This authoritative textbook - the second volume of a comprehensive three-volume course on theoretical astrophysics - deals with stellar physics. Designed to help graduate students and researchers develop an understanding of the key physical processes governing stars and stellar systems, it teaches the fundamentals, and then builds on them to give the reader an in-depth understanding of advanced topics. The book's modular design allows the chapters to be approached individually, yet seamless transitions create a coherent and connected whole. It can be used alone or in conjunction with Volume I, which covers a wide range of astrophysical processes, and the forthcoming Volume III, on galaxies and cosmology. After reviewing the key observational results and nomenclature used in stellar astronomy, the book develops a solid understanding of central concepts including stellar structure and evolution, the physics of stellar remnants, pulsars, binary stars, the sun and planetary systems, interstellar medium and globular clusters. Throughout, the reader's comprehension is developed and tested with more than seventy-five exercises. This indispensable volume provides graduate students with a self-contained introduction to stellar physics, and will allow them to master the material sufficiently to read and engage in research with heightened understanding.
For several decades since its inception, Einstein's general theory of relativity stood somewhat aloof from the rest of physics. Paradoxically, the attributes which normally boost a physical theory - namely, its perfection as a theoreti cal framework and the extraordinary intellectual achievement underlying i- prevented the general theory from being assimilated in the mainstream of physics. It was as if theoreticians hesitated to tamper with something that is manifestly so beautiful. Happily, two developments in the 1970s have narrowed the gap. In 1974 Stephen Hawking arrived at the remarkable result that black holes radiate after all. And in the second half of the decade, particle physicists discovered that the only scenario for applying their grand unified theories was offered by the very early phase in the history of the Big Bang universe. In both cases, it was necessary to discuss the ideas of quantum field theory in the background of curved spacetime that is basic to general relativity. This is, however, only half the total story. If gravity is to be brought into the general fold of theoretical physics we have to know how to quantize it. To date this has proved a formidable task although most physicists would agree that, as in the case of grand unified theories, quantum gravity will have applications to cosmology, in the very early stages of the Big Bang universe. In fact, the present picture of the Big Bang universe necessarily forces us to think of quantum cosmology.
This volume provides comprehensive coverage of all aspects of cosmology and extragalactic astronomy at an advanced level. Beginning with an overview of the key observational results and necessary terminology, it goes on to cover important topics including the theory of galactic structure and galactic dynamics, structure formation, cosmic microwave background radiation, formation of luminous galaxies in the universe, intergalactic medium and active galactic nuclei. Topics are developed in a contemporary fashion, with emphasis on currently active research areas. This self-contained text has a modular structure, and contains over one hundred worked exercises. It can be used alone, or in conjunction with the previous two accompanying volumes (Volume I: Astrophysical Processes, and Volume II: Stars and Stellar Systems). The textbook develops all aspects of extragalactic astronomy and cosmology in a detailed and pedagogical way, and will be invaluable to researchers and graduate students of extragalactic astronomy, astrophysics and theoretical physics.
Covering all aspects of gravitation in a contemporary style, this advanced textbook is ideal for graduate students and researchers in all areas of theoretical physics. The 'Foundation' section develops the formalism in six chapters, and uses it in the next four chapters to discuss four key applications - spherical spacetimes, black holes, gravitational waves and cosmology. The six chapters in the 'Frontier' section describe cosmological perturbation theory, quantum fields in curved spacetime, and the Hamiltonian structure of general relativity, among several other advanced topics, some of which are covered in-depth for the first time in a textbook. The modular structure of the book allows different sections to be combined to suit a variety of courses. Over 200 exercises are included to test and develop the reader's understanding. There are also over 30 projects, which help readers make the transition from the book to their own original research.
An innovative textbook that provides a unique approach to beginning research in cosmology and high energy astrophysics through a series of problems and answers.
Revenue management (RM) has emerged as one of the most important new business practices in recent times. This book is the first comprehensive reference book to be published in the field of RM. It unifies the field, drawing from industry sources as well as relevant research from disparate disciplines, as well as documenting industry practices and implementation details. Successful hardcover version published in April 2004.
This book deals with an important class of many-body systems: those where the interaction potential decays slowly for large inter-particle distances; in particular, systems where the decay is slower than the inverse inter-particle distance raised to the dimension of the embedding space. Gravitational and Coulomb interactions are the most prominent examples, however it has become clear that long-range interactions are more common than previously thought. A satisfactory understanding of properties, generally considered as oddities only a couple of decades ago, has now been reached: ensemble inequivalence, negative specific heat, negative susceptibility, ergodicity breaking, out-of-equilibrium quasi-stationary-states, anomalous diffusion. The book, intended for Master and PhD students, tries to gradually acquaint the reader with the subject. The first two parts describe the theoretical and computational instruments needed to address the study of both equilibrium and dynamical properties of systems subject to long-range forces. The third part of the book is devoted to applications of such techniques to the most relevant examples of long-range systems.
