Bioactive natural products are an excellent source of novel therapeutics. The search for bioactive molecules from nature continues to play a major role in developing new generation natural products of therapeutic importance. The present critical review includes research work carried out by active researchers in natural products’ chemistry, pharmacology and therapeutics, and their implications in antidiabetic medications. This compiled scientific information will be a useful resource for future research especially in indentifying promising leads and direction for the development of novel drugs including useful adjuvants for the treatment of diabetic patient. The present therapeutic approaches in the treatment of diabetes are mainly focused to lower the elevated blood glucose by reducing its absorption in gastrointestinal tract, enhancing the sensitivity of insulin, controlling or modulating hepatic glucose output, and increased utilization of the glucose by the peripheral tissues. Involvement of oxidative stress and its impact on the cellular damage in diabetes mellitus has been established and could be a useful paradigm for the development of novel antihyperglycemics along with other therapeutic strategies. The present review also highlights the effects of various herbs, phytoconstituents, phytochemicals, microbial metabolites, and products of marine origins on hyperglycemic/diabetic conditions. Furthermore, efforts were made to discuss novel molecular targets such as insulin-signaling pathways, peroxisome proliferative activating receptor-γ, and G-protein-coupled receptors that are participating in enhancing/influencing insulin secretion, critical carbohydrate metabolism pathways, endoplasmic reticulum stress-related pathways, intracellular events associated intracellular inflammation, and chromatin-modification pathways involvement in antidiabetic activity and their significance.
The World Cup returned to England after 20 years; the Almanack tells the story of the tournament and pays a tribute to the winners. What did it take to win? Writers include Sir Viv Richards, Ian Chappell, Yuvraj Singh. Mike Brearley discusses India's reaction to the new and untested, and finds a pattern there. British actor and director Harry Burton recalls his playing days with Nobel Laureate and cricket fan Harold Pinter. Former CBI chief R K Raghavan details the match fixing saga that nearly brought Indian cricket to its knees while Nandan Kamat seeks a law against fixing. Gulu Ezekiel details the collector's life, and what makes it special. Andreas Campomar writes about a commemorative game in Argentina, where cricket has been played for 150 years. Writers include the world's finest, Gideon Haigh, Rahul Bhattacharya, Geoff Lemon, Andrew Fernando, Sidhartha Monga, Sandeep Dwivedi, Neil Manthorp, Peter Lalor, Tim Wigmore. Unmukt Chand describes his struggles while Karunya Keshav and Snehal Pradhan capture the drama and the possibilities in women's cricket around the world. The quality of the writing remains consistently high while there are surprises and breath-taking material galore. The Six Cricketers of the Year and the Personality of the Year take their place among the other Wisden India Almanack staples: obituaries, book reviews, chronicles and the editor's notes. Mumbai's dramatic IPL win and the tournament details and commentary give the season at a glance. Who are the some of the country's best-known club cricketers, those who played for years and became local celebrities but seldom went on to bigger things? Wisden India Almanack tells their story. The international season, the domestic season complete with the details of the first class and other matches and records from the lower levels to the international, have been meticulously collected in this, the most respected annual cricket reference manual.
Wisden has grown through the years to embrace innovation and maintain its status as the most revered and cherished brand in cricket. The 'Bible of Cricket', Wisden Cricketers' Almanack has been published every year since 1864. Wisden's Cricketers of the Year Awards, one of the oldest honours in the sport, dates back to 1889. The Almanack, known for editorial excellence, has been a perennial bestseller in the UK. The third edition with India-specific content is even more engrossing. Contributors include Ramachandra Guha, Ian Chappell, Ajit Wadekar, Amol Rajan, Osman Samiuddin, Dileep Premachandran, Prashant Kidambi, Ruchir Joshi, Rajdeep Sardesai, Akash Chopra, Jarrod Kimber, and Jack Hobbs.
Wisden has grown through the years to embrace innovation and maintain its status as the most revered and cherished brand in cricket. The 'Bible of Cricket', Wisden Cricketers' Almanack has been published every year since 1864. Wisden's Cricketers of the Year Awards, one of the oldest honours in the sport, dates back to 1889. The Almanack, known for editorial excellence, has been a perennial bestseller in the UK. The fourth edition with India-specific content is even more engrossing. Contributors include Ramachandra Guha, Ian Chappell, Ajit Wadekar, Amol Rajan, Osman Samiuddin, Dileep Premachandran, Prashant Kidambi, Ruchir Joshi, Rajdeep Sardesai, Akash Chopra, Jarrod Kimber, and Jack Hobbs
Wisden India Almanack, now in it's sixth edition pays homage to India's women cricketers, who over the past couple of years have been among the most talked-about, the most keenly followed and the most vociferously encouraged in the country. Starting with Menon and including Karunya Keshav, Sharda Ugra, Lawrence Booth, Aakash Chopra, Amrit Mathur, Simon Barnes, Ian Chappell, Shehan Karunatilaka, Bhagwat Chandrasekhar, Erapalli Prasanna, Samanth Subramanian and many more, the discerning reader has plenty to read and savour over 800 pages.
The fifth edition of Wisden India Almanack has essays from the best writers, and those from other fields who are passionate about the sport, like the CEO of Microsoft, Satya Nadella. The coverage of domestic cricket is both extensive and original. The Almanack is actually four books in one: a volume of essays, a book of records, an annual of matches played, and a miscellany of unusual occurrences, all of which make for a great read. It is a treat for the cricket fanatic, and for those interested in fine writing and intriguing stories.
Now in a fully updated Fifth Edition, Shnider and Levinson's Anesthesia for Obstetrics, continues to provide the comprehensive coverage that has made it the leading reference in the field. The rising number of Cesarean births and the more advanced age of first-time mothers in the United States have brought with them an increased risk for complications, making the role of the obstetric anesthesiologist increasingly important. This comprehensive reference addresses maternal and fetal physiology; fetal assessment; anesthesia and analgesia in both vaginal and Ceserean delivery; neonatal well-being; management of fetal, maternal, and anesthetic complications; and management of coexisting disorders in the mother. The Fifth Edition includes a new editorial team, a new full-color format, and new sections on Assessment of the Fetus, Anesthesia for Cesarean Delivery; Neonatal Well-Being: Old and New Concepts; Ethical, Medical, and Social Challenges and Issues; Maternal Safety, Difficult and Failed Intubation, Morbidity, and Mortality; and Anesthetic Considerations for Reproductive, In-Utero, and Non-Obstetric Procedures
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