The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the "hallmarks of cancer" and thus his theory was discredited. This book aims to provide evidence, through case studies, that cancer is primarily a metabolic disease requring metabolic solutions for its management and prevention. Support for this position is derived from critical assessment of current cancer theories. Brain cancer case studies are presented as a proof of principle for metabolic solutions to disease management, but similarities are drawn to other types of cancer, including breast and colon, due to the same cellular mutations that they demonstrate.
The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the "hallmarks of cancer" and thus his theory was discredited. This book aims to provide evidence, through case studies, that cancer is primarily a metabolic disease requring metabolic solutions for its management and prevention. Support for this position is derived from critical assessment of current cancer theories. Brain cancer case studies are presented as a proof of principle for metabolic solutions to disease management, but similarities are drawn to other types of cancer, including breast and colon, due to the same cellular mutations that they demonstrate.
Since its inception in 1938, the Liga de Beisbol Professional de Puerto Rico has launched the careers of numerous island players, including Ruben Gomez, Jerry Morales, Orlando Cepeda, Vic Power, Ruben Sierra and the greatest of all Puerto Rican stars, Roberto Clemente. For many "imports," the league has been a stepping stone to major league stardom. In its early years, many of the league's stars came from the Negro Leagues: Satchel Paige, Josh Gibson, Buck Leonard, Monte Irvin and Roy Campanella were just a few of the African American stars who graced the Puerto Rican diamonds in the 1940s and early 1950s. The Santurce outfield of 1954 featured one of the finest outfields in baseball history: Clemente, Willie Mays, and Puerto Rican star Bob Thurman. Through the mid-1980s, many major league teams sent their up-and-coming stars to Puerto Rico for a final bit of seasoning--Cal Ripken, Jr., Tony Gwynn, Johnny Bench, Rickey Henderson, Phil Niekro, Hank Aaron and Robin Yount were among them. They played for such future league big league managers as Frank Robinson, Jim Fregosi and Kevin Kennedy, while the balls and strikes were called by Nestor Chylak, Doug Harvey, Dale Ford and many other future major league umpires.
Why the War on Cancer Has Failed and What That Means for More Effective Prevention and Treatment A groundbreaking look at the role of water in living organisms that ultimately brings us closer to answering the riddle of the etiology of, and therapy and treatment for, cancer When President Nixon launched the War on Cancer with the signing of the National Cancer Act of 1971 and the allocation of billions of research dollars, it was amidst a flurry of promises that a cure was within reach. The research establishment was trumpeting the discovery of oncogenes, the genes that supposedly cause cancer. As soon as we identified them and treated cancer patients accordingly, cancer would become a thing of the past. Fifty years later it’s clear that the War on Cancer has failed—despite what the cancer industry wants us to believe. New diagnoses have continued to climb; one in three people in the United States can now expect to battle cancer during their lifetime. For the majority of common cancers, the search for oncogenes has not changed the treatment: We’re still treating with the same old triad of removing (surgery), burning out (radiation), or poisoning (chemotherapy). In Cancer and the New Biology of Water, Thomas Cowan, MD, argues that this failure was inevitable because the oncogene theory is incorrect—or at least incomplete—and based on a flawed concept of biology in which DNA controls our cellular function and therefore our health. Instead, Dr. Cowan tells us, the somatic mutations seen in cancer cells are the result of a cellular deterioration that has little to do with oncogenes, DNA, or even the nucleus. The root cause is metabolic dysfunction that deteriorates the structured water that forms the basis of cytoplasmic—and therefore, cellular—health. Despite mainstream medicine’s failure to bring an end to suffering or deliver on its promises, it remains illegal for physicians to prescribe anything other than the “standard of care” for their cancer patients—no matter how dangerous and ineffective that standard may be—and despite the fact that gentler, more effective, and more promising treatments exist. While Dr. Cowan acknowledges that all of these treatments need more research, Cancer and the New Biology of Water is an impassioned plea from a long-time physician that these promising treatments merit our attention and research dollars and that patients have the right to information, options, and medical freedom in matters of their own life and death.
A History of the Concerto may be read from cover to cover, but readers may also use the extensive index to focus on specific concertos and their composers. Numerous musical examples illuminate critical points. While some readers may want to study the more detailed analyses with scores in hand, this is not essential for an understanding of the text.
