This issue of Surgical Oncology Clinics of North America, edited by Thomas Weber, MD, is devoted to Genetic Testing in Surgical Oncology. Articles in this issue include: The Critical Importance of Timely Genetic Testing; Securing and Documenting Cancer Family History in the Age of the Electronic Medical Record; Cancer Family Registries: Vital Tools for Patient Management and Cancer Genetics Translational Research; The Genetics of Breast Cancer; The Genetics of Colorectal Cancer: HNPCC, FAP MYH, and Hamartomatous Syndromes Including Peutz-Jeghers and Jevenile Polyposis; Hereditary Gastric Cancer Syndromes; Hereditary Pancreatic Cancer Syndromes; Hereditary Melanoma: Genetics and Multidisciplinary Management; Multiple Endocrine Neoplasia: Genetics and Clinical Management; Sequence Variants of Uncertain Significance (VUS): What To Do When Genetic Testing Results Are Not Definitive; Confidentiality and the Risk of Genetic Discrimination: What Surgeons Need to Know; and A Certified Genetic Counselor: A Crucial Clinical Resource in the Management of Patients with Suspected Hereditary Solid Tumor Syndromes.
Horticultural Plant Breeding is a complete and comprehensive resource for the development of new cultivars or clones of horticultural crops. It covers the basic theories that underpin plant breeding and applies Mendelian, quantitative and population inheritance practices in smaller populations where the individual plant has high value. Specific traditional breeding methods are also covered, with an emphasis on how these methods are adapted for horticultural species. In addition, the integration of biotechnologies with traditional breeding methodologies is explored, with an emphasis on specific applications for fruits, vegetables and ornamental crop species. Presented in focused sections, Horticultural Plant Breeding addresses historical perspectives and context, and genetics as a critical foundation of plant breeding. It highlights treatments of the various components of breeding programs, such as breeding objectives, germplasm, population engineering, mating systems, enhanced selection methods, established breeding methods applicable to inbreeding and outcrossing situations, and post-breeding activities. - Provides a complete and comprehensive resource for those involved in the development of new cultivars or clones of horticultural crops - Guides readers to the most appropriate breeding strategy including potential integration of traditional and biotechnology strategies that will best achieve a cost-effective outcome - Will include access to 20 narrated slide sets to facilitate additional understanding
Appealing to a wide audience, this ground-breaking handbook takes an in-depth look at soccer match analysis, highlighting the latest in match analysis research and the innovative technologies now being used by professional soccer clubs around the world. Bridging the gap between research, theory and practice, these methods can be used by coaches, sport scientists and fitness coaches to assess and improve: styles of play, technical ability and physical fitness objective performance feedback to players the development of specific training routines use of available notation software, video analysis and manual systems understanding of current academic research in soccer notational analysis. This is the first book to focus exclusively on football, and is based on the authors' extensive experience in academic and professional match analysis.
Twenty-four years ago, Hellmut Fritzsche came to our laboratory to evaluate our work in amorphous materials. He came many times, sometimes bringing his violin to play with our youngest son, to talk, to help, to discover, and to teach. The times with him were always exciting and rewarding. There was a camaraderie in the early years that has continued and a friendship that has deepened among Iris and me and Hellmut, Sybille and their children. The vision that Hellmut Fritzsche shared with me, the many important contributions he made, the science that he helped so firmly to establish, the courage he showed in the time of our adversity, and the potential that he recognized put all of us in the amorphous field, not only his close friends and collaborators, in his debt. He helped make a science out of intuition, and played an important role not only in the experimental field but also in the basic theoretical aspects. It has been an honor to work with Hellmut through the years.
Since 1984, the year of the publication of its first edition, the famous “Blue Guide” has been the international reference for paediatricians and neuropaediatricians with regard to epileptic syndromes in infants, children and adolescents. This 6th edition reviews some of the most noteworthy developments in the field, particularly in epileptic syndromes, but also focuses on the genetic aspects of the syndromes and their development. Progress brought about by advances in neuroimaging is also discussed in addition to specific etiologies such as parasitic diseases and immune and autoimmune diseases. The different backgrounds of the contributors - coordinators and authors – ensure that the book’s longstanding reputation for objectivity and seriousness, built over almost 35 years, remain well-deserved. This book written by the current leading specialists is recognized worldwide as the international reference in epilepsy.
