This book concerns the life and theatrical career of the great native-born English composer and musician of the eighteenth century, Thomas Augustine Arne (1710-1778), best known today as the composer of "Rule, Britannia." It will appeal to those interested in the mid-to-late eighteenth-century London and Dublin theatre, opera, and music scenes.
At the Bench shows how you can save time and boost profits when repairing or fabricating gold and silver jewelry. Featuring more than 200 photographs, it offers step-by-step instruction on resizing rings, repairing chain, setting stones, retipping prongs, and building component parts, among other essential skills. It also includes a guide to bench preparation and practices, easy-to-use charts for ring sizing and karat conversion, and tips for taking in repairs.
Has the American university gained the whole world but lost its soul? Christian universities must reimagine excellence in a time of exile, placing the liberating arts before the liberal arts and focusing on the worship, love, and knowledge of God as central to academia. This pioneering work charts the history of the university and casts an inspiring vision for the future of higher education.
An integrated presentation of the basic science and clinical applications of anticancer agents Aimed at both undergraduate and postgraduate readers, this unique text provides readers with a fully-integrated presentation of all aspects of the science of anticancer drugs, including their chemistry, pharmacology, and clinical applications. After heart disease, cancer is the number one killer worldwide, and the tumor microenvironment is forever changing, creating an ever-greater demand for safer, more effective anticancer agents. In response to that demand, the $100 billion cancer drug market continues to grow, with our increased understanding of cancer leading to new drugs being used clinically almost every year. Anticancer Therapeutics is divided into three sections. Section 1 is an introduction to cancer and therapeutics, and covers the etiology and cellular and molecular basis of cancer. In Section 2, the authors focus on the anticancer agents — their discovery, synthesis, mode of action, mechanisms of resistance, and adverse reactions. Section 3 focuses on specific cancers, explaining how and why the various agents discussed in Section 2 are used, both individually and in combination, to treat different cancers. Integrates aspects of basic science, including chemistry and pharmacology and clinical medicine in relation to cancer therapeutics Written by an author team comprising specialists in medicinal chemistry, pharmacology, and oncology Features full-color images throughout illustrating how drugs bind to cellular targets and exert their pharmacological effect Divided into three sections, covering the etiology and cellular and molecular basis of cancer, anticancer agents, and drug applications for different cancers. Providing the reader with an integrated understanding of all aspects of the science of anticancer agents, this is an ideal textbook for undergraduates studying medicine, nursing, medicinal chemistry, pharmacy, pharmacology and other allied heath / life sciences. It is also a valuable bench reference for pharmacists, medics, and pharmaceutical researchers working in both academia and industry.
Shifting faculty roles in a changing landscape Ernest L. Boyer's landmark book Scholarship Reconsidered: Priorities of the Professoriate challenged the publish-or-perish status quo that dominated the academic landscape for generations. His powerful and enduring argument for a new approach to faculty roles and rewards continues to play a significant part of the national conversation on scholarship in the academy. Though steeped in tradition, the role of faculty in the academic world has shifted significantly in recent decades. The rise of the non-tenure-track class of professors is well documented. If the historic rule of promotion and tenure is waning, what role can scholarship play in a fragmented, unbundled academy? Boyer offers a still much-needed approach. He calls for a broadened view of scholarship, audaciously refocusing its gaze from the tenure file and to a wider community. This expanded edition offers, in addition to the original text, a critical introduction that explores the impact of Boyer's views, a call to action for applying Boyer's message to the changing nature of faculty work, and a discussion guide to help readers start a new conversation about how Scholarship Reconsidered applies today.
What did it mean for people of color in nineteenth-century America to speak or write "white"? More specifically, how many and what kinds of meaning could such "white" writing carry? In ReWriting White, Todd Vogel looks at how America has racialized language and aesthetic achievement. To make his point, he showcases the surprisingly complex interactions between four nineteenth-century writers of color and the "standard white English" they adapted for their own moral, political, and social ends. The African American, Native American, and Chinese American writers Vogel discusses delivered their messages in a manner that simultaneously demonstrated their command of the dominant discourse of their times-using styles and addressing forums considered above their station-and fashioned a subversive meaning in the very act of that demonstration. The close readings and meticulous archival research in ReWriting White upend our conventional expectations, enrich our understanding of the dynamics of hegemony and cultural struggle, and contribute to the efforts of other cutting-edge contemporary scholars to chip away at the walls of racial segregation that have for too long defined and defaced the landscape of American literary and cultural studies.
Antibacterial agents act against bacterial infection either by killing the bacterium or by arresting its growth. They do this by targeting bacterial DNA and its associated processes, attacking bacterial metabolic processes including protein synthesis, or interfering with bacterial cell wall synthesis and function. Antibacterial Agents is an essential guide to this important class of chemotherapeutic drugs. Compounds are organised according to their target, which helps the reader understand the mechanism of action of these drugs and how resistance can arise. The book uses an integrated “lab-to-clinic” approach which covers drug discovery, source or synthesis, mode of action, mechanisms of resistance, clinical aspects (including links to current guidelines, significant drug interactions, cautions and contraindications), prodrugs and future improvements. Agents covered include: agents targeting DNA - quinolone, rifamycin, and nitroimidazole antibacterial agents agents targeting metabolic processes - sulfonamide antibacterial agents and trimethoprim agents targeting protein synthesis - aminoglycoside, macrolide and tetracycline antibiotics, chloramphenicol, and oxazolidinones agents targeting cell wall synthesis - β-Lactam and glycopeptide antibiotics, cycloserine, isonaizid, and daptomycin Antibacterial Agents will find a place on the bookshelves of students of pharmacy, pharmacology, pharmaceutical sciences, drug design/discovery, and medicinal chemistry, and as a bench reference for pharmacists and pharmaceutical researchers in academia and industry.
