Angiogenesis (formation of new vessels from pre-existing ones) is a crucial early event in the process of tumor development. New vessels supply the tumor with nutrients that are needed for further local growth and enable distant metastases (Folkman 1995). Judah Folkman (1971) highlighted the potential therapeutic imp- cations of tumor angiogenesis. He hypothesized that if tumor angiogenesis is inhibited, then tumor growth and metastasis will be impaired greatly or even impossible. The subsequent quest for endogenous and exogenous inhibitors of angiogenesis has yielded a variety of promising therapeutic agents that block one or more angiogenic pathways, a few of which have been approved by the FDA (e. g. , bevacizumab, sorafenib, sunitinib) for use as single agents or in combination with chemotherapy in specific populations of cancer patients (Sessa et al. 2008). There has also been a dramatic expansion in the exploration of novel anti-angiogenic agents pre-clinically and in clinical trials (Ferrara 2002). Some of the most promising data comes from the development of agents that inhibit one of the key growth factors involved in tumor angiogenesis – vascular endothelial growth factor (VEGF) (Ferrara et al. 2003). Bevacizumab is a monoclonal antibody against VEGF that was the first an- angiogenic agent that improved significantly the overall survival of patients with colorectal and non-squamous non-small cell lung cancer (Ferrara et al. 2005). Various agents that target tumor angiogenesis are currently under investigation in different cancer types in many clinical trials (Ferrara and Kerbel 2005).
Across the East Coast, the dead are rising. Cities are overrun with them, decaying corpses with an insatiable hunger for human meat... When Ben Ackerman finds himself in the middle of the zombie apocalypse, he can only think about saving his son, Jake. Unfortunately for Ben, Jake lives with his mother, about two-hundred miles away. The morning it all goes down, Ben embarks on a journey to rescue his son from this grave new world. However, there are worse things than zombies patrolling the NewJersey border... Meet the Barker Brothers. Three fun-loving country boys with a love for guns, fried chicken, and their mother. After running into Ben and his small band of travelers, the Barker Brothers offer their hospitality, a room and food for as long as they need. Only, there's an undisclosed price to pay, and it might just cost Ben and his friends their lives... Less Than Human is a 50,000 word horror/apocalyptic thriller. Contains explicit content...
Glenn Rand, longtime photographic educator, and Tim Meyer, Lead Portrait Instructor at Brooks Institute, have collaborated to create a thorough and balanced textbook on the modern techniques and practice of portrait photography. They have crafted a definitive resource for professionals, students, and avid amateurs wishing to advance their skills in this discipline. Glenn and Tim begin by discussing lessons from the masters and the history of photographic portraiture. They build on this foundation and cover all of the technical and aesthetic components of understanding and producing outstanding portraits. Extensive illustrations illuminate the concepts discussed, and the works of outstanding photographers serve as examples of how to apply the lessons in this book. This second edition offers even more illustrations and photographic examples and an expanded discussion about posing. Topics include: Quality of light and the portrait Ambient, continuous, and strobe light sources Understanding light modifiers and enhancers Mastering lighting ratios Importance and selection of backgrounds Extensive coverage of lighting setups Understanding light meters and metering in portraiture Lighting patterns on the human face Facial analysis Composition in portraiture Posing for various types of portraits Eliciting appropriate expression The fine art portrait Portraiture for the masses
Between Heaven and Hell, Stands Humanity... Several years after the incident in Nebraska that left her emotionally and physically scarred, Andrea McCloud focuses on living a normal life. But when fate intervenes and comes knocking on Andrea's door, her life is thrown back into the fire. Her son is kidnapped by a society of men hellbent on plunging the world into eternal darkness. With the help of Danny Samson and a few new allies, Andrea must uncover the secrets surrounding her son's kidnapping and help stop the worst possible outcome: The Apocalypse. Demon Blood: Gateways is a 90,000 word horror novel. It is book two in the series.
The injury risk in football is quite high and every player will incur more or less severe injuries in the course of their career. This is due to the stop-and-go character of the game, frequent physical contacts, changes of direction and the intensity of the game. This places very specific demands on the players. Additionally, football players may suffer from illnesses requiring appropriate treatment to avoid possible long-term health consequences. This book provides the reader with advice on the treatment and prevention of illnesses and football-related injuries. The most recent discoveries in performance diagnostics provide coaches and players with better tools to address the fitness requirements of the players or the training recommendations. These tools can also be of help in assembling a team. In this book, the authors provide up-to-date sports medical findings taken from practical experience with world class teams and make them accessible for the readers.
While light is required to make a photograph, light alone is not enough. More often, it is the way the light has been modified and shaped that brings an image to life. In this book, Glenn Rand and Tim Meyer offer a comprehensive approach to the tools and techniques photographers can use to shape the light—creating the style, energy, emotion, and feeling that make a photograph exceptional. Clear text is paired with ample before-and-after images and diagrams to make learning easy. Beginning with the physics of light, the authors show you how to predict light’s interaction with the surface of the subject/object you are photographing. Based on this, you can begin to make informed decisions about what kinds of modifiers will help you achieve the look you want. Using softboxes, umbrellas, masks, gels, reflectors, and more, you’ll learn to precisely control the light’s diffused edge and ratio for precise, flawless results.
