Stuart Kauffman here presents a brilliant new paradigm for evolutionary biology, one that extends the basic concepts of Darwinian evolution to accommodate recent findings and perspectives from the fields of biology, physics, chemistry and mathematics. The book drives to the heart of the exciting debate on the origins of life and maintenance of order in complex biological systems. It focuses on the concept of self-organization: the spontaneous emergence of order that is widely observed throughout nature Kauffman argues that self-organization plays an important role in the Darwinian process of natural selection. Yet until now no systematic effort has been made to incorporate the concept of self-organization into evolutionary theory. The construction requirements which permit complex systems to adapt are poorly understood, as is the extent to which selection itself can yield systems able to adapt more successfully. This book explores these themes. It shows how complex systems, contrary to expectations, can spontaneously exhibit stunning degrees of order, and how this order, in turn, is essential for understanding the emergence and development of life on Earth. Topics include the new biotechnology of applied molecular evolution, with its important implications for developing new drugs and vaccines; the balance between order and chaos observed in many naturally occurring systems; new insights concerning the predictive power of statistical mechanics in biology; and other major issues. Indeed, the approaches investigated here may prove to be the new center around which biological science itself will evolve. The work is written for all those interested in the cutting edge of research in the life sciences.
This major work offers a new interpretation of the witchcraft beliefs of European intellectuals between the fifteenth and eighteenth centuries, showing how these beliefs fitted rationally with other beliefs of the period and how far the nature of rationality is dependent on its historical context.
Michel Foucault’s work is rich with implications and insights concerning spatiality, and has inspired many geographers and social scientists to develop these ideas in their own research. This book, the first to engage Foucault’s geographies in detail from a wide range of perspectives, is framed around his discussions with the French geography journal Hérodote in the mid 1970s. The opening third of the book comprises some of Foucault’s previously untranslated work on questions of space, a range of responses from French and English language commentators, and a newly translated essay by Claude Raffestin, a leading Swiss geographer. The rest of the book presents specially commissioned essays which examine the remarkable reception of Foucault’s work in English and French language geography; situate Foucault’s project historically; and provide a series of developments of his work in the contemporary contexts of power, biopolitics, governmentality and war. Contributors include a number of key figures in social/spatial theory such as David Harvey, Chris Philo, Sara Mills, Nigel Thrift, John Agnew, Thomas Flynn and Matthew Hannah. Written in an open and engaging tone, the contributors discuss just what they find valuable - and frustrating - about Foucault’s geographies. This is a book which will both surprise and challenge.
The garden has always been a place of peace and perseverance, of nurture and reward. Using contemporary neuroscience, psychoanalysis, and compelling real-life stories, The Well-Gardened Mind investigates the remarkable effects of nature on our health and well-being."--Dust jacket.
Drawing on two years of ethnographic fieldwork and over 150 interviews with gang-affiliated youth in the "Taylor Park" neighborhood on Chicago's South Side, Ballad of the Bullet reveals that those coming of age in America's poorest neighborhoods are developing new, creative, and online strategies for making ends meet. Dislocated by the erosion of the crack economy and the splintering of corporatized gangs, these young people exploit the unique affordances of digital social media to capitalize on an emerging online market for urban violence (or, more accurately, a market for the representation of urban violence). In the past, violence functioned primarily as a means of social control, allowing urban youth to compete in illegal street markets and defend the social statuses otherwise denied to them by mainstream society. Today, with the rise of platforms like YouTube, Instagram, and Twitter, violence has become a premier cultural commodity in and of itself. By amassing millions of clicks, views, and followers, these young people convert their online displays of violence into vital offline resources, including cash, housing, drugs, sex, and, for a very select few, a ticket out of poverty" --
An analysis of the intellectual and emotional life of ancient Mesoamerican people through studies of figural works and inscriptions. All of human experience flows from bodies that feel, express emotion, and think about what such experiences mean. But is it possible for us, embodied as we are in a particular time and place, to know how people of long ago thought about the body and its experiences? In this groundbreaking book, three leading experts on the Classic Maya (ca. AD 250 to 850) marshal a vast array of evidence from Maya iconography and hieroglyphic writing, as well as archaeological findings, to argue that the Classic Maya developed an approach to the human body that we can recover and understand today. Starting with a cartography of the Maya body as depicted in imagery and texts, the authors explore how the body was replicated in portraiture; how it experienced the world through ingestion, the senses, and the emotions; how the body experienced war and sacrifice and the pain and sexuality; how words, often heaven-sent, could be embodied; and how bodies could be blurred through spirit possession. From these investigations, the authors convincingly demonstrate that the Maya conceptualized the body in varying roles, as a metaphor of time, as a gendered, sexualized being, in distinct stages of life, as an instrument of honor and dishonor, as a vehicle for communication and consumption, as an exemplification of beauty and ugliness, and as a dancer and song-maker. Their findings open a new avenue for empathetically understanding the ancient Maya as living human beings who experienced the world as we do, through the body.
