and chairs of the sessions had the challenging and exciting problem of selecting invived and contributed talks for the conferences and the workshop from the influx of abstracts mentioning new results and ideas. The success of the conference was determined by these contributions. Scientists from 15 countries gave 70 talks, presented 176 posters and submitted 146 papers, which are published in the present volume of proceedings.
For the first time in a single book, Non-Linear Instabilities in Plasmas and Hydrodynamics presents the underlying physics of fast secondary instabilities. This exceptionally well-written, introductory book discusses the basic ideas of the physics of secondary or induced, nonlinear instabilities in wave-sustaining media. The authors, world-renowned experts in the field, have brought together the results of papers scattered throughout the literature to explain subjects as diverse as fluctuation chaos, wave-turbulent instabilities, vortex dynamos, beam-plasma interactions, plasma confinement, and the origins of typhoons in the Earth's atmosphere and magnetic fields in galaxies. Paving the way for new and exciting research in the future, this broad, interdisciplinary book enables a wide range of physicists to apply the concepts discussed to obtain new results in plasma physics, space physics, hydrodynamics, and geophysics.
Human biological liquids contain numerous low- and high-molecular weight surfactants. The human organism contains interfaces with enormous surfaces. The physicochemical and biochemical processes taking place at these interfaces are extremely important for the vital functions of the organism as a whole, and the interfacial properties may reflect peculiarities of age and sex, health and disease. The present book is the first attempt to systematically present the results of dynamic and equilibrium surface tensions measurements of serum and urine samples that were obtained from healthy humans of various sex and age, and to compare these results with measurements of biological liquids obtained from patients suffering from various diseases or with measurements of amniotic fluid obtained from women at various stages of pregnancy.Pulmonary medicine, especially neonatology, has systematically used interfacial tensiometry for studying pulmonary surfactant. In this particular area, significant progress was achieved in the treatment of diseases related to alterations of the lung surfactant system. We believe that, similar to the progress in pulmonary medicine attributed to surface chemical studies of lung surfactant, progress in other medical branches could be expected through studies of interfacial characteristics of other human biological liquids.For several years the authors of this book have been engaged in studies aimed at the improvement of the maximum bubble pressure method, resulting in the development of computer controlled tensiometers which are capable of measuring dynamic surface tensions within a wide range of surface lifetime. In addition to the measurement techniques, a correct interpretation and analysis of the tensiometric data obtained is extremely important. The kinetic theory of adsorption from solutions, and the theory of equilibrium adsorption layers of surfactant/protein mixtures provide the basis for both the choice of the most characteristic parameters of tensiograms and the analysis of the results. Some theoretical models describing the adsorption of proteins are presented in Chapter 1. The main theoretical and experimental issues related to the maximum bubble pressure technique as applied to biological liquids are presented in Chapter 2. A more detailed discussion of the differences of the various methods in use for measuring dynamic surface tension of biological fluids is provided in Chapter 3. Chapter 4 gives data from patients with kidney disease, Chapter 5 from patients with rheumatic diseases, Chapter 6 with pulmonary diseases, Chapter 7 with diseases of the central nervous system, and Chapter 8 with neoplasms.Dynamic interface tensiometry of human biological liquids is a fascinating new method which deserves a broad use for prospective studies of various diseases.
Modern Biogeochemistry is aimed to generalize modern ideas of biogeochemical developments during the last decades. It is designed to support a general course in biogeochemistry, and as such, is likely to have a broad market among the many universities and colleges that are adding such courses to their curricula. This book aims to supplement the existing textbooks by providing modern understanding of biogeochemistry, from evolutionary biogeochemistry to practical applications of biogeochemical ideas such as human biogeochemistry, biogeochemical standards and biogeochemical technologies. To a certain extent this textbook is a summary of both scientific results of various authors and classes in biogeochemistry, that have been given to students by authors during the last 5 to 10 years at different universities throughout the world such as Cornell, Moscow, Seoul and Bangkok. Biogeochemistry is becoming an increasingly popular subject for graduate and postgraduate education. Courses in ecology, geography, biology, chemistry, environmental science, public health and environmental engineering all tend to have a biogeochemical component in their syllabuses to a greater or lesser extent.
