This book is intended for students of computational systems biology with only a limited background in mathematics. Typical books on systems biology merely mention algorithmic approaches, but without offering a deeper understanding. On the other hand, mathematical books are typically unreadable for computational biologists. The authors of the present book have worked hard to fill this gap. The result is not a book on systems biology, but on computational methods in systems biology. This book originated from courses taught by the authors at Freie Universität Berlin. The guiding idea of the courses was to convey those mathematical insights that are indispensable for systems biology, teaching the necessary mathematical prerequisites by means of many illustrative examples and without any theorems. The three chapters cover the mathematical modelling of biochemical and physiological processes, numerical simulation of the dynamics of biological networks and identification of model parameters by means of comparisons with real data. Throughout the text, the strengths and weaknesses of numerical algorithms with respect to various systems biological issues are discussed. Web addresses for downloading the corresponding software are also included.
In nineteenth-century England, all is going well for reclusive Mr Norell, who has regained some of the power of England's magicians from the past, until a rival magician, Jonathan Strange, appears and becomes Mr Norrell's pupil.
Susanna Wesley, long celebrated in Methodist mythology as mother of the movement's founders, now takes place as a practical theologian in her own right. This collection of her letters, spiritual diary, and longer treatises (only one of which was published in her lifetime) shows her to be more than the nurturing mother of Wesleyan legend. It also reveals her to be a well-educated woman in conversation with contemporary theological, philosophical, and literary works. Her quotations and allusions include Locke, Pascal, and Herbert, as well as a number of now forgotten theologians. In some of her work, one can distinguish doctrinal and spiritual leanings, such as Arminianism and Christian perfection, that would later find wide expression in the spread of Methodism. Further, her writings demonstrate her readiness, for conscience's sake, to stand up to the men in her life--father, husband, and sons---and the three incarnations of English Protestantism they represented: respectively, Puritanism, the Established Church, and the new Methodist movement. Tracing these incidents in her letters and diaries, a reader can begin to understand how spirituality, even an otherwise conservative one in rather restrictive times, can serve to empower the voice of women.
Prayers were sought for a mate who would love her as much as she had him. Reluctant to go to the not so nice seen of the bar theme, told God he would have to place him on her lap had not anticipated this man to be the one who could make her life miserable. Taking away the little monies she received from an accident, her struggles in life was nothing compared to the hell she was to face. Sure there was a brief period of happiness but hell was soon placed at her feet leaving her to ask the question: had her prayers been answered by God or Satan himself?
Known for her deliciously wicked romances, Carr now brings together a reformed bad boy and a misunderstood good girl. One thing's for sure--the longer she stays in town, the more ready this reformed bad boy is to shed his uniform and show Stephanie a whole new side to serve and protect.
