In this book, the four leading experts on the ACE inhibitors donepezil, galantamine, and rivastigmine and the NMDA receptor antagonist memantine explain the practical pharmacology of these symptomatic drugs with the aim of providing a sound basis for their clinical use in patients with Alzheimer’s disease. In addition, an introductory chapter considers the basic theory of pharmacology for Alzheimer’s disease and the book closes with an overview of the ways in which symptomatic drugs for dementia are used. The wide acceptance of the amyloid cascade hypothesis has led to vigorous development of disease-modifying drugs for Alzheimer’s disease, such as amyloid vaccinations and gamma- or beta-secretase inhibitors. The failure of clinical trials of these drugs to yield satisfactory results has, however, meant that for the time being patients continue to be treated only with symptomatic drugs. There is accordingly a need to become more proficient in the use of symptomatic medicines, and it is against the background of this quest that Practical Pharmacology for Alzheimer’s Disease will be of wide interest.
This open access book offers both conceptual and empirical descriptions of how to "frame" sustainability challenges. It defines "framing" in the context of sustainability science as the process of identifying subjects, setting boundaries, and defining problems. The chapters are grouped into two sections: a conceptual section and a case section. The conceptual section introduces readers to theories and concepts that can be used to achieve multiple understandings of sustainability; in turn, the case section highlights different ways of comprehending sustainability for researchers, practitioners, and other stakeholders. The book offers diverse illustrations of what sustainability concepts entail, both conceptually and empirically, and will help readers become aware of the implicit framings in sustainability-related discourses. In the extant literature, sustainability challenges such as climate change, sustainable development, and rapid urbanization have largely been treated as "pre-set," fixed topics, while possible solutions have been discussed intensively. In contrast, this book examines the framings applied to the sustainability challenges themselves, and illustrates the road that led us to the current sustainability discourse. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.
“Exotic, entertaining . . . [an] exceptional first novel.”—San Francisco Chronicle The year is 1861. After two centuries of isolation, Japan has opened its doors to the West. And as foreign ships threaten to rain destruction on the Shogun’s castle in Edo, a small group of American missionaries has arrived to spread the word of their God. They have yet to realize that their future in Japan has already been foreseen. For a young nobleman has dreamt that his life will be saved by an outsider in the New Year. . . and it is said that Lord Genji has the gift of prophecy. What happens next—when the handsome lord meets an appa rently reformed gunslinger and a woman in flight from her own destructive beauty—sets the stage for a remarkable adventure. For as this unlikely band embarks on a journey through a landscape bristling with danger, East and West, flesh and spirit, past and future, collide in ways no one—least of all Genji—could have imagined. Praise for Cloud of Sparrows “The book seizes you from start to finish.”—The Washington Post “Adventure-filled.”—Entertainment Weekly “Rich . . . with an ambitious, unexpected ending that cuts deeper than a samurai sword.”—San Francisco Chronicle
“Exotic, entertaining . . . [an] exceptional first novel.”—San Francisco Chronicle The year is 1861. After two centuries of isolation, Japan has opened its doors to the West. And as foreign ships threaten to rain destruction on the Shogun’s castle in Edo, a small group of American missionaries has arrived to spread the word of their God. They have yet to realize that their future in Japan has already been foreseen. For a young nobleman has dreamt that his life will be saved by an outsider in the New Year. . . and it is said that Lord Genji has the gift of prophecy. What happens next—when the handsome lord meets an appa rently reformed gunslinger and a woman in flight from her own destructive beauty—sets the stage for a remarkable adventure. For as this unlikely band embarks on a journey through a landscape bristling with danger, East and West, flesh and spirit, past and future, collide in ways no one—least of all Genji—could have imagined. Praise for Cloud of Sparrows “The book seizes you from start to finish.”—The Washington Post “Adventure-filled.”—Entertainment Weekly “Rich . . . with an ambitious, unexpected ending that cuts deeper than a samurai sword.”—San Francisco Chronicle
This is an in-depth practical examination of the newly developed Lightweight Treated Soil Method, based on the extensive research and experience of two leading recognized experts. Indispensable to geotechnical and construction engineers or to researchers and professionals interested in coastal engineering techniques, geotechnical engineering or geomaterials, it comprises a full review of the lightweight treated soil method and its applications, along with numerous case-studies throughout Japan.
Race for Empire offers a profound and challenging reinterpretation of nationalism, racism, and wartime mobilization during the Asia-Pacific war. In parallel case studies—of Japanese Americans mobilized to serve in the United States Army and of Koreans recruited or drafted into the Japanese military—T. Fujitani examines the U.S. and Japanese empires as they struggled to manage racialized populations while waging total war. Fujitani probes governmental policies and analyzes representations of these soldiers—on film, in literature, and in archival documents—to reveal how characteristics of racism, nationalism, capitalism, gender politics, and the family changed on both sides. He demonstrates that the United States and Japan became increasingly alike over the course of the war, perhaps most tellingly in their common attempts to disavow racism even as they reproduced it in new ways and forms.