This book presents and analyzes the essential data on nanoscale metal clusters dispersed in, or chemically bonded with polymers. Special attention is paid to the in situ synthesis of the nanocomposites, their chemical interactions, and the size and distribution of the particles in the polymer matrix. Numerous novel nanocomposites are described with regard to their mechanical, electrophysical, optical, magnetic, catalytic and biological properties. Their applications, present and future, are outlined.
We started our work on theoretical methods in the phys ics of high pressures (in connec tion with geophysical applications) in 1956, and we immediately encountered many problems. Naturally, we searched the published Iiterature for solutions to these problems but whenever we failed to find a solution or when the solution did not satisfy us, we attempted to solve the problern ourselves. We realized that other investigators working in the physics of high pres sures would probably encounter the same problems and doubts. Therefore, we decided to write this book in order to save our colleagues time and effort. Apart from the descriptions of ex perimental methods, the book deals only with those problems which we encountered in our own work. Allproblems in high-pressure physics have, at present, only approximate solutions, which are very rough. Therefore, it is not surprising that different investigators approach the same problems in different ways. Our approach does not prejudge the issue and we are fully aware that there are other points of view. Our aim was always to solve a glven problern on a physical basis. For example, the concept of the Grüneisenparameter needs further develop ment but it is based on reliable physical ideas. On the other hand, Simon's equation for the melting curve has, in our opinion, no clear physical basis and is purely empirical. Equations of this type are useful in systematic presentation of the experimental material but they are un suitable for any major extrapolation.
One service mathematics has rendered the 'Bt mm ... - si j'avait su comment en revenir, human race. It has put common sense back je n'y serais point alIe.' Jules Verne where it belongs. on the topmost shelf next to the dusty canister labelled 'discarded non The series is divergent; therefore we may be sense'. Eric T. Bell able to do something with it. O. Heavisidc Mathematics is a tool for thought. A highly necessary tool in a world where both feedback and non linearities abound. Similarly, all kinds of parts of mathematics serve as tools for other parts and for other sciences. Applying a simple rewriting rule to the quote on the right above one finds such statements as: 'One service topology has rendered mathematical physics .. .'; 'One service logic has rendered com puter science .. .'; 'One service category theory has rendered mathematics .. .'. All arguably true. And all statements obtainable this way form part of the raison d'etre of this series.
As a large variety of transducers are required for the current needs of NDT applications, this book gives a consolidated account regarding the basic principles, applications, advantages and limitations, design considerations, materials and methods used for their evaluation and calibration etc. by the technocrats and professionals involved in ultrasonic NDT.
Here is the first book to treat the control of sexuality in plants. The authors provide a thorough review of the literature and discuss many new findings from their laboratory. They include a review of the evolution and genetics of sexuality, including new data on the effect of primary environmental factors on sex expression and the influence of phytohormones on the expression of sexuality as a function of age. The work discussed here has significant implications for plant breeding. Agronomists, horticulturists, and plant physiologists will find practical information on procedures to use in the field or the green house, as well as a thorough introduction to the principles of flowering and fruiting.
