Quantitative Molecular Pharmacology and Informatics in Drug Discovery Michael Lutz, Section Head, Cheminformatics Group and Terry Kenakin, Principal Research Scientist, Glaxo Wellcome Research and Development, Research Triangle Park, NC, USA Quantitative Molecular Pharmacology and Informatics in Drug Discovery combines pharmacology, genetics and statistics to provide a complete guide to the modern drug discovery process. The book discusses the pharmacology of drug testing and provides a detailed description of the statistical methods used to analyze the resulting data. Application of genetic and genomic tools for identification of biological targets is reviewed in the context of drug discovery projects. Covering both the theoretical principles upon which the techniques are based and the practicalities of drug discovery, this informative guide. * outlines in step-by-step detail the advantages and disadvantages of each technology and approach and links these to the type of chemical target being sought after in the drug discovery process; and, * provides excellent demonstrations of how to use powerful pharmacological and statistical tools to optimize high-throughput screening assays. Written by two internationally known and well-regarded experts, this book is an essential reference for research and development scientists working in the pharmaceutical and biotechnology industries. It will also be useful for postgraduates studying pharmacology and applied statistics.
Every Indiana Hoosiers fan has a bucket list of activities to take part in at some point in their lives. But even the most die-hard fans haven't done everything there is to experience in and around Bloomington, Indiana. From visiting the campus to copying Keith Smart's jump shot to win the 1987 national championship, author Terry Hutchens and Bill Murphy provide ideas, recommendations, and insider tips for must-see places and can't-miss activities near the Assembly Hall. But not every experience requires a trip to campus; long-distance Hoosiers fans can cross some items off their list from the comfort of their own homes. Whether you're attending every home game or supporting the Hoosiers from afar, there's something for every fan to do in The Indiana Hoosiers Fans' Bucket List.
Awarded first place in the 2019 AJN Book of the Year Awards in the Gerontologic Nursing category second place in the Advanced Practice Nursing category. Gain expert primary care of older adults with a case-based approach to geriatric primary care and multimorbidity management Written by two leading academic and clinical experts in geriatric primary care, Case Studies in Geriatric Primary Care and Multimorbidity Management, 1st Edition uses detailed Exemplar Case Studies and Practice case studies to teach you how to think like an expert geriatric clinician. Because most older adults have more than one condition when seeking care, both Exemplar and Practice Case Studies place a strong emphasis on "multimorbidity" management, (the management of patients with a host of complex, interacting conditions). To provide extensive practice in learning how to think like an expert, case studies reflect the reality that care does not necessarily begin or end in the primary care setting, cases move fluidly from primary care to acute care to inpatient rehabilitation to assisted living to long-term care. Building on foundational introductory chapters, cases also call on you to develop interprofessional collaboration skills and reflect the diversity of today's older adults, in terms of age (young-old to old-old), gender, culture, ethnicity, sexuality, socioeconomic status, and more! As you work through both basic-level and advanced Practice Case Studies, you can make extensive notes in the printed book and then go online to submit answers for grading and receive expert feedback for self-reflection. - NEW! Introductory unit on the core principles of caring for older adults gives you a strong foundation in the principles of geriatric primary care and multimorbidity management. - NEW! and UNIQUE! Exceptionally detailed, unfolding Exemplar Case Studies demonstrate how an expert advanced practitioner "thinks clinically" to provide care to older adults with multiple conditions. - NEW and UNIQUE! Exceptionally detailed, unfolding Practice Case Studies emphasize patient diversity and multimorbidity management across healthcare settings to help you develop advanced clinical reasoning skills for geriatric primary care. - NEW and UNIQUE! Strong emphasis on multimorbidity management focuses on caring for older adults with multiple chronic conditions. - NEW! Emphasis on the continuum of care across settings reflects the reality that care does not necessarily begin or end in the primary care setting but can move from primary care to acute care to inpatient rehabilitation to assisted living to long-term care, and so forth. - NEW! Online answer submission for grading and expert feedback for self-reflection. - NEW! Emphasis on patient diversity reflects the makeup of today's older adult, population in terms of age (young-old to old-old), gender, culture, ethnicity, sexuality, socioeconomic status, and more. - NEW! Emphasis on interprofessional collaboration use Exemplar Case Studies and Practice Case Studies to allow you to demonstrate your interprofessional collaboration skills.
