Fully revised and updated, Essentials of Communication Sciences and Disorders, Second Edition is an accessible and engaging introductory resource for students new to communication sciences and disorders. This text covers basic information about speech disorders in both children and adults, while numerous case scenarios and personal stories paint a vivid picture of the profession. Important Notice: The digital edition of this book is missing some of the images or content found in the physical edition.
Thoroughly revised and updated, this Fourth Edition is the most comprehensive, current reference on lung cancer, with contributions from the world's foremost surgeons, radiation oncologists, medical oncologists, pulmonologists, and basic scientists. Coverage includes complete information on combined modality treatments for small cell and non-small cell lung cancer and on complications of treatment and management of metastases. Emphasis is also given to early detection, screening, prevention, and new imaging techniques. This edition has expanded thoracic oncology chapters including thymus, mesothelioma, and mediastinal tumors, more detailed discussion of targeted agents, and state-of-the-art information on newer techniques in radiotherapy. Other highlights include more international contributors and greater discussion of changes in lung cancer management in each region of the world. A new editor, Giorgio Scagliotti, MD from the University of Turin, has coordinated the accounts of European activities. A companion website includes the full text online and an image bank.
Selected from the world’s leading comprehensive cancer textbook, this tightly focused resource provides you with the practical, cutting-edge information you need to provide the best cancer care to each patient. Cancer of the Skin: From Cancer: Principles & Practice of Oncology, 10th Edition, offers a comprehensive and balanced view of this rapidly changing field, meeting the needs of oncology/hematology practitioners, fellows, and others who need an in-depth understanding of skin cancers. The print reference gives you the solid, dependable guidance you have come to expect from this outstanding title, and the Inkling version features new quarterly updates written by a team of experts selected by the authors. Delivers focused, comprehensive information on cancer of the skin drawn from the world’s leading cancer textbook, DeVita, Hellman, and Rosenberg’s Cancer: Principles & Practice of Oncology. Covers the full range of skin cancers, including nonmelanoma skin cancer, actinic keratosis, basal cell carcinoma, squamous cell carcinoma, angiosarcoma, microcystic adnexal carcinoma, and more; as well as cutaneous melanoma, including molecular biology; and genetic testing in skin cancer. Discusses in detail the growing importance of prevention and screening, giving you the understanding you need to improve your patients’ chances for a healthier, cancer-free life. Explains how the latest developments in biologic therapy applies to skin cancer. Provides exhaustive coverage of combined modality cancer treatment, helping you determine when and how to integrate modalities in patient treatment. Ensures that you are fully up to date thanks to easy, mobile access to quarterly updates.
Selected from the world’s leading comprehensive cancer textbook, this tightly focused resource provides you with the practical, cutting-edge information you need to provide the best cancer care to each patient. Colon and Other Gastrointestinal Cancers: Cancer: Principles & Practice of Oncology, 10th Edition, offers a comprehensive and balanced view of this rapidly changing field, meeting the needs of oncology practitioners, fellows, and others who need an in-depth understanding of colon and GI cancer. The print reference gives you the solid, dependable guidance you’ve come to expect from this outstanding title, and the Inkling version features new quarterly updates written by a team of experts selected by the authors.
Selected from the world’s leading comprehensive cancer textbook, this tightly focused resource provides you with the practical, cutting-edge information you need to provide the best cancer care to each patient. Cancer of the Breast: Cancer: Principles & Practice of Oncology, 10th Edition, offers a comprehensive and balanced view of this rapidly changing field, meeting the needs of oncology practitioners, fellows, and others who need an in-depth understanding of breast cancer. The print reference gives you the solid, dependable guidance you’ve come to expect from this outstanding title, and the Inkling version features new quarterly updates written by a team of experts selected by the authors.