From the New York Times bestselling author of The Winter Sea and The Vanished Days When a woman brings a small wooden carving into the art dealership, claiming it once belonged to a Russian Empress, Nicola Marter’s boss believes it is worthless. But Nicola has an unwanted, if rare, psychic gift. Holding 'The Firebird' in her hands, she knows this woman is telling the truth. Compelled to uncover its true history, Nicola must put her own past behind her. She contacts an old flame who can access the past in a way no one else can. Together they can find the real story of 'The Firebird'… Following history from Scotland, to Belgium and to St Petersburg, The Firebird is a sweeping story of love, sacrifice, courage and redemption. A journey that spans centuries and lifetimes to connect the past with the future. Praise for Susanna Kearsley ‘Sometimes an author catches lightning in a bottle, and Susanna Kearsley has done just that’ New York Journal of Books ‘A deeply engaging romance and a compelling historical novel’ Bernard Cornwell, author of The Last Kingdom ‘Kearsley is nothing less than a magician weaving together the past and the present in yet another marvellous, genre-bending, romantic, mysterious and utterly unputdownable novel’ M J Rose, author of Seduction ‘Will stay with you long after you put it down. Her deft touch with historical intrigue is matched only by her delivery of a contemporary heroine who is as unique as she is memorable’ Deanna Raybourn, author of The Dark Enquiry ‘Fascinating, immersive and twisty – twists not only of plot, but of character and time’ Diana Gabaldon, author of the Outlander series
Reflective Teaching in Higher Education is the definitive textbook for those wanting to excel at teaching in the sector. Informed by the latest research in this area, the book offers extensive support for those at the start of an academic career and career-long professionalism for those teaching in higher education. Written by an international collaborative author team of experts led by Paul Ashwin, Reflective Teaching in Higher Education offers two levels of support: - practical guidance for day-to-day teaching, covering key issues such as strategies for improving learning, teaching and assessment, curriculum design, relationships, communication, and inclusion - evidence-informed 'principle's to aid understanding of how theories can effectively inform teaching practices, offering ways to develop a deeper understanding of teaching and learning in higher education In addition to new case studies from a wider variety of countries than ever before, this new edition includes discussion of: - What is meant by 'agency' - Gender, ethnicity, disability and university teaching - Digital learning spaces and social media - Teaching career development for academics - Decolonising the curriculum - Assessment and feedback practices - Teaching excellence and 'learning gain' - 2015 UN General Assembly 2030 Agenda for Sustainable Development reflectiveteaching.co.uk provides a treasure trove of additional support. It includes supplementary sector specific material to support for considering questions around society's educational aims, and much more besides.
Latin American Thought examines the relationship between philosophy and rationality in Latin American thought, the nature of justice, human rights, and cultural identity, and other questions that have concerned Latin American thinkers from the colonial period to the present day. From the Mayans, Aztecs, and Incas to the present day, reveals the assembly of interesting philosophical arguments offered by Latin Americans. Nuccetelli traces Latin American thought through questions concerning rationality, gender discrimination, justice, human rights, reparation for historically dispossessed peoples, and relativism vs. universalism - all matters of continuing concern in Spanish and Portuguese-speaking parts of the world . Amongst issues of heated controversy from the early twentieth century to the present, also explores how Latin Americans and their descendants abroad think of their own cultural identity, of US mass-culture and philosophy, and of the vexing problem of which name, if any, to use when referring to this exceedingly diverse ethnic group. Many of the philosophical questions raised by Latin American thinkers are problems that have concerned philosophers at different times and in different places throughout the Western tradition. But in fact the issues are not altogether the same - for they have been adapted to capture problems presented by new circumstances, and Latin Americans have sought resolutions in ways that are indeed novel. This book explains how well-established philosophical traditions gave rise in the "New World" to a distinctive manner of thinking. There was no clean sweep of the past and an attempt to start over: rather, Latin American thinkers mostly welcomed European ideas at whatever pace such traditions happened to arrive. It is then no surprise that, for instance, Scholasticism became the accepted view under Spanish rule, and began to lose its grip only when the rulers did. But what does seem surprising is the radical way in which those traditions were transformed to account for problems that, though familiar, were now seen intake light of new circumstances. A distinctive Latin American way of thinking about such problems emerged from the project of "recycling" European philosophical traditions, some of which were already obsolete in Europe at the time their transplant took place. Thus theories commonly taken to be incompatible within Western traditions in philosophy were absorbed by Latin American thought-- and, in their newly acquired forms, such theories are even now at the basis of proposed solutions to many practical and philosophical problems. The book explores that recycling process. Above all, it aims to determine whether the various cultures that met in the "New World" could now be said to have come to share a common identity. This is in fact an issue which has preoccupied Latin Americans since at least the beginning of the 19th century, when their countries won their independence. But, in connection with this, it is also important to ask how Latin Americans have thought about the relationship between philosophy and rationality, and about other issues belonging to the major areas of philosophy such as epistemology, moral philosophy, and political philosophy, as well their application to vital social issues, including education and the emancipation of women. These are all taken up by the author, who pays special attention to questions of gender discrimination, justice, human rights, reparation for historically dispossessed peoples, and the role of education-- all matters of continuing concern in Latin American thought, from its earliest stirrings to the present day.
