Taotao Tong's Books

Technology Standard of Pipe Jacking

By: Lu Wang,Zhiguo Wu,Yong Chen,Zhaoquan Wang,Chunwen Yan,Taotao Tong

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Technology Standard of Pipe Jacking

By: Lu Wang,Zhiguo Wu,Yong Chen,Zhaoquan Wang,Chunwen Yan,Taotao Tong

This book summarizes the technical method and construction process of pipe jacking. It has a total of 17 chapters and one appendix. It includes how to prepare the pipe jacking construction, how to choose the pipe and equipment for jacking, how to choose the engineering environment, how to do the geological survey before jacking, how to design the working pit, what's the procedure of pipe jacking, how to do the measurement and monitoring during jacking, how to do the treatment and acceptance after jacking, and so on. Appendix contains reference tables for pipe jacking archives, which might aid readers in understanding the book's content. This book's language is simple to read, and it has a wealth of graphics. Even those without a foundational understanding of pipe jacking could read and comprehend it with ease. This regulation could be the fundamental discipline for pipeline jacking projects. It is the important basis and criterion for the design, construction, management, inspection, and acceptance of pipeline jacking.

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Page Count

187

Publisher

Springer Nature

Published Date

ISBN 10

9819955971

ISBN 13

9789819955978

Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II)

Thiol “Switch-on” Fluorescent Probes, Thioredoxin Reductase Inhibitors and Endoplasmic Reticulum Targeting Agents

By: Taotao Zou

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Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II)

Thiol “Switch-on” Fluorescent Probes, Thioredoxin Reductase Inhibitors and Endoplasmic Reticulum Targeting Agents

By: Taotao Zou

This thesis focuses on the development of gold- and non-classical platinum-based anti-cancer agents that display distinctively different anti-cancer mechanisms compared to the commonly used cisplatin. These metal complexes contain N-heterocyclic carbene (NHC) ligands which are able to form strong M-C(NHC) bonds, conferring high stability and favorable lipophilicity, reactivity and binding specificity of metal complexes on biomolecules. The author demonstrates significant advances made in anti-cancer gold(III), gold(I) and platinum(II) complexes. Detailed chemical synthesis, in vitro and/or in vivo anti-cancer activities are clearly presented including: (i) a class of Au(III) complexes containing a highly fluorescent N^N^N ligand and NHC ligand that simultaneously act as fluorescent thiol “switch-on” probes and anti-cancer agents; (ii) a dinuclear gold(I) complex with a mixed diphosphine and bis(NHC) ligand displaying favorable stability and showing significant inhibition of tumor growth in two independent mice models with no observable side effects; and (iii) a panel of stable luminescent cyclometalated platinum(II) complexes exhibiting high specificity to localize to the endoplasmic reticulum (ER) domain, inducing ER stress and cell apoptosis. These works highlight the clinical potential that gold and platinum complexes offer for cancer treatment.

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Page Count

175

Publisher

Springer

Published Date

ISBN 10

9811006571

ISBN 13

9789811006579

Technology Standard of Pipe Jacking

By: Lu Wang,Zhiguo Wu,Yong Chen,Zhaoquan Wang,Chunwen Yan,Taotao Tong

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Technology Standard of Pipe Jacking

By: Lu Wang,Zhiguo Wu,Yong Chen,Zhaoquan Wang,Chunwen Yan,Taotao Tong

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

187

Publisher

Springer Nature

Published Date

ISBN 10

9819955971

ISBN 13

9789819955978

Book's by Taotao Tong

Technology Standard of Pipe Jacking

Technology Standard of Pipe Jacking

Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II)

Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II)

Technology Standard of Pipe Jacking

Technology Standard of Pipe Jacking

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