The latest edition of this volume features an extensively revised and expanded collection of immunohematology and transfusion medicine case studies, comprised of clinical vignettes and antibody panels with questions following each case. Arranged in a workbook format, the text presents cases based on real patient problems and covers a number of common issues and challenging problems in blood banking and transfusion practice. Discussion and resolution of each case is provided in a separate answer section, including up-to-date information on pertinent advances in the field. This third edition updates information on existing case chapters and references and adds a variety of new case chapters. The enhanced title of this edition reflects upon the wider array of covered topics, including in-depth case studies of hemostasis and a second section with blood donation and cellular therapy topics. New features include a key to covered topics for each case and a case-difficulty rating scale. Written by experts in the field, Immunohematology, Transfusion Medicine, Hemostasis, and Cellular Therapy: A Case Study Approach, Third Edition is an interactive tool that makes blood banking and transfusion medicine memorable, practical, and relevant to residents, fellows, laboratory technologists, and anyone interested in gaining and updating their knowledge in the field
Examining a topic that has been the subject of more than 300 articles since it was first conceived nearly 20 years ago, this monograph describes for the first time in one volume the basic theory and multitude of applications in the study of differential subordinations.
The standard-setting text in oncology for 40 years, DeVita, Hellman and Rosenberg’s Cancer: Principles and Practice of Oncology, 12th Edition, provides authoritative guidance and strategies for managing every type of cancer by stage and presentation. Drs. Vincent T. DeVita, Jr., Theodore S. Lawrence, and Steven A. Rosenberg oversee an outstanding team of expert contributing authors who keep you up to date and fully informed in this fast-changing field. This award-winning reference is also continually updated on Health Library and VitalSource platforms for the life of the edition.
The landmark text that has guided generations of hematologists and related practitioners―updated with the latest research findings and improved format and presentation Long revered for its comprehensiveness and extraordinary depth of detail, Williams Hematology provides essential coverage of the origins, pathophysiological mechanisms, and management of benign and malignant disorders of blood and marrow cells and coagulation proteins. The text contains a wealth of basic science and translational pathophysiology for optimal, lifelong learning. Experts in research and clinical hematology, the editors are known worldwide for their contributions to the field. This new edition contains everything that has made Williams Hematology the go-to resource for decades and has been updated with new chapters and critical new research into the molecular mechanisms responsible for hematological disorders and the impact on diagnosis and treatment. And the new format enables you to access each chapter via content modules covering key topics, with summaries, infographics, and cases―all linked to review questions for self-assessment. The full-color presentation integrates images of blood and tissue findings where they are cited in the text. NEW TO THIS EDITION: Updated and revised content reflecting the latest research and developments Convenient format that streamlines the learning process and improves retention Additional chapters added on: Immune Checkpoint Inhibitors Immune Cell Therapy: Chimeric Antigen Receptor T Cell Therapy Immune Cell Therapy Dendritic Cell and Natural Killer Cell Therapy The processes of cell death and survival Application of Big Data and Deep Learning in Hematology Williams Hematology Cases with multiple-choice questions including detailed explanations—perfect preparation for the boards Continuously updated online content with comprehensive drug therapy database and other resources
DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology, 10th edition has garnered universal acclaim as the world’s definitive, standard-setting oncology reference. More than 400 respected luminaries explore today’s most effective strategies for managing every type of cancer by stage of presentation - discussing the role of all appropriate therapeutic modalities as well as combined-modality treatments. This multidisciplinary approach will help your cancer team collaboratively face the toughest clinical challenges and provide the best possible care for every cancer patient. Access the complete contents online or on your mobile device, with quarterly updates reflecting late-breaking developments in cancer care, free for the first year on LWW Health Library. Take full advantage of the latest advances with brand-new chapters on Hallmarks of Cancer, Molecular Methods in Cancer, Oncogenic Viruses, Cancer Screening, and new sections on Genetic testing and counseling for cancer, plus comprehensive updates throughout – including coverage of the newest biologic therapies. Make optimal, well-coordinated use of all appropriate therapies with balanced, multidisciplinary advice from a surgeon, a medical oncologist, and a radiation oncologist in each major treatment chapter. Review the latest molecular biology knowledge for each type of cancer and its implications for improved management. Make the best decisions on cancer screening and prevention, palliative care, supportive oncology, and quality-of-life issues
This work presents a comprehensive model of supply chain management. Experienced executives from 20 companies clearly define supply chain management, identifying those factors that contribute to its effective implementation. They provide practical guidelines on how companies can manage supply chains, addressing the role of all the traditional business functions in supply chain management and suggest how the adoption of a supply chain management approach can affect business strategy and corporate performance.
