The API (Association of Physicians of India) Textbook of Medicine consists of 28 sections across two comprehensive volumes covering a wide range of medical disorders. Fully revised and with 1588 images, illustrations and tables, this new edition has many new chapters on topics including nanotechnology and nano-medicine, and clinical approach to key manifestations. Each section is dedicated to a different medical phenomenon, including clinical pharmacology, endocrinology, dermatology, infectious diseases and nutrition. Also included is online access to teaching modules for teachers and students, questions and answers, an atlas/image bank, echocardiography and video EEG and common medical procedures with voice over.
Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids addresses several issues related to safe and effective delivery of nucleic acids (NAs) using nanoparticles. A further emphasis would be laid on the mechanism of delivery of NAs, the barriers encountered and the strategies adapted to combat them. An exhaustive account of the advantages as well shortcomings of all the delivery vectors being employed in delivery of various NAs will be provided. On final note the regulatory aspects of nanoparticles mediated NA would be discussed, with focus on their clinical relevance. The design and development of nucleic acid-based therapeutics for the treatment of diseases arising from genetic abnormalities has made significant progress over the past few years. NAs have been widely explored for the treatment of cancer and infectious diseases or to block cell proliferation and thereby caused diseases. Advances in synthetic oligonucleotide chemistry resulted in synthesis of NAs that are relatively stable in in vivo environments. However, cellular targeting and intracellular delivery of NAs still remains a challenge. Further development of NA-based therapeutics depends on the progress of safe and effective carriers for systemic administration. Nanomedicine has facilitated availability of vectors with diminished cytotoxicity and enhanced efficacy which are rapidly emerging as systems of choice. These vectors protect NAs from enzymatic degradation by forming condensed complexes along with targeted tissue and cellular delivery. During the past few years, a myriad reports have appeared reporting delivery of NAs mediated by nanoparticles. This book will provide an overview of nanoparticles being employed in the in vitro and in vivo delivery of therapeutically relevant NAs like DNA, siRNA, LNA, PNA, etc. Provides a complete overview of the applicatiosn of nanomedicine in the delivery of nucleic acids, from characterization of nanoparticles, to in vitro and in vivo studies Discusses delivery issues of less well explored nucleic acids, like PNAs, Ribozymes, DNAzymes, etc. Summarizes the current state of research in nucleic acid delivery and underscores the future of nanomedicine in this field
New, Now, Next. Consumers' ever growing appetite to acquire new products and their short courtship with them has kept manufacturers busy not only expending resources at an alarming rate, but also depleting these resources and giving rise to waste and pollution at a correspondingly increasing and disturbing rate. Traditional manufacturing methods th
Grass pea (Lathyrus sativus L.) is an important cool-season legume species with wide genetic diversity spread across the continents. With the climate change scenario it has emerged as a viable crop option for fragile agro-ecosystems, where successful cultivation of major crop species is apparently not difficult. However, grass pea seeds are known to have a neurotoxin known as β-N-oxalyl-l-α, β-diaminopropionic acid (β-ODAP). Its overconsumption as a staple food in an unbalanced diet for an extended period of 3–4 months can cause spastic paraparesis of the legs in human beings. Therefore, β-ODAP needs to be reduced through genetic means to a safe level for human consumption. Unfortunately, a paucity of efforts towards development of genetic and genomic resources for this species has hampered the progress in breeding low ODAP varieties in the past. Some progress has been made in recent years for collection, conservation, characterization, evaluation and utilization of Lathyrus genetic resources at the national and international levels, resulting in large ex situ collections in various gene banks of the world. These resources need to be systematically characterized and evaluated for genetic improvement through conventional and contemporary approaches. In spite of a large number of wild relatives with useful traits, no significant efforts have been made for alien gene transfer in grass pea. This chapter reviews the present status of genetic and genomic resources of Lathyrus and their use in current breeding programmes.
Annotation The Department of Zoology in Dr. Hari Singh Gour University of Madhya Pradesh has endeavoured to publish the proceedings of the seminar on ‘Environmental Pollution—Impact Assessment due to Industrialisation’ under the able editorship of Dr. V.S. Bais and Dr. U.S. Gupta.
Written Indian history begins in sixth century bc with the history of Magadh (present day states of Jharkhand and Bihar). For almost a millennium Magadh dominated Indian history. The situation changed when Islamicized Turks entered India. The Mughals who followed the Turks ensured Bihar's economic prosperity; Patna became the most important centre of Himalayan trade. European Companies visited Patna to obtain a variety of goods, local as well as Himalayan. In the mid-eighteenth century Bihar and Bengal fell into the hands of Englishmen. A new chapter began. At the turn of the nineteenth century, Industrial Revolution began in Britain. The East India Company stopped trading in textiles. Instead, they promoted cotton cultivation in order that cotton was available to British textile factories. They promoted cultivation of indigo, needed by the textile manufacturing factories coming up. Land revenue source of the government's prime income, was collected even when agricultural output suffered massively. The government took deep interest in opium production but paid the cultivators less than the market price. British interference in agricultural matters caused wide spread agrarian distress. Indian society encountered many socio-religious reform movements. Raja Rammohun Roy and Swami Dayanand were major proponents of the new order. Stress was laid on gender equality, women empowerment and the modern system of education. Institutions for training doctors, engineers and scientists were opened. As time progressed, by and large, Biharis accepted the changes. Eventually social reform movements turned into the freedom movement in which Biharis played a leading role. This comprehensive volume is indispensable for scholars working on Bihar and modern and medieval South Asia. Please note: Taylor & Francis does not sell or distribute the Hardback in India, Pakistan, Nepal, Bhutan, Bangladesh and Sri Lanka
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