Comprehensive and lavishly illustrated, McKee's Pathology of the Skin, 5th Edition, is your reference of choice for up-to-date, authoritative information on dermatopathology. You'll find clinical guidance from internationally renowned experts along with details on etiology, pathogenesis, histopathology, and differential diagnosis – making this unique reference unparalleled in its wealth of clinical and histopathological material. The 5th Edition of this classic text is a must-have resource for practicing dermatopathologists and general pathologists who sign out skin biopsies. - Covers pathological aspects of skin diseases in addition to providing superb descriptions and illustrations of their clinical manifestations – the only available reference with this unique combination of features. - Integrates dermatopathology, clinical correlations, and clinical photographs throughout, and features bulleted lists of clinical features and differential diagnosis tables for easy reference. - Contains more than 5,000 superb histopathologic and clinical illustrations that demonstrate the range of histologic manifestations. - Brings you fully up to date with key molecular aspects of disease, the capabilities and limitations of molecular diagnostics, and targeted/personalized medicine. - Features up-to-date information on biologics, drug eruptions, and other developments in therapeutics. - Helps you stay current with the latest diagnostic tumor markers and other new developments in immunohistochemistry. - Includes a completely revised chapter on cutaneous lymphoma that reflects recent WHO-EORTC classification changes, as well as new coverage of sentinel lymph node biopsy for melanoma. - Shares the knowledge of the main editor Dr. J. Eduardo Calonje, along with co-editors Thomas Brenn, and Alexander Lazar, and new co-editor Steven D. Billings who offers expertise on both dermatopathology and soft tissue tumors. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
The Retirement Series documents Jefferson's written legacy between his return to private life on 4 March 1809 and his death on 4 July 1826. During this period Jefferson founded the University of Virginia and sold his extraordinary library to the nation, but his greatest legacy from these years is the astonishing depth and breadth of his correspondence with statesmen, inventors, scientists, philosophers, and ordinary citizens on topics spanning virtually every field of human endeavor."--
“Mr. Thomas has understood [the Spanish Civil War] incredibly well and has written it superbly. A full, vivid and deeply serious treatment of a great subject.”—Vincent Sheean, The New York Times Book Review A masterpiece of the historian’s art, Hugh Thomas’s The Spanish Civil War remains the best, most engrossing narrative of one of the most emblematic and misunderstood wars of the twentieth century. Revised and updated with significant new material, including new revelations about atrocities perpetrated against civilians by both sides in this epic conflict, this “definitive work on the subject” (Richard Bernstein, The New York Times) has been given a fresh face forty years after its initial publication in 1961. In brilliant, moving detail, Thomas analyzes a devastating conflict in which the hopes, dreams, and dogmas of a century exploded onto the battlefield. Like no other account, The Spanish Civil War dramatically reassembles the events that led a European nation, in a continent on the brink of world war, to divide against itself, bringing into play the machinations of Franco and Hitler, the bloodshed of Guernica, and the deeply inspiring heroics of those who rallied to the side of democracy. Communists, anarchists, monarchists, fascists, socialists, democrats -- the various forces of the Spanish Civil War composed a fabric of the twentieth century itself, and Thomas masterfully weaves the diffuse and fascinating threads of the war together in a manner that has established the book as a genuine classic of modern history. “Stands without rivals as the most balanced and comprehensive book on the subject.”—American Historical Review
Spaghetti Westerns--mostly produced in Italy or by Italians but made throughout Europe--were bleaker, rougher, grittier imitations of Hollywood Westerns, focusing on heroes only slightly less evil than the villains. After a main filmography covering 558 Spaghetti Westerns, another section provides filmographies of personnel--actors and actresses, directors, musical composers, scriptwriters, cinematographers. Appendices provide lists of the popular Django films and the Sartana films, a listing of U.S.-made Spaghetti Western lookalikes, top ten and twenty lists and a list of the genre's worst.