This book contains the expanded lecture notes of the 32nd Saas-Fee Advanced Course. The three contributions present the central themes in modern research on the cold universe, ranging from cold objects at large distances to the physics of dust in cold clouds.
The First volume gives an overview of the enzymes involved in DNA synthesis and modification; the second volume deals with the RNA-enzymes. Although the major emphasis of the book is on eukaryotic enzymes, a separate chapter dealing with prokaryotic DNA repair enzymes has been included to discuss the major advances in this field in recent years. There are two separate chapters on RNA polymerases to provide a comprehensive coverage of the enzymes from lower eukaryotes, plants and higher eukaryotes.
Microbial Diversity: Current Perspectives and Potential Applications is woven around the recent global perceptions of microbial diversity in its all embracing facets. Diversity perspectives are discussed in the context of ecosystem dynamics, taking into consideration environments that are rather unique to microorganisms. Considerable thrust is placed on the role that microorganisms play in sustainable production systems. Microbe-plant interaction arena is highlighted through the discussion of mycorrhizal partners, on which depends not only the plant community structure but also abatement of abiotic and biotic stresses. Other mutualist, rhizobia gets its due coverage whereas plant disease component carries examples from both, fungal and viral disease point of view. Considerable emphasis is placed on a discussion of the environmental issues such as the approaches that will lead to newer bioremediation technologies. No discussion of microbial diversity is complete without their implications in animal and human health. Discussed in this context are L-arginases in cancer therapy as also bioactives from cyanobacteria. Genomics and pathogenicity of two groups of viruses, viz., blue tongue and flaviviruses is highlighted whereas keratinophilic fungal forms are discussed in the context of dermatophytic infections. This volume also carries a fair number of articles on commercial microbiology.
Development economics is a branch of economics which largely deals with the economic aspects of the development process in developing countries with a focus on methods of promoting economic growth while also dealing "with the economic, social, political and institutional mechanisms, both public and private, necessary to bring about rapid...and large-scale improvements in levels of living for the peoples" living in developing countries. This new book presents the latest research in this growing field.
What have scientists learned about the causes of autism spectrum disorder (ASD)? Can parents do anything to prevent it? Why do different kids have such different symptoms, and what are the best ways to deal with them? Will there ever be a cure? From leading autism researchers Raphael Bernier, Geraldine Dawson, and Joel Nigg, this accessible guide helps parents put the latest advances to work for their unique child. From the impact of sleep, exercise, diet, and technology, to which type of professional help might be the right fit, the authors cover it all with expertise and compassion. Above all, they emphasize that current progress makes this an encouraging time for anyone who wants to help children and teens on the spectrum live to their fullest potential.
In order to understand how the brain works, it is essential to know WHAT is computed by different brain systems, and HOW those computations are performed. This is the aim of Brain Computations: What and How. Pioneering in its approach, this book will be of interest to all scientists interested in brain function and how the brain works
With the 13th edition, Wintrobe’s Clinical Hematology once again bridges the gap between the clinical practice of hematology and the basic foundations of science. Broken down into eight parts, this book provides readers with a comprehensive overview of: Laboratory Hematology, The Normal Hematologic System, Transfusion Medicine, Disorders of Red Cells, Hemostasis and Coagulation; Benign Disorders of Leukocytes, The Spleen and/or Immunoglobulins; Hematologic Malignancies, and Transplantation. Within these sections, there is a heavy focus on the morphological exam of the peripheral blood smear, bone marrow, lymph nodes, and other tissues. With the knowledge about gene therapy and immunotherapy expanding, new, up-to-date information about the process and application of these therapies is included. Likewise, the editors have completely revised material on stem cell transplantation in regards to both malignant and benign disorders, graft versus host disease, and the importance of long-term follow-up of transplantation survivors.
Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. Now updated online for the life of the edition, DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology, 11th Edition keeps you up to date in this fast-changing field. Every quarter, your eBook will be updated with late-breaking developments in oncology, including new drugs, clinical trials, and more.
A guide to "when to" and "what to" rather than "how to," this book provides evidence-based surgical reviews to provide credible answers to age-old surgical management questions. The management issues presented are oriented toward interventions and use evidence-based techniques to assess the safety and efficacy of new treatments and rehabilitative or preventative interventions. Each chapter is organized around the key questions essential to delineating the current status of evidence related to the subject reviewed. Publications from the past decade are cited that provide Level I and II evidence using the Oxford scale. Throughout Elective General Surgery, careful assessment of the validity of intervention studies and the strength of the evidence that they provide underlies the choices of cited publications. The information presented in this volume guides the scientific surgeon in providing state-of-the-art care and in optimizing the use of medical resources without losing sight of the need to address the unique needs of individual patients.
