Chronic pain includes many types of conditions from a variety of causes. This book is designed to help those suffering from chronic pain learn to better manage pain so they can get on with living a satisfying, fulfilling life. This resource stresses four concepts: each person with chronic pain is unique, and there is no one treatment or approach that is right for everybody; there are many things people with chronic pain can do to feel better and become more active and involved in life; with knowledge and experimentation, each individual is the best judge of which self-management tools and techniques are best for him or her; and, the responsibility for managing chronic pain on a daily basis rests with the individual and no one else. Acknowledging that overcoming chronic pain is a daily challenge, this workbook provides readers with the tools to overcome that test. A Moving Easy Program CD, which offers a set of easy-to-follow exercises that can be performed at home, is also included.
The object of this book is to educate both new and experienced preparers to deal with the numerous changes relating to the filing of the 2008 Form 990 series of tax returns. While the old 990 had just two schedules to complete, the new form has 16 schedules. This book offers a practical, hands-on approach to completing the new challenging form. Major Topics: [ Changes in filing requirements for Form 990 and 990EZ phased in thresholds [ Electronic filing requirements [ New: Preparation of the new required summary of the organization's mission, activities, and current and prior years' financial results [ Revised: Statement of program service accomplishments - reporting of new, ongoing, and discontinued achievements and their related revenue and expenses [ New: Statements regarding other IRS filings and tax compliance [ New: Governance, management, and disclosure- information regarding governing body and its management, policies, and disclosure [ Revised: Compensation schedules for offices, directors, and key employees
Describes ways in which individuals can be pressured, influenced, and manipulated and discusses how to avoid falling into common traps by peers, advertising, groupthink, and the media.
Best practices for Data Protection and Privacy is an authoritative, insider's perspective on best practices for safeguarding sensitive information and intellectual property. Featuring partners and chairs from some of the nation's leading law firms, these experts guide the reader through the inner workings of data protection audits, privacy policies, cybercrime, customer notification, identity theft, and both current and proposed federal and state privacy laws. These top lawyers also offer advice on reacting to a breach of data security, implementing policies to better protect data, understanding an attorney's role in protection strategies, enforcing data protection violations, and analyzing the effect of the economy on data protection. Finally, these leaders reveal their strategies for meeting client expectations, planning defensively, and keeping abreast of change. The different niches represented and the breadth of perspectives presented enable readers to get inside some of the great legal minds of today, as these experienced lawyers offer up their thoughts around the keys to success within this dynamic and fast-paced field.
Focuses on the spiritual, technical, and esoteric dimensions of martial arts. Includes biographies of prominent masters and information on associations.
Recounts the story behind English astronomer Richard Carrington's observations of a mysterious explosion on the surface of the sun and how his understanding that the sun's magnetism directly influences the Earth helped usher in the modern era of astronomy.
The purpose of this book is to give a clear and straightforward account of the remarkable properties of the nicotinic receptor for acetylcholine, a membrane protein involved in chemical transduction in the nervous system that is also the target of a widely used drug, nicotine. This molecule also happens to be the first pharmacological receptor and ion channel ever to have been identified. Jean-Pierre Changeux has played a leading role with Stuart J. Edelstein in the investigation of nicotinic acetylcholine receptors and allosteric proteins. The aim of this book is not only to review the most recent experimental and theoretical breakthroughs in the study of the nicotinic receptor, but also to give the reader a sense of the intellectual excitement and adventure that accompanied the various stages of discovery. This richly illustrated volume furnishes an exceptional opportunity for scientists and students to follow the course of a major advance in our understanding of the molecular basis of brain functions. Jean-Pierre Changeux is honorary professor at the Collège de France and at the Institut Pasteur, a member of the French Academy of Sciences. In addition to L’Homme neuronal [Neuronal Man] he is the author of Raison et Plaisir and L’Homme de vérité. He is also co-author, with Alain Connes, of Matière à penser [Conversations on Mind, Matter, and Mathematics] and, with Paul Ricœur, of La Nature et la Règle [What Makes Us Think?]. All thought-provoking works. Stuart J. Edelstein is Professor of Biochemistry at the University of Geneva and a foreign associate member of the Academy of Sciences. "The nicotinic acetylcholine receptor has served for many decades as the prototype for neurotransmitter receptors. Acetylcholine was the first neurotransmitter shown to be involved in the fonction of the mammalian brain and its nicotinic receptor the first receptor to be characterized. Jean-Pierre Changeux is the indisputable pioneer in this field. This volume summarizes with great lucidity the history of a highly important topic in neuroscience." Paul Greengard, Nobel laureate in Medecine - The Rockefeller University "From the molecule to thought itself - an extraordinary journey! Changeux and Edelstein are uniquely qualified to relate this utterly fascinating story, whose philosophical implications are no less important than the scientific research underlying them." Jean-Marie Lehn, Nobel laureate in Chemistry - ISIS-Université Louis Pasteur, Strasbourg "The human brain is as much a chemical as an electrical network. Its intricacy and sophistication set it apart from any known technical device. The groundbreaking papers by Monod, Jacob, Wyman, and Changeux in the 1960s on chemical regulation and control were eye-opening for all us who