In October 2017, Nobel laureate Sydney Brenner (Physiology or Medicine, 2002) gave four lectures on the history of Molecular Biology, its impact on Neuroscience and the great scientific questions that lie ahead.Sydney Brenner has been at the centre of the development of molecular biology, being a key player in shaping the Laboratory for Molecular Biology in Cambridge into a cradle of research, where pioneering and seminal discoveries in the field for over half a century have resulted in more than half a dozen Nobel Prizes.His memory is a treasure trove of the history of the field with innumerable anecdotes on other leading scientists in the past 60 years. These lectures trace the history and recount some of those anecdotes. His interlocutor Terry Sejnowski is the Francis Crick professor at the Salk Institute for Biological Studies and the Laboratory Head of its Computational Neurobiology Laboratory. Terry and Sydney are long-term collaborators and they share many stories and memories.The recorded lectures are the basis for this book. It aims to preserve the history of molecular biology and to also raise scientific questions that have resulted from the work of Sydney, Terry and others. It should be read by everybody who is interested in the generation, history and impact of great ideas as recounted by one of the legends of 20th century science.Published in collaboration with Institute Para Limes.
Sydney Brenner was born in South Africa and educated at the University of Witwatersrand, Johannesburg (Medicine and Science). He then moved to Oxford and received a D.Phil in 1952, before joining the MRC Unit in the Cavendish Laboratory in Cambridge in 1956. His various accomplishments include serving as the Director of MRC Laboratory of Molecular Biology in Cambridge, founding the Molecular Science Institute in Berkeley, holding the position of Distinguished Professor at the Salk Institute, La Jolla. And during his last years, Sydney Brenner played a key role in shaping research and development in the biomedical sector in Singapore as A*Star Senior Fellow.He was one of the greatest biologists of the 20th century and was awarded the Nobel Prize in 2002 for his pioneering work in the field of molecular biology. He was also known for his boundless curiosity, sharp intellect and courage to speak with clarity and characteristic wit as evident in this delightful book which is a compilation of the columns that he wrote for Current Biology in the late '90s.
In October 2017, Nobel laureate Sydney Brenner (Physiology or Medicine, 2002) gave four lectures on the history of Molecular Biology, its impact on Neuroscience and the great scientific questions that lie ahead.Sydney Brenner has been at the centre of the development of molecular biology, being a key player in shaping the Laboratory for Molecular Biology in Cambridge into a cradle of research, where pioneering and seminal discoveries in the field for over half a century have resulted in more than half a dozen Nobel Prizes.His memory is a treasure trove of the history of the field with innumerable anecdotes on other leading scientists in the past 60 years. These lectures trace the history and recount some of those anecdotes. His interlocutor Terry Sejnowski is the Francis Crick professor at the Salk Institute for Biological Studies and the Laboratory Head of its Computational Neurobiology Laboratory. Terry and Sydney are long-term collaborators and they share many stories and memories.The recorded lectures are the basis for this book. It aims to preserve the history of molecular biology and to also raise scientific questions that have resulted from the work of Sydney, Terry and others. It should be read by everybody who is interested in the generation, history and impact of great ideas as recounted by one of the legends of 20th century science.Published in collaboration with Institute Para Limes.
Founded in 1959, by John Kendrew, the Journal of Molecular Biology was the first journal devoted to this new and revolutionary science. To celebrate the thirtieth anniversary of the Journal, the current editor, Sydney Brenner, has selected a number of papers from the first hundred volumes. They include the seminal papers on genetic regulation by Jacob and Monod and on allostery by Monod, Changeux and Jacob. Also included are many important papers on structural biology and molecular genetics and papers reflecting the initial developments in DNA cloning and sequencing.Of value to all biologists with an interest in the molecular basis of living systems, the book is a personal selection by the Editor. Readers are encouraged to compare it with their own choice from the Journal of Molecular Biology.