Recent archaeological research on California includes a greater diversity of models and approaches to the region’s past, as older literature on the subject struggles to stay relevant. This comprehensive volume offers an in-depth look at the most recent theoretical and empirical developments in the field including key controversies relevant to the Golden State: coastal colonization, impacts of comets and drought cycles, systems of power, Polynesian contacts, and the role of indigenous peoples in the research process, among others. With a specific emphasis on those aspects of California’s past that resonate with the state’s modern cultural identity, the editors and contributors—all leading figures in California archaeology—seek a new understanding of the myth and mystique of the Golden State.
Updated with the latest DNA findings and a new foreword by Gregg Olsen! The definitive book on John Wayne Gacy, written by the prosecutor who spearheaded the investigation, arrest, and conviction of one of America's most horrific killers--now in trade paperback for the first time and with a new foreword by #1 New York Times bestselling author Gregg Olsen. The Real Story Of John Wayne Gacy-- By The Man Who Helped Catch Him He was a model citizen. A hospital volunteer. And one of the most sadistic serial killers of all time. But few people could see the cruel monster beneath the colorful clown makeup that John Gacy wore to entertain children in his Chicago suburb. Few could imagine what lay buried beneath his house of horrors--until a teenaged boy disappeared before Christmas in 1978, leading prosecutor Terry Sullivan on the greatest manhunt of his career. Reconstructing the investigation--from records of violence in Gacy's past and DNA evidence confirming the identities of additional victims, to the gruesome discovery of 29 corpses of abused boys in Gacy's crawlspace and four others found in the nearby river--Sullivan's shocking eyewitness account takes you where few true crime books ever go: inside the heart of a serial murder investigation and trial. This updated edition features new revelations, a foreword from bestselling author Gregg Olsen, and 16 pages of dramatic photos.
Written by and for Nurse Practitioners from a unique collaborative perspective, Primary Care: A Collaborative Practice, 4th Edition, prepares you to provide care for all of the major disorders of adults seen in the outpatient setting. Evidence-based content reflects the latest guidelines for primary care of hundreds of conditions, including hypertension, diabetes, and sexually transmitted infections. Now in full color, the 4th Edition includes chapters on emerging topics such as genetics, obesity, lifestyle management, and emergency preparedness. Combining a special blend of academic and clinical expertise, the author team provides a practical text/reference that promotes a truly collaborative primary care practice. Comprehensive, evidence-based content incorporates the latest standardized guidelines for primary care in today's fast-paced, collaborative environment. Unique! A collaborative perspective, reflecting the key roles of NPs, MDs, PAs, PharmDs, and others, promotes seamless continuity of care. A consistent format from chapter to chapters facilitates learning and clinical reference value. Diagnostics and Differential Diagnosis boxes provide a quick reference for diagnosing disorders and helping to develop effective management plans. Physician Consultation icons highlight situations or conditions in which consultation is either recommended or necessary. Emergency Referral icons identify signs and symptoms that indicate the need for immediate referral to an emergency facility. Co-management with Specialists discussions help you provide truly collaborative care in the outpatient setting. Complementary and alternative therapies are addressed where supported by solid research evidence.
Vivid and racy, a deep-dive into tabloids from their sixteenth-century beginnings to the National Inquirer and beyond. The Newsmongers unfolds the seedy history of tabloid journalism, from the first printed “Strange Newes” sheets of the sixteenth century to the sensationalism of today’s digital age. The narrative weaves from Regency gossip writers through New York’s “yellow journalism” battles to the “sex and sleaze” Sun of the 1970s; and from the Brexit-backing populism of the Daily Mail to the celebrity-obsessed Mail Online of the 2000s. Colorful figures such as Daniel Defoe, Lord Northcliffe, Joseph Pulitzer, William Randolph Hearst, Hugh Cudlipp, Rupert Murdoch, and Robert Maxwell are brought to vivid life. From scandalous confessions to the Leveson Inquiry into the behavior of the British press, the book explores journalists’ unscrupulous methods, taking in phone hacking, privacy breaches, and bribery. And now, in the digital era, The Newsmongers shows how popular journalism has succumbed to so-called churnalism while a certain royal is seeking revenge on the tabloids today.
