New and Improved SI Edition-Uses SI Units Exclusively in the TextAdapting to the changing nature of the engineering profession, this third edition of Fundamentals of Machine Elements aggressively delves into the fundamentals and design of machine elements with an SI version. This latest edition includes a plethora of pedagogy, providing a greater u
This book studies the role played by Jews in the explosion of cultural innovation in Vienna at the turn of the century, which had its roots in the years following the Ausgleich of 1867 and its demise in the sweeping events of the 1930s. The author shows that, in terms of personnel, Jews were predominant throughout most of Viennese high culture, and so any attempts to dismiss the "Jewish aspect" of the intelligentsia are refuted. The book goes on to explain this "Jewish aspect," dismissing any unitary, static model and adopting a historical approach that sees the "Jewishness" of Viennese modern culture as a result of the specific Jewish backgrounds of most of the leading cultural figures and their reactions to being Jewish.
Explains the role of reactive intermediates in biological systems as well as in environmental remediation With its clear and systematic approach, this book examined the broad range of reactive intermediate that can be generated in biological environments, detailing the fundamental properties of each reactive intermediate. Readers gain a contemporary understanding of how these intermediates react with different compounds, with an emphasis on amino acids, peptides, and proteins. The author not only sets forth the basic chemistry and nature of reactive intermediates, he also demonstrates how the properties of the intermediates presented in the book compare with each other. Oxidation of Amino Acids, Peptides, and Proteins begins with a discussion of radical and non-radical reactive species as well as an exploration of the significance of reactive species in the atmosphere, disinfection processes, and environmental remediation. Next, the book covers such topics as: Thermodynamics of amino acids and reactive species and the effect of metal-ligand binding in oxidation chemistry Kinetics and mechanisms of reactive halogen, oxygen, nitrogen, carbon, sulfur and phosphate species as well as reactive high-valent Cr, Mn, and Fe species Reactivity of the species with molecules of biological and environmental importance Generation of reactive species in the laboratory for kinetics studies Oxidation of amino acids, peptides, and proteins by permanganate, ferryl, and ferrate species Application of reactive species in purifying water and treating wastewater With this book as their guide, readers will be able to assess the overall effects of reactive intermediates in biological environments. Moreover, they’ll learn how to apply this knowledge for successful water purification and wastewater treatment.
Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. Now updated online for the life of the edition, DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology, 11th Edition keeps you up to date in this fast-changing field. Every quarter, your eBook will be updated with late-breaking developments in oncology, including new drugs, clinical trials, and more.
These proceedings of the 15th International Conference on Wear of Materials focus on the friction and wear of materials in various applications under different environments from the nanometer scale to the meter scale. The conference provides a unique international forum for researchers and practitioners from different disciplines to exchange latest results. Coverage includes: . Wear assessment and monitoring . Wear modeling, mechanisms, mapping and prediction . Wear-corrosion testing and control . Surface engineering for wear and wear-corrosion control . Development of new wear test methods and wear test methodologies . Wear of materials for biomedical applications . Wear of non-equilibrium materials: from atomic dimensions to the micro-scale . Wear of hard and superhard materials . Wear of materials in the earthmoving, minerals processing and mining industries
Specifically focusing on fluid film, hydrodynamic, and elastohydrodynamic lubrication, this edition studies the most important principles of fluid film lubrication for the correct design of bearings, gears, and rolling operations, and for the prevention of friction and wear in engineering designs. It explains various theories, procedures, and equations for improved solutions to machining challenges. Providing more than 1120 display equations and an introductory section in each chapter, Fundamentals of Fluid Film Lubrication, Second Edition facilitates the analysis of any machine element that uses fluid film lubrication and strengthens understanding of critical design concepts.