The Basset Table follows the fortunes of Lady Reveller, who runs a table where her friends play the card game basset, and her struggle to avoid marrying Lord Worthy. Meanwhile, Lady Reveller’s cousin, Valeria, spends her time conducting scientific experiments and dissections, but her father intends to marry her off to the bluff sea-captain Hearty. How can Lady Reveller be persuaded to forego the delights of gambling? And how can Valeria avoid an unwanted marriage? This witty play paints a seductive picture of the thrills of the Restoration gaming table and challenges contemporary stereotypes of the learned lady. Appendices to this Broadview Edition include materials on female education, gambling, and writing for the stage, as well as eighteenth- and nineteenth-century critical writing on Centlivre and The Basset Table.
Another excellent historical adventure from Susanna Gregory featuring 17th-century spy Thomas Chaloner ------------------------ London in the spring of 1665 is a city full of fear. There is plague in the stews of St Giles, the Dutch fleet is preparing to invade, and a banking crisis threatens to leave Charles II's government with no means of paying for the nation's defence. Amid the tension, Thomas Chaloner is ordered to investigate the murder of Dick Wheler, one of the few goldsmith-bankers to have survived the losses that have driven others to bankruptcy - or worse. At the same time, a French spy staggers across the city, carrying the plague from one parish to another. Chaloner's foray into the world of the financiers who live in and around Cheapside quickly convinces him that they are just as great a threat as the Dutch, but their power and greed thwart him at every turn. Meanwhile, the plague continues to spread across the city, and the body count from the disease and from the fever of avarice starts to rise alarmingly . . .
New York Times and USA Today Bestseller! "A thrilling, haunting, and deeply romantic story." -Rachel Hore, internationally bestselling author of The Memory Garden "Whatever time we have," he said, "it will be time enough." Eva Ward returns to the only place she truly belongs, the old house on the Cornish coast, seeking happiness in memories of childhood summers. There she finds mysterious voices and hidden pathways that sweep her not only into the past, but also into the arms of a man who is not of her time. But Eva must confront her own ghosts, as well as those of long ago. As she begins to question her place in the present, she comes to realize that she too must decide where she really belongs. From Susanna Kearsley, author of the New York Times bestseller The Winter Sea and a voice acclaimed by fans of Gabaldon, du Maurier, and Niffenegger alike, The Rose Garden is a haunting exploration of love, family, the true meaning of home, and the ties that bind us together. Praise for New York Times and USA Today bestseller The Winter Sea : "Lifts readers straight into another time and place to smell the sea, feel the castle walls, and sense every emotion. These are marks of a fantastic storyteller." -RT Book Reviews Top Pick of the Month, 4 1⁄2 stars "Ingenious...a creative tour de force. Sometimes an author catches lightning in a bottle, and Susanna Kearsley has done just that." -New York Journal of Books
This volume includes her essays on slavery, secession, women's role, and political economy, fully annotated, along with an Introduction by Michael O'Brien, Chair of the Editorial Board of the Southern Texts Society.
Susanna Haswell Rowson, a popular and prolific writer, actress, and educator in the late eighteenth and early nineteenth centuries, had a truly transatlantic life and career, moving twice from England to America and publishing extensively in both countries. A transatlantic sensibility informs her fictionalized “history” of America, Reuben and Rachel, which traces ten generations of an extended family, beginning with the marriage of Christopher Columbus’s son to a native Peruvian princess, moving through the Tudor succession crises and the colonial settlement of New England, and ending with the title characters, who leave England for America, renounce titles of nobility, and consider their children “true-born Americans.” In Rowson’s representation, the American character derives from fusion and hybridity, the results of intermarriage across racial, religious and national lives.