White provides the most comprehensive scholarly compilation of fictional work of legal suspense in existence. Primarily a bibliography of novels, it also annotates plays, scripts for film and television, novelizations, and short-story collections about lawyers and the law. The idea behind the principal of selection is to disdain labels that reduce the variety of the legal thriller to a subgenre of mystery fiction. Novels that range from suspense thrillers through science fiction to the philosophical novel are included if justice is thematically important. It is therefore an eclectic reference source beyond a compilation of books about lawyers as protagonists. Its biographical and scholarly information about authors, major and minor, and their novels or works is traditionally encyclopedic and objective regardless of whether the work has been genre-defined, or worse—deified as a classic or denigrated as a bestseller. Many novels included are long out of print, but historically interesting for their contribution to the lineage of the courtroom drama, showing that the history of the legal thriller is one of the major branches of modern literature since the Age of Reason. The criterion of justice denoted moves beyond the fact of lawyers and courtrooms to select seminal novels like Robert Travers' Anatomy of a Murder as well as the romantic potboiler. Among the more than 2,000 works are the Perry Mason novels of Erle Stanley Gardner, John Mortimer's Rumpole series, along with a staple of fiction by major authors of the genre like John Lescroart, Lisa Scottoline, Margaret Maron, Scott Turow, and John Grisham. There are also individual works by Shakespeare, Goethe, Kafka, Camus, and Twain delineating humanity's obsession with the law as its shining prop of civilization and, alternative, béte-noire of the common individual caught up in its maw. The appendices include comments by lawyer-novelist Michael A. Kahn, a historical introduction to the legal thriller, craft notes by writers and prominent trial lawyers responding to author and lawyer questionnaires, bibliography of critical sources and articles, series characters, and the legal terminology found in courtroom dramas and novels. An essential reference tool for scholars, researchers as well as the occasional reader of legal thrillers.
Through the example of Baltimore, Maryland, David Taft Terry explores the historical importance of African American resistance to Jim Crow laws in the South’s largest cities. Terry also adds to our understanding of the underexplored historical period of the civil rights movement, prior to the 1960s. Baltimore, one of the South largest cities, was a crucible of segregationist laws and practices. In response, from the 1890s through the 1950s, African Americans there (like those in the South’s other major cities) shaped an evolving resistance to segregation across three themes. The first theme involved black southerners’ development of a counter-narrative to Jim Crow’s demeaning doctrines about them. Second, through participation in a national antisegregation agenda, urban South blacks nurtured a dynamic tension between their local branches of social justice organizations and national offices, so that southern blacks retained self-determination while expanding local resources for resistance. Third, with the rise of new antisegregation orthodoxies in the immediate post-World War II years, the urban South’s black leaders, citizens, and students and their allies worked ceaselessly to instigate confrontations between southern white transgressors and federal white enforcers. Along the way, African Americans worked to define equality for themselves and to gain the required power to demand it. They forged the protest traditions of an enduring black struggle for equality in the urban South. By 1960 that struggle had inspired a national civil rights movement.
2007 AJN Book of the Year Award Winner Now you can get back to the part of your job that matters most...caring for your patients! Primary Care: A Collaborative Practice, 3rd Edition is a focused and thorough primary care reference that covers a multitude of adult disorders and related issues. It presents disorders alphabetically so you can quickly find what you're looking for and it addresses disorders and issues not usually found in other primary care books — including barotrauma, rehabilitation, and domestic violence. Plus, each disorder is discussed from a primary care perspective, so you are given the information you need to treat your adult patients in a caring, cost-effective manner. Diagnostic and Differential Diagnosis Boxes aid in test selection and diagnosis. Includes easy-to-find special icons for Emergency and Physician Referral Boxes to indicate conditions that require immediate referral to a specialist or emergency room. Health Promotion Content in many sections highlight the importance of health teaching and health promotion in the care of patients. Management sections incorporate evidence-based recommendations including specialty organization guideline recommendations and current, ongoing research findings. Collaborative format recognizes the importance of comprehensive, cost-effective collaborative patient care. Features a 10-page, 4-color plate section with high-quality photos of physical findings. Thoroughly covers cardiac conditions and office emergencies, areas not usually discussed in detail in other primary care texts. Includes a new introductory unit concerning the business and practical aspects of nurse practitioner practice. New Collaboration in Research chapter contains information regarding the clinical partnership or collaboration with academic colleagues. New Population-Based Care chapter addresses the fact that health care systems are beginning to become more community focused. The role of the health care provider is expanding to provide programs that focus on community needs. New Chronic Disease Management Teams chapter provides current research-based information regarding a team-oriented approach to care of the patient with chronic health issues. New Reimbursement chapter addresses the financial issues facing the NP in private practice. New Infectious Diseases unit addresses the most current health care issues in primary care, including mutating infections and emerging infectious diseases.