were doing experimental research in ths field, and they have turned out to be crucial for understanding biological evolution and learning in a broad sense. Since then Changeux and Edelstein have achieved international fame for their work on nicotinic acetylcholine receptors, amply documented in this masterful account." Manfred Eigen, Nobel laureate in Chemistry - Max Planck Institute for Biophysical Chemistry, Göttingen "One hesitates to call this book a monograph, for despite its comprehensive treatment of a complex subject it is not meant solely for specialized readers. In concentrating on a single class of neuroreceptors, the nicotinic acetylcholine receptor, it seeks to draw out general principles which apply more widely. It will therefore be welcomed not only by serious workers and students in the field of neurobiology, but also by anyone interested in the broader field of neuroscience." Sir Aaron Klug OM FRS, Nobel laureate in Chemistry - University of Cambridge "Changeux and Edelstein have provided a concise yet highly comprehensive account of perhaps the prototypical neurotransmitter complex, the nicotinic acetylcholine receptor. The story of how the roles played by this signal transduction system in nicotine dependence, learning, memory, and the processes of cognition came to be unraveled is an exciting saga, both beautiful and profound. A lovely historico-scientific document." Floyd E. Bloom, Professor Emeritus - The Scripps Research Institute "Changeux and Edelstein describe a classically Cartesian process of scientific investigation that leads to a most non-Cartesian conclusion. Having elucidated the mechanisms of action and interaction by which the various elements that make up the nicotinic acetylcholine receptor operate throughout the nervous system, from neuromuscular junctions to the brain itself, the authors turn to the role of thse structures and mechanisms in supporting cognition and giving access to consciousness - thus parting ways with Descartes and the view that the mind is able somehow to exist independently of the body. A work of truly remarkable erudition and insight." Roger Guillemin, Nobel laureate in Medicine - Salk Institute for Biological Studies “This book is unlike any recent scientific book. It is more like a forty-year research meeting in one of the world’s most creative neurobiology laboratories—an intellectual tour de fortcheat surveys the developmental trends and achievements of twentieth-century neuroscience in molecular, structural, and functional terms. The book therefore becomes an extraordinary educational saga, moving from Sir Henry Dale’s pharmacology of nicotine to genetic diseases involving mutations of the cation channel function of nicotinic acetylcholine receptors. Research into these archetypal proteins has been carried out by pharmacologists, biochemists, molecular biologists, electrophysiologists, behavioral scientists, and geneticists, with Jean-Pierre Changeux and his coworkers participating in every aspect of this remarkable inquiry. Nicotinic acetylcholine receptors are the workhorse of the fast actions of the chemical signal acetylcholine, abundantly transmitted in both the peripheral and the central nervous system. Thanks to their variable sub- unit composition they come in many flavors, mediating control of voluntary muscles in the periphery and helping to regulate reward functions, cognition, and memory in the brain. This rich functionality leads the authors to describe models of neuromuscular junction development as well a global workspace model of cognitive function and its role in effortful learning. The nicotinic acetylcholine receptor was among the first ligand-gated ion channels to be sequenced and studied by patch-clamp methods. It has been the object of neurobiological research in England, France, Germany, Japan, and the United States, with contributions of equal weight being made by many teams of researchers over a number of decades, all carefully chronicled and explained by the authors. This book is to be highly recommended to young scientists who want to discover into how many fields a single protein molecule can take them—from snake venom action to myasthenia gravis, addiction, learning, and schiz- ophrenia—if they are willing patiently to learn new research techniques rather than specialize in a single method or instrument. To investigate the nicotinic acetylcholine receptor in all its aspects requires a Renaissance mind, and it is exactly this that Changeux and Edelstein have brought to bear on one of the most studied topics in neuroscience of the last century.” TAMAS BARTFAI, Chair and Professor, Department of Neuropharmacology The Scripps Research Institute
The acetylcholine nicotinic receptor is among the most studied receptors in neuroscience. Involved in muscle contraction and a wide variety of other neurological functions, including the processing of nicotine, it was the first receptor to be isolated and observed at the molecular level, providing a major research pathway for scientists working in neuroscience, biochemistry, pharmacology, and behavioral science. This book describes four decades of scientific research that inform our current understanding of this receptor. Jean-Pierre Changeux and Stuart J. Edelstein played important roles in pioneering research on the acetylcholine nicotinic receptor and on allosteric proteins, and here they reveal the complete scientific trajectory of that research. They begin with a historical perspective, describing how several fields converged around a single receptor and then explain the initial receptor purification and characterization. Subsequent chapters trace the investigations into various aspects of receptor structure and function, including the chemical structure of the binding site, the identity and properties of the ion channel, and the mechanism of signal transmission. In the final portion of the book, Changeux and Edelstein discuss recent studies on the three-dimensional structure of the receptor molecule and share their novel understanding of inherited diseases such as congenital myasthenia and epilepsy. They also address the integration of the receptor into its synaptic membrane environment and its distribution, physiology, and regulation in brain functions and cognition. Richly illustrated and lucidly written, this book provides an exceptional opportunity for scientists and students to follow a historic advance in our knowledge of molecular mechanisms and the workings of the brain.
