This volume focuses on various aspects of interleukin-27 (IL-27), especially its potential for clinical applications. The authors discuss the downstream signaling from the IL-27 receptor and its molecular targets in immune cells including Th1, Th2, Th17, Treg, Tr1, Tfh, B cells, DCs and macrophages. The inhibition of Th17 cells by IL-27 is vital for the maintenance of the feto-maternal tolerance and the prevention of lupus, multiple sclerosis, autoimmune uveitis, immune thrombocytopenia and atherosclerosis. However, the same inhibitory capabilities compromise the immune response to bacterial pathogens, and IL-27 is a pathogenic factor in sepsis and tuberculosis. Also covered are the conflicting reports on the role of IL-27 in rheumatoid arthritis, the effect of IL-27 on epithelia, which seems to play a role in asthma, psoriasis and inflammatory bowel diseases, and the direct cytotoxic and anti-vascular effects of IL-27, which make it a promising agent for the treatment of cancer. Accordingly, this volume will be of interest to researchers and clinicians alike.
Neon Knight Forever is a detailed study of one of the most misunderstood superhero series that dares to ask the most heretical question for all Bat-fans: what if Batman & Robin is actually a valuable achievement in big-budget superhero cinema? The Batman franchise has remained one of the most lucrative and varied lines of superhero-based titles outside its original comic book, with adaptations from filmmakers such as Christopher Nolan, Tim Burton, and Zack Snyder. However, among the many facets of Batman, there is one which remains on the margins of Bat-history, being treated as the most obscure or misconceived: the Batman duology directed by Joel Schumacher between 1995 and 1997, a creation which is seen by many fans as the "wrong" approach to the Batman mythos. Neon Knight Forever accounts for the initial rejection of Schumacher's version and explores modern attempts to rehabilitate Schumacher's vision of the infamous Neon Knight. Through discussing the formal foundations underlying both Batman Forever and Batman & Robin and featuring claims from the Schumacher online fandom, Zaglewski embraces the adaptation as a valuable addition to the Batman universe.
This volume focuses on various aspects of interleukin-27 (IL-27), especially its potential for clinical applications. The authors discuss the downstream signaling from the IL-27 receptor and its molecular targets in immune cells including Th1, Th2, Th17, Treg, Tr1, Tfh, B cells, DCs and macrophages. The inhibition of Th17 cells by IL-27 is vital for the maintenance of the feto-maternal tolerance and the prevention of lupus, multiple sclerosis, autoimmune uveitis, immune thrombocytopenia and atherosclerosis. However, the same inhibitory capabilities compromise the immune response to bacterial pathogens, and IL-27 is a pathogenic factor in sepsis and tuberculosis. Also covered are the conflicting reports on the role of IL-27 in rheumatoid arthritis, the effect of IL-27 on epithelia, which seems to play a role in asthma, psoriasis and inflammatory bowel diseases, and the direct cytotoxic and anti-vascular effects of IL-27, which make it a promising agent for the treatment of cancer. Accordingly, this volume will be of interest to researchers and clinicians alike.
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