Understand and apply the scientific advances that are revolutionizing cancer research and practice with Cancer: Principles and Practice of Oncology: Primer of the Molecular Biology of Cancer. Derived from DeVita, Hellman, and Rosenberg’s Cancer: Principles and Practice of Oncology – widely hailed as the definitive clinical reference in oncology – the second editon of this popular Primer focuses on the molecular biology information that is of critical importance to research scientists and clinical oncologists alike. Get up-to-date, dependable coverage of every important frontier in aspect of the molecular biology of cancer with contributions from a noteworthy roster of leading scientists and clinicians, featuring an updated version of the classic “Hallmarks of Cancer” by Hanahan and Weinberg See how molecular biology advances are impacting clinical practice with separate chapters on each of the 19 most common cancer types. Navigate the challenges and ethical dilemmas of cancer genetics with a thorough section chapters on genetic counseling and genetic testing.
DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology, 10th edition has garnered universal acclaim as the world’s definitive, standard-setting oncology reference. More than 400 respected luminaries explore today’s most effective strategies for managing every type of cancer by stage of presentation - discussing the role of all appropriate therapeutic modalities as well as combined-modality treatments. This multidisciplinary approach will help your cancer team collaboratively face the toughest clinical challenges and provide the best possible care for every cancer patient. Access the complete contents online or on your mobile device, with quarterly updates reflecting late-breaking developments in cancer care, free for the first year on LWW Health Library. Take full advantage of the latest advances with brand-new chapters on Hallmarks of Cancer, Molecular Methods in Cancer, Oncogenic Viruses, Cancer Screening, and new sections on Genetic testing and counseling for cancer, plus comprehensive updates throughout – including coverage of the newest biologic therapies. Make optimal, well-coordinated use of all appropriate therapies with balanced, multidisciplinary advice from a surgeon, a medical oncologist, and a radiation oncologist in each major treatment chapter. Review the latest molecular biology knowledge for each type of cancer and its implications for improved management. Make the best decisions on cancer screening and prevention, palliative care, supportive oncology, and quality-of-life issues
This title, first published in 1965, provides an analysis of the forces and mechanisms governing the formation of the overall level of money prices. Even though this problem has a long history, and in spite of its obvious practical importance, it remains one of the most poorly understood questions in economic theory. This title will be of interest to students of monetary economics and the history of economic thought.
Computations, Glassy Materials, Microgravity and Non-Destructive Testing is a compilation of the papers presented during the Third IUMRS International Conference on Advanced Materials International Union of The Materials Research Societies that discussed the concepts and methods behind glassy materials. The book is divided into parts. Part 1 tackles the progresses in sol-gel science and technology; the reaction mechanisms of ormosils and effects of ultrasonic irradiation; and the preparation of different glasses and their properties. Part 2 covers topics such as the neural network system for the identification of materials; the use of computers for simulations of many-body systems; computer system for meeting the supercomputing needs of materials; quality control of materials information by knowledge base; and the development of knowledgebase system for computer-assisted alloy design. Part 3 deals with the properties of different materials, the concepts, and the techniques behind them, and Part 4 discusses the non-destructive evaluation. The text is recommended for chemists and engineers in the field of materials science, especially those who wish to know more about the progress in its field of research.
Selected from the world’s leading comprehensive cancer textbook, this tightly focused resource provides you with the practical, cutting-edge information you need to provide the best cancer care to each patient. Prostate and Other Genitourinary Cancers: Cancer: Principles & Practice of Oncology, 10th Edition, offers a comprehensive and balanced view of this rapidly changing field, meeting the needs of oncology practitioners, fellows, and others who need an in-depth understanding of prostate and GU cancer. The print reference gives you the solid, dependable guidance you’ve come to expect from this outstanding title, and the Inkling version features new quarterly updates written by a team of experts selected by the authors.
The most readable, most comprehensive book in its field, Clinical Gynecologic Oncology, 9th Edition is the leading reference for diagnosis and treatment of gynecologic cancers – a must-have reference for improving outcomes and providing effective care. A "who’s who" list of contributing authors, under the editorial direction of Drs. Philip DiSaia and William Creasman, provides expert guidance on clinical presentations and management, now fully up to date with a brand-new design for faster, easier reference. Contains useful appendices covering staging, screening, nutritional therapy, toxicity criteria, blood component therapy, and radiation therapy. Covers hot topics such as multi-panel genetic testing, target therapies, sentinel node concept in endometrial cancer and vulvar cancer, and robotic surgery. Updates include new quick-reference features such as key point boxes with bulleted lists, highlighted key text, enhanced chapter outlines, and a brand-new design throughout. Includes up-to-date references and algorithms, making this text a comprehensive resource for clinical practice, personal study, and exam review. Helps you take advantage of the latest advances in early detection and improved treatment options for gynecologic cancers, especially uterine and cervical cancers.