This is the third edition of the well-known guide to close-range photogrammetry. It provides a thorough presentation of the methods, mathematics, systems and applications which comprise the subject of close-range photogrammetry, which uses accurate imaging techniques to analyse the three-dimensional shape of a wide range of manufactured and natural objects.
The far north coast of Scotland. Spring 1745. It begins with a murder. But is it a murder when someone is forced to kill his brother, so that he might save his own life? The guilty man is a nobody, a poor fisherman. The person who arrogantly and unthinkingly makes him commit this terrible act, simply to see how he behaved, is the richest man in Scotland, the Earl of Dunbeath. Dunbeath invents his game of life the Prisoner s Dilemma. He invites his old friend, David Hume, to Caithness to play the new game with him. But into their planned discussions blow two survivors from a shipwreck - the beautiful and brilliant Sophie Kant and the calm, charismatic captain, Alexis Zweig. What follows is a claustrophobic and fast-moving game of cat and mouse, as the characters drive relentlessly towards their destinies in life and death, love and betrayal and the passion they each have to achieve their different ambitions. Under the game-playing, the deceits and feints, the science and the philosophy, is a simple tale of three utterly determined and ruthless men struggling to the death to succeed in the race for an extraordinary woman. Which of them will win? How? And why? ,
A groundbreaking guide to the universe and how our latest deep-space discoveries are forcing us to revisit what we know—and what we don't. On March 21, 2013, the European Space Agency released a map of the afterglow of the Big Bang. Taking in 440 sextillion kilometres of space and 13.8 billion years of time, it is physically impossible to make a better map: we will never see the early universe in more detail. On the one hand, such a view is the apotheosis of modern cosmology, on the other, it threatens to undermine almost everything we hold cosmologically sacrosanct. The map contains anomalies that challenge our understanding of the universe. It will force us to revisit what is known and what is unknown, to construct a new model of our universe. This is the first book to address what will be an epoch-defining scientific paradigm shift. Stuart Clark will ask if Newton's famous laws of gravity need to be rewritten; if dark matter and dark energy are just celestial phantoms? Can we ever know what happened before the Big Bang? What’s at the bottom of a black hole? Are there universes beyond our own? Does time exist? Are the once immutable laws of physics changing?
Illustrating essential aspects of adaptive image processing from a computational intelligence viewpoint, the second edition of Adaptive Image Processing: A Computational Intelligence Perspective provides an authoritative and detailed account of computational intelligence (CI) methods and algorithms for adaptive image processing in regularization, edge detection, and early vision. With three new chapters and updated information throughout, the new edition of this popular reference includes substantial new material that focuses on applications of advanced CI techniques in image processing applications. It introduces new concepts and frameworks that demonstrate how neural networks, support vector machines, fuzzy logic, and evolutionary algorithms can be used to address new challenges in image processing, including low-level image processing, visual content analysis, feature extraction, and pattern recognition. Emphasizing developments in state-of-the-art CI techniques, such as content-based image retrieval, this book continues to provide educators, students, researchers, engineers, and technical managers in visual information processing with the up-to-date understanding required to address contemporary challenges in image content processing and analysis.