The idea of optimization runs through most parts of control theory. The simplest optimal controls are preplanned (programmed) ones. The problem of constructing optimal preplanned controls has been extensively worked out in literature (see, e. g. , the Pontrjagin maximum principle giving necessary conditions of preplanned control optimality). However, the concept of op timality itself has a restrictive character: it is limited by what one means under optimality in each separate case. The internal contradictoriness of the preplanned control optimality ("the better is the enemy of the good") yields that the practical significance of optimal preplanned controls proves to be not great: such controls are usually sensitive to unregistered disturbances (includ ing the round-off errors which are inevitable when computer devices are used for forming controls), as there is the effect of disturbance accumulation in the control process which makes controls to be of little use on large time inter vals. This gap is mainly provoked by oversimplified settings of optimization problems. The outstanding result of control theory established in the end of the first half of our century is that controls in feedback form ensure the weak sensitivity of closed loop systems with respect to "small" unregistered internal and external disturbances acting in them (here we do not need to discuss performance indexes, since the considered phenomenon is of general nature). But by far not all optimal preplanned controls can be represented in a feedback form.
This book is devoted to an investigation of some important problems of mod ern filtering theory concerned with systems of 'any nature being able to per ceive, store and process an information and apply it for control and regulation'. (The above quotation is taken from the preface to [27]). Despite the fact that filtering theory is l'argely worked out (and its major issues such as the Wiener-Kolmogorov theory of optimal filtering of stationary processes and Kalman-Bucy recursive filtering theory have become classical) a development of the theory is far from complete. A great deal of recent activity in this area is observed, researchers are trying consistently to generalize famous results, extend them to more broad classes of processes, realize and justify more simple procedures for processing measurement data in order to obtain more efficient filtering algorithms. As to nonlinear filter ing, it remains much as fragmentary. Here much progress has been made by R. L. Stratonovich and his successors in the area of filtering of Markov processes. In this volume an effort is made to advance in certain of these issues. The monograph has evolved over many years, coming of age by stages. First it was an impressive job of gathering together the bulk of the impor tant contributions to estimation theory, an understanding and moderniza tion of some of its results and methods, with the intention of applying them to recursive filtering problems.
Chemical Kinetics of Gas Reactions explores the advances in gas kinetics and thermal, photochemical, electrical discharge, and radiation chemical reactions. This book is composed of 10 chapters, and begins with the presentation of general kinetic rules for simple and complex chemical reactions. The next chapters deal with the experimental methods for evaluating chemical reaction mechanisms and some theories of elementary chemical processes. These topics are followed by discussions on certain class of chemical reactions, including unimolecular, bimolecular, and termolecular reactions. The remaining chapters examine gas reactions, such as molecular collisions, photochemical reactions, chemical reactions in electrical discharge, chain reactions, and combustion. This book will be of value to reaction kinetics engineers and researchers.
One of the key problems of failure-free operation of machinery is prevention of corrosion. The global scale of modern production makes this problem even more critical. At the beginning of the 21st century industrial contami- tion and the corrosion-active nature of the environment reached a level such that corrosive damage of materials became commensurate with their prod- tion volume and expenditure on anticorrosion protection of machines became comparable with investments in basic production. Anticorrosion techniques changed from being an auxiliary service to industrial enterprises into a dev- oping, scienti?cally intensive and generously ?nanced branch of production. Polymers occupy a very speci?c place amongst anticorrosion techniques. Polymers combine good chemical resistance with impermeability to di?- ent media and unusual deformation characteristics. The main principle of their application as anticorrosion means is the creation of a tight barrier that insulates metal machine parts or constructions from corrosion agents. The advantages of polymers allow the creation of such a barrier at minimal cost,providingprotectionoftheworkingmachinesfromcorrosion,combining their manufacture with preservation and decreasing the cost of anticorrosion. This is one of the main reasons why world production of polymer materials increased by almost 50% in the past decade.
Provides comprehensive coverage of all aspects of clay seals, from the formation of deposits and an analysis of their composition and properties, to the physical relationships between these clay seals and the environments in which they are found. Looks at seven different types of clay seals from a number of sites, highlighting important properties and methods of analysis used to distinguish and classify clay seals. The final part of the book deals with modelling the state and properties of clay seals occurring at various depths, showing variations in porosity and strength at different lithogenesis stages. Additionally, the authors consider the possibility of predicting screening properties of clay seals using computer programs.
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