The seventeenth and eighteenth centuries represent a period of remarkable intellectual vitality in British philosophy, as figures such as Hobbes, Locke, Hume, and Smith attempted to explain the origins and sustaining mechanisms of civil society. Their insights continue to inform how political and moral theorists think about the world in which we live. From Moral Theology to Moral Philosophy reconstructs a debate which preoccupied contemporaries but which seems arcane to us today. It concerned the relationship between reason and revelation as the two sources of mankind's knowledge, particularly in the ethical realm: to what extent, they asked, could reason alone discover the content and obligatory character of morality? This was held to be a historical, rather than a merely theoretical question: had the philosophers of pre-Christian antiquity, ignorant of Christ, been able satisfactorily to explain the moral universe? What role had natural theology played in their ethical theories - and was it consistent with the teachings delivered by revelation? Much recent scholarship has drawn attention to the early-modern interest in two late Hellenistic philosophical traditions - Stoicism and Epicureanism. Yet in the English context, three figures above all - John Locke, Conyers Middleton, and David Hume - quite deliberately and explicitly identified their approaches with Cicero as the representative of an alternative philosophical tradition, critical of both the Stoic and the Epicurean: academic scepticism. All argued that Cicero provided a means of addressing what they considered to be the most pressing question facing contemporary philosophy: the relationship between moral philosophy and moral theology.
The purpose of this book is to give a clear and straightforward account of the remarkable properties of the nicotinic receptor for acetylcholine, a membrane protein involved in chemical transduction in the nervous system that is also the target of a widely used drug, nicotine. This molecule also happens to be the first pharmacological receptor and ion channel ever to have been identified. Jean-Pierre Changeux has played a leading role with Stuart J. Edelstein in the investigation of nicotinic acetylcholine receptors and allosteric proteins. The aim of this book is not only to review the most recent experimental and theoretical breakthroughs in the study of the nicotinic receptor, but also to give the reader a sense of the intellectual excitement and adventure that accompanied the various stages of discovery. This richly illustrated volume furnishes an exceptional opportunity for scientists and students to follow the course of a major advance in our understanding of the molecular basis of brain functions. Jean-Pierre Changeux is honorary professor at the Collège de France and at the Institut Pasteur, a member of the French Academy of Sciences. In addition to L’Homme neuronal [Neuronal Man] he is the author of Raison et Plaisir and L’Homme de vérité. He is also co-author, with Alain Connes, of Matière à penser [Conversations on Mind, Matter, and Mathematics] and, with Paul Ricœur, of La Nature et la Règle [What Makes Us Think?]. All thought-provoking works. Stuart J. Edelstein is Professor of Biochemistry at the University of Geneva and a foreign associate member of the Academy of Sciences. "The nicotinic acetylcholine receptor has served for many decades as the prototype for neurotransmitter receptors. Acetylcholine was the first neurotransmitter shown to be involved in the fonction of the mammalian brain and its nicotinic receptor the first receptor to be characterized. Jean-Pierre Changeux is the indisputable pioneer in this field. This volume summarizes with great lucidity the history of a highly important topic in neuroscience." Paul Greengard, Nobel laureate in Medecine - The Rockefeller University "From the molecule to thought itself - an extraordinary journey! Changeux and Edelstein are uniquely qualified to relate this utterly fascinating story, whose philosophical implications are no less important than the scientific research underlying them." Jean-Marie Lehn, Nobel laureate in Chemistry - ISIS-Université Louis Pasteur, Strasbourg "The human brain is as much a chemical as an electrical network. Its intricacy and sophistication set it apart from any known technical device. The groundbreaking papers by Monod, Jacob, Wyman, and Changeux in the 1960s on chemical regulation and control were eye-opening for all us who were doing experimental research in ths field, and they have turned out to be crucial for understanding biological evolution and learning in a broad sense. Since then Changeux and Edelstein have achieved international fame for their work on nicotinic acetylcholine receptors, amply documented in this masterful account." Manfred Eigen, Nobel laureate in Chemistry - Max Planck Institute for Biophysical Chemistry, Göttingen "One hesitates to call this book a monograph, for despite its comprehensive treatment of a complex subject it is not meant solely for specialized readers. In concentrating on a single class of neuroreceptors, the nicotinic acetylcholine receptor, it seeks to draw out general principles which apply more