As the most common health-care intervention, prescription drug use shares the most important characteristics of the health-care system in the United States. When everything works well, it makes possible breathtakingly successful applications of science to the prevention and cure of human suffering. But everything doesn‘t always work well. Pharmaceu
This concise and carefully developed text offers a reader friendly guide to the basics of time-resolved spectroscopy with an emphasis on experimental implementation. The authors carefully explain and relate for the reader how measurements are connected to the core physical principles. They use the time-dependent wave packet as a building block for understanding quantum dynamics, progressively advancing to more complex topics. The topics are discussed in paired sections, one discussing the theory and the next presenting the related experimental methods. A wide range of readers including students and newcomers to the field will gain a clear and practical understanding of how to measure aspects of molecular dynamics such as wave packet motion, intramolecular vibrational relaxation, and electron-electron coupling, and how to describe such measurements mathematically.
Success of an organization is increasingly dependent on its capability to create an environment in order to improve productivity of knowledge work. This book focuses on the concepts, models and technologies that are used to design and implement such an environment. It develops the vision of a modular, yet highly integrated enterprise knowledge infrastructure and presents an idealized architecture replete with current technologies and systems. The most important streams of technological development that are covered in the book are communication, collaboration, document and content management, e-learning, enterprise portals, business process management, information life cycle management, information retrieval and visualization, knowledge management, mobile computing, application and network infrastructure, Semantic Web and social software. It includes learning goals, exercises and case examples that help the reader to easily understand and practice the concepts.
Laser-driven proton beams are still in their infancy but already have some outstanding attributes compared to those produced in conventional accelerators. One such attribute is the typically low beam emittance. This allows excellent resolution in imaging applications like proton radiography. This thesis describes a novel imaging technique - the proton streak camera - that the author developed and first used to measure both the spatial and temporal evolution of ultra-strong electrical fields in laser-driven plasmas. Such investigations are of paramount importance for the understanding of laser-plasma interactions and, thus, for optimization of laser-driven particle acceleration. In particular, the present work investigated micrometer-sized spherical targets after laser irradiation. The confined geometry of plasmas and fields was found to influence the kinetic energy and spatial distribution of accelerated ions. This could be shown both in experimental radiography images and and in numerical simulations, one of which was selected for the cover page of Physical Review Letters.
How films help us understand the inevitable death of Earth and humanity Negative Life: The Cinema of Extinction brings cinema studies, queer theory, and psychoanalysis into novel configuration around the concept of negative life, a sundering of human and nonhuman relations. Engaging a philosophical and cinematic corpus that rejects the pastoralism of “entanglement” or “enmeshment,” Steven Swarbrick and Jean-Thomas Tremblay counter ecocritical pieties and cut a new path for theory. They examine films by Julian Pölsler, Kelly Reichardt, Lee Isaac Chung, Mahesh Mathai, Paul Schrader, and others that exemplify the existential contradictions currently intensifying amid the sixth mass extinction. Each case study testifies formally and thematically to negative life as a structural condition of thought and film. Together, the cases reveal the unlivable dimension of life and art, where form, desire, and nonbelonging tarry with the future-oriented promise of ecostudies—where all that lives connects. Negative Life militates against this promise, showing that faith in connection is a dead end.
Stories of Tonality in the Age of François-Joseph Fétis explores the concept of musical tonality through the writings of the Belgian musicologist François-Joseph Fétis (1784–1867), who was singularly responsible for theorizing and popularizing the term in the nineteenth century. Thomas Christensen weaves a rich story in which tonality emerges as a theoretical construct born of anxiety and alterity for Europeans during this time as they learned more about “other” musics and alternative tonal systems. Tonality became a central vortex in which French musicians thought—and argued—about a variety of musical repertoires, be they contemporary European musics of the stage, concert hall, or church, folk songs from the provinces, microtonal scale systems of Arabic and Indian music, or the medieval and Renaissance music whose notational traces were just beginning to be deciphered by scholars. Fétis’s influential writings offer insight into how tonality ingrained itself within nineteenth-century music discourse, and why it has continued to resonate with uncanny prescience throughout the musical upheavals of the twentieth and twenty-first centuries.
This fascinating study follows the fortunes of the Höchstetter family, merchant-manufacturers and financiers of Augsburg, Germany, in the late-fifteenth and early-sixteenth centuries, and sheds light on the economic and social history of failure and resilience in early modern Europe. Carefully tracing the chronology of the family’s rise, fall and transformation, it moves from the micro- to the macro-level, making comparisons with other mercantile families of the time to draw conclusions and suggest insights into such issues as social mobility, capitalist organization, business techniques, market practices and economic institutions. The result is a microhistory that offers macro-conclusions about the lived experience of early capitalism and capitalistic practices. This book will be valuable reading for advanced students and researchers of economic, financial and business history, legal history and early modern European history.
This book examines the complex interrelationship between charity, confession, and capital in the orphanages of Augsburg, one of early modern Europe's great manufacturing and mercantile centers. The product of monumental, original research, if offers a thorough-going revision of current historical scholarship on poor relief, social discipline, organization building, and emergent capitalism.
