Vitamin D and bone, Linking the fields of vitamin D and bone with those of the nucleus and mitotic spindle, Nucleus structure and dynamics, Organization of the nucleus, Microtubules and associated proteins, Mitosis and spindle assembly, Control and mechanism of spindle formation and dynamics, Materials and methods, NuSAP, and novel MAP involved in spindle organization, NuSAP expression in cultured osteoblasts: regulation during development and by 1,25-dihydroxyvitamin D3, Analysis of NuSAP gene expression at the tissue level and chromosomal localization of human and mouse NuSAP, Developmentally regulated expression of NuSAP in the rat testis and mouse embryo, Chromosomal localization of human and mouse Nusap, General discussion and perspectives.
Bringing much-needed humour to another chaotic year in politics, Britain's Best Political Cartoons 2023 offers a tour of the most high-profile, notorious and absurd news stories of the year, as seen through the eyes of our nation's finest satirists. This collection features the work of Peter Brookes, Steve Bell, Morten Morland, Nicola Jennings, Christian Adams, Dave Brown, Brian Adcock and many more, alongside captions from Britain's leading cartoon expert. The result is a sharply observed, stunningly creative and side-splittingly funny guide to another year like no other. It is the perfect gift for friends, family, or just for yourself. __________________________________________________________________ 'A wonderful book . . . A beautiful thing to look at . . . Our brilliant cartoonists show there is still something to satirise . . . A great stocking filler.' Giles Coren 'A blockbuster collection of the year's funniest political cartoons . . . [compiled by] Britain's leading authority on political cartoons . . . It made us chuckle.' Eamonn Holmes
Town and country planning has never been more important to the UK, nor more prominent in national debate. Planning generates great controversy: whether it’s spending £80m and four years’ inquiry into Heathrow’s Terminal 5, or the 200 proposed wind turbines in the Shetland Isles. On a smaller scale telecoms masts, take-aways, house extensions, and even fences are often the cause of local conflict. Town and Country Planning in the UK has been extensively revised by a new author group. This 15th Edition incorporates the major changes to planning introduced by the coalition government elected in 2010, particularly through the National Planning Policy Framework and associated practice guidance and the Localism Act. It provides a critical discussion of the systems of planning, the procedures for managing development and land use change, and the mechanisms for implementing policy and proposals. It reviews current policy for sustainable development and the associated economic, social and environmental themes relevant to planning in both urban and rural contexts. Contemporary arrangements are explained with reference to their historical development, the influence of the European Union, the roles of central and local government, and developing social and economic demands for land use change. Detailed consideration is given to • the nature of planning and its historical evolution • the role of the EU, central, regional and local government • mechanisms for developing policy, and managing these changes • policies for guiding and delivering housing and economic development • sustainable development principles for planning, including pollution control • the importance of design in planning • conserving the heritage • community engagement in planning The many recent changes to the system are explained in detail – the new national planning policy framework; the impact of the loss of the regional tier in planning and of the insertion of neighbourhood level planning; the transition from development control to development management; the continued and growing importance of environmental matters in planning; community engagement; partnership working; changes to planning gain and the introduction of the Community Infrastructure Levy; and new initiatives across a number of other themes. Notes on further reading are provided and at the end of the book there is an extensive bibliography, maintaining its reputation as the ‘bible’ of British planning.
Urban Policy and Practice is a practical and critical guide to urban policy in contemporary Britain. The book covers a range of topics including: * Quality and consumerism in the public sector * Community development * Public Health * Environmental issues * Local intervention in the creation of skills and jobs Case studies are drawn from housing, planning, the social services, economic development, and local government finance. Throughout, the concern is for a clear analysis of corporate strategies, democratic control and sustainable development.
The book aims to integrate our understanding of mammalian societies into a novel synthesis that is relevant to behavioural ecologists, ecologists, and anthropologists. It adopts a coherent structure that deals initially with the characteristics and strategies of females, before covering those of males, cooperative societies and hominid societies. It reviews our current understanding both of the structure of societies and of the strategies of individuals; it combines coverage of relevant areas of theory with coverage of interspecific comparisons, intraspecific comparisons and experiments; it explores both evolutionary causes of different traits and their ecological consequences; and it integrates research on different groups of mammals with research on primates and humans and attempts to put research on human societies into a broader perspective.