Inorganic Geochemistry of Coal explains how to determine the concentrations and modes of occurrence of elements in coal, how to diminish adverse effects of toxic elements on the environment and human health, which elements in coal could be industrially utilized, and which elements can be successfully used as indications for deciphering depositional environments and tectonic evolution. As coal use will remain at an all-time high for the next several decades, there is a critical need for understanding the properties of this fuel to ensure efficient use, encourage its economic by-product potential, and to help minimize its negative technological, environmental and health impacts. - Features dozens of never-before published illustrations of critical features of the inorganic geochemistry of coal - Covers both the theory and applications of the topic, including case studies to serve as real-world examples - Includes a chapter on the health and environmental impacts of the mining, development and use of coal
This book, Bacteriophages in health and disease, is an effort to provide an introduction to the breadth of roles that phages play or can play in our everyday lives. To capture this variety of phage roles in human conditions, both natural and applied, the book is divided into three parts. A brief introduction to various concepts and terminology associated with phages is provided in chapter 1. Part I (chapters 2-6) considers the role of phages in the natural state. That is, where phages are, how they contribute directly to disease, the underlying mechanism by which phages do this, and how they can contribute indirectly to disease, that is, to pathogen evolution. Part II (chapters 7-11) considers various phage-based technologies other than the use of whole phages to combat bacterial infections (i.e. besides phage therapy). This includes in particular the use of both modified and 'disembodied' phage parts. Phages thus can serve as carriers and delivery vehicles of DNA and also of other chemicals, including serving as vectors for either gene therapy or DNA vaccines. Part III (chapters 12-17) covers phage-based antibacterial strategies. It includes chapters on: phage translocation, safety and immunomodulation; phage therapy of wounds and related purulent infections; phage therapy of non-wound infections; phage-based enzybiotics; and phage-based control of bacterial pathogens in food. The final chapter of this book is targeted to would-be phage therapy experimentalists, one that considers, in light of phage properties, how phage therapy protocols may be developed in terms of the use of animal models of bacterial disease.
**Selected for Doody's Core Titles® 2024 in Transplantation Surgery** From basic science to practical clinical tools, Chronic Kidney Disease, Dialysis, and Transplantation, 4th Edition provides you with the up-to-date, authoritative guidance you need to safely and effectively manage patients with chronic renal disease. Covering all relevant clinical management issues, this companion volume to Brenner and Rector's The Kidney presents the knowledge and expertise of renowned researchers and clinicians in the fields of hemodialysis, peritoneal dialysis, critical care nephrology, and transplantation – for an all-in-one, indispensable guide to every aspect of this fast-changing field. - Contains expanded content on economics and outcomes of treatment, as well as acute kidney injury. - Covers hot topics such as the genetic causes of chronic kidney disease, ethical challenges and palliative care, and home hemodialysis. - Discusses the latest advances in hypertensive kidney disease, vitamin D deficiency, diabetes management, transplantation, and more. - Provides a clear visual understanding of complex information with high-quality line drawings, photographs, and diagnostic and treatment algorithms. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. Now updated online for the life of the edition, DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology, 11th Edition keeps you up to date in this fast-changing field. Every quarter, your eBook will be updated with late-breaking developments in oncology, including new drugs, clinical trials, and more.