Choose health. Choose strength. Choose the StrongPath. Choosing the StrongPath is a book about the most insidious health crisis in the world, Sarcopenia, a muscle-wasting and frailty disease. It impacts all of us as we age, unless we proactively prevent it. As a world-renowned investigator and case builder, Fred Bartlit has done this once again with this book. He and coauthor Steven Droullard, along with muscle physiology expert Dr. Marni Boppart, want to share a little known fact with the world: You don’t have to fall apart as you get older. Through carefully calibrated progressive strength training and supporting nutrition, you can stave off sarcopenia, along with dozens of other age-related illnesses. Using scientific evidence and real-life case studies, Choosing the StrongPath offers a clear path away from a steady decline in the last third of your life and toward a healthier, happier you.
Computational Physics is designed to provide direct experience in the computer modeling of physical systems. Its scope includes the essential numerical techniques needed to "do physics" on a computer. Each of these is developed heuristically in the text, with the aid of simple mathematical illustrations. However, the real value of the book is in the eight Examples and Projects, where the reader is guided in applying these techniques to substantial problems in classical, quantum, or statistical mechanics. These problems have been chosen to enrich the standard physics curriculum at the advanced undergraduate or beginning graduate level. The book will also be useful to physicists, engineers, and chemists interested in computer modeling and numerical techniques. Although the user-friendly and fully documented programs are written in FORTRAN, a casual familiarity with any other high-level language, such as BASIC, PASCAL, or C, is sufficient. The codes in BASIC and FORTRAN are available on the web at http://www.computationalphysics.info. They are available in zip format, which can be expanded on UNIX, Window, and Mac systems with the proper software. The codes are suitable for use (with minor changes) on any machine with a FORTRAN-77 compatible compiler or BASIC compiler. The FORTRAN graphics codes are available as well. However, as they were originally written to run on the VAX, major modifications must be made to make them run on other machines.
Monoclonal antibodies (MAbs) are currently the major class of protein bio therapeutic being developed by biotechnology and pharmaceutical companies. Monoclonal Antibodies discusses the challenges and issues revolving around development of a monoclonal antibody produced by recombinant DNA technology into a therapeutic agent.This book covers downstream processing which includes design of processes to manufacture the formulation, formulation design, fill and finish into closure systems and routes of administration. The characterization of the final drug product is covered where the use of biophysical methods combined with genetic engineering is used to understand the solution properties of the formulation. The latter has become very important since many indications such as arthritis and asthma require the development of formulations for subcutaneous delivery (SC). The development of formulations for IV delivery is also important and comes with a different set of challenges. The challenges and strategies that can overcome these limitations are discussed in this book, starting with an introduction to these issues, followed by chapters detailing strategies to deal with them. Subsequent chapters explore the processing and storage of mAbs, development of delivery device technologies and conclude with a chapter on the future of mAbs in therapeutic remedies. - Discusses the challenges to develop MAbs for intravenous (IV) and subcutaneous delivery (SC) - Presents strategies to meet the challenges in development of MAbs for SC and IV administration - Discusses the use of biophysical analytical tools coupled with MAb engineering to understand what governs MAb properties at high concentration
Das Handbuch stellt gewöhnliche ebenso wie spezielle Probleme in der gynäkologischen Klinik in Form evidenzbasierter Behandlungsformen dar und benennt die diagnostischen und therapeutischen Möglichkeiten, die heute zur Verfügung stehen. Datenerhebung, Entscheidungsanalyse, Kosten und Ergebnisse sind die Prozessstufen, die detailliert dargestellt werden. Jedes Kapitel beginnt mit einem klinischen Profil der Krankheit bzw. Beschwerde und stellt eine Methodologie vor, die auf Daten datenbasierende Entscheidungsanalysen verwendet, um schließlich zu einer Behandlungsempfehlung zu gelangen. Ein "Entscheidungs-Baum" führt Faktoren wie Behandlungsoptionen, erwartete Ergebnisse und Kosten zusammen. Evidenzgrade und Levels werden im Layout unterschiedlich dargestellt und helfen bei der Orientierung. Mit diesem Band liegt das erste konsequent evidenzbasierte Werk zur perioperativen und unterstützenden Versorgung in der gynäkologischen Onkologie vor.
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