This book introduces charnolophagy (CP) as energy-driven, lysosomal-dependent mitochondrial inclusion-specific pleomorphic Charnoly body (CB) autophagy (ATG) involving free radical-induced Ca2+ dyshomeostasis, ΔΨ collapse, and ATP depletion in congenital diseases, pressure ulcers, metabolic diseases, hepatic diseases, diabetes, obesity, inflammatory diseases, musculoskeletal diseases, sarcopenia, cachexia, respiratory diseases, gastrointestinal diseases, hyperlipidemia, skin and hair diseases, pulmonary diseases, cardiovascular diseases, renal diseases, sepsis-induced multi-organ failure, reproductive diseases, inflammatory diseases, ophthalmic diseases, neurodegenerative diseases, drug addiction, aging, microbial (including COVID-19) infections, and belligerent malignancies implicated in early morbidity and mortality and disease-specific spatiotemporal, targeted, safe, and effective evidence-based personalized theranostic charnolopharmacotherapeutics to cure them. Basic DRESS and GELS principles, nanoparticles to cure chronic multidrug-resistant (MDR) diseases, antioxidants as free radical scavengers, CB antagonists, CP regulators, and CS stabilizers to curb CB molecular pathogenesis (CBMP) are described for better quality of life and longevity. Specific guidelines for environmental protection and preservation of zoological and botanical species at the verge of extinction, Triple "I" Hypothesis for mitochondrial quality control, and transcriptional regulation of CSexR and CSendoR to cure chronic diseases are presented. Novel CP index is introduced to evaluate MDR malignancies and other chronic diseases. WHO, CDC, FDA, NIH, policy planners, cosmetologists, trichologists, players, athletes, dancers, wrestlers, equestrians, young women, aging population, toxicologists, environmental protectionists, pharmaceutical industry, biomedical scientists, researchers, medical students, physicians, nurses, paramedical professionals, and global audience will be interested in this interesting book to prevent pandemics and raise healthcare awareness.
The global demand for energy is met mainly by fossil fuels. Their excessive and indiscriminate use, coupled with increasing demand for energy, will soon deplete their existing reserves. Therefore, it is extremely important to find alternative, environment-friendly, and ecologically sound sources of energy for meeting the present and future energy requirements. Biogas Technology: Towards Sustainable Development makes an attempt to explore the potential of utilizing biodegradable biomass as fuel and manure.
Case Based Reviews in Pediatric Pulmonology is a comprehensive collection of reviews covering all aspects of paediatric pulmonology, from disorders of the upper respiratory tract to pulmonary diseases in the paediatric intensive care unit. The book is divided into 46 chapters across nine sections, beginning with disorders of the upper respiratory tract, and congenital disorders of the reparatory tract such as larnygomalacia and diaphragmatic hernia. Further sections cover wheezing disorders, respiratory tract infections, suppurative and interstitial lung diseases and pleural diseases. The final two sections focus on paediatric pulmonary diseases requiring intensive care, and miscellaneous respiratory disorders. Each chapter in Case Based Reviews in Pediatric Pulmonology begins with a case scenario and provides guidance on the assessment and appropriate treatment of the relevant disorder, followed by a key points summary. Key Points Comprehensive collection of reviews covering a wide range of paediatric pulmonary disorders Each chapter presents a case scenario along with assessment and treatment of each disorder Key points summary at end of each chapter
The Charnolosome as a Novel Nanothereranostic Biomarker: Overcoming Future Challenges in Medicine provides an overview of the charnolosome and its potential as a biomarker of cell injury. Based on the author's original discovery of the charnoly body in the developing, undernourished rat cerebellar Purkinje neurons, this book delves into the potential for utilizing this mitochondria and lysosomal-derived intracellular organelle as a nanotheranostic biomarker to prevent and cure various diseases. The book discusses the cellular, molecular, genetic, and epigenetic mechanisms of charnolosomes and charnolosome-derived nano-vesicles. It also investigates the molecular mechanisms underlying auto-inflammatory, autoimmune, and infectious diseases resulting from their compromised mitochondrial bioenergetics, and the potential use of the charnolosome in preventing and curing such conditions. - Shares the latest knowledge on the charnolosome and charnolosome-derived nano-vesicles and their significance at a cellular and molecular level - Considers the charnolosome in relation to a range of conditions, including neurodegenerative, metabolic, and multi-drug resistant systemic diseases - Presents future perspectives of the charnolosome in personalized nanotheranostics
This authoritative handbook provides the information and insight you need to avoid common medico-legal pitfalls Cancer care represents a significant portion of total U.S. health care spending. Mistakes come at great costs to the individual clinician and the entire healthcare system. One misstep can destroy an otherwise stellar medical career. Clinicians must be versed in the interface of law and medicine so that they can practice medicine more effectively and economically. Understanding the Principles and Practice of Legal Oncology delivers expert advice on how to avoid lawsuits while at the same time contributing to the reduction of healthcare costs and improving patient access. You'll learn how to steer clear of the most common legal hazards and mitigate any anxiety over the need to perform additional workups and documentations. Packed with clinical vignettes and relevant legal principles, this is an essential resource for physicians, surgeons, nurses, researchers, medical physicists, technicians, and those who are in the business of taking care of patients. Features Explores the legal ramifications of prescribing vs. not prescribing opioids in the current stricter regulation landscape Covers the ethical considerations of using artificial intelligence to manage cancer treatment Explains the legal implications of not ordering screening tests when patients request them Describes the goals of a peer review, which is not always in good faith Refines the process on how to give proper informed consent Clears up what to say or not to say in a deposition if a patient files a lawsuit Elucidates the liability of practicing medicine as an employee in a hospital setting Outlines how to use midlevel providers safely, and much more
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