Thought provoking and original, Tennisology delves into the science, psychology, and history of the world’s most popular individual sport in search of the factors that truly influence successful on-court play. The findings will not only surprise you but also change the way you approach the game. Based on the latest research, statistics, and analysis, Tennisology provides fascinating insights and observations on development, conditioning, and performance: • How and when the skills of the game are best learned • Why pressure affects some players but not others • Whether observing others can improve individual play • Whether there is a link between player personality and style of play • How and why height influences serve velocity • Whether great players are born or developed You will also discover how to apply the laws of physics to improve accuracy and consistency of shots and serves; how to structure training to minimize fatigue in lengthy matches; and how technology has affected the way the game is played, officiated, and coached. From the historical roots of modern tennis to the physical attributes that define the game, Tennisology will captivate you and make you think. It is a must-read for passionate players, coaches, and fans alike.
In the last few years, a large number of books on microprocessors have appeared on the market. Most of them originated in the context of the 4-bit and the 8-bit microprocessors and their comparatively simple structure. However, the techno-logical development from 8-bit to 16-bit microprossors led to processor components with a substantially more complex structure and with an expanded functionality and also to an increase in the system architecture's complexity. This books takes this advancement into account. It examines 16-bit micro-processor systems and descrihes their structure, their behavior and their programming. The principles of computer or ganization are treated at the component level. This is done by means of a detailed examination of the characteristic functionali ty of microprocessors. Furthermore the interactions between hardware and software, that are typical of microprocessor technology, are introduced. Interfacing techniques are one of the focal points of these considerations. This puplication is organized as a textbook and is intended as a self-teaching course on 16-bit microprocessors for students of computer science and communications, design engineers and users in a wide variety of technical and scientific fields. Basic knowledge of boolean algebra is assumed. The choice of material is based on the 16-bit microprocessors that are currently available on the market; on the other hand, the presentation is not bound to anyone of these microprocessors.
This book is an outcome of the round table conference held in 1984 in Switzerland. It deals with decision of decentralization, structure of decentralized units, external power of decentralized unit, financial autonomy and decentralization and the protection of the basic rights.
Currently this is the book providing a thorough introduction and a unified theoretical basis for the interpretation of equilibrium transport processes in amorphous hydrogenated tetrahydrally coordinated semiconductors - a topic of great interest to physicists and material scientists (first devices for practical applications are already being manufactured). Most of the relevant literature is reviewed with particular emphasis on the approach developed by the authors. It explains most of the experimental data and allows the extraction of information about microscopic transport processes and parameters from equilibrium transport data. This work treats electronic transport in the mentioned type of semiconductors and in particular in a-Si:H and a-Ge:H. From elementary concepts the theory is developed towards higher degrees of completeness and sophistication. Further refinements for coping with the complexity of real systems are given. The comparison of theory with experiment is an important part of the book.
A novel book that argues that, contrary to received wisdom, some adverse selection in insurance markets is beneficial to society as a whole. It is for all those interested in public policy arguments about insurance and discrimination: policymakers, academics, actuaries, underwriters, disability activists, geneticists and other medical professionals.
The Washington Manual of Outpatient Internal Medicine is designed as a companion to the Manual of Medical Therapeutics, addressing the most common encounters in outpatient internal medicine - for example, hypertension and diabetes. Disorders treated in the ambulatory setting fall outside traditional internal medicine; therefore, chapters also cover dermatology, otolaryngology, neurology and psychiatry and ophthalmology. The 2nd edition includes a complete update of all chapters.