widely. It will therefore be welcomed not only by serious workers and students in the field of neurobiology, but also by anyone interested in the broader field of neuroscience." Sir Aaron Klug OM FRS, Nobel laureate in Chemistry - University of Cambridge "Changeux and Edelstein have provided a concise yet highly comprehensive account of perhaps the prototypical neurotransmitter complex, the nicotinic acetylcholine receptor. The story of how the roles played by this signal transduction system in nicotine dependence, learning, memory, and the processes of cognition came to be unraveled is an exciting saga, both beautiful and profound. A lovely historico-scientific document." Floyd E. Bloom, Professor Emeritus - The Scripps Research Institute "Changeux and Edelstein describe a classically Cartesian process of scientific investigation that leads to a most non-Cartesian conclusion. Having elucidated the mechanisms of action and interaction by which the various elements that make up the nicotinic acetylcholine receptor operate throughout the nervous system, from neuromuscular junctions to the brain itself, the authors turn to the role of thse structures and mechanisms in supporting cognition and giving access to consciousness - thus parting ways with Descartes and the view that the mind is able somehow to exist independently of the body. A work of truly remarkable erudition and insight." Roger Guillemin, Nobel laureate in Medicine - Salk Institute for Biological Studies “This book is unlike any recent scientific book. It is more like a forty-year research meeting in one of the world’s most creative neurobiology laboratories—an intellectual tour de fortcheat surveys the developmental trends and achievements of twentieth-century neuroscience in molecular, structural, and functional terms. The book therefore becomes an extraordinary educational saga, moving from Sir Henry Dale’s pharmacology of nicotine to genetic diseases involving mutations of the cation channel function of nicotinic acetylcholine receptors. Research into these archetypal proteins has been carried out by pharmacologists, biochemists, molecular biologists, electrophysiologists, behavioral scientists, and geneticists, with Jean-Pierre Changeux and his coworkers participating in every aspect of this remarkable inquiry. Nicotinic acetylcholine receptors are the workhorse of the fast actions of the chemical signal acetylcholine, abundantly transmitted in both the peripheral and the central nervous system. Thanks to their variable sub- unit composition they come in many flavors, mediating control of voluntary muscles in the periphery and helping to regulate reward functions, cognition, and memory in the brain. This rich functionality leads the authors to describe models of neuromuscular junction development as well a global workspace model of cognitive function and its role in effortful learning. The nicotinic acetylcholine receptor was among the first ligand-gated ion channels to be sequenced and studied by patch-clamp methods. It has been the object of neurobiological research in England, France, Germany, Japan, and the United States, with contributions of equal weight being made by many teams of researchers over a number of decades, all carefully chronicled and explained by the authors. This book is to be highly recommended to young scientists who want to discover into how many fields a single protein molecule can take them—from snake venom action to myasthenia gravis, addiction, learning, and schiz- ophrenia—if they are willing patiently to learn new research techniques rather than specialize in a single method or instrument. To investigate the nicotinic acetylcholine receptor in all its aspects requires a Renaissance mind, and it is exactly this that Changeux and Edelstein have brought to bear on one of the most studied topics in neuroscience of the last century.” TAMAS BARTFAI, Chair and Professor, Department of Neuropharmacology The Scripps Research Institute
Vanities of the Eye investigates the cultural history of the senses in early modern Europe, a time in which the nature and reliability of human vision was the focus of much debate. In medicine, art theory, science, religion, and philosophy, sight came to be characterised as uncertain or paradoxical - mental images no longer resembled the external world. Was seeing really believing? Stuart Clark explores the controversial debates of the time - from the fantasies and hallucinations of melancholia, to the illusions of magic, art, demonic deceptions, and witchcraft. The truth and function of religious images and the authenticity of miracles and visions were also questioned with new vigour, affecting such contemporary works as Macbeth - a play deeply concerned with the dangers of visual illusion. Clark also contends that there was a close connection between these debates and the ways in which philosophers such as Descartes and Hobbes developed new theories on the relationship between the real and virtual. Original, highly accessible, and a major contribution to our understanding of European culture, Vanities of the Eye will be of great interest to a wide range of historians and anyone interested in the true nature of seeing.
