Advances in high-throughput sequencing technologies have enabled cost-effective sequencing of a single human genome at an unprecedented rate, facilitating scientific endeavours never imagined possible before. These improvements have transformed the field of cancer genomics, allowing the complete molecular characterization of individual cancer genomes. However, the promise of unveiling the complexity of cancer has lent itself to yet another level of complexity, the task of managing and integrating the massive amount of data that is generated as part of such experiments. There is a need to manage and store large sequence datasets such that they can be accessed and shared readily but, more importantly, there is a need for their thorough and efficient analysis. Developments and improvements in computer hardware and processing power have eliminated the data storage and access issues. Additionally, bioinformatic algorithms and software, designed specifically for the analysis of cancer genomic data, are now able comprehensively to profile the mutations in a cancer sample, to provide a probability score for their role as disease drivers and to identify potential actionable targets. Although the functional validation of putative driver mutations will remain a necessity, continued improvements in sequencing technologies and analysis tools promise to provide increasingly reliable computational analysis of cancer genomes.
RELEASE DATE - EARLY JUNE 2010To make the next giant step in consciousness and to chart a sustainable course for humanity's future, we need to reconsider some of our deepest notions of faith and religion. Our environment, some say, is on the brink of collapse. Our governments answer to corporate interests instead of to us, and our religious institutions continue to preach more bigotry, hatred, and judgment.We still have time to steer humanity's destiny, but many believe we have less than a century left to do so. The changes, logical in the extreme, involve each and every one of us rethinking who and what we are, then reassessing our lives based on a new understanding, solidly gounded in reason.
Barley: Chemistry and Technology, Second Edition is an important resource for any cereal chemist, food scientist, or crop scientist who needs to understand the development, structure, composition, and end-use properties of the barley grain for cultivation, trade, and utilization. Editors Peter R. Shewry and Steven E. Ullrich bring together a wide range of international authorities on barley to create this truly unique, encyclopedic reference work that covers the massive increase in barley knowledge over the past 20 years, since the first edition of this book was published. Barley: Chemistry and Technology, Second Edition offers the latest coverage of barley’s applications in milling, breeding, and production for food, feed, malting, brewing, distilling, and biofuels. It delivers a complete update of the latest knowledge of barley’s many components, from the genetic and molecular level to its many constituents, such as proteins, carbohydrates, arabinoxylans, minerals, lipids, terpenoids, phenolics, and vitamins. This important book also includes chapters on barley’s plant and grain development from both the physiological and genetic perspectives, making it an important resource not only for cereal and food scientists but also for crop scientists involved in breeding, agronomy, and related plant sciences New coverage includes: Updated, comprehensive knowledge on barley’s components, including proteins, carbohydrates, arabinoxylans, and bioactive effects New end-use ideas for barley as an ingredient in food products Nonfood industrial applications for barley, including biofuels A new chapter on barley’s health benefits Molecular breeding for malting quality
The category of learning disabilities continues to be among the most contentious in special education. Much of the debate and dissent emanates from a lack of understanding about its basic nature. The failure to evolve a comprehensive and unified perspective about the nature of learning disabilities has resulted in the concept being lost. The loss is best illustrated through the failure to answer this seemingly simple question: What is a learning disability? Using historical, empirical, theoretical, conceptual, and philosophical analyses, this volume explores a number of problems and issues facing the field of learning disabilities. The chapters cover historical influences, definitional problems, primary characteristics, assessment practices, theoretical development, major themes, research and measurement models, and long-term outcomes. The goal is to explicate the nature of learning disabilities by analyzing what it was supposed to be, what it has become, and what it might be. A predominant theme running through this text is the necessity for the field of learning disabilities to regain integrity by recapturing its essence.
Every successful sports coach knows that good teaching and social practices are just as important as expertise in sports skills and tactics. Now in a fully revised and updated fourth edition, and introducing a new author team, Understanding Sports Coaching introduces theories and practices while exploring pedagogical, social and cultural concepts underpinning good sports coaching practice. Broken into four sections, Understanding Sports Coaching examines the complex interplay between coach, athlete, coaching programme and social context, and encourages coaches to develop an open and reflective approach to their own coaching practice. It covers key aspects of coaching theories and practice, including important and emerging topics, such as: • leadership • athlete learning • emotion in coaching • culture as meaning making • quality in coaching • talent identification and development • philosophy and sports coaching Understanding Sports Coaching also includes a full range of practical exercises and extended case studies designed to encourage coaches to critically reflect upon their own coaching strategies, their interpersonal skills and important issues in contemporary sports coaching. This is an essential textbook for any degree-level course in sports coaching, and for any professional coach looking to develop their coaching expertise.