The life and works of Queen Christina of Sweden (1626-1689) have often been obscured behind a haze of Iurid myths and legends. This book looks again at her notorious abdication of 1654, seeing it against the background of her reputation as a "libertine", a heterodox religious thinker. Her subsequent conversion to Catholicism is therefore understood as a consequence of messianic and millenarian expectations during those turbulent years, and her bizarre attempt in 1657 to become the ruler of Naples is revealed to be the political wing of a comprehensive religious and intellectual philosophy.
Do you want to...Help distribute money to the poor and be given a fee to do so? Share in Al Qaeda's hidden gold? Help a young girl orphaned in the tsunami? In their highly entertaining and often shocking new book James Morton and Susanna Lobez follow up their bestselling Gangland Australia by delving into the world of Australian con artists such as Mario Condello, Helen Demidenko, Christopher Skase, Brenton Jarrett, Peter Foster, Lola Montez and Fairlie Arrow. Here are highly talented men and women and their tricks: changing paper into banknotes, selling other people's property, faking deaths, and forging paintings; promising miracle cures and impersonating aristocracy, preachers, military gents, lawyers and doctors. In fact, whatever it takes to separate the unwary from their money. Read about the scams and think twice about that offer that seems almost too good to be true.
This book reconstructs the impact of Plato’s words for the modern reader. In the Republic, Plato presented his schematization of human intellectual development, and called for collaboration between writer and reader. The response presented in this book results in a new theoretical framework for engaging with Plato’s dialogues. Susanna Saracco analyzes the epistemic function of Plato’s written words and explores Plato’s higher order pedagogy, in which students are not mere learners and teachers are not the depositories of the truth.
Taking you through the year day by day, The Hull Book of Days contains quirky, eccentric, amusing and important eventsand facts from different periods in the history of the city. Ideal for dipping into, this addictive little book will keep you entertained and informed.Featuring hundreds of snippets of information gleaned from the vaults of Hull’s archives and covering the social, criminal, political, religious, industrial, military and sporting history of the city, it will delight residents and visitors alike.
Illuminates the friendships that have influenced, nourished, inspired, and haunted the author--and sometimes torn her apart--each of which has its own lessons that she seeks to understand.
This book examines Southerners' claims to loyal citizenship in the reunited nation after the American Civil War. Southerners - male and female; elite and non-elite; white, black, and American Indian - disagreed with the federal government over the obligations citizens owed to their nation and the obligations the nation owed to its citizens. Susanna Michele Lee explores these clashes through the operations of the Southern Claims Commission, a federal body that rewarded compensation for wartime losses to Southerners who proved that they had been loyal citizens of the Union. Lee argues that Southerners forced the federal government to consider how white men who had not been soldiers and voters, and women and racial minorities who had not been allowed to serve in those capacities, could also qualify as loyal citizens. Postwar considerations of the former Confederacy potentially demanded a reconceptualization of citizenship that replaced exclusions by race and gender with inclusions according to loyalty.
Justice and the Ethics of Legal Interpretation addresses how it is that legal texts -laws, statutes and regulations – can, and do have meaning. Conventionally, legal decisions are justified with reference to language. But since language is always open to interpretation, and so cannot fully justify any legal decision, there is a responsibility that is inherent in legal interpretation itself. In this book, Susanna Lindroos-Hovinheimo uncovers and analyses this responsibility – which, she argues, is not limited by the text that is being interpreted (and through its mediation, by the legal system). It is not simply a responsibility to read well; it implies a responsibility for the effects of the interpretation in a particular situation and with regard to those whose case is being decided. Ultimately, it is a responsibility to do justice. It is these two aspects of responsibility that are conceptualised here as the two key dimensions of the ethics of legal interpretation: the textual and the situational. Drawing on the work of Wittgenstein, Gadamer, Derrida and Levinas, Justice and the Ethics of Legal Interpretation offers a fresh approach to long-standing questions about language and meaning in law. It will be of enormous value to those with interests in jurisprudence and legal theory.
