Today all companies either source globally, sell globally, or compete with some company that does. This handbook provides a comprehensive understanding and assessment of the field of global logistics and supply chain management.
Robin campus in Schaumburg and the realization of Roosevelt as a metropolitan university, creating a vivid portrait of the educational context of large community colleges throughout the northwest suburbs, the development of a community advisory board that helped secure funds, and the improved morale of faculty and administration.
The major purpose of this book is to review the evidence supporting the concept that intrinsic cell survival programs can be activated by a variety of mildly noxious stimuli or pharmacologic agents to confer protection against the deleterious effects of ischemia/reperfusion (I/R). We begin with a discussion of the concept of hormesis (a term used most extensively in the toxicologic literature which refers to biphasic cellular responses that depend on concentration or intensity of a stimulus), review the seminal studies that led to the discovery of the cardioprotective effects of ischemic preconditioning, and outline its therapeutic potential (Chapter 1). This is followed by a summary of our current understanding of the mechanisms of I/R injury (Chapter 2), as this provides several points of intervention in limiting postischemic tissue injury that may be targeted by the adaptive programs invoked by conditioning stimuli. Chapters 3 and 4 focus on the mechanisms underlying ischemic pre-, post-, and remote conditioning, which establishes the mechanistic rationale for development of pharmacologic conditioning strategies that may mimic the remarkably powerful effects of ischemic conditioning (and are covered in Chapter 5). Lifestyle interventions, including exercise, caloric restriction, and consumption of alcoholic beverages and/or phytochemicals, that may induce hormetic responses will also be reviewed in this chapter. While the promise for conditioning as a therapeutic approach is enormous, there are obstacles to its practical application in patients, which are covered in Chapter 6. The final chapter (Chapter 7) examines the extension of our mechanistic understanding of the signaling pathways invoked by conditioning stimuli into the realm of gene therapy and to the preservation of stem cell viability in the harsh ischemic environment as natural translational outgrowths of preconditioning into therapeutics.
The Massachusetts General Hospital is widely respected as one of the world's premier psychiatric institutions. Now, preeminent authorities from MGH present the newly updated edition of Massachusetts General Hospital Comprehensive Clinical Psychiatry, a unique medical reference book that continues to simplify your access to the current clinical knowledge you need - both in print and online! It provides practical approaches to a wide variety of clinical syndromes and settings, aided by stunning graphics and hundreds of questions and answers geared to each chapter. You'll have convenient access to all the authoritative answers necessary to overcome any clinical challenge. User-friendly, highly templated organization with abundant boxed summaries, bulleted points, case histories, algorithms, references, and suggested readings. Peerless, hands-on advice from members of the esteemed MGH Department of Psychiatry helps you put today's best approaches to work for your patients. Interactive and downloadable Q&As for each chapter allow you to test your retention of the material covered. In-depth coverage of many unique areas, including Psychiatric and Substance Use Disorders in Transitioning Adolescents and Young Adults; Neuroanatomical Systems Relevant to Neuropsychiatric Disorders; Legal and Ethical Issues in Psychiatry; Military Psychiatry; and Approaches to Collaborative Care and Primary Care Psychiatry. Features full, new DSM-5 criteria; new art, tables, and key points; and new Alzheimer's Disease guidelines. Highlights recent developments in the field, such as neurotherapeutics, new psychotropics, military psychiatry, collaborative care, ensuring your knowledge is thoroughly up to date. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
Put today's best approaches to work for your patients with this practical guide to cutting-edge psychopharmacologic and somatic treatments for psychiatric and neurologic conditions. Comprised of key chapters from the second edition of Stern et al.'s Massachusetts General Hospital Comprehensive Clinical Psychiatry, this user-friendly resource focuses on current psychotropic treatments, electroconvulsive therapy, and neurotherapeutics, making it an ideal quick reference for psychiatrists, psychologists, internists, and nurse practitioners. - Stay current with hot topics in the field, including the use of antiepileptic drugs in psychiatry, ADHD medications, and often-overlooked areas such as treatment of pain. - Benefit from the authoritative content of the parent text, MGH Comprehensive Clinical Psychiatry, 2nd Edition, now featuring new art, new tables, and key points, and updated to DSM-5 where relevant. - Get detailed coverage of antidepressants, antipsychotics, and antianxiety medications, as well as drug interactions, side effects, and treatment adherence. - Quickly find the information you need with a user-friendly, highly templated format that features abundant boxed summaries, bulleted points, case histories, algorithms, references, and suggested readings. - Test your knowledge of psychopharmacology and neurotherapeutics with interactive, downloadable multiple-choice questions with detailed answers for each chapter.
Following three printings of the First Edition (1978), the publisher has asked for a Second Edition to bring the contents up to date. In doing so the authors aim to show how the newer microscopies are related to the older types with respect to theoretical resolving power (what you pay for) and resolution (what you get). The book is an introduction to students, technicians, technologists, and scientists in biology, medicine, science, and engineering. It should be useful in academic and industrial research, consulting, and forensics; how ever, the book is not intended to be encyclopedic. The authors are greatly indebted to the College of Textiles of North Carolina State University at Raleigh for support from the administration there for typing, word processing, stationery, mailing, drafting diagrams, and general assistance. We personally thank Joann Fish for word process ing, Teresa M. Langley and Grace Parnell for typing services, Mark Bowen for drawing graphs and diagrams, Chuck Gardner for photographic ser vices, Deepak Bhattavahalli for his work with the proofs, and all the other people who have given us their assistance. The authors wish to acknowledge the many valuable suggestions given by Eugene G. Rochow and the significant editorial contributions made by Elizabeth Cook Rochow.
Whether or not you've heard of PCBs (polychlorinated biphenyls), it's likely that this toxic chemical can be found in your cells. PCBs were invented in 1920 for the electronics industry, fueled the WWII military machine, then were put to domestic uses, and finally came to be present in every corner of the earth. Because PCBs were outlawed in 1976, most people think they are no longer a threat. However, like many industrial chemicals, PCBs persist in our environment and continue to accumulate in practically every life form on earth, becoming more concentrated in the tissues of those highest on the food chain--like us. In Biocidal, investigative journalist Ted Dracos explores the science behind how PCBs affect the environment, amphibians, fish, and mammals. He also draws on extensive research to document the connection between PCBs and catastrophic human illness. From the beginning--even as workers in the first manufacturing plants quickly began to suffer skin lesions, boils, liver failure, and death--the industry denied the danger of its chemicals and manipulated science, regulatory agencies, and the government to continue to make and distribute PCBs throughout the next half-century. Dracos provides the latest scientific findings in the heated controversy that surrounds the continued health impacts of PCBs, ranging from cancer to immunosupression, endocrine disruption, fetal brain development, reproductive abnormalities, and even autism. Yet Biocidal is optimistic, leaving readers with a complete and surprisingly uncomplicated blueprint of what can be done--and is being done--to counter the risks and damages of PCBs and other industrial chemicals.
The story of the National Cancer Institute's involvement in virus and cancer research is not wholly centered on research alone. Challenged with the goal of a cancer cure, the Institute always found itself on the verge of a discovery but never able to follow through. The Virus and Cancer Program was authorized by Congress in 1958 and ended in 1971 with the passage of the National Cancer Act.
Robin campus in Schaumburg and the realization of Roosevelt as a metropolitan university, creating a vivid portrait of the educational context of large community colleges throughout the northwest suburbs, the development of a community advisory board that helped secure funds, and the improved morale of faculty and administration.
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