Takashi Daimon's Books

Dose-Finding Designs for Early-Phase Cancer Clinical Trials

A Brief Guidebook to Theory and Practice

By: Takashi Daimon,Akihiro Hirakawa,Shigeyuki Matsui

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Dose-Finding Designs for Early-Phase Cancer Clinical Trials

A Brief Guidebook to Theory and Practice

By: Takashi Daimon,Akihiro Hirakawa,Shigeyuki Matsui

This book provides a comprehensive introduction to statistical methods for designing early phase dose-finding clinical trials. It will serve as a textbook or handbook for graduate students and practitioners in biostatistics and clinical investigators who are involved in designing, conducting, monitoring, and analyzing dose-finding trials. The book will also provide an overview of advanced topics and discussions in this field for the benefit of researchers in biostatistics and statistical science. Beginning with backgrounds and fundamental notions on dose finding in early phase clinical trials, the book then provides traditional and recent dose-finding designs of phase I trials for, e.g., cytotoxic agents in oncology, to evaluate toxicity outcome. Included are rule-based and model-based designs, such as 3 + 3 designs, accelerated titration designs, toxicity probability interval designs, continual reassessment method and related designs, and escalation overdose control designs. This book also covers more complex and updated dose-finding designs of phase I-II and I/II trials for cytotoxic agents, and cytostatic agents, focusing on both toxicity and efficacy outcomes, such as designs with covariates and drug combinations, maximum tolerated dose-schedule finding designs, and so on.

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Page Count

146

Publisher

Springer

Published Date

ISBN 10

4431555854

ISBN 13

9784431555858

Modern Dose-Finding Designs for Cancer Phase I Trials: Drug Combinations and Molecularly Targeted Agents

By: Akihiro Hirakawa,Hiroyuki Sato,Takashi Daimon,Shigeyuki Matsui

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Modern Dose-Finding Designs for Cancer Phase I Trials: Drug Combinations and Molecularly Targeted Agents

By: Akihiro Hirakawa,Hiroyuki Sato,Takashi Daimon,Shigeyuki Matsui

This book deals with advanced methods for adaptive phase I dose-finding clinical trials for combination of two agents and molecularly targeted agents (MTAs) in oncology. It provides not only methodological aspects of the dose-finding methods, but also software implementations and practical considerations in applying these complex methods to real cancer clinical trials. Thus, the book aims to furnish researchers in biostatistics and statistical science with a good summary of recent developments of adaptive dose-finding methods as well as providing practitioners in biostatistics and clinical investigators with advanced materials for designing, conducting, monitoring, and analyzing adaptive dose-finding trials. The topics in the book are mainly related to cancer clinical trials, but many of those topics are potentially applicable or can be extended to trials for other diseases. The focus is mainly on model-based dose-finding methods for two kinds of phase I trials. One is clinical trials with combinations of two agents. Development of dose-finding methods for two-agent combination trials requires reasonable models that can adequately capture joint toxicity probabilities for two agents, taking into consideration possible interactions of the two agents on toxicity probability such as synergistic or antagonistic effects. Another is clinical trials for evaluating both efficacy and toxicity outcomes in single- and two-agent combination trials. These methods are often applied to the phase I trials including MTAs because the toxicity and efficacy for a MTA does not monotonically increase with dose, but the efficacy often increases initially with the dose and then plateaus. Successful software implementations for several dose-finding methods are introduced in the book, and their operating characteristics in practice are discussed. Recent advance of the adaptive dose-finding methods in drug developments are also provided.

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Page Count

100

Publisher

Springer

Published Date

ISBN 10

4431555730

ISBN 13

9784431555735

The Japanese Sake Bible

Everything You Need to Know About Great Sake (With Tasting Notes and Scores for Over 100 Top Brands)

By: Brian Ashcraft,Takashi Eguchi

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The Japanese Sake Bible

Everything You Need to Know About Great Sake (With Tasting Notes and Scores for Over 100 Top Brands)

