A century has already passed since FRIEDRICH MIESCHER, working at Strasbourg and Basel, began his study of protamine, one of the basic nuclear proteins of cells. It was first established by KOSSEL that protamine represents the simplest known protein. In the conviction that research into the nature of protamine would shed light on that of other typical proteins, a group of researchers in Germany followed MIESCHER and laid the foundations of protein chemistry. A general view of prot amines was thus built up by KOSSEL, working at Strasbourg, Berlin, Marburg an der Lahn, and Heidelberg, FELIX at Heidelberg, Munich, and Frankfurt am Main, and WALDSCHMIDT-LEITZ at Prague and Munich. Concepts and techniques established by these studies have been widely utilized for research on other typical proteins. The revolutionary advances in chemical and physical techniques after W orId War II extended the sphere of research to Tokyo in the Far East. Prof. FELIX' visit in 1955 greatly encouraged our research group in Tokyo. His death in August 1960 constituted a sad loss to protein chemistry and stimulated our group to assume responsibility for carrying on the studies. In the following decade we in Tokyo have been able to add a new development to the results on the chemical structure of protamines accumulated by the Eurqpean researchers over a period of about fifty years.
This first book on high-speed atomic force microscopy (HS-AFM) is intended for students and biologists who want to use HS-AFM in their research. It provides straightforward explanations of the principle and techniques of AFM and HS-AFM. Numerous examples of HS-AFM studies on proteins demonstrate how to apply this new form of microscopy to specific biological problems. Several precautions for successful imaging and the preparation of cantilever tips and substrate surfaces will greatly benefit first-time users of HS-AFM. In turn, the instrumentation techniques detailed in Chapter 4 can be skipped, but will be useful for engineers and scientists who want to develop the next generation of high-speed scanning probe microscopes for biology. The book is intended to facilitate the first-time use of this new technique, and to inspire students and researchers to tackle their own specific biological problems by directly observing dynamic events occurring in the nanoscopic world. Microscopy in biology has recently entered a new era with the advent of high-speed atomic force microscopy (HS-AFM). Unlike optical microscopy, electron microscopy, and conventional slow AFM, it allows us to directly observe biological molecules in physiological environments. Molecular “movies” created using HS-AFM can directly reveal how molecules behave and operate, without the need for subsequent complex analyses and roundabout interpretations. It also allows us to directly monitor morphological change in live cells, and dynamic molecular events occurring on the surfaces of living bacteria and intracellular organelles. As HS-AFM instruments were recently commercialized, in the near future HS-AFM is expected to become a common tool in biology, and will enhance and accelerate our understanding of biological phenomena.
The difficult mission of a regime change: Toshio Nishi gives an account of how America converted the Japanese mindset from war to peace following World War II.
Explores the science and technology of lithographic processes and resist materials and summarizes the most recent innovations in semiconductor manufacturing. Considers future trends in lithography and resist material technology. Reviews the interaction of light, electron beams, and X-rays with resist materials.
This textbook is an accessible overview of the broad field of organic electrochemistry, covering the fundamentals and applications of contemporary organic electrochemistry. The book begins with an introduction to the fundamental aspects of electrode electron transfer and methods for the electrochemical measurement of organic molecules. It then goes on to discuss organic electrosynthesis of molecules and macromolecules, including detailed experimental information for the electrochemical synthesis of organic compounds and conducting polymers. Later chapters highlight new methodology for organic electrochemical synthesis, for example electrolysis in ionic liquids, the application to organic electronic devices such as solar cells and LEDs, and examples of commercialized organic electrode processes. Appendices present useful supplementary information including experimental examples of organic electrosynthesis, and tables of physical data (redox potentials of various organic solvents and organic compounds and physical properties of various organic solvents).