Wave Optics in Infrared Spectroscopy starts where conventional books about infrared spectroscopy end. Whereas the latter are based on the Bouguer-Beer-Lambert law, the cornerstones of this book are wave optics and dispersion theory. This gap between both levels of theory is bridged to allow a seamless transition from one to the other. Based on these foundations, the reader is able to choose which level of theory is adequate for the particular problem at hand. Advanced topics like 2D correlation analysis, chemometrics and strong coupling are introduced and viewed from a wave optics perspective. Spectral mixing rules are also considered to better understand spectra of heterogeneous samples. Finally, optical anisotropy is examined to allow a better understanding of spectral features due to orientation and orientational averaging. This discussion is based on a 4 x 4 matrix formalism, which is used not only to simulate and analyze complex materials, but also to understand vibrational circular dichroism from a (semi-) classical point of view. Wave Optics in Infrared Spectroscopy is written as a tool to reunite the fragmented field of infrared spectroscopy. It will appeal to chemists, physicists, and chemical/optical engineers. - Assists the reader (including those with less physical science backgrounds) in using more of the extensive benefits that infrared spectroscopy can provide by making them better aware and informed about the higher-level theory - Foundations of the book are built on wave optics and dispersion theory versus the Bouguer-Beer-Lambert law of conventional infrared spectroscopy literature - Limits of lower level of theory are explained in detail - Provides a thorough introduction to more sophisticated topics with a smooth transition from lower to higher-level theory
Managing a successful transition of the current energy supply system to less carbon emitting options, ensuring a safe and secure supply during the whole process and in the long term, is one of the largest challenges of our time. Various approaches and first implementations show that it is not only technological issue, but also a matter of societal acceptance and acceptability, considering basic ethic values of the society. The main foci of the book are, thus, to develop an understanding about the specific challenges of the scientific policy advice in the area, to explore typical current approaches for the analysis of future energy systems and to develop criteria for the quality assessment and guidelines for the improvement of such studies. The book provides assistance to the interpretation of existing studies and guidelines for setting up and carrying out new analyses as well as for communicating and applying the results. Thereby, it aims to support the involved actors such as the respective scientific experts and researchers as well as decision makers, energy suppliers, stakeholders and the interested public in designing procedures for a successful transition process. The study elaborates consistent interdisciplinary advice as contribution for realising a continuously safe and secure, long-term viable energy supply in spite of diverse interests, multi-level responsibilities, multi-dimensional processes, large uncertainties and lack of knowledge about future developments.
This volume of Progress in Heterocyclic Chemistry (PHC) is the eleventh annual review of the literature, covering the work published on most of the important heterocyclic ring systems during 1998, with inclusions of earlier materials as appropriate. In addition, this year there are three specialized reviews. Martine Demeunynck and Arnaud Tatibouët present recent chemistry of Tröger's Base in Chapter 1. Pedro Merino reviews the reactions of metalated heterocycles with carbonyl compounds in Chapter 2. John Joule summarizes the remarkable nucleophilic substitution chemistry on the indole five-membered ring in Chapter 3. The subsequent chapters deal with recent advances in the field of heterocyclic chemistry arranged by increasing ring size and with emphasis on synthesis and reactions. Due to the ever increasing amount of material to be surveyed, the authors were encouraged to provide selective and critical reviews of the more significant papers where space does not allow comprehensive coverage.
Organized on a combined basis of chronology and of structural and functional hierarchy, This comprehensive text describes all aspects of proteins--biosynthesis, evolution, dynamics, ligand binding, catalysis, and energy transduction--not just their structures. This edition (first was 1984) is thoroughly updated--especially in the area of protein biosynthesis--and features end-of-chapter exercises and problems, many of which require the student to consult the cited literature in order to obtain the answer. Annotation copyright by Book News, Inc., Portland, OR
Annotation The field of molecular biology has revolutionized the study of biology. The applications to medicine are enormous, ranging from diagnostic techniques for disease and genetic disorders, to drugs, to gene therapy. Focusing on the fundamentals of molecular biology and encompassing all aspects of the expression of genetic information, the Encyclopedia of Molecular Biology will become the first point of reference for both newcomers and established professionals in molecular biology needing to learn about any particular aspect of the field.
