Principles of Stem Cell Biology and Cancer: Future Applications and Therapeutics Tarik Regad, The John van Geest Cancer Research Centre, Nottingham Trent University, UK, Thomas J. Sayers, Centre for Cancer Research, National Cancer Institute, Frederick, USA and Robert Rees The John van Geest Cancer Research Centre, Nottingham Trent University, UK The field of cancer stem cells is expanding rapidly, with many groups focusing on isolating and identifying cancer stem cell populations. Although some progress has been made developing efficient cancer therapies, targeting cancer stem cells remains one of the important challenges facing the growing stem cell research community. Principles of Stem Cell Biology and Cancer brings together original contributions from international experts in the field to present the very latest information linking stem cell biology and cancer. Divided into two parts, the book begins with a detailed introduction to stem cell biology with a focus on the characterization of these cells, progress that has been made in their identification, as well as future therapeutic applications of stem cells. The second part focuses on cancer stem cells and their role in cancer development, progression and chemo-resistance. This section of the book includes an overview of recent progress concerning therapies targeting cancer stem cells. Features: An authoritative introduction to the link between stem cell biology and cancer. Includes contributions from leading international experts in the field. Well-illustrated with full colour figures throughout. This book will prove an invaluable resource for basic and applied researchers and clinicians working on the development of new cancer treatments and therapies, providing a timely publication of high quality reviews outlining the current progress and exciting future possibilities for stem cell research.
In Expression vs. Equality, J. Tobin Grant and Thomas J. Rudolph argue that although public opinion plays a vital role in judicial rulings on the legalities of various finance reform options, political scientists have yet to realize fully the complexities and nuances of public attitudes toward campaign financing. The issue of campaign finance reform exposes a real conflict between the core democratic values of equality and expression. Economic inequalities, reformers argue, allow certain groups and individuals to exert undue influence in the political process, thereby threatening the democratic value of political equality. Opponents tend to frame the issue as a question of free speech: restrictions on campaign contributions are viewed as a threat to the democratic value of political expression. In the context of campaign finance, how do committed Americans rank the importance of equality and expression? How do they resolve the conflict between these competing democratic values? The answers to these questions, say the authors, depend heavily on whose influence and whose rights are perceived to be at stake. Using a series of unique experiments embedded in a national survey of the American electorate, they find that citizens' commitment to the values of expression and equality in the campaign finance system is strongly influenced by their feelings or affect toward those whose rights and influence are perceived to be at stake. Freedom of speech is more highly valued in contexts where the respondent agrees with the issue in question; equity, on the other hand, is more highly valued when the respondent disagrees with the issue. These findings have implications not only for the continuingpublic debate over campaign finance reform, but also for our understanding of how citizens make tradeoffs between competing democratic values.
There are things that everyone should know that our educational system doesnt cover well, if at all things such as what knowledge is, ethics, how we make decisions, money, property, government, international relations, financial industry regulation, energy, employment, education, drug use, immigration, the concept of community, and how to manage your money. The purpose of this book is to try to rectify this situation.
In the bitter air fighting over Western Europe during the last year of the war, no fewer than 37 pilots became aces flying Merlin-engined Spitfires, whilst 72 other aces increased their scores flying them. This book traces the achievements of the pilots flying the iconic Spitfire in Northwest Europe, and examines how the steady technological improvements that were made throughout the Spitfire's service life improved its capabilities in the air. Based at airfields throughout southern England, Merlin engine Spitfires provided the bulk of the air cover for the D-Day landings and it was an RCAF Spitfire which claimed the first ever ME 262 jet kill. 36 colour profiles covering a broad spectrum of nationalities, units, pilots, theatres and markings complement thorough research throughout this comprehensive account of these crucial fighter aircraft.