Clinical interviewing with adults is both an art and a science. This handbook will appeal to a wide range of clinical researchers, therapists, interns, and graduate students new to the complexities of the clinical interview and diagnostic process. The comprehensive range of topics and coverage that includes case illustrations with dialogue and differential diagnosis and co morbidity will be highly attractive features to researchers, professional therapists, and graduate students. The Hersen and Thomas team is highly qualified to succeed in this ambitious set of three projects." —Carolyn Brodbeck, Chapman University The Handbook of Clinical Interviewing with Adults is one of three interrelated handbooks on the topic of interviewing for specific populations. It presents a combination of theory and practice plus concern with diagnostic entities for readers who work, or one day will work, with adults in clinical settings.The volume begins with general issues (structured versus unstructured interview strategies, mental status examinations, selection of treatment targets and referrals, writing up the intake interview, etc.), moves to a section on major disorders most relevant to adult clients (depression, bipolar disorder, agoraphobia, posttraumatic stress disorder, eating disorders, alcohol and drug abuse, sexual dysfunction, etc.), and concludes with a chapter on special populations and issues (neurologically impaired patients, older adults, behavioral health consultation, etc.).
We have lost the war on cancer. At the beginning of the last century, one person in twenty would get cancer. In the 1940s it was one out of every sixteen people. In the 1970s it was one person out of ten. Today one person out of three gets cancer in the course of their life. The cancer industry is probably the most prosperous business in the United States. In 2014, there will be an estimated 1,665,540 new cancer cases diagnosed and 585,720 cancer deaths in the US. $6 billion of tax-payer funds are cycled through various federal agencies for cancer research, such as the National Cancer Institute (NCI). The NCI states that the medical costs of cancer care are $125 billion, with a projected 39 percent increase to $173 billion by 2020. The simple fact is that the cancer industry employs too many people and produces too much income to allow a cure to be found. All of the current research on cancer drugs is based on the premise that the cancer market will grow, not shrink. John Thomas explains to us why the current cancer industry prospers while treating cancer, but cannot afford to cure it in Part I. In Part II, he surveys the various alternative cancer therapies that have been proven effective, but that are not approved by the FDA.
The author traces the evolution of baseball through the life of scout Charlie Metro--player, coach, manager, scout, and inventor from the Great Depression through the 1980s. Original.
This lively book takes us back to the first performances of five famous musical compositions: Monteverdi's Orfeo in 1607, Handel's Messiah in 1742, Beethoven's Ninth Symphony in 1824, Berlioz's Symphonie fantastique in 1830, and Stravinsky's Sacre du printemps in 1913. Thomas Forrest Kelly sets the scene for each of these premieres, describing the cities in which they took place, the concert halls, audiences, conductors, and musicians, the sound of the music when it was first performed (often with instruments now extinct), and the popular and critical responses. He explores how performance styles and conditions have changed over the centuries and what music can reveal about the societies that produce it. Kelly tells us, for example, that Handel recruited musicians he didn't know to perform Messiah in a newly built hall in Dublin; that Beethoven's Ninth Symphony was performed with a mixture of professional and amateur musicians after only three rehearsals; and that Berlioz was still buying strings for the violas and mutes for the violins on the day his symphony was first played. Kelly's narrative, which is enhanced by extracts from contemporary letters, press reports, account books, and other sources, as well as by a rich selection of illustrations, gives us a fresh appreciation of these five masterworks, encouraging us to sort out our own late twentieth-century expectations from what is inherent in the music.
The composer's diaries, translated for the first time, with commentary on his distinctive musical aesthetics and his relationship to artistic cross-currents in Czechoslovakia, France, and America.
This wide-ranging guide introduces (or reintroduces) readers to movie musicals past and present, enabling them to experience the development of this uniquely American art form—and discover films they'll love. This comprehensive guide covers movie musicals from their introduction with the 1927 film The Jazz Singer through 2015 releases. In all, it describes 125 movies, opening up the world of this popular form of entertainment to preteens, teens, and adults alike. An introduction explains the advent of movie musicals; then, in keeping with the book's historical approach, films are presented by decade and year with overviews of advances during particular periods. In this way, the reader not only learns about individual films but can see the big picture of how movie musicals developed and changed over time. For each film covered, the guide offers basic facts—studio, director, songwriters, actors, etc.—as well as a brief plot synopsis. Each entry also offers an explanation of why the movie is noteworthy, how popular it was or wasn't, and the influence the film might have had on later musicals. Sidebars offering brief biographies of important artists appear throughout the book.
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