Fibrous Proteins will give an overview over some of the most important fibrous proteins including amyloids, collagens, fibrin, flagella, intermediate filaments, microtubules, silks concerning structure and function and possible applications as biomaterials.While our knowledge on globular proteins has been increasing over the past decades, fibrillar
From listing the steps involved in a sensory evaluation project to presenting advanced statistical methods, Sensory Evaluation Techniques, Fourth Edition covers all phases of sensory evaluation. Like its bestselling predecessors, this edition continues to detail all sensory tests currently in use, to promote the effective employment of these tests, and to describe major sensory evaluation practices. The expert authors have updated and added many areas in this informative guide. New to this edition are expanded chapters on qualitative and quantitative consumer research and the SpectrumTM method of descriptive sensory analysis that now contains full descriptive lexicons for numerous products, such as cheese, mayonnaise, spaghetti sauce, white bread, cookies, and toothpaste. Also new in this chapter is a set of revised flavor intensity scales for crispness, juiciness, and some common aromatics. The book now includes an overview of Thurstonian scaling that examines the decision processes employed by assessors during their evaluations of products. Another addition is a detailed discussion of data-relationship techniques, which link data from diverse sources that are collected on the same set of examples. With numerous examples and sample tests, Sensory Evaluation Techniques, Fourth Edition remains an essential resource that illustrates the development of sensory perception testing.
This new edition of a bestseller covers all phases of performing sensory evaluation studies, from listing the steps involved in a sensory evaluation project to presenting advanced statistical methods. Like its predecessors, Sensory Evaluation Techniques, Fifth Edition gives a clear and concise presentation of practical solutions, accepted methods,
Students, residents, and instructors swear by Andreoli and Carpenter’s Cecil Essentials of Medicine because it presents just the right amount of information, just the right way. Edited by the late Thomas E. Andreoli, MD as well as Ivor Benjamin, MD, Robert C. Griggs, MD, and Edward J. Wing, MD, it focuses on core principles and how they apply to patient care, covering everything you need to know to succeed on a medical rotation or residency. Masterful editing and a user-friendly full-color design make absorbing and retaining information as effortless as possible. New chapters on "Pre- and Post-Operative Care" and "Palliative Care," plus the integration of molecular biology and other new horizons in medicine, familiarize you with the most current clinical concepts. An expanded International Editorial Board provides increased input from respected practitioners worldwide. Excellent images and clinical photographs vividly illustrate the appearance and clinical features of disease. Masterful editing and a user-friendly full-color design make absorbing and retaining information as effortless as possible.
Vitamin C, also known for its role in fighting off the common cold, serves as the antioxidant vitamin. This vitamin helps the body form collagen, a protein that builds bone structure, bone cartilage and blood vessels. Another function of Vitamin C is its absorption of iron, which aids in bone maintenance for stronger bodies and cleaner teeth. This can be accomplished by keeping a well balanced diet and eating healthy. In addition, Vitamin C assists in fighting off cardiovascular disease as well. But not only does Vitamin C aid the human body. Researchers have studied the affects Vitamin C holds upon other living organisms, such as plant cells. This book dives into cutting edge research on Vitamin C and its many functions in the earth's natural environment.
Annotation The field of molecular biology has revolutionized the study of biology. The applications to medicine are enormous, ranging from diagnostic techniques for disease and genetic disorders, to drugs, to gene therapy. Focusing on the fundamentals of molecular biology and encompassing all aspects of the expression of genetic information, the Encyclopedia of Molecular Biology will become the first point of reference for both newcomers and established professionals in molecular biology needing to learn about any particular aspect of the field.
Nearly thirty years ago, in 1974, the volume on Angiotensin edited by Irvine H.Page and F. Merlin Bumpus expanded the Handbook of Experimental Pharmacology. Even after two decades the multiplicity of its actions appears not to have been fully discovered. To call attention to its many functions is one of the purposes of this book. This new edition of the volume on Angiotensin attempts to provide an updated account of the knowledge and findings accumulated since the complexity of angiotensin was so accurately recognized.
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