In the rugged and unforgiving land of the American frontier, where honor and loyalty can be as dangerous as a loaded gun, Cortland Enders finds himself entangled in a web of obligation and deceit. When he crosses the path of a powerful man, he becomes a fugitive from the law. Desperate to avoid prison, Cort is forced to accept an agreement with Sienna, the influential widow of his late friend and employer and current owner of the Circle H Ranch. In exchange for his freedom, he must play the role of her new husband. The catch? She’s dying, and Cort will inherit the ranch. For anyone else, it would seem like the deal of a lifetime, but for a free spirit like Cort, it’s almost worse than prison. Now free, Cort is instructed to find a young lady to help tend to Sienna in her waning days. That’s when he meets Lark Garrin, the woman who will turn his world upside down. A scarred beauty of uncommon strength and courage, she immediately captures Cort's heart. Sparks fly, and he is torn between his loyalty to Sienna and his growing feelings for Lark. But danger lurks in the shadows. The demons from Lark's past are hunting her, and Cort must resurrect his gunfighting skills to protect both the woman he loves and the legacy of the ranch he's sworn to safeguard. In this gripping tale of love, honor, and sacrifice, Cort and Lark must trust one another and face their deepest fears head-on to defeat the forces threatening everything they hold dear.
This book deals with the work of both Thomas William Coke and his son, their agents and their tenants at Holkham through the nineteenth century and into the early years of the twentieth. It shows how far even the most dynamic landlord needed a progressive tenantry and how far the tenantry relied on the landlord for the provision of good farm buildings and other capital expenditure.
Norfolk has a wealth of important archaeological sites, historic buildings and landscapes. This guide is the first to use them to tell the county's rich history. Starting with real footprints of people who lived here nearly 1 million years ago, A History of Norfolk in 100 Places will take you on a chronological journey through prehistoric monuments, Roman forts, medieval churches and Nelson's Monument, right up to twentieth-century defensive sites. With detailed entries illustrated by aerial photographs and ground-level shots, here you will find a reliable guide to historic places that are either open to the public, or are visible from public roads or footpaths for you to explore.
This book explores the ways in which the American writers Gertrude Stein, Ernest Hemingway, and Zora Neale Hurston used modernist primitivism to assert a uniquely American literary identity in the face of European cultural hegemony. The extended Introduction traces the history of primitivism from a classical rhetorical trope to its emergence in the twentieth century as aesthetic, exemplified by Picasso and his use of African masks, that combined new work in the human sciences especially anthropology and psychology, with new ideas in the visual arts to challenge traditional ideas of realism and artistic accomplishment. The first two chapters bring together visual evidence, published and unpublished writings, and linguistic theory to give the first detailed account of the theoretical and gender concerns of the Stein-Picasso collaboration, which culminated in Picasso's Les demoiselles d'Avignon and Stein's Melanctha. In the final two chapters, the author shows how both Hemingway and Hurston participated in the racialist scientific debates of the 1920s and used primitivism to find their respective artistic voices: Hemingway in his use of American Indians in recasting his life narratives in the Nick Adams stories, and Hurston in her attempts to use her anthropological training to construct a mythic African-American past.
