The field of Supramolecular Chemistry has rapidly evolved over the last 2 decades to the point where it is now influences a diverse range of research areas, drives technological breakthroughs, and often results in breathtaking feats of ingenuity along the way. None of these advancements would be possible without the creativity and talent of Supramolecular Chemists throughout the world, and this Research Topic aims to celebrate those scientists leading the way - the "Suprastars." Contributors to this collection were nominated by the Editorial Board of Frontiers in Chemistry, and by showcasing their work here, we aim to provide both a snapshot of the current field and also a glimpse what the next decade might hold. We welcome Original Research and Review articles, in themes including but not limited to: · Host-guest systems and host-guest interactions · Threaded molecules and slide-ring materials · Supramolecular polymers · Metallocycles and metallocages · Molecular machines and motors · Molecular sensors (chemosensors) · Nanoreactors and nanocarriers · Supramolecular catalysts · Metal-ligand assemblies · Self-assembly and directed self-assembly · Dynamic combinatorial chemistry · Foldamers · Biological supramolecular chemistry (including DNA and enzymes) · Experimental and theoretical aspects of bonding in supramolecular chemistry · Supramolecular chemistry at surfaces · Charged (anion and cation) and small molecule receptor chemistry · Developments in theoretical and practical aspects of supramolecular chemistry