When it comes to detecting, diagnosing and treating women who have, or are suspected of having, ovarian cancer, there are significant opportunities for well-informed healthcare professionals to intervene in a meaningful way. 'Fast Facts: Ovarian Cancer' examines the areas that will have the biggest effect in clinical practice, including: • the evidence for and against screening • the valuable role of genetic testing in identifying at-risk women • if and when to operate • strategies to overcome platinum resistance • the impact of targeted therapies. From the tools that will help establish a swift diagnosis to the risks and benefits of palliative salvage surgery, this refreshingly readable resource captures the key knowledge that every busy healthcare professional needs in order to make better health decisions for patients with ovarian cancer. Contents: • Epidemiology and prevention • Pathophysiology and classification • Genetic testing • Diagnosis, staging and grading • Surgery • Chemotherapy • Recurrent ovarian cancer • Targeted therapies • Non-epithelial ovarian cancers • Follow-up and palliative surgery • Useful resources
The assessment, remediation, and redevelopment of manufactured gas plant (MGP) sites pose a significant technical and financial challenge to successor property owners, including municipalities and other public entities undertaking brownfields revitalization, and to their consulting environmental engineers. Due to the toxicity of many coal tar constituents, sites contaminated as a result of gasworks operations pose a significant threat to public health. This book will discuss the history of the manufactured gas industry in Massachusetts (the largest in the US), as well as the toxicity of gasworks waste products, technical challenges in the cleanup process, and the process for site cleanups.
Taking a comparative approach, Alan T. Wood traces the evolution of democracy from its origins in prehistoric times and describes democratic growth in thirteen Asian countries from Japan in East Asia to Pakistan in South Asia and examines key issues such as: * How does the democratic experience in Asia, in countries with unique and totalitarian political traditions, compare with democracies worldwide? * Is the aspiration to freedom universal or is it a product of western ideas and institutions?
Cellulose is not only a major constituent of wood and natural textile fibers. It also serves as a polymeric starting material for products used in many areas of industry and every-day-life. The handbook, written by leading experts in the field, is divided in two volumes: In the first volume general information on cellulose structure and properties is given as well as the principles of homogeneous and heterogenous cellulose reactions and degradation pathways. Analytical methods for the characterization of cellulose are also described. The second volume of the book covers synthetic routes to the various classes of cellulose derivatives. Structured according to the principles of organic chemistry the achievements of today's reaction theory are considered and supplemented by an extensive collection of working procedures. The third part deals with the latest developments and future trends in cellulose chemistry - from progress in cellulose processing to the supramolecular chemistry of new derivatives of cellulose. This extensive coverage makes the book a standard work for graduate students entering this fascinating field of research, but also chemists, biologists and engineers who are active in chemical processing of cellulose will find a wealth of information.
Hegemony, Discourse, and Political Strategy revisits a question that has long fascinated socialists, progressives, democrats, Greens, and Marxists – how do left-wing forces win at politics? Thirty-five years ago, Ernesto Laclau and Chantal Mouffe tackled this puzzle in ground-breaking fashion, by drawing on a signature blend of linguistics, Marxist theory, and poststructuralism that came to be known as post-Marxist Discourse Theory (PDT). This book takes up the legacy of Laclau and Mouffe, and elaborates PDT into a full-fledged theory of political strategy for the first time. It argues that post-Marxism provides the foundations for a form of discourse analysis that can explain how political strategies play out as well as why they fail or succeed. Its empirical potential to illuminate the dynamics of hegemonic struggles is demonstrated through a case study focusing on the contestation and politicization of EU trade policy in the European Parliament.
Diseases of the Spine and Spinal Cord reviews the full spectrum of disorders affecting this region including primary spinal tumors and metastases, infection, degenerative diseases, and trauma. Presenting an inter-disciplinary perspective, the book includes up-to-date information on therapy [including neurosurgical], new information on developmental disorders of the spine, and a definitive chapter on trauma, including information on biomechanics. A separate chapter on pain syndromes also is included.