Life in the Market Ecosystem, the second book inthe Nature of Liberty trilogy, confronts evolutionary psychology head on. It describes the evolutionary psychologists’ theory of gene-culture co-evolution, which states that although customs and culture are not predetermined by anyone’s genetic makeup, one’s practice of a custom can influence the likelihood of that person having children and grandchildren. Therefore, according to the theory, customs count as evolutionary adaptations. Extending that theory further, as entire systems of political economy—capitalism, socialism, and hunter-gatherer subsistence—consist of multiple customs and institutions, it follows that an entire political-economic system can likewise be classified as an evolutionary adaptation. Considering that liberal-republican capitalism has, insofar as the system has been implemented, done more to reduce the mortality rate and secure human fertility than other models of societal structure, it stands to reason that liberal-republican capitalism is itself a beneficent evolutionary adaptation. Moreover, as essential tenets of Rand’s Objectivism—individualism, observation-based rationality, and peaceable self-interest—have been integral to the development of the capitalist ecosystem, important aspects of the Objectivism are worthwhile adaptations as well. This book shall uphold that position, as well as combat critiques by evolutionary psychologists and environmentalists who denounce capitalism as self-destructive. Instead, capitalism is the most sustainable and fairest political model. This book argues that of all the philosophies, Objectivism is the one that is most fit for humanity.
*Winner of an honorable mention from theSociety for Social Work and ResearchforOutstanding Social Work Book AwardMad Science argues that the fundamental claims of modern American psychiatry are based on misconceived, flawed, and distorted science. The authors address multiple paradoxes in American mental health research, including the remaking of coercion into scientific psychiatric treatment, the adoption of an unscientific diagnostic system that controls the distribution of services, and how drug treatments have failed to improve the mental health outcome.When it comes to understanding and treating mental illness, distortions of research are not rare, misinterpretation of data is not isolated, and bogus claims of success are not voiced by isolated researchers seeking aggrandizement. This book's detailed analysis of coercion and community treatment, diagnosis, and psychopharmacology reveals that these characteristics are endemic, institutional, and protected in psychiatry. They are not just bad science, but mad science.This book provides an engaging and readable scientific and social critique of current mental health practices. The authors are scholars, researchers, and clinicians who have written extensively about community care, diagnosis, and psychoactive drugs. This paperback edition makes Mad Science accessible to all specialists in the field as well as to the informed public.
Native American tribes, including Cherokee, Creek, and Shawano, passed through Asheville and Western North Carolina, building towns and villages along the banks of the Swannanoa and French Broad Rivers for more than 1,000 years. The first white settlers arrived in the Swannanoa Valley in October of 1784. After the Civil War, Asheville became a haven for the wealthy elite of Charleston and Philadelphia; as the resort era blossomed, so too did Asheville. Second only to Miami in its treasure trove of Art Deco landmarks, Asheville is an architectural and historical time capsule of national significance. It is a community with a rich heritage and history in the arts, including textiles, pottery, and modernist art. Today Asheville is at a crossroads; attempting to balance the environmental and natural attractions of the area with commercial development is and will be one of Asheville's greatest challenges.
Social workers provide more mental health services than any other profession, yet recent biomedical trends in psychiatry appear to minimize the importance of their traditional concerns, which focus on the social environment that accompanies mental disorders and their treatment. In twenty-four chapters written by distinguished scholars this book not only calls attention to this emerging problem and challenges conventional mental health beliefs and practices, but also raises provocative questions: Has social work become too closely associated with psychiatry and too quick to adopt a medical approach? Has the focus on the therapeutic relationship negated social work's commitment to social reform? Is the social worker marginalized by the emphasis in mental health on biochemistry and psychopharmacology? This book calls on social workers and other health care professionals to be more skeptical about diagnosis, community treatment, evidence-based practice, psychotherapy, medications, and managed care.