Life is an intricate tapestry of emotions: moments that tug at our hearts and instances that leave us in stitches. Every day, we navigate the quirks and peculiarities of those around us, choosing to either embrace the humour or let annoyance take the reins. Why not revel in the comedic interludes hidden within life’s juxtapositions? In Rags and Riches, Susanna invites readers into a delightful collection filled with laughter, wit, and true tales. From whimsical articles to heartfelt poems, she captures the essence of real people and the memorable moments that have shaped their lives. Many stories bring to life the eclectic guests that have crossed Susanna’s threshold, while others shine a spotlight on the charming exchanges she shares with her vivacious granddaughter. ‘One of her guests, a specialist medical doctor, laughs, “Susanna, you know I’m known as ‘The Cleaner.’ One weekend I was asked to be the medic in charge of a small hospital of nineteen patients. By the end of the weekend, sixteen of them had died.” “What did you do? One look at you and they all decided their lives weren’t worth living? Seriously?” “Yes, I’m that girl!” “Now when any hospital needs to move patients on – they know who to ask.” “Yes, the cleaner!”’ Articles used to be written on rags, which would be posted around the towns for people to read. They looked forward to their weekly rag. The book title includes ‘Riches’ because stories enrich our lives.
From Technological Humanity to Bio-technical Existence can be framed as a metaphysics of the present. It starts from the current epoch, an era increasingly marked not only by technology but also by technics in the most general sense, and asks how this affects human existence. The book asks what is called technics, what is called humanity, how these relate to one another, and how changes in these notions oblige us to revise the philosophical notion of existence. It investigates how the idea of technological humanity—of technology as an extension and instrument of the human—is discovered and deconstructed by Martin Heidegger, Helmuth Plessner, Michel Foucault, Jacques Derrida, Bernard Stiegler, and Giorgio Agamben. Finally, the book presents a new idea of bio-technical existence, one that underlies these philosophers' works without being fully elaborated. This idea—of technics as a condition of humanity that humans share with other living and technical beings—is the author's own philosophical proposition and the final result of the book.
Travel writer, explorer and novelist. 'Gaunts never give up', the motto of Mary's ancestor, Prince John of Gaunt (1340-1399) was quoted by Mary's father, William Gaunt, to his children. In the 1880s, Mary Gaunt was one of the first women admitted to Melbourne University. Miss Gaunt's desire to study law was denied since male academics believed women incapable of studying 'difficult' subjects. In 1909, Mary, now widowed, led her own expedition into the West African jungle, staying in remote villages to gather information for her book 'Alone in West Africa'. In 1913, in the absence of sealed roads, Mary travelled in a bone-shaking mule cart from Peking to the edge of the Gobi desert and returned to Europe on a Russian troop train. Her amazing experiences in China and Russia produced two more travel books. Mary donated her royalties to the Red Cross to help Belgian refugees. For many years she lived in Italy and, during World War Two, died in France. Prelude: Outwitting Mussolini1. 'Gaunts never give up'2. Encountering prejudice at university3. Finding Doctor Right4. Mary postpones a visit to China5. Africa - the 'Dark Continent'6. Heading a band of naked warriors7. 'Madame, you have the heart of a lion'8. 'Murder Hill' and German Togoland9. Black magic among the Ashanti10. The male dinosaurs of Londonís RGS11. Through Tsarist Russia to Peking12. Inside the walls of the Forbidden City13. A political assassination14. The Great Wall of China15. 'Behind every small foot is a jar of tears'16. Chengde and the hunting palace of the Manchu17. The temple of the Three Mountains18. 'Please keep your last bullet for yourself'19. Last days in China20. Exploring the Amur River and Saghalien21. On a troop train through Siberia22. St Petersburg and after23. Captured by Germans24. The Gaunts in wartime25. The final years of a cosmopolitan author
Understanding Latin Literature is a highly accessible, user-friendly work that provides a fresh and illuminating introduction to the most important aspects of Latin prose and poetry. This second edition is heavily revised to reflect recent developments in scholarship, especially in the area of the later reception and reverberations of Latin literature. Chapters are dedicated to Latin writers such as Virgil and Livy and explore how literature related to Roman identity and society. Readers are stimulated and inspired to do their own further reading through engagement with a wide selection of translated extracts and through understanding the different ways in which they can be approached. Central throughout is the theme of the fundamental connections between Latin literature and issues of elite Roman culture. The versatile and accessible structure of Understanding Latin Literature makes it suitable for both individual and class use.
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