The Weimar Republic (1918-1933) was a crucial moment not only in German history but also in the history of both crime fiction and criminal science. This study approaches the period from a unique perspective - investigating the most notorious criminals of the time and the public's reaction to their crimes. The author argues that the development of a new type of crime fiction during this period - which turned literary tradition on its head by focusing on the criminal and abandoning faith in the powers of the rational detective - is intricately related to new ways of understanding criminality among professionals in the fields of law, criminology, and police science. Considering Weimar Germany not only as a culture in crisis (the standard view in both popular and scholarly studies), but also as a culture of crisis, the author explores the ways in which crime and crisis became the foundation of the Republic's self-definition. An interdisciplinary cultural studies project, this book insightfully combines history, sociology, literary studies, and film studies to investigate a topic that cuts across all of these disciplines.
In the years between the world wars, Manhattan's Fourteenth Street-Union Square district became a center for commercial, cultural, and political activities, and hence a sensitive barometer of the dramatic social changes of the period. It was here that four urban realist painters--Kenneth Hayes Miller, Reginald Marsh, Raphael Soyer, and Isabel Bishop--placed their images of modern "new women." Bargain stores, cheap movie theaters, pinball arcades, and radical political organizations were the backdrop for the women shoppers, office and store workers, and consumers of mass culture portrayed by these artists. Ellen Wiley Todd deftly interprets the painters' complex images as they were refracted through the gender ideology of the period. This is a work of skillful interdisciplinary scholarship, combining recent insights from feminist art history, gender studies, and social and cultural theory. Drawing on a range of visual and verbal representations as well as biographical and critical texts, Todd balances the historical context surrounding the painters with nuanced analyses of how each artist's image of womanhood contributed to the continual redefining of the "new woman's" relationships to men, family, work, feminism, and sexuality.
Though the history of the German railway system is often associated with the transportation of Jews to labor and death camps, Todd Presner looks instead to the completion of the first German railway lines and their role in remapping the cultural geography and intellectual history of Germany's Jews. Treating the German railway as both an iconic symbol of modernity and a crucial social, technological, and political force, Presner advances a groundbreaking interpretation of the ways in which mobility is inextricably linked to German and Jewish visions of modernity. Moving beyond the tired model of a failed German-Jewish dialogue, Presner emphasizes the mutual entanglement of the very categories of German and Jewish and the many sites of contact and exchange that occurred between German and Jewish thinkers. Turning to philosophy, literature, and the history of technology, and drawing on transnational cultural and diaspora studies, Presner charts the influence of increased mobility on interactions between Germans and Jews. He considers such major figures as Kafka, Heidegger, Arendt, Freud, Sebald, Hegel, and Heine, reading poetry next to philosophy, architecture next to literature, and railway maps next to cultural history. Rather than a conventional, linear history that culminates in the tragedy of the Holocaust, Presner produces a cultural mapping that articulates a much more complex story of the hopes and catastrophes of mobile modernity. By focusing on the spaces of encounter emblematically represented by the overdetermined triangulation of Germans, Jews, and trains, he introduces a new genealogy for the study of European and German-Jewish modernity.
In the years following the Civil War, a veritable army of homeless men swept across America's "wageworkers' frontier" and forged a beguiling and bedeviling counterculture known as "hobohemia." Celebrating unfettered masculinity and jealously guarding the American road as the preserve of white manhood, hoboes took command of downtown districts and swaggered onto center stage of the new urban culture. Less obviously, perhaps, they also staked their own claims on the American polity, claims that would in fact transform the very entitlements of American citizenship. In this eye-opening work of American history, Todd DePastino tells the epic story of hobohemia's rise and fall, and crafts a stunning new interpretation of the "American century" in the process. Drawing on sources ranging from diaries, letters, and police reports to movies and memoirs, Citizen Hobo breathes life into the largely forgotten world of the road, but it also, crucially, shows how the hobo army so haunted the American body politic that it prompted the creation of an entirely new social order and political economy. DePastino shows how hoboes—with their reputation as dangers to civilization, sexual savages, and professional idlers—became a cultural and political force, influencing the creation of welfare state measures, the promotion of mass consumption, and the suburbanization of America. Citizen Hobo's sweeping retelling of American nationhood in light of enduring struggles over "home" does more than chart the change from "homelessness" to "houselessness." In its breadth and scope, the book offers nothing less than an essential new context for thinking about Americans' struggles against inequality and alienation.
Todd Butler here proposes a new epistemology of early modern politics, one that sees-as did writers of the period-human thought as a precursor to political action. By focusing not on reason or the will but on the imagination, Butler uncovers a political culture in seventeenth-century England that is far more shifting and multi-polar than has been previously recognized. Pursuing the connection between individual thought and corporate political action, he also charts the existence of a discourse that grounds modern scholarly interests in the representational nature of early modern politics - its images, rituals and entertainment-within a language early moderns themselves used. Through analysis of a wide variety of seventeenth-century texts, including the writings of Francis Bacon and Thomas Hobbes, Caroline Court masques, and the poetry and prose of John Milton, he reveals a society deeply concerned with the fundamentally imaginative nature of politics. It is a strength of the study that Butler looks at unusual or slighted texts by these authors alongside their more canonical texts. The study also ranges widely across disciplines, engaging literature alongside both natural and political philosophy. By emphasizing the human mind rather than human institutions as the primary site of the period's political struggles, this study reframes critical understandings of seventeenth-century English politics and the texts that helped define them.
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