The acetylcholine nicotinic receptor is among the most studied receptors in neuroscience. Involved in muscle contraction and a wide variety of other neurological functions, including the processing of nicotine, it was the first receptor to be isolated and observed at the molecular level, providing a major research pathway for scientists working in neuroscience, biochemistry, pharmacology, and behavioral science. This book describes four decades of scientific research that inform our current understanding of this receptor. Jean-Pierre Changeux and Stuart J. Edelstein played important roles in pioneering research on the acetylcholine nicotinic receptor and on allosteric proteins, and here they reveal the complete scientific trajectory of that research. They begin with a historical perspective, describing how several fields converged around a single receptor and then explain the initial receptor purification and characterization. Subsequent chapters trace the investigations into various aspects of receptor structure and function, including the chemical structure of the binding site, the identity and properties of the ion channel, and the mechanism of signal transmission. In the final portion of the book, Changeux and Edelstein discuss recent studies on the three-dimensional structure of the receptor molecule and share their novel understanding of inherited diseases such as congenital myasthenia and epilepsy. They also address the integration of the receptor into its synaptic membrane environment and its distribution, physiology, and regulation in brain functions and cognition. Richly illustrated and lucidly written, this book provides an exceptional opportunity for scientists and students to follow a historic advance in our knowledge of molecular mechanisms and the workings of the brain.
Professor Sprague has assembled a list of Kentuckians who migrated migrated to Illinois. Passing over conventional record sources, he has used information from published county histories and county atlases. Arranged in tabular format under the county of origin, entries include some or all of the following information: the name of the Kentucky migrant, his birthdate, the names of his parents and places of birth (if known), and the date of migration.
Hunting Down Social Darwinism is the third and final installment in the trilogy, The Nature of Liberty. The trilogy gives a secular, ethical defense of laissez-faire capitalism, inspired by Ayn Rand’s ideas. The trilogy’s first book, The Freedom of Peaceful Action, provided the philosophic theory behind the ethics of a free-enterprise system based on the individual rights to life, liberty, and private property which John Locke described. The second installment, Life in the Market Ecosystem, explained how free enterprise functions much as a natural ecosystem wherein behavioral norms develop, bottom-up, from repeat interactions among individual participants in the economy. As such defenses of free enterprise are frequently criticized as “social Darwinism,” however, this third and final installment of the trilogy asks the question, “What is social Darwinism?” The book embarks on a hunt for the term’s meaning, explores social Darwinism’s beginnings, and examines whether it is fair to describe such nineteenth-century free-market advocates as Herbert Spencer and William Graham Sumner as social Darwinists. It then addresses the accusation that the free-market Darwinism commonly ascribed to Spencer and Sumner rationalized bigotry and founded the pseudoscience of eugenics. In the process, the book refutes various myths about the topic popularized by such scholars as Richard Hofstadter and John Kenneth Galbraith. The extent to which the popular narratives about social Darwinism prove to be inaccurate holds enormous ramifications for current controversies. It has implications for debates over the ethical appropriateness of reducing taxpayer spending on social welfare programs, and also sheds new light on the pros and cons of attempts to apply biological evolutionary theory to the study of human social institutions. Additionally discussed is the manner in which various prominent figures in economics, evolutionary psychology, and Complexity Theory have grown famous for advancing ideas which Spencer and Sumner originated, even as such figures simultaneously downplay the importance of Spencer and Sumner to their field. Following the hunt for social Darwinism, this work sums up the trilogy with some final thoughts on the importance that liberty holds for every effort to live life to the fullest.