This book summarizes and analyzes the biology, ecology, exploitation and management of small cetaceans in Japan. It describes the various types of cetacean fisheries in Japan and their historical development, the life histories and ecologies of the main species involved, and the history and problems of conservation and management. The data show that in some cases the number of small cetaceans harvested exceed sustainable limits and have led to depletion of populations. The book provides a case study of what can go wrong when the needs of industry and conservation collide. The descriptions of life history and ecology are relevant to issues of conservation and management, not just for cetaceans, but for all fisheries around the world.
This book aims to compile some of the important results from the latest research in climate variation and prediction studies with a focus on the role of the ocean, particularly in the Indo-Pacific region. Several new modes of ocean-atmosphere climate variations have been discovered in the last decade, and the advance of climate models have made it possible to predict some of these modes several seasons ahead. This has improved the society's ability to use model predictions to mitigate climate disaster risks. Leading experts in the field were invited to contribute to this book in order to compile a comprehensive review for the benefit of researchers as well as general readers interested in the subject."--
The author describes the Sankin Kōtai System,a policy institututed by the Tokugawa shoguns requiring alternate year residency of daimyōs in Edo. It's aim was to exert control on the feudal lords.
Visit any large metropolitan area in the world, and you'll feel theurgent need for innovative solutions to the many problems that facethe modern urban center. Geo-Space Urban Design offers a revolutionary proposal that willlead future urban growth quite literally in a differentdirection--down. Gideon Golany and Toshio Ojima clearly demonstratethat subsurface urban expansion is not only practical and feasible,but also that it can reverse many of the negative effects normallyassociated with urban expansion. They present a comprehensive andsystematic plan for developing underground spaces fortransportation, delivery systems, infrastructure, residences,shopping and commercial spaces, and social and cultural activities.The authors focus on integrating geo-space with existingabove-ground structures and offer well-illustrated examples ofspecific design theories and methods. They also anticipate avariety of contingent issues, such as land ownership, legal rights,and psychological adjustment to underground living andworking. Three case studies of Japanese projects that use underground spacefor shopping, transportation, and infrastructure explore the entirespectrum of issues surrounding the design, construction, andongoing operation of the facility, including form, function, andefficiency; health, safety, and comfort; legal issues; and specialmanagement and security considerations. Geo-space projects inMontreal and Paris are also examined. Geo-Space Urban Design appeals to a broad range of professionals,all of whom have important roles to play in the creation andoperation of the cities of the future. For urban designers,architects, and civil and architectural engineers, this book offersboth an eye-opening vision and a challenge to create viable spacesthat will revolutionize urban life; landscape architects,geographers, and environmentalists will find opportunities toredefine the relationship between society and the natural world;and psychologists, social scientists, and government officials willdiscover new levels of human adaptability, interaction, andcooperation. In this revolutionary book, two leading figures explain howgeo-space design and construction will enable urban planners tocope with the most difficult challenges posed by the continuedexpansion of metropolitan areas, including * Land preservation--conserving precious agricultural land in theface of rapid urban expansion * High urban land prices--making economical use of limited space inurban centers with soaring property values * Efficient urban scale--shrinking overextended and inefficientutility networks * Response to stressful climate--reducing energy consumption inregions subject to extremes of hot or cold weather The authors explore every facet of geo-space and point out thechallenges and opportunities these projects will hold for urbandesigners, architects, civil engineers, architectural engineers,landscape architects, geographers, environmentalists,psychologists, social scientists, and government officials.
Micro/Nano Robotics and Automation technologies have rapidly grown associated with the growth of Micro and Nanotechnologies. This book presents a summary of fundamentals in micro-nano scale engineering and the current state of the art of these technologies. “Micro-Nanorobotic Manipulation Systems and their Applications” introduces these advanced technologies from the basics and applications aspects of Micro/Nano-Robotics and Automation from the prospective micro/nano-scale manipulation. The book is organized in 9 chapters including an overview chapter of Micro/Nanorobotics and Automation technology from the historical view and important related research works. Further chapters are devoted to the physics of micro-nano fields as well as to material and science, microscopes, fabrication technology, importance of biological cell, and control techniques. Furthermore important examples, applications and a concise summary of Micro-Nanorobotics and Automation technologies are given.