Seminar paper from the year 2020 in the subject Business economics - Trade and Distribution, grade: 1,3, BSP Business School Berlin (form. Potsdam), language: English, abstract: Climate change is a global problem. According to the majority opinion of renowned experts, humans are to blame for this development. In recent years, industrialization has caused the levels of greenhouse gases in the earth's atmosphere to rise rapidly. The consequences are clearly noticeable in our daily lives, such as rising average temperatures or more frequent extreme weather events. Recent events, such as the diesel scandal, have fueled discussions about the CO2 tax as a more effective measure to deal with climate change. In addition, the diesel scandal showed how the environment is being negligently treated in favor of profit. This has led me to critically analyze emissions trading as one of the current environmental policy measures to reduce greenhouse gases. This is because it is seen in the EU as a particularly powerful tool for achieving climate targets. However, it often also serves as a basis for argumentation against further measures for the environment by companies. The question that occurs to me is what opportunities and risks could arise for Germany from emissions trading. In order to be able to answer this question, it is first necessary to give an initial overview of the topic. It will be explained which functions emissions trading should fulfill and what differences there are between global emissions trading and that in the EU. I then present the scientific findings on emissions and emissions trading to date. Based on the research and the knowledge gained from it, I am able to answer the key question. Finally, my conclusion follows.
Everything is sixty-nine."It happened suddenly. Overnight. Inside Spring Lakes Assisted Living, seven residents - sixty-nine years of age - died mysterious deaths. Only... they aren't really dead. Their bodies remain still, their staring eyes void of life; yet their hearts continue to beat, their lungs fight for oxygen, and somewhere within their petrified bodies their souls cling to life. No one has a rational explanation for what's happening. Three investigators from the CDC are dispatched to the facility in hopes of finding answers, but what they discover is far beyond human comprehension. Something terrifying has come to town. An unseen entity that leeches off the living, the dead, and everything in between. 69 is a brand new short novel of cosmic horror from Tim Meyer, author of The Switch House and Kill Hill Carnage.
Seminar paper from the year 2019 in the subject Business economics - Business Management, Corporate Governance, grade: 1.7, BSP Business School Berlin (form. Potsdam), language: English, abstract: In this work the author carries out a strategic analysis of the automobile company Audi. Using different models, the current market position of Audi will be presented. The author will also outline how the brand deals with its competitors, which are the biggest threats to Audi and what could be improved. The work concludes with a brief outlook into the future. Since the founding of the automobile company Audi, it has been developing and producing vehicles with a focus on innovation and future concepts. Today, Audi is one of the three major German automobile manufacturers, producing the complete range of economy, sports, luxury and SUV models.
I am not a monster. Ray Bridges, a professional electronics salesman, is looking for love in all the strange places. He spends most nights sneaking into support group meetings for the disabled in order to satisfy his deepest, darkest desires-to hook up with unfortunate, down-on-their-luck women who've recently lost a limb. There's a name for Ray's preference; it's called acrotomophilia, a paraphilia involving amputees.Conflicted, Ray wishes he could change. But he can't. His body won't let him. Nor will his mind. He's destined to live this life, forever. That is . . . until he meets the perfect girl. Falls in love with her. Only problem: her arms and legs are attached.Unable to find her attractive, Ray embarks on a dark, twisted journey of self-discovery, one that will force him to make an impossible choice: abandon his pursuit of true love or find a way to make it work, even if that means getting the girl of his dreams to shed an appendage. Weird, comedic, and often raunchy, Limbs is the craziest love story ever told.
Take a trip up the Black Hill, where shapeless things await your arrival. Bring back a piece of some lost world. Stop an ancient monster from feasting on innocent minds. Travel back through time to stop the apocalypse. Enter portals into alternate realities and avoid the wrath of unseen gods. Cosmic calamities. Bloodthirsty beasts. Science gone wrong. It's all here for you, beyond the Black Star Constellations. From the fingertips of Tim Meyer, author of the award-winning short novel, The Switch House, comes twenty-two terrifying stories of the weird and unnatural. Black Star Constellations collects previously published stories as well as thirteen brand new tales. THE STORIES: THE STARGAZER LOST IMPORT NO MAKEUP THE CHORUS BOY LOVER'S HILL LET ME BE YOUR BUTTERFLY THE BUTCHER OF BROOKLYN PURPLE CHEESE THE SKY, HOW IT SHOULD BE GRUME DEATH LOVER ON THE EARS OF DEAF GODS A RIDE ON THE RAINBOW THE CITY OF BONES HOW TO KILL A BEAR WITH A BOW AND ARROW SIREN'S END BEYOND THE BLACK HILL APERTURE YE SINNERS, COME DANCE WITH ME THROUGHWAYS THE PUMPKIN PEOPLE COME AT MIDNIGHT FOR THE LOVE OF THE TREE
For some kids, Long Lake, Georgia is home. But for fourteen-year-old Baker Gray, it's just another stop, another town in another state. Because of his mother's nomadic lifestyle, he's never had a best friend, never kissed a girl, and he's certainly never met anyone like Cassandra Larsson-the enigmatic, older girl whose idea of fun blurs the line between right and wrong. Being hopelessly led by emotions he's never felt, Baker finds himself plodding along dark paths paved by the girl he thinks he may love-a road to self-destruction, where vigilante justice is encouraged and bloodshed is an art form.
Thank you for visiting our website. Would you like to provide feedback on how we could improve your experience?
This site does not use any third party cookies with one exception — it uses cookies from Google to deliver its services and to analyze traffic.Learn More.