A well-illustrated and comprehensive analysis of the treatment of diabetic retinopathy, this book covers current treatment options and guidelines, whilst also providing a detailed discussion of emerging therapeutic targets. Existing therapeutic options are covered in depth, with a major focus on anti-vascular endothelial growth factor drugs and sustained release corticosteroids, including a review of trial results supporting current treatment guidelines. The use of agents off-label is also discussed. Controversial topics are discussed in detail with an emphasis on helping the reader make informed decisions, particularly when treating patients for which several treatment approaches may be appropriate because trial data does not clearly define the best option. Emerging therapeutic areas are evaluated, as work continues to identify agents that produce superior morphologic responses and visual acuity gains by targeting other molecules that contribute to diabetic retinopathy. Promising new drugs, targets and delivery systems are identified, and their development analysed.
The story of Australian-born Sir Hubert Wilkins and the Nautilus is usually a brief footnote, if mentioned at all, of Arctic exploration history. However, it is a tale of daring enterprise and of men captivated by the pursuit of noble deeds. Having leased and extensively modified a decommissioned vintage World War I U.S. Navy submarine, the Wilkins-Ellsworth Trans Arctic Submarine Expedition of 1931 was marked by controversy from its inception. Many considered it a huge publicity stunt, especially the planned rendezvous at the North Pole with the German airship Graf Zeppelin. The Nautilus did make it into the Arctic but suspected sabotage ended Sir Huberts quest to be the first to use a submarine to cross the Arctic Ocean by way of the North Pole. An oceanographer, historian and author, Dr. Nelson is a Fellow of the Marine Technology Society, a member of the Explorers Club and the former president of the American Oceanic Organization.
Written by an interdisciplinary team of scholars, this substantial volume offers a wide-ranging examination, from a Christian perspective, of the many complexities surrounding gender relations, showing how they have changed and how they still need to change if we are to be the men and women God meant us to be. No other book treats the systemic embedding of gender issues in all areas of life.
On March 31, 1943, the musical Oklahoma! premiered and the modern era of the Broadway musical was born. Since that time, the theatres of Broadway have staged hundreds of musicals--some more noteworthy than others, but all in their own way a part of American theatre history. With more than 750 entries, this comprehensive reference work provides information on every musical produced on Broadway since Oklahoma's 1943 debut. Each entry begins with a brief synopsis of the show, followed by a three-part history: first, the pre-Broadway story of the show, including out-of-town try-outs and Broadway previews; next, the Broadway run itself, with dates, theatres, and cast and crew, including replacements, chorus and understudies, songs, gossip, and notes on reviews and awards; and finally, post-Broadway information with a detailed list of later notable productions, along with important reviews and awards.
The story of Australian-born Sir Hubert Wilkins and the Nautilus is usually a brief footnote, if mentioned at all, of Arctic exploration history. However, it is a tale of daring enterprise and of men captivated by the pursuit of noble deeds. Having leased and extensively modified a decommissioned vintage World War I U.S. Navy submarine, the Wilkins-Ellsworth Trans Arctic Submarine Expedition of 1931 was marked by controversy from its inception. Many considered it a huge publicity stunt, especially the planned rendezvous at the North Pole with the German airship Graf Zeppelin. The Nautilus did make it into the Arctic but suspected sabotage ended Sir Huberts quest to be the first to use a submarine to cross the Arctic Ocean by way of the North Pole. An oceanographer, historian and author, Dr. Nelson is a Fellow of the Marine Technology Society, a member of the Explorers Club and the former president of the American Oceanic Organization.
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