Sydney Brenner was born in South Africa and educated at the University of Witwatersrand, Johannesburg (Medicine and Science). He then moved to Oxford and received a D.Phil in 1952, before joining the MRC Unit in the Cavendish Laboratory in Cambridge in 1956. His various accomplishments include serving as the Director of MRC Laboratory of Molecular Biology in Cambridge, founding the Molecular Science Institute in Berkeley, holding the position of Distinguished Professor at the Salk Institute, La Jolla. And during his last years, Sydney Brenner played a key role in shaping research and development in the biomedical sector in Singapore as A*Star Senior Fellow.He was one of the greatest biologists of the 20th century and was awarded the Nobel Prize in 2002 for his pioneering work in the field of molecular biology. He was also known for his boundless curiosity, sharp intellect and courage to speak with clarity and characteristic wit as evident in this delightful book which is a compilation of the columns that he wrote for Current Biology in the late '90s.
This established text is the only introduction to qualitative research methodologies in the field of library and information management. Its extensive coverage encompasses all aspects of qualitative research work from conception to completion, and all types of study in a variety of settings from multi-site projects to data organization. The book features many case studies and examples, and offers a comprehensive manual of practice designed for LIS professionals. This new edition has been thoroughly revised and includes three new chapters. It has been updated to take account of the substantial growth in the amount and quality of web-based information relevant to qualitative research methods and practice, and the many developments in software applications and resources. The authors have identified a clear need for a new chapter on the evaluation of existing research, as a gateway into new research for information professionals. The final chapter, 'Human Resources In Knowledge Management', takes the form of a model case study, and is an 'ideal' qualitative investigation in an information setting. It exemplifies many of the approaches to qualitative research discussed in earlier chapters. Readership: Directed primarily at the beginner researcher, this book also offers a practical refresher in this important area for the more experienced researcher. It is a useful tool for all practitioners and researchers in information organizations, whether libraries, archives, knowledge management centres, record management centres, or any other type of information service provider.
The little-known story of the woman who walked 1,500 miles to Rome to challenge the pope in 1621. Four centuries ago, an Englishwoman completed an astonishing walk to Rome. A Catholic, Mary Ward had already defied the authorities in her native country. In 1621 she walked across Europe to ask the Pope to allow her to set up schools for girls. “There is no such difference between men and women that women may not do great things,” she said. But Mary’s vision of equality between men and women angered the Church, and the pope threw her into prison. Her story is not only fascinating in its own right—it also shines a refreshingly new light on the Tudor/Stuart era. Mary’s uncles are the Gunpowder Plotters. Her sponsors are archdukes, prince-archbishops, and the emperor of the Holy Roman Empire. In Rome she spars with Pope Urban VIII and the Roman Inquisition, just as they are also dealing with the troublemaker Galileo. As the story sweeps from Yorkshire to Rome, from Vienna and Munich to Prague, and back to England, we see Mary dodging pirates in the Channel, witch hunts in Germany, and the plague in Italy. We see travelers crossing the Alps, and prisoners smuggling out letters written in invisible lemon juice. Ranging from the resplendent courts in Brussels and Munich to the siege of York in the English Civil War, this biography is a remarkable portrait of seventeenth-century European life.
This new edition of the well-known innovative study of the relations of the peoples of West Africa in the precolonial period covers a period of some four or five hundred years, up to the last decades of the nineteenth century. Smith takes account of outside influences but focuses primarily on what happened between African states before the partition of the area and the establishment of colonies.
The work features over 280 works by more than 170 Australian artists drawn from a period of acquisitions which began with the consitution of the MCA in May 1989."--p. 17.
Deals with the most basic notion of linear algebra, to bring emphasis on approaches to the topic serving at the elementary level and more broadly. A typical feature is where computational algorithms and theoretical proofs are brought together. Another is respect for symmetry, so that when this has some part in the form of a matter it should also be reflected in the treatment. Issues relating to computational method are covered. These interests may have suggested a limited account, to be rounded-out suitably. However this limitation where basic material is separated from further reaches of the subject has an appeal of its own. To the `elementary operations' method of the textbooks for doing linear algebra, Albert Tucker added a method with his `pivot operation'. Here there is a more primitive method based on the `linear dependence table', and yet another based on `rank reduction'. The determinant is introduced in a completely unusual upside-down fashion where Cramer's rule comes first. Also dealt with is what is believed to be a completely new idea, of the `alternant', a function associated with the affine space the way the determinant is with the linear space, with n+1 vector arguments, as the determinant has n. Then for affine (or barycentric) coordinates we find a rule which is an unprecedented exact counterpart of Cramer's rule for linear coordinates, where the alternant takes on the role of the determinant. These are among the more distinct or spectacular items for possible novelty, or unfamiliarity. Others, with or without some remark, may be found scattered in different places.