Step-by-step images, board-style review questions, and coverage of new blocks make this highly respected title a must-have reference for clinical practice. Written by Andrew T. Gray, MD, PhD, one of the pioneers of the use of ultrasound to guide needle placement, Atlas of Ultrasound-Guided Regional Anesthesia, 3rd Edition, shows you how to safely and effectively use the latest methods and applications of this technique. - Helps ensure correct needle placement with numerous 3-D and long-axis views that clearly depict surrounding structures. - Includes coverage of 11 new blocks: Adductor Canal, Posterior Femoral Cutaneous, Pectoral, Quadratus Lumborum, Pudendal, Paravertebral, Transversus thoracis, Supraorbital, Transtracheal, Greater Occipital and Lesser Occipital. - Features access to 20 author-narrated videos showing proper placement of needles using ultrasound guidance, including 11 new videos: Forearm (ulnar, median and radial), Ankle (tibial, saphenous, superficial peroneal, deep peroneal, sural), Paravertebral, Adductor Canal, and Catheters. - Presents several new chapters, including Regional Anesthesia in Resource-Constrained Environments and Safety of Ultrasound Guided Regional Blocks. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
Trends indicate that the metabolic syndrome will become the leading risk factor for heart disease. Now more than ever you need an all-in-one reference that provides the tools and practical advice you need to: Identify at-risk patients Explain individual contributing factors Aid in patient education and motivation Direct comprehensive care and Choose the most appropriate interventions Comprehensively revised to reflect leading-edge research and now organized to facilitate easy access to essential information and clinically-relevant guidance, Metabolic Syndrome and Cardiovascular Disease, 2e offers this and more. Not only will you receive a solid understanding of the pathophysiology underlying the metabolic syndrome and cardiovascular disease but also the rationale for today’s most effective treatments. What’s new? Filled with timely new content, this updated edition covers: New discoveries that have changed our understanding of the pathogenesis and interrelationship of metabolic syndrome, cardiovascular disease (CHD), and type 2 diabetes mellitus (DM) The relevance of mitochondria and telomeres Sleep and its impact on cardiometabolic health The pivotal interplay between insulin and forkhead transcriptionfactors Calorie restriction research Bariatric surgery experiences and outcomes In addition, each chapter includes essential information on comorbidities, interventions, and pharmacotherapeutic options – an exclusive feature found only in the second edition!
In this age of terrorism, world and national security as well as policing the streets of our country have become an increasingly important objective. This book brings together international experts on stress, resiliency and performance. These experts draw on the latest research with military and police personnel to provide an integrated perspective on the psychological pressures involved in this type of work, as well as practical recommendations on how to optimize human performance in security operations. This book examines the research and practical applications to the field of security opera.
This volume surveys the chemistry and cancer-causing properties of the polycyclic hydrocarbons benzo[a]pyrene and benzo[e]pyrene. Benzo[a]pyrene is a pollutant formed whenever organic matter is burnt: it occurs in soot, tar, cigarette smoke and automobile exhaust, and in small amounts in the atmosphere, in water and in soil. It produces cancer in small mammals and is probably also carcinogenic in humans. It has been widely studied both as a measure of industrial pollution and as a model compound in studies of the mechanism of induction of cancer. Information about the compound is scattered through the scientific literature in various journals, conference proceedings and other publications; this book is the first to gather all this information together for easy reference. It includes chapters on the synthesis, physical and chemical properties of benzopyrene, its metabolism, interaction with DNA and induction of mutation and cancer, and also its environmental occurrence and analysis. There are copious references to the original literature. The volume will provide a valuable source of reference for: cancer reseach scientists; environmental scientists working in the area of pollution monitoring, public health, industrial safety, food and drugs; chemists and biochemists.
With the 13th edition, Wintrobe’s Clinical Hematology once again bridges the gap between the clinical practice of hematology and the basic foundations of science. Broken down into eight parts, this book provides readers with a comprehensive overview of: Laboratory Hematology, The Normal Hematologic System, Transfusion Medicine, Disorders of Red Cells, Hemostasis and Coagulation; Benign Disorders of Leukocytes, The Spleen and/or Immunoglobulins; Hematologic Malignancies, and Transplantation. Within these sections, there is a heavy focus on the morphological exam of the peripheral blood smear, bone marrow, lymph nodes, and other tissues. With the knowledge about gene therapy and immunotherapy expanding, new, up-to-date information about the process and application of these therapies is included. Likewise, the editors have completely revised material on stem cell transplantation in regards to both malignant and benign disorders, graft versus host disease, and the importance of long-term follow-up of transplantation survivors.