For two generations historians have debated the significance of the New Deal, arguing about what it tried and tried not to do, whether it was radical or reactionary, and what its origins were. They have emphasized the National Recovery Administration, Agricultural Adjustment Administration, Tennessee Valley Authority, or the various social and labor legislation to illustrate an assortment of arguments about the "real" New Deal. Here James Olson contends that the little-studied Reconstruction Finance Corporation was the major New Deal agency, even though it was the product of the Hoover Administration. Pouring more than ten billion dollars into private businesses during the 1930s in a strenuous effort to "save capitalism," the RFC was the largest, most powerful, and most influential of all New Deal agencies, proving that the main thrust of the New Deal was state capitalism--the use of the federal government to shore up private property and the status quo. As national and international money markets collapsed in 1930, Hoover created an RFC with a structure similar to that of his War Finance Corporation. The agency was given two billion dollars to make low-interest loans to commercial banks, savings banks, other financial institutions, and railroads. With modifications, it survived the ultimate collapse of the economy in 1933 and went on to become the central part of the New Deal's effort to preserve fundamental American institutions. Originally published in 1988. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.
Social workers provide more mental health services than any other profession, yet recent biomedical trends in psychiatry appear to minimize the importance of their traditional concerns, which focus on the social environment that accompanies mental disorders and their treatment. In twenty-four chapters written by distinguished scholars this book not only calls attention to this emerging problem and challenges conventional mental health beliefs and practices, but also raises provocative questions: Has social work become too closely associated with psychiatry and too quick to adopt a medical approach? Has the focus on the therapeutic relationship negated social work's commitment to social reform? Is the social worker marginalized by the emphasis in mental health on biochemistry and psychopharmacology? This book calls on social workers and other health care professionals to be more skeptical about diagnosis, community treatment, evidence-based practice, psychotherapy, medications, and managed care.
Reporting on the latest advances made in treating multiple sclerosis (MS) and continuing the high standards set by earlier editions, the Handbook of Multiple Sclerosis, Third Edition examines a wide range of topics from etiology to treatment options. Analyzes recent developments in the natural history, immunopathology, lesion evolution, and
A panoramic social history of hurricanes in the Caribbean The diverse cultures of the Caribbean have been shaped as much by hurricanes as they have by diplomacy, commerce, or the legacy of colonial rule. In this panoramic work of social history, Stuart Schwartz examines how Caribbean societies have responded to the dangers of hurricanes, and how these destructive storms have influenced the region's history, from the rise of plantations, to slavery and its abolition, to migrations, racial conflict, and war. Taking readers from the voyages of Columbus to the devastation of Hurricane Katrina, Schwartz looks at the ethical, political, and economic challenges that hurricanes posed to the Caribbean’s indigenous populations and the different European peoples who ventured to the New World to exploit its riches. He describes how the United States provided the model for responding to environmental threats when it emerged as a major power and began to exert its influence over the Caribbean in the nineteenth century, and how the region’s governments came to assume greater responsibilities for prevention and relief, efforts that by the end of the twentieth century were being questioned by free-market neoliberals. Schwartz sheds light on catastrophes like Katrina by framing them within a long and contentious history of human interaction with the natural world. Spanning more than five centuries and drawing on extensive archival research in Europe and the Americas, Sea of Storms emphasizes the continuing role of race, social inequality, and economic ideology in the shaping of our responses to natural disaster. Some images inside the book are unavailable due to digital copyright restrictions.
Adaptive image processing is one of the most important techniques in visual information processing, especially in early vision such as image restoration, filtering, enhancement, and segmentation. While existing books present some important aspects of the issue, there is not a single book that treats this problem from a viewpoint that is directly li
First published in 1991, Stuart Bruchey’s study is a historical tribute to the financial innovation of the American Stock Exchange. He chronicles the heyday of Wall Street – from events leading to the Great Depression, through the New Deal and World War II, to the electronic era, the crash of’87, and the new realities and global opportunities of the 1990s. We observe with fascination the transformation of the relocated outdoor Curb market on Broad Street to its cavernous indoor trading facility on Trinity Place, where it’s been ever since – the first trading "posts" topped with light fixtures reminiscent of the outdoor lampposts they replaced. Bruchey relives for us the introduction of the first CRT terminals on the trading floor and the gradual, yet inevitable, influence of technology on the trading process. His study of modernization brings us right into the world of equity options, derivatives and other creative products introduced in latter part of the twentieth century – investment vehicles designed to serve an increasingly sophisticated and demanding marketplace of investors.
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