This book integrates and assesses the vast and rapidly growing literature on strategic leadership, which is the study of top executives and their effects on organizations. The basic premise is that in order to understand why organizations do the things they do, or perform the way they do, we need to deeply comprehend the people at the top-- their experiences, abilities, values, social connections, aspirations, and other human features. The actions--or inactions--of a relatively small number of key people at the apex of an organization can dramatically affect organizational outcomes. The scope of strategic leadership includes individual executives, especially chief executive officers (CEOs), groups of executives (top management teams, or TMTs); and governing bodies (particularly boards of directors). Accordingly, the book addresses an array of topics regarding CEOs (e.g., values, personality, motives, demography, succession, and compensation); TMTs (including composition, processes, and dynamics); and boards of directors (why boards look and behave the way they do, and the consequences of board profiles and behaviors). Strategic Leadership synthesizes what is known about strategic leadership and indicates new research directions. The book is meant primarily for scholars who strive to assess and understand the phenomena of strategic leadership. It offers a considerable foundation on which professionals involved in executive search, compensation, appraisal and staffing, as well as board members who evaluate executive performance and potential, might build their tools and perspectives.
This by now well-known pioneering dialogue on Freudian analysis is concerned not with therapeutic implications, individual or social, of psychoanalysis or of any other brand of psychology, but solely with the status of psychoanalysis as a scientific theory. Matching talents with a distinguished group of philosophers and social scientists, psychoanalysts made their claims and willingly subject them to the methodological scrutiny common to the sciences and the philosophy of science. This book records one of the few times in the United States that a distinguished group of psychoanalysts met with an equally distinguished group of philosophers of science in a free, critical interchange of view on the scientific status of the field. While a sense of the event’s excitement is captured here, it also had clear results, such as an expanded notion of psychoanalysis as a scientific theory, and a clear realization that certain elements in psychoanalysis are substantially beyond the boundaries of causal inference or the rules of logic. Two opening statements by Heinz Hartmann and Ernest Nagel set the tone for the debate and discussion that followed. These are followed by social scientific statements of Abram Kardiner, Ernest van den Haag, and Alex Inkeles, followed by the philosophers Morris Lazerowitz, Donald C. Williams, and Anthony Flew. Such distinguished scholars as Adolf Grunbaum, Michael Scriven, Gail Kennedy, Arthur Pap, Philipp Frank. Arthur C. Danto, Max Black and others, round out this pioneering effort in the literature of intellectual combat. Sidney Hook applies to his vision of psychoanalysis the same compelling rigor he applied to other would-be advocates of a science beyond ordinary scientific method or safeguards. He nonetheless points out that even therapeutic success is not the last word, but must itself be tested on a variety of measures: statistical no less than analytical. This remains a courageous and disturbing work, one that commands attention among practicing psychiatrists, psychoanalysts—and their would-be patients.
Prefaces are like speeches before the c- tain; they make even the most self-forgetful performers seem self-conscious. — William Allen Neilson The study of phenomena and processes at the phase boundaries of m- ter is the realm of the surface scientist. The tools of his trade are drawn from across the spectrum of the various scienti?c disciplines. It is therefore interesting that, in investigating the properties of such boundaries, the s- facist must transcend the interdisciplinary boundaries between the subjects themselves. In this respect, he harkens back to the days of renaissance man, when knowledge knew no boundaries, and was pursued simply for its own sake, in the spirit of enlightenment. Chemisorption is a gas-solid interface problem, involving the inter- tion of a gas atom with a solid surface via a charge-transfer process, during which a chemical bond is formed. Because of its importance in such areas as catalysis and electronic-device fabrication, the subject of chemisorption is of interest to a wide range of surfacists in physics, chemistry, materials science, as well as chemical and electronic engineering. As a result, a vast lite- ture has been created, though, despite this situation, there is a surprising scarcity of books on the subject. Moreover, those that are available tend to be experimentally oriented, such as, Chemisorption: An Experimental - proach (Wedler 1976). On the theoretical side, The Chemisorption Bond (Clark 1974) provides a good introduction, but is limited in not describing the more advanced techniques presently in use.
This book is full of practical teaching ideas, techniques for communicating with parents, and administrative strategies to motivate and inspire. Once you pick it up, you will want to share this book with other teachers.
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