This book provides a comprehensive overview of the mechanical distinctions between fretting damage under axial or bending external forces and fretting damage under a torsional load. It emphasizes the importance of studying practical accident cases to efficiently acquire technical skills. The book is structured around the fundamental technologies of material science, tribology, and mechanics, which are vital for understanding and addressing technical issues. The author has incorporated all fretting countermeasure technologies, which were previously often sensory and empirical in nature, and repositioned them as technologies grounded in fundamental principles. The book proposes an economical approach to product operation that maintains reliability by integrating not only design technology but also maintenance practices. It delves into specific materials, such as titanium alloys and aluminum alloys, which have seen increased use for weight reduction in industries like aerospace. In this book, “Critical Distance Stress Theory” that can easily derive the fatigue limit and fatigue life of the stress singular field at the contact edge was presented. As a result, the fretting fatigue strength and life can be predicted from the same FEM stress analysis as the normal stress concentration part. And finally, introducing a novel fretting mechanical model, the book focuses on scenarios where pressure force (N) and repeated tangential force (F) are applied to two planar objects, with the tangential force being transmitted solely through friction at the contact surface. This model finds relevance in turbine blade connection structures, among other applications. The author references Asai's research example, which encompasses fretting mechanical analysis, fretting wear evaluation, fatigue assessment, and structural damping evaluation using this model.
This first book on high-speed atomic force microscopy (HS-AFM) is intended for students and biologists who want to use HS-AFM in their research. It provides straightforward explanations of the principle and techniques of AFM and HS-AFM. Numerous examples of HS-AFM studies on proteins demonstrate how to apply this new form of microscopy to specific biological problems. Several precautions for successful imaging and the preparation of cantilever tips and substrate surfaces will greatly benefit first-time users of HS-AFM. In turn, the instrumentation techniques detailed in Chapter 4 can be skipped, but will be useful for engineers and scientists who want to develop the next generation of high-speed scanning probe microscopes for biology. The book is intended to facilitate the first-time use of this new technique, and to inspire students and researchers to tackle their own specific biological problems by directly observing dynamic events occurring in the nanoscopic world. Microscopy in biology has recently entered a new era with the advent of high-speed atomic force microscopy (HS-AFM). Unlike optical microscopy, electron microscopy, and conventional slow AFM, it allows us to directly observe biological molecules in physiological environments. Molecular “movies” created using HS-AFM can directly reveal how molecules behave and operate, without the need for subsequent complex analyses and roundabout interpretations. It also allows us to directly monitor morphological change in live cells, and dynamic molecular events occurring on the surfaces of living bacteria and intracellular organelles. As HS-AFM instruments were recently commercialized, in the near future HS-AFM is expected to become a common tool in biology, and will enhance and accelerate our understanding of biological phenomena.
A century has already passed since FRIEDRICH MIESCHER, working at Strasbourg and Basel, began his study of protamine, one of the basic nuclear proteins of cells. It was first established by KOSSEL that protamine represents the simplest known protein. In the conviction that research into the nature of protamine would shed light on that of other typical proteins, a group of researchers in Germany followed MIESCHER and laid the foundations of protein chemistry. A general view of prot amines was thus built up by KOSSEL, working at Strasbourg, Berlin, Marburg an der Lahn, and Heidelberg, FELIX at Heidelberg, Munich, and Frankfurt am Main, and WALDSCHMIDT-LEITZ at Prague and Munich. Concepts and techniques established by these studies have been widely utilized for research on other typical proteins. The revolutionary advances in chemical and physical techniques after W orId War II extended the sphere of research to Tokyo in the Far East. Prof. FELIX' visit in 1955 greatly encouraged our research group in Tokyo. His death in August 1960 constituted a sad loss to protein chemistry and stimulated our group to assume responsibility for carrying on the studies. In the following decade we in Tokyo have been able to add a new development to the results on the chemical structure of protamines accumulated by the Eurqpean researchers over a period of about fifty years.
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