This timely and evocative issue of Rheumatic Disease Clinics explores important current and controversial topics in the treatment of osteoporosis. And it answers some tough questions! Here are some examples. How long do I treat my patient? Is there a place for bone turnover markers? How much Vitamin D should I recommend? Controversies around calcium and Vitamin D are explored regarding the coronary risk and pancreatic issues. Emerging therapies are presented, including sclerostin and oral calcitonin. Long-term safety concerns of antiresporptive therapy (ONJ, atypical fracture, would healing) are explained. The utility and limitations of FRAX are covered, as well as Prolia and the RANKL pathway. An update on glucocorticoid induced OP is given. The reader is also brought up to date on men’s health issues and OP. This is an essential issue for any practicing rheumatologist to stay current in the field.
Different conceptions of the world and of reality have made witchcraft possible in some societies and impossible in others. How did the people of early modern Europe experience it and what was its place in their culture? The new essays in this collection illustrate the latest trends in witchcraft research and in cultural history in general. After three decades in which the social analysis of witchcraft accusations has dominated the subject, they turn instead to its significance and meaning as a cultural phenomenon - to the 'languages' of witchcraft, rather than its causes. As a result, witchcraft seems less startling than it once was, yet more revealing of the world in which it occurred.
Our work began where the greatest classical morphologists left off; their best work was the start of ours. As our work progressed, the rigidity of basic, previous embryological principles was broken down as scientific knowledge advanced. At the same time, the molecular, biological characterization of the cell surface receptor systems progressed enormously with the invention of NUMEROUS monoclonal antibodies. Thus, thymology became once again very important because the thymus is the first and central organ of the human immunological system. Then, the question of immuno-neuroendocrine regulation arose and has only been partially answered. Our book seeks to explore what has not been explored. The topic of thymic epithelial cells is a unique one and has never been explored in any previous book as it is explored in this one. Only a handful of great thymologists remain in the world today, especially after the great loss the medical community suffered with the passing of Dr. Good, the list includes but is not limited to: Dr. Ritter and Dr. Kendall in England, Dr. Savino in Brazil, Dr. Dardenne in France, Dr. von Gaudecker in Germany, a few others in Belgium and Holland, and it is our hope that Dr. Bodey is among them. Nonetheless, a book on the thymus has not been written in the last five years and a book such as this one has never been. This book is based on a 30-year period of research and includes references from a broad range of sources spanning the globe and all sources, even those that were the beginning of thymic research. The book, thus, is uniquely well rounded, more so that previous works.
The Freedom of Peaceful Action is the first installment of the trilogy The Nature of Liberty, which makes an ethical philosophic case for individual liberty and the free market against calls for greater government regulation and control. The trilogy makes a purely secular and nonreligious ethical case for the individual’s rights to life, liberty, private property, and the pursuit of happiness as championed by the U.S. Founding Fathers. Inspired by such philosophic defenders of free enterprise as John Locke, Herbert Spencer, and Ayn Rand, The Nature of Liberty shows that such individual rights are not imaginary or simply assertions, but are institutions of great practical value, making prosperity and happiness possible to the degree that society recognizes them. The trilogy demonstrates the beneficence of the individual-rights approach by citing important findings in the emerging science of evolutionary psychology. Although the conclusions of evolutionary psychology have been long considered to be at odds with the philosophies of individual liberty and free markets, The Nature of Liberty presents a reconciliation that reveals their ultimate compatibility, as various important findings of evolutionary psychology, being logically applied, confirm much of what philosophic defenders of liberty have been saying for centuries. Moreover, proceeding from the viewpoint of Rand, this work argues that the structure of society most conducive to practical human well-being is commensurately the most moral and humane approach as well. The trilogy’s first installment, The Freedom of Peaceful Action, focuses on the secular, philosophic foundation for a society based on individual rights. Starting from a defense of the efficacy of observational reason against criticisms from Immanuel Kant and Karl Popper, it demonstrates how a philosophic position of individual liberty and free markets is the logical result of the consistent application of human reason to observing human nature. This installment demonstrates that any political system that wishes for its citizens to thrive must take human nature into account, and that an accounting of human nature reveals that a system of maximum liberty and property protection is the one must conducive to peace and human well-being.
This will help us customize your experience to showcase the most relevant content to your age group
Please select from below
Login
Not registered?
Sign up
Already registered?
Success – Your message will goes here
We'd love to hear from you!
Thank you for visiting our website. Would you like to provide feedback on how we could improve your experience?
This site does not use any third party cookies with one exception — it uses cookies from Google to deliver its services and to analyze traffic.Learn More.