Taking the mass Italian immigration of the late 19th century as his starting point and drawing on dozens of oral histories and a diverse array of primary sources in English and Italian, Guglielmo focuses on how perceptions of Italians' race and color were shaped in one of America's great centers of immigration and labor, Chicago. His account skillfully weaves together the major events of Chicago immigrant history--the "Chicago Color Riot" of 1919, the rise of Italian organized crime, and the rise of industrial unionism--with national and international events--such as the rise of fascism and the Italian-Ethiopian War of 1935-36--to present the story of how Italians approached, learned, and lived race. By tracking their evolving position in the city's racial hierarchy, Guglielmo reveals the impact of racial classification--both formal and informal--on immigrants' abilities to acquire homes and jobs, start families, and gain opportunities in America. White on Arrival was the winner of the 2004 Frederick Jackson Turner Award of the Organization of American Historians
The End of Alzheimer's: The Brain and Beyond, Second Edition is the first comprehensive overview on the molecular basis of Alzheimer's outside of the brain, merging the most recent findings within the field into a single book. It aims to educate the reader on the many overlooked aspects of Alzheimer's disease that occur outside the brain. This book uniquely provides step-by-step, peer-reviewed evidence that the current research model may be misguided and that a new and emerging model is more accurate. It carefully outlines the molecular research in Alzheimer's outside the brain and argues that a more thorough, whole-body diagnosis will provide better answers about its causes and lead to new treatments. It is beneficial to researchers who need to be apprised of the emerging science on the causes of Alzheimer's, and will hopefully redirect many into new avenues of cellular research and discovery. - Comprehensive literature-based summary of the current state of molecular Alzheimer's disease research - Details the shortcomings of the prevailing model and therapeutics in development - Reviews blood-based biomarkers for Alzheimer's and their link to amyloid- and Tau-independent causes outside the brain - Describes the tissues outside the brain impacted by Alzheimer's and the underlying molecular causes - Explains the whole-body risks associated with Alzheimer's, along with concomitant measures to slow or prevent the disease - Provides a protocol to properly research, evaluate, measure, diagnose, and potentially treat Alzheimer's patients
Systems Neuroscience in Depression provides a comprehensive overview of the normal and depressed brain processes as studied from a systems neuroscience perspective. Systems neuroscience uses a wide variety of approaches to study how networks of neurons form the bases of higher brain function. A broad overview is discussed starting with a background from neurodevelopment and neural understanding as well as novel treatment approaches for depression. This book covers basic developmental aspects and depressive psychopathology, as well as the basic scientific background from animal models and experimental research. Current advances in systems neuroscience are highlighted in studies from child and adolescent psychiatry. Integrated approaches are presented with regards to genetics, neuroimaging and neuroinflammation as well as neuroendocrinology. The field of systems and network neuroscience is evolving rapidly and this book provides a greatly needed resource for researchers and practitioners in systems neuroscience and psychiatry. - Knowledge covering the whole life span from early to later life - Comprehensively written chapters developing from molecules via epigenetics and neural circuits to clinical neuroscience - Understanding the neurobiology of major depressive disorder - Integrating stress and environmental factors with molecular underpinnings - More than 25 illustrations and tables
Nicotinic Acetylcholine Receptors in Health and Disease provides the latest information Nicotinic acetylcholine receptors (nAChRs), which are involved in numerous diseases, including Alzheimer's, Parkinson's, and schizophrenia, and are important potential translational targets for treatment of these diseases, as well as therapy for addiction. This book focuses on the roles and function of nAChRs inside and outside of the nervous system, with an emphasis on translational implications and future prospects for the treatment of numerous disorders. This greater understanding of the basic neurobiology and clinical roles of nAChRs provides important insights for future clinical treatments of many major disorders. - Describes the roles, expression and function of nicotinic receptors - Includes receptor involvement, both inside and outside the nervous system - Details nicotinic receptor involvement in Alzheimer's, Parkinson's, Cancer, Schizophrenia, and more - Emphasizes future treatment prospects of disorders via modulation of nAChR signaling
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