Featuring more than 1,200 illustrations, including over 800 in full color, this book presents a stepwise approach to the surgical management of the most challenging cases in diabetic limb salvage. The book covers acute and chronic diabetic foot and ankle wounds and guides surgical decision-making in different case scenarios, including prophylactic, elective, trauma, and revisional surgery. Emphasis is on the multidisciplinary team approach. Topics covered include surgical reconstruction of the acute and chronic Charcot foot and ankle; local random, muscle and pedicle flaps for soft tissue coverage of the diabetic foot; equinus deformity and the diabetic foot; surgical management of malunions and nonunions; and autogeneous bone grafting and orthobiologics.
Since the 1980's, market-based instruments for environmental policy have become increasingly important. Focusing on environmental taxation in practice, this volume collects key contributions on a wide range of topics, including comparisons of environmental taxation schemes in different countries, political economy issues and key aspects of concrete implementation. It presents a wealth of ex-ante and ex-post analyses, intended as a source of guidance for policy implementation and research. The volume features a full-length introduction locating the literature on environmental taxation in practice in a wider context of theoretical and applied issues.
Environmental epidemiology is the study of the environmental causes of disease in populations and how these risks vary in relation to intensity and duration of exposure and other factors like genetic susceptibility. As such, it is the basic science upon which governmental safety standards and compensation policies for environmental and occupational exposure are based. Profusely illustrated with examples from the epidemiologic literature on ionizing radiation and air pollution, this text provides a systematic treatment of the statistical challenges that arise in environmental health studies and the use epidemiologic data in formulating public policy, at a level suitable for graduate students and epidemiologic researchers. After a general overview of study design and statistical methods for epidemiology generally, the book goes on to address the problems that are unique to environmental health studies, special-purpose designs like two-phase case-control studies and countermatching, statistical methods for modeling exposure-time-response relationships, longitudinal and time-series studies, spatial and ecologic methods, exposure measurement error, interactions, and mechanistic models. It also discusses studies aimed at evaluating the public health benefits of interventions to improve the environment, the use of epidemiologic data to establish environmental safety standards and compensation policy, and concludes with emerging problems in reproductive epidemiology, natural and man-made disasters like global warming, and the global burden of environmentally caused disease. No other book provides such a broad perspective on the methodological challenges in this field at a level accessible to both epidemiologists and statisticians.
Nasal continuous positive airway pressure ventilation is the gold standard in the treatment of obstructive sleep apnea. Long-term compliance rates are about 60%. Therefore, several alternative treatment options are of special interest. Beside conservative therapies, various surgical concepts exist. The field of surgery for sleep disordered breathing has rapidly grown with new instrumentation and surgical techniques in the last 10 years. Surgeons in these fields have to attend scientific meetings, participate in workshops, and read the literature to stay up to date. In our sleep laboratories we conduct 30 polysomnographies each night. Each year, we perform almost 1,000 surgical procedures for sleep disordered breathing apart from numerous other conservative and apparative treatment modalities. Referring to our expe- ence and the present literature, we tried to give new information on surgical techniques in this second edition. The chapters are grouped in different anatomical fields of interest. We wanted to give general advice and specific new hints for the surgery of sleep disordered breathing so that the reader learns basic techniques followed by more advanced surgery. In addition to the illustrated surgical descriptions, the chapters contain informations about indications and contraindications of each surgical procedure and the postoperative care. Special interest has been dedicated to evidence-based medicine. So in each chapter, there is a table of references summarizing the effectiveness of the procedure and EBM grade.