The role of molecular genetics in the treatment of malignancy continues to grow at an astonishing rate. Today’s subspecialized multidisciplinary approach to oncology has incorporated advances in targeted molecular therapy, prognosis, risk assessment, and prevention—all based at least in part on molecular diagnostics and imaging. Inside this cutting-edge resource, readers will explore broad, comprehensive perspectives on the current trends in molecular diagnosis of cancer and personalized cancer medicine. Authoritative discussions share insights from noted experts in cancer research, clinical trials, molecular diagnostics, personalized therapy, bioinformatics, and federal regulations. From the basic mechanisms of carcinogenesis to the most advanced molecular screening, staging, and treatment technologies, readers will discover clear and straightforward discussions directly relevant to patient diagnosis and care.
This book represents a classic compilation of current knowledge about mouse development and its correlates to research in cell biology, molecular biology, genetics, and neuroscience. Emphasis is placed on the research strategy, experimental design, and critical analysis of the data, disguishing this from other books that only focus on protocols for mouse developmental research. Selected chapters are indexed to electronic databases such as GeneBank, GenBank, Electronic Mouse Atlas, and Transgenic/Knockout, further increasing the utility of this book as a reference.*Broad-based overview of mouse development from fundamental to specialist levels*Extensive coverage of a wide range of developmental mutations of the mouse*Excellent benchmark illustrations of brain, craniofacial, gut and heart development*In-depth experiment-based assessment of concepts in mammalian development*Focus on models of specific relevance to human development*Comprehensive reference to key literature and electronic databases related to mouse development*High-quality full-color production
Zeitlin's study centers on the seventeenth century, one of the most interesting and creative periods of Chinese literature and politically one of the most traumatic, witnessing the overthrow of the Ming, the Manchu conquest, and the subsequent founding of the Qing. Drawing on fiction, drama, poetry, medical cases, and visual culture, the author departs from more traditional literary studies, which tend to focus on a single genre or author. Ranging widely across disciplines, she integrates detailed analyses of great literary works with insights drawn from the history of medicine, art history, comparative literature, anthropology, religion, and performance studies. The Phantom Heroine probes the complex literary and cultural roots of the Chinese ghost tradition. Zeitlin is the first to address its most remarkable feature: the phenomenon of verse attributed to phantom writers - that is, authors actually reputed to be spirits of the deceased. This book should appeal to readers interested in Chinese studies, gender studies, comparative literature, performance studies, the history of religion, and of course, ghost stories and the occult
Accurate clinical observations are fundamental to competent and safe healthcare practice. The Biological Basis of Clinical Observations gives readers the understanding needed to perform clinical observations accurately, make accurate judgements about the patient’s condition and make accurate decisions concerning patient care. This useful textbook integrates clear explanations of the techniques involved in making clinical observations, alongside the biological knowledge which gives them meaning. For each topic, it explains the pathological basis for variations in observed results, focusing on relevant anatomy and physiology, genetics and pharmacology, and the basic principles of care. In addition to new chapters on blood tests and pregnancy, the text has been updated throughout. It now incorporates increased coverage of paediatrics, movement and the musculo-skeletal system, the lymphatic system, pregnancy, diabetes, homeostasis and infection, among other areas. Topics discussed include: temperature cardiovascular observations respiratory observations urinary and bowel observations neurological observations nutrition fluid balance skin drug side effects, interactions and allergies. The Biological Basis of Clinical Observations is a unique text which integrates explanations of essential procedures with the biological knowledge that underpins practice. It is essential reading for all nursing and health students preparing for clinical practice.
In a field where even experts may find that years have elapsed since they last encountered a child with a given disorder, it is essential for the clinician to have a comprehensive source of practical and highly illustrated information covering the whole spectrum of metabolic disease to refer to. The second edition of this highly regarded book, authored by three of the foremost authorities in pediatric metabolic medicine, fulfils this need by providing an invaluable insight into the problems associated with metabolic diseases. For ease of reference, Atlas of Metabolic Disease is divided into sections of related disorders, such as disorders of amino acid metabolism, lipid storage disorders and mitochondrial diseases, with an introductory outline where appropriate summarizing the biochemical features and general management issues. Within sections each chapter deals with an individual disease, starting with a useful summary of major phenotypic expression and including clear and helpful biochemical pathways, identifying for the reader exactly where the defect is occurring. Throughout the book, plentiful photographs, often showing extremely rare disorders, are an invaluable aid to diagnosis.