By: Brian Ashcraft,Takashi Eguchi

**2021 Gourmand Cookbook Award Winner for Japan in Spirits and Other Drinks** The Japanese Sake Bible is the ultimate book about Japan's national drink--from its history, culture and production methods to how to choose the best sake and recommended food pairings. Author Brian Ashcraft--the author of the popular guide Japanese Whisky--has put together lively commentaries based on dozens of interviews with master brewers and sake experts across Japan. His fascinating stories are accompanied by over 300 full-color photographs, maps and drawings. A unique feature of this book is that it includes reviews, tasting notes, scores and a buying guide for over 100 of the leading sake brands, written by respected Japanese sake expert Takashi Eguchi. These include all the sakes most commonly found outside Japan. Each sake has a photo of the label, tasting notes, a score and recommended food pairings. Information on the leading brewers is provided, and the sakes are grouped by flavor profile. Japanese sake is brewed worldwide today and is winning over many converts. A foreword by sake connoisseur and world-renowned DJ Richie Hawtin addresses the spread in global popularity and the shared mission of making this specialty beverage as accessible as possible. With the help of this book you'll soon become an expert in selecting, serving and enjoying Japan's favorite drink.

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Page Count

441

Publisher

Tuttle Publishing

Published Date

ISBN 10

146292140X

ISBN 13

9781462921409

Dose-Finding Designs for Early-Phase Cancer Clinical Trials

A Brief Guidebook to Theory and Practice

By: Takashi Daimon,Akihiro Hirakawa,Shigeyuki Matsui

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Dose-Finding Designs for Early-Phase Cancer Clinical Trials

A Brief Guidebook to Theory and Practice

By: Takashi Daimon,Akihiro Hirakawa,Shigeyuki Matsui

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Page Count

146

Publisher

Springer

Published Date

ISBN 10

4431555854

ISBN 13

9784431555858

Modern Dose-Finding Designs for Cancer Phase I Trials: Drug Combinations and Molecularly Targeted Agents

By: Akihiro Hirakawa,Hiroyuki Sato,Takashi Daimon,Shigeyuki Matsui

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Modern Dose-Finding Designs for Cancer Phase I Trials: Drug Combinations and Molecularly Targeted Agents

By: Akihiro Hirakawa,Hiroyuki Sato,Takashi Daimon,Shigeyuki Matsui

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Page Count

100

Publisher

Springer

Published Date

ISBN 10

4431555730

ISBN 13

9784431555735

More Origami With Explanations: Fun With Folding And Math

By: Jeanine Meyer,Takashi Mukoda

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More Origami With Explanations: Fun With Folding And Math

By: Jeanine Meyer,Takashi Mukoda

Find out Origami with Explanations: Fun with Folding and MathOrigami, paper folding, originated hundreds of years ago in China and Japan, with independent discovery across the world. Today people do origami, create new models, share their work, and discover mathematical principles. This book continues the approach of Origami with Explanations; but is independent, with basic instructions repeated. Carefully written instructions, using photos and diagrams, will turn you into a successful folder and stimulate your own creativity. The models in this book include action models, money folds, beautiful and useful containers, and modular origami. Mathematics topics touched on include improving estimates, tessellations, mathematical induction, flat-foldability, and fold-and-cut. The Explanations section provide insight into the origami and introduce or re-introduce you to basic and advanced subjects in mathematics.

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Page Count

276

Publisher

World Scientific

Published Date

ISBN 10

9811219486

ISBN 13

9789811219481

Book's by Takashi Daimon

Dose-Finding Designs for Early-Phase Cancer Clinical Trials

Dose-Finding Designs for Early-Phase Cancer Clinical Trials

Modern Dose-Finding Designs for Cancer Phase I Trials: Drug Combinations and Molecularly Targeted Agents

Modern Dose-Finding Designs for Cancer Phase I Trials: Drug Combinations and Molecularly Targeted Agents

The Japanese Sake Bible

The Japanese Sake Bible

Dose-Finding Designs for Early-Phase Cancer Clinical Trials

Dose-Finding Designs for Early-Phase Cancer Clinical Trials

Modern Dose-Finding Designs for Cancer Phase I Trials: Drug Combinations and Molecularly Targeted Agents

Modern Dose-Finding Designs for Cancer Phase I Trials: Drug Combinations and Molecularly Targeted Agents

More Origami With Explanations: Fun With Folding And Math

More Origami With Explanations: Fun With Folding And Math

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