Taking the reader through the underlying principles of molecular translational dynamics, this book outlines the ways in which magnetic resonance, through the use of magnetic field gradients, can reveal those dynamics. The measurement of diffusion and flow, over different length and time scales, provides unique insight regarding fluid interactions with porous materials, as well as molecular organisation in soft matter and complex fluids. The book covers both time and frequency domain methodologies, as well as advances in scattering and diffraction methods, multidimensional exchange and correlation experiments and orientational correlation methods ideal for studying anisotropic environments. At the heart of these new methods resides the ubiquitous spin echo, a phenomenon whose discovery underpins nearly every major development in magnetic resonance methodology. Measuring molecular translational motion does not require high spectral resolution and so finds application in new NMR technologies concerned with 'outside the laboratory' applications, in geophysics and petroleum physics, in horticulture, in food technology, in security screening, and in environmental monitoring.
Inside the 3rd edition of this esteemed masterwork, hundreds of the most distinguished authorities from around the world provide today's best answers to every question that arises in your practice. They deliver in-depth guidance on new diagnostic approaches, operative technique, and treatment option, as well as cogent explanations of every new scientific concept and its clinical importance. With its new streamlined, more user-friendly, full-color format, this 3rd edition makes reference much faster, easier, and more versatile. More than ever, it's the source you need to efficiently and confidently overcome any clinical challenge you may face. Comprehensive, authoritative, and richly illustrated coverage of every scientific and clinical principle in ophthalmology ensures that you will always be able to find the guidance you need to diagnose and manage your patients' ocular problems and meet today's standards of care. Updates include completely new sections on "Refractive Surgery" and "Ethics and Professionalism"... an updated and expanded "Geneitcs" section... an updated "Retina" section featuring OCT imaging and new drug therapies for macular degeneration... and many other important new developments that affect your patient care. A streamlined format and a new, more user-friendly full-color design - with many at-a-glance summary tables, algorithms, boxes, diagrams, and thousands of phenomenal color illustrations - allows you to locate the assistance you need more rapidly than ever.
Although nuclear magnetic resonance is perhaps best known for its spectacular utility in medical tomography, its potential applicability to fields such as biology, materials science, and chemical physics is being increasingly recognized as laboratory NMR spectrometers are adapted to enable small scale imaging. This excellent introduction to the subject explores principles and common themes underlying two key variants of NMR microscopy, and provides many examples of their use. Methods discussed are not only important to fundamental biological and physical research, but have applications to a wide variety of industries, including those concerned with petrochemicals, polymers, biotechnology, food processing, and natural product processing. The wide range of scientists interested in NMR microscopy will want to own a copy of this book.
A Doody's Core Title for 2023! The #1 Textbook in Pharmacotherapy providing optimal patient outcomes using evidence-based medication therapies—updated with the latest advances and guidelines For more than 30 years, DiPiro’s Pharmacotherapy has been the essential textbook for learning how to properly select, administer, and monitor drugs―everything needed to provide safe, effective drug therapy across all therapeutic categories. This new edition has been fully updated with the latest evidence-based information and recommendations. With content from 300 expert contributors, this valuable resource offers detailed descriptions of common and uncommon disease states, including treatment by pharmacologic and non-pharmacologic means. Each disease chapter opens with a Patient Care Process, helping readers understand the collaborative care model in which pharmacists work and communicate with other healthcare providers for effective coordinated care. Here's why DiPiro's Pharmacotherapy: A Pathophysiologic Approach is the perfect learning tool for students, pharmacists, and other healthcare providers: All chapters provide the most current, reliable, and relevant information available Key concepts are included at the beginning of each chapter Clinical Presentation boxes concisely outline disease signs and symptoms New: Beyond the Book feature points readers to multimedia resources to deepen their understanding of the material Diagnostic flow diagrams, treatment algorithms, dosing guideline recommendations, and monitoring approaches clearly distinguish treatment pathways New: Drug monitoring tables have been added Patient care process boxes help readers know how to communicate with other health care providers New: Additional FREE E-Chapters are available on AccessPharmacy New: Over 2000 Review Questions to help prepare students!
Learn the essential principles of pharmacotherapy and how they apply to today’s healthcare Pharmacotherapy Principles & Practice, Third Edition uses a solid evidence-based approach to teach you how to design, implement, monitor, and evaluate medication therapy. This trusted text provides everything you need to gain an in-depth understanding of the principles essential optimal pharmacotherapy of disease. In order to be as clinically relevant as possible, the disease states and treatments discussed focus on disorders most often seen in clinical practice. Chapters were written or reviewed by pharmacists, nurse practitioners, physician assistants, and physicians who are authorities in their fields. The book opens with an introductory chapter followed by chapters on pediatrics, geriatrics, and palliative care. The remainder of the text consists of ninety-eight disease-based chapters that review etiology, epidemiology, pathophysiology, and clinical presentation, followed by therapeutic recommendations for drug selection, dosing, and patient monitoring.
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