In the year 1311, in the highest tower of Cloud of Sparrows Castle, a beautiful woman sits by the window, watching as enemies gather below and fires spread through the night. As she calmly awaits her fate, she begins to write, carefully setting down on a scroll the secret history of the Okumichi clan…of the gift of prophecy they share and the extraordinary destiny that awaits them. For six centuries, these remarkable writings lay hidden—until they are uncovered by an American woman, a missionary named Emily Gibson, who arrived in Edo harbor in 1861, in flight from a tragic past. Soon an extraordinary man would enter her life: Lord Genji of the Okumichi clan, a nobleman with a gift of prophecy who must defend his embattled family—and confront forbidden feelings for an outsider in his midst. Emily, too, soon finds herself at a turning point; courted by two westerners, she knows her heart belongs to the one man she cannot have. But Emily has found a mission of her own: translating Genji’s ancestral history, losing herself in an epic tale of heroism and forbidden love. For here is the story of Lady Shizuka, the beautiful witch-princess who has enchanted Okumichi men for generations…of Genji’s ancestors, Lord Hironobu and Lord Kiyori, and of the terrible betrayals that befell them…and of Genji’s parents: a wastrel father and his child bride whose tragic love has shaped Genji as a leader and as a man. As Emily sifts through the fragile scrolls, she begins to see threads of her own life woven into the ancient writings. And as past and present collide, a hidden history comes to life, and with it a secret prophecy that has been shrouded for centuries, and may now finally be revealed. Takashi Matsuoka’s spellbinding novel is infused with spectacle, intricately woven, magically told. Autumn Bridge is a feast for the senses, a work of truly dazzling storytelling.
Scale and Scope is Alfred Chandler's first major work since his Pulitzer Prize-winning The Visible Hand. Representing ten years of research into the history of the managerial business system, this book concentrates on patterns of growth and competitiveness in the United States, Germany, and Great Britain, tracing the evolution of large firms into multinational giants and orienting the late twentieth century's most important developments. This edition includes the entire hardcover edition with the exception of the Appendix Tables.
The role of engineering communities in taking Japan from a defeated war machine into a peacetime technology leader. Naval, aeronautic, and mechanical engineers played a powerful part in the military buildup of Japan in the early and mid-twentieth century. They belonged to a militaristic regime and embraced the importance of their role in it. Takashi Nishiyama examines the impact of war and peace on technological transformation during the twentieth century. He is the first to study the paradoxical and transformative power of Japan’s defeat in World War II through the lens of engineering. Nishiyama asks: How did authorities select and prepare young men to be engineers? How did Japan develop curricula adequate to the task (and from whom did the country borrow)? Under what conditions? What did the engineers think of the planes they built to support Kamikaze suicide missions? But his study ultimately concerns the remarkable transition these trained engineers made after total defeat in 1945. How could the engineers of war machines so quickly turn to peaceful construction projects such as designing the equipment necessary to manufacture consumer products? Most important, they developed new high-speed rail services, including the Shinkansen Bullet Train. What does this change tell us not only about Japan at war and then in peacetime but also about the malleability of engineering cultures? Nishiyama aims to counterbalance prevalent Eurocentric/Americentric views in the history of technology. Engineering War and Peace in Modern Japan, 1868–1964 sets the historical experience of one country’s technological transformation in a larger international framework by studying sources in six different languages: Chinese, English, French, German, Japanese, and Spanish. The result is a fascinating read for those interested in technology, East Asia, and international studies. Nishiyama's work offers lessons to policymakers interested in how a country can recover successfully after defeat.
This is the first book to provide an in-depth presentation of photosensitive polyimides for electronic and photonic applications. The authors are leading specialists in this field from Japan, Europe and the U.S. From the Preface Aromatic polyimides were developed originally as thermostable flexible polymer films for space applications. Now polyimides have found widespread use in the manufacture of electronic devices and have been employed in increasingly diverse areas of electronics and information technology. In addition to their excellent thermal stability and high processability, a wide range of chemical and physical properties provided by molecular engineering makes polyimides highly versatile in the electronics and information industries. Lithography of polyimides is an inevitable process in using polyimides for microelectronic fields, and hence increasing research has been devoted to developing photosensitive polyimides, which make it unnecessary to use photoresists for patterning polyimides and diminishing markedly the number of steps in fabrication of various electronic devices. In addition, the development of technology of photosensitive polyimides is expected to play a great role in manufacturing photonic devices in the near future, when the design and control of hyper fine structures . . . including higher thermal stability and better processability would be essential.
Throughout the world 10 million tons of wood are used every year for paper-making, cellulose preparations, tobacco filters, cloth and dietary supplements. Wood is mainly composed of polysaccharides and lignin which are hydrophilic and hydrophobic respectively. This book describes the academic approaches to native bonds between lignin and the carbohhydrates in wood and other plants. The roles of lignin-carbohydrates complexes are discussed for practical use and wood processing. The authors describe the close relationship between lignin-carbohydrate complexes and biobleaching of kraft pulp, and the residual lignin in kraft pulp and their contribution to benzylated wood foaming. In addition they introduce the artificial lignin-carbohydrate bond formation and an enzymic degradation of lignin-carbohydrate bonds.
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