Offering today's most authoritative, comprehensive coverage of sleep disorders, Kryger's Principles and Practice of Sleep Medicine, 7th Edition, is a must-have resource for sleep medicine specialists, fellows, trainees, and technicians, as well as pulmonologists, neurologists, and other clinicians who see patients with sleep-related issues. It provides a solid understanding of underlying basic science as well as complete coverage of emerging advances in management and treatment for a widely diverse patient population. Evidence-based content, hundreds of full-color illustrations, and a wealth of additional resources online help you make well-informed clinical decisions and offer your patients the best possible care. - Contains new chapters on sleep in intersex and transgender individuals; sleep telemedicine and remote PAP adherence monitoring; and sleep and the menstrual cycle, as well as increased coverage of treatment and management of pediatric patients. - Includes expanded sections on pharmacology, sleep in individuals with other medical disorders, and methodology. - Discusses updated treatments for sleep apnea and advancements in CPAP therapy. - Offers access to 95 video clips online, including expert interviews and sleep study footage of various sleep disorders. - Meets the needs of practicing clinicians as well as those preparing for the sleep medicine fellowship examination or recertification exams, with more than 950 self-assessment questions, answers, and rationales online. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
This analysis of the United States health care system reviews developments in organization and governance, health financing, health care provision, health reforms, and health system performance. The U.S. system has both considerable strengths and notable weaknesses. It has a large and well-trained health workforce, a wide range of high-quality medical specialists as well as secondary and tertiary institutions, a robust health sector research program, and, for selected services, among the best medical outcomes in the world. But it also suffers from incomplete coverage of its citizenry, health expenditure levels per person far exceeding all other countries, poor objective and subjective indicators of quality and outcomes, and an unequal distribution of resources and outcomes across the country and among different population groups. Because of the adoption of the Affordable Care Act in 2010, and subsequent revisions to it, the U.S. is facing a period of enormous change. There is a great need to improve coverage and improve equity, better ensure quality outcomes, and find ways to better control expenditures. Health Systems in Transition: USA provides an in-depth discussion of these issues and a thorough review of the U.S. health care system.
Increasingly our critical infrastructures are reliant on computers. We see examples of such infrastructures in several domains, including medical, power, telecommunications, and finance. Although automation has advantages, increased reliance on computers exposes our critical infrastructures to a wider variety and higher likelihood of accidental failures and malicious attacks. Disruption of services caused by such undesired events can have catastrophic effects, such as disruption of essential services and huge financial losses. The increased reliance of critical services on our cyberinfrastructure and the dire consequences of security breaches have highlighted the importance of information security. Authorization, security protocols, and software security are three central areas in security in which there have been significant advances in developing systematic foundations and analysis methods that work for practical systems. This book provides an introduction to this work, covering representative approaches, illustrated by examples, and providing pointers to additional work in the area. Table of Contents: Introduction / Foundations / Detecting Buffer Overruns Using Static Analysis / Analyzing Security Policies / Analyzing Security Protocols
An updated guide to the most current information available for determining how to use NMR spectroscopy to differentiate chiral compounds Differentiation of Chiral Compounds Using NMR Spectroscopy offers a thoroughly revised second edition to the essential volume that puts the focus on the chiral systems that are commercially available and have been widely vetted for use in NMR spectroscopy. The text covers a broad range of reagents that make it possible to determine the enantiomeric purity and assign the absolute configuration of many classes of compounds. Comprehensive in scope, the text describes the chiral NMR differentiating agents as derivatizing agents, solvating agents, metal-based reagents and liquid crystals and gels, and explains the range and types of compounds for which they can be used for analysis. New to this edition are the most recent findings in the field as well as the development of advanced NMR measurement techniques that allow for the simplification of complex spectra resulting in more readily identified enantiodifferentiation. This important resource: Includes the most recent coverage of a large range of compounds that can be analyzed using chiral NMR reagents Explores the use of chiral NMR reagents and explains their relationship to the stereochemistry of the analyzed molecules Offers the essential information needed to help decide which method is the best NMR method to apply to a class or molecules Contains experimental strategies for using the reagents that are likely to improve the quality of the results Differentiation of Chiral Compounds Using NMR Spectroscopy is a comprehensive guide designed for investigators planning to use NMR spectroscopy to determine enantiomeric purity or assign the absolute configuration of a compound.
A comprehensive overview of the use of NMR spectroscopy for chiral discrimination Discrimination of Chiral Compounds Using NMR Spectroscopy concisely covers the broad array of reagents that make it possible to determine the optical purity and assign the absolute configuration of many classes of compounds. It describes chiral NMR derivatizing agents, solvating agents, metal-based reagents, and liquid crystals and discusses the range and types of compounds for which they can be used for analysis. After an overview of chiral reagents and methodologies, this reference: * Includes comprehensive coverage of the chiral reagents that have been reported * Catalogs the range of compounds for which different reagents have been shown to be effective * Includes specialty categories such as liquid crystals, ionic liquids, and the formation of chiral aggregates from achiral building blocks that do not fit into the broader categories * Offers experimental strategies for using the reagents that are likely to improve the quality of the results This guide describes the various systems and their overall utility, but goes further to show the full scope of the field as a way of guiding investigations into the optimal chiral reagents for use in NMR spectroscopy. It's a practical reference for organic chemists in the pharmaceutical industry, academia, and other areas, NMR spectroscopists, and researchers involved in the isolation and structure determination of natural products.
Written by a field insider with more than 20 years of experience in the development and application of atomic spectroscopy instrumentation, the Practical Guide to ICP-MS offers key concepts and guidelines in a reader-friendly format that is superb for those with limited knowledge of the technique. This reference discusses the fundamental principles
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