This guide to the emerging language of creative industries field is a valuable resource for researchers and students alike. Concise, extensively referenced, and accessible, this this is an exceptionally useful reference work." - Gauti Sigthorsson, Greenwich University "There could be no better guides to the conceptual map of the creative industries than John Hartley and his colleagues, pioneers in the field. This book is a clear, comprehensive and accessible tool-kit of ideas, concepts, questions and discussions which will be invaluable to students and practitioners alike. Key Concepts in Creative Industries is set to become the corner stone of an expanding and exciting field of study" - Chris Barker, University of Wollongong Creativity is an attribute of individual people, but also a feature of organizations like firms, cultural institutions and social networks. In the knowledge economy of today, creativity is of increasing value, for developing, emergent and advanced countries, and for competing cities. This book is the first to present an organized study of the key concepts that underlie and motivate the field of creative industries. Written by a world-leading team of experts, it presents readers with compact accounts of the history of terms, the debates and tensions associated with their usage, and examples of how they apply to the creative industries around the world. Crisp and relevant, this is an invaluable text for students of the creative industries across a range of disciplines, especially media, communication, economics, sociology, creative and performing arts and regional studies.
The Civil War was the most traumatic event in American history, pitting Americans against one another, rending the national fabric, leaving death and devastation in its wake, and instilling an anger that has not entirely dissipated even to this day, 150 years later. This updated and expanded two-volume second edition of the Historical Dictionary of the Civil War relates the history of this war through a chronology, an introductory essay, an extensive bibliography, and hundreds of cross-referenced dictionary entries on persons, places, events, institutions, battles, and campaigns. This book is an excellent access point for students, researchers, and anyone wanting to know more about the Civil War.
Natives of the Motor City, "Detroit Free Press" columnist Sharp and "Detroit News" feature writer and morning radio talk-show host Foster take on the top Detroit sports debates of all time.
A&P may be complicated, but learning it doesn't have to be! Anatomy & Physiology, 11th Edition uses a clear, easy-to-read approach to tell the story of the human body's structure and function. Color-coded illustrations, case studies, and Clear View of the Human Body transparencies help you see the "Big Picture" of A&P. To jump-start learning, each unit begins by reviewing what you have already learned and previewing what you are about to learn. Short chapters simplify concepts with bite-size chunks of information. - Conversational, storytelling writing style breaks down information into brief chapters and chunks of information, making it easier to understand concepts. - 1,400 full-color photographs and drawings bring difficult A&P concepts to life and illustrate the most current scientific knowledge. - UNIQUE! Clear View of the Human Body transparencies allow you to peel back the layers of the body, with a 22-page, full-color insert showing the male and female human body along several planes. - The Big Picture and Cycle of Life sections in each chapter help you comprehend the interrelation of body systems and how the structure and function of these change in relation to age and development. - Interesting sidebars include boxed features such as Language of Science and Language of Medicine, Mechanisms of Disease, Health Matters, Diagnostic Study, FYI, Sport and Fitness, and Career Choices. - Learning features include outlines, key terms, and study hints at the start of each chapter. - Chapter summaries, review questions, and critical thinking questions help you consolidate learning after reading each chapter. - Quick Check questions in each chapter reinforce learning by prompting you to review what you have just read. - UNIQUE! Comprehensive glossary includes more terms than in similar textbooks, each with an easy pronunciation guide and simplified translation of word parts — essential features for learning to use scientific and medical terminology! - NEW! Updated content reflects more accurately the diverse spectrum of humanity. - NEW! Updated chapters include Homeostasis, Central Nervous System, Lymphatic System, Endocrine Regulation, Endocrine Glands, and Blood Vessels. - NEW! Additional and updated Connect It! articles on the Evolve website, called out in the text, help to illustrate, clarify, and apply concepts. - NEW! Seven guided 3-D learning modules are included for Anatomy & Physiology.
Discover the less-well-known side of Chicago and enjoy funky shops and eateries, truly unique museums and galleries, and obscure theater and music venues.
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