Create more powerful, flexible applications using a new extension of the XML standard Programmers are finding that the XMI extension of the XML standard provides a lot more flexibility in writing software for sharing data. Written by one of the principal authors of XMI, this book provides programmers with everything they need to know to best utilize this extension. The authors cover the basics first, detailing the essential concepts and explaining how XMI relates to XML and UML. Readers will then learn how to program with XMI, including how to express data in XMI, create XMI documents with Java, and merge documents. Samples of real-world XMI applications are also included throughout the book that show how IBM is using XMI with data warehousing and how to convert simple relational databases into XMI. CD-ROM includes sample XMI source code and software tools for developing XMI and XML applications.
A chemocentric view of the molecular structures of antibiotics, their origins, actions, and major categories of resistance Antibiotics: Challenges, Mechanisms, Opportunities focuses on antibiotics as small organic molecules, from both natural and synthetic sources. Understanding the chemical scaffold and functional group structures of the major classes of clinically useful antibiotics is critical to understanding how antibiotics interact selectively with bacterial targets. This textbook details how classes of antibiotics interact with five known robust bacterial targets: cell wall assembly and maintenance, membrane integrity, protein synthesis, DNA and RNA information transfer, and the folate pathway to deoxythymidylate. It also addresses the universe of bacterial resistance, from the concept of the resistome to the three major mechanisms of resistance: antibiotic destruction, antibiotic active efflux, and alteration of antibiotic targets. Antibiotics also covers the biosynthetic machinery for the major classes of natural product antibiotics. Authors Christopher Walsh and Timothy Wencewicz provide compelling answers to these questions: What are antibiotics? Where do antibiotics come from? How do antibiotics work? Why do antibiotics stop working? How should our limited inventory of effective antibiotics be addressed? Antibiotics is a textbook for graduate courses in chemical biology, pharmacology, medicinal chemistry, and microbiology and biochemistry courses. It is also a valuable reference for microbiologists, biological and natural product chemists, pharmacologists, and research and development scientists.
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