Battle the growing arthritis epidemic by taking steps now. Arthritis is truly an epidemic: more than 40 million Americans currently have arthritis, it is the leading cause of disability among people age 65 and older, and the overall annual costs to society are figured to be more than 65 billion. While it is present in nearly everyone by age 70, the problem is growing as arthritis more commonly appears in people as young as their 30s. But there is good news -- while you can't cure arthritis, you can stave it off or manage it and dramatically improve your life. The New Science of Overcoming Arthritis offers a plan for anyone who wants to prevent or reverse their pain, discomfort, and limitations. It is the first book on arthritis that incorporates the latest research and treatment strategies for a disease that the vast majority of baby boomers will inevitably have to learn to live with. What's more, it provides younger generations with an easy-to-follow game plan for minimizing and even avoiding the more debilitating aspects of arthritis. It answers the most pressing questions, including: Why do we get arthritis? Which arthritis supplements are worthwhile? What are the best arthritis exercise and diet strategies? Which alternative therapies are sensible and safe? What is the latest science about stem cells and future therapies involving our genes and biology? Dr. Vangsness, a seasoned surgeon and team physician for USC Athletics, specializes in sports injuries and is a medical advisor on the cutting edge of arthritis research. He provides practical advice culled from his years working with star collegiate athletes, who are often on the front line in uncovering the best practices for dealing with injuries and the deterioration of the body's joints. While genetics play a large role in determining who will suffer from arthritis, and even how severely, there are strategies for staying active, pain-free, and healthy no matter who you are.
Admiral of the Fleet of the Soviet Union Sergei G. Gorshkov was the product of a tradition unlike those of his Western contemporaries. He had a unique background of revolution, civil war, world wars, and the forceful implementation of an all-controlling communist dictatorship. Out of this background of violence and overwhelming transformation came a man with a vivid appreciation of the role and value of navies, but with his own unique ideas about the kind of navy that the Soviet Union required and the role that navy should play in Soviet military and national strategy. Western naval observers have persisted in attempting to define Admiral Gorshkov in Western naval terms. Many of these observers have been baffled when they found that the man and his actions simply did not fit conventional narratives. This book lays out the tradition, background, experiences, and thinking of the man as they relate to the development of the Soviet Navy that Gorshkov commanded for almost three decades and that was able to directly challenge the maritime dominance of the United States—a traditional sea power. His influence persists to this day, as the Russian Navy that is at sea in the twenty-first century is, to a significant degree, based on the fleet that Admiral Gorshkov built.
This is the second edition of the third volume in the Monographs on Pathology of Laboratory Animals series. Since the first edition, new information has developed at a remarkable pace. Both editions propose standardized nomenclature that is being used internationally, gaining significant acceptance. The result is improved communications of pathologic data to regulatory agencies and in scientific publications worldwide. New information on the nature and variability of preneoplastic lesions in the liver of laboratory rodents is included in this edition. The book expands data on the accompanying changes in enzyme activity in affected liver cells. Spongiosis hepatis in the rat and its relation to spongiotic pericytoma are discussed thoroughly. Information on many other pathologic entities is brought up to date and new ones are added to this second edition, making it an even more useful and expanded reference text.
Offering today's most authoritative, comprehensive coverage of sleep disorders, Kryger's Principles and Practice of Sleep Medicine, 7th Edition, is a must-have resource for sleep medicine specialists, fellows, trainees, and technicians, as well as pulmonologists, neurologists, and other clinicians who see patients with sleep-related issues. It provides a solid understanding of underlying basic science as well as complete coverage of emerging advances in management and treatment for a widely diverse patient population. Evidence-based content, hundreds of full-color illustrations, and a wealth of additional resources online help you make well-informed clinical decisions and offer your patients the best possible care. - Contains new chapters on sleep in intersex and transgender individuals; sleep telemedicine and remote PAP adherence monitoring; and sleep and the menstrual cycle, as well as increased coverage of treatment and management of pediatric patients. - Includes expanded sections on pharmacology, sleep in individuals with other medical disorders, and methodology. - Discusses updated treatments for sleep apnea and advancements in CPAP therapy. - Offers access to 95 video clips online, including expert interviews and sleep study footage of various sleep disorders. - Meets the needs of practicing clinicians as well as those preparing for the sleep medicine fellowship examination or recertification exams, with more than 950 self-assessment questions, answers, and rationales online. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
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