The critical drug information you need for clinical practice and board preparation—in one, convenient portable guide Pharmacotherapy Handbook delivers both the key points pharmacists needs to know in practice and the information students studying for the boards needs to pass. The Handbook delivers the essential information you need to confidently make drug therapy decisions for more than 140 diseases and disorders most commonly encountered in a clinical setting. Whether you’re a student, pharmacist, or hospital administrator, you’ll find answers quickly and easily in this reliable, carry-anywhere guide. Featuring a convenient alphabetized presentation, the book utilizes text, tables, figures, and treatment algorithms to make important drug data readily accessible and easily understandable. This updated eleventh edition includes new chapters on the pharmacists’ patient care process, opioid use disorder, and superficial fungal infections. Each chapter is organized in a consistent format: Disease state definition Pathophysiology Clinical presentation Diagnosis Treatment Evaluation of therapeutic outcomes Nine appendices include Pediatric Pharmacotherapy, Geriatric Assessment, Critical Care Patient Assessment, Drug Allergies, Drug-Induced Hematologic Disorders, Drug-Induced Liver Disease, Drug-Induced Pulmonary Disease, Drug-Induced Kidney Disease, and Drug-Induced Ophthalmic Disorders
Textbook of Pediatric Rheumatology examines the full spectrum of rheumatologic diseases and non-rheumatologic musculoskeletal disorders in children and adolescents, detailing the presentation, differential diagnosis, course, management, and prognosis of every major condition. Drs. James T. Cassidy, Ross E. Petty, Ronald M. Laxer, and Carol B. Lindsley discuss recent developments in diagnosis, treatment, genetics, immunology, imaging, and more. Diagnose and treat effectively through exhaustive reviews of the complex symptoms and signs and lab abnormalities that characterize these clinical disorders. Choose treatment protocols based on the best scientific evidence available today. Apply the knowledge and experience of the leading experts in the field. Keep current with coverage of new topics including macrophage activation syndrome, pediatric sarcoidosis, uveitis, imaging, and occupational and physical therapy. Tap into detailed discussions of recent advances in the field, new research on the immunologic mechanisms of inflammatory disease, and new developments on biologic treatments for arthritis in ten new chapters. Master complex concepts and key techniques with a full-color design and full-color illustrations.
Using a horizontal format, which allows for exhaustive cross-referencing, this title features over 500,000 lines of code listed and numbered sequentially and corresponding to the commentary in the second part of the book. The CD-ROM features the code plus software that allows users to search for specific features.
Atrophy of gonadotrophin producing cells Exogenously LH synthesis administered androgens and release or anabolic steroids are decreased Prostate Testes Normal function. Testosterone synthesis in The deficit of endogenously Leydig cells is decreased. The synthesized testosterone is exogenously administered compensated for by the steroid is not able to exogenously administered compensate for the deficit of steroid endogenously synthesized testosterone Figure 2 Intratesticular and serum testosterone concentrations after treatment with andro gens or anabolic steroids in order to substitute for the peripheral androgen deficiency and to achieve azoospermia. Because this steroid is alkylated in position 17, toxic effects on liver function can not be excluded. Danazol offers no advantages as compared with other anabolic steroids; rather, disadvantages. Numerous experiments of this type have been performed during the last 40 or 50 years. The outcome in each case was more or less identical: with a certain dose of an androgen or anabolic steroid it is possible to inhibit spermatogenesis without interfering with other androgen-dependent func tions, including libido (potentia coeundi) and accessory sexual glands. On the basis of this pharmacological-endocrinological background, androgens and anabolic steroids can be used for male fertility control, and several clinical trials have been performed during the last 10-15 years. Some of 1 these studies 2-23 are mentioned in Table 2.
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