In Neuropsychological Aspects of Substance Use Disorders, internationally recognized experts provide clinicians with the most up to date information on the neuropsychology of substance use disorders based on the empirical literature. Substance use disorders continue to be a major health concern in the United States and worldwide, although their causes and effective treatments remain elusive. Research in this area has expanded dramatically over the past two decades and provided insights into psychobiological, behavioral, and genetic factors that contribute to the onset and maintenance of substance use disorders and associated neuropsychological abnormalities. This research has provided a strong empirical foundation that has direct implications for clinical neuropsychological practice and created a need to provide the practitioner with a cogent and up-to-date summary of current developments, which is the goal of this volume. Chapters in this volume are organized into three sections that are designed to provide a translational overview of basic research and treatment findings regarding addictions, neuropsychological and neurological sequalae of the most common substances of abuse, and consideration of special issues that might confound interpretation of neuropsychological test results. Section I provides an overview of addictions, including diagnoses based on the DSM-IV, as well as the most current conceptualizations of addiction from psychobiological, genetic, and behavioral and no economics perspectives, providing the reader with a broad evidence-based conceptual framework. Section II reviews the most common substances of abuse including coverage of structural and functional neuroimaging findings, epidemiological evidence, and neuropsychological sequelae. Substances included in this section represent the most commonly encountered drugs of abuse. Section III includes coverage of the number of special topics, including specific issues related to psychiatric, medical, and neurological comorbidities. Topics included in this section represent areas of common concerns faced by clinical neuropsychologists in the interpretation and application of neuropsychological test results.
The Evolution of Memory Systems sets out a bold and exciting new theory about memory. It proposes that several memory systems arose during evolution and that they did so for the same general reason: to transcend problems and exploit opportunities encountered by specific ancestors at particular times and places in the distant past.
The only professional resource to focus exclusively on research methods in forensic psychology With specific advice on topics of particular importance to forensic specialists, Research Methods in Forensic Psychology presents state-of-the-discipline summaries of the issues that relate to psychology and law research. Edited by renowned experts in the field, this resource features contributions by leading scholars in forensic psychology and law, with discussion of relevant topics such as: Meta-analysis Jury decision making Internet-based data collection Legal research techniques for the social scientist Offender treatment Competence to stand trial Criminal profiling False confessions and interrogations Trial-related psycho-legal issues Accuracy of eyewitnesses and children Violence risk assessment This comprehensive guide is designed for a wide range of scholars and legal professionals, presenting a succinct overview of the field of psychology and law as viewed by some of the world's foremost experts.
Written and extensively updated by an author team that includes former and current law enforcement officers, Introduction to Policing focuses on the thought-provoking, contemporary issues that underscore the challenging and rewarding world of policing. The authors skillfully balance research and practice to offer students an overview of both the foundations of policing and the expanded role of today’s police officers. Evolving with the modern realities of the field, the Fourth Edition discusses major new and ongoing impactful events, such as the political shift marked by the U.S. presidential election of 2016 and expanded coverage of women and minorities in policing. The accessible and engaging writing style, coupled with unique coverage of the issues of policing in multicultural communities, the impact of technology on policing, and policing strategies and procedures, make this bestselling book a must-have for policing courses. This title is accompanied by a complete teaching and learning package.
James Jones's spiritual beliefs were central to his great World War II trilogy From Here to Eternity. The Thin Red Line, and Whistle, as well as to the rest of his fiction. In this first book-length exploration of the subject, Steven Carter argues that Jones's ideas about reincarnation, karma, and spiritual evolution were heavily influenced by transcendentalism, theosophy, and Oriental religions. The author places Jones in what he identifies as a tradition of American literary Orientalism that includes Emerson, Thoreau, Kerouac, Ginsberg, and others. Carter bases his argument on extensive research into American literature and criticism coupled with visits and personal correspondence with Jones.
Designed to help medical educators implement better assessment methods, tools, and models directly into training programs, Practical Guide to the Evaluation of Clinical Competence, 2nd Edition, by Drs. Eric S. Holmboe, Steven J. Durning, and Richard E. Hawkins, is a hands-on, authoritative guide to outcomes-based assessment in clinical education. National and international experts present an organized, multifaceted approach and a diverse combination of methods to help you perform effective assessments. This thoroughly revised edition is a valuable resource for developing, implementing, and sustaining effective systems for evaluating clinical competence in medical school, residency, and fellowship programs. Each chapter provides practical suggestions and assessment models that can be implemented directly into training programs, tools that can be used to measure clinical performance, overviews of key educational theories, and strengths and weaknesses of every method. Guidelines that apply across the medical education spectrum allow you to implement the book’s methods in any educational situation. New chapters on high-quality assessment of clinical reasoning and assessment of procedural competence, as well as a new chapter on practical approaches to feedback. Reorganized for ease of use, with expanded coverage of Milestones/Entrustable Professional Assessments (EPAs), cognitive assessment techniques, work-based procedural assessments, and frameworks. The expert editorial team, renowned leaders in assessment, is joined by global leader in medical education and clinical reasoning, Dr. Steven Durning.
The Carmarthenshire Battalion was one of the early units raised in 1914 as a result of Lord Kitchener's expansion of the regular army for the duration of the Great War. This book profiles the 'Carmarthen Pals', a battalion which fought with great distinction during many of World War One's most significant campaigns.
Steven Foster has one speed: Full-Throttle! It's that commitment to going flat out that, in 2013, led him to embark on a thirty-four-day, thirty-four-state, 13,000-mile solo motorcycle ride along