Town and Country Planning in the UK provides one of the most authoritative and comprehensive accounts of British planning history, institutions, legislation, policies, processes and practices. This 16th edition has been substantially revised and re-organised to provide an up-to-date overview of the planning systems in the four nations of the UK, supported by analyses, interpretations, illustrations and examples from planning practice. The new edition features: details of the legislative and policy changes since 2015 and discussion of their implications, including the early stages of the Levelling Up and Regeneration Act, 2023 discussion of environmental policies and programmes and the impact of Brexit on environmental regulatory landscape in Britain changes to climate change and resilience policies, notably the government’s ‘Net Zero’ agenda and their implications for planning updates to the substantive issues in plan-making, especially the responses to the shortage of affordable housing and the development of major infrastructure changes to the processes involved in plan-making and development management an expanded and revised chapter on design to include the growing significance of public health in the built environment major revisions to the chapter on rural planning revisions of the text on planning theory especially in relation to management of conflicts over the use and development of land extended discussion of politics, professionalism and participation in planning The 16th edition of Town and Country Planning in the UK is an ideal starting point for those who are studying or working in the planning field, and for other professionals who need to locate their work in the planning context.
Audio Drama and Modernism traces the development of political and modernist sound drama during the first 40 years of the 20th Century. It demonstrates how pioneers in the phonograph age made significant, innovative contributions to sound fiction before, during, and after the Great War. In stunning detail, Tim Crook examines prominent British modernist radio writers and auteurs, revealing how they negotiated their agitational contemporaneity against the forces of Institutional containment and dramatic censorship. The book tells the story of key figures such as Russell Hunting, who after being jailed for making ‘sound pornography’ in the USA, travelled to Britain to pioneer sound comedy and montage in the pre-Radio age; Reginald Berkeley who wrote the first full-length anti-war play for the BBC in 1925; and D.G. Bridson, Olive Shapley and Joan Littlewood who all struggled to give a Marxist voice to the working classes on British radio.
Ageing, the decline in survival and bodily functions, caused by damage to macromolecules and tissues is intrinsically linked to life. Although universal and unavoidable, ageing does not occur in a uniform way. In the general population, it is actually a continuously distributed phenotype, in which genetic as well as environmental factors play an interactive role and explain the large interindividual differences between biological and chronological age. Cardiovascular disorders, which find there origins in deterioration of the structure and function of the large arteries, explain a large part of morbidity and mortality in industrialized societies. In this doctoral dissertation, the focus was on telomere length and arterial stiffness as biomarkers of biological and arterial ageing, respectively. It was investigated to what extent genetic and environmental determinants of oxidative stress and inflammation impact on the ageing process. Contents include: Introduction, Arterial ageing in cardiovascular risk prediction, Genetic and environmental factors in biological and arterial ageing, Telomere length and possible link to X chromosome, Role of smoking, oxidative stress and the -174 G/C interleukin-6 polymorphism in biological and vascular ageing, Environmental factors in arterial ageing, Blood pressure and blood selenium: a cross-sectional and a longitudinal population study, Endothelial function and outdoor temperature, General Discussion, Summary, Short Curriculum Vitae.
Public Places Urban Spaces, 2e, is a thorough introduction to the principles of urban design theory and practice. Authored by experts in the fields of urban design and planning, it is designed specifically for the 2,500 postgraduate students on Urban Design courses in the UK, and 1,500 students on undergraduate courses in the same subject. The 2e of this tried and trusted textbook has been updated with relevant case studies to show students how principles have been put into practice. The book is now in full color and in a larger format, so students and lecturers get a much stronger visual package and easy-to-use layout, enabling them to more easily practically apply principles of urban design to their projects. Sustainability is the driving factor in urban regeneration and new urban development, and the new edition is focused on best sustainable design and practice. Public Places Urban Spaces is a must-have purchase for those on urban design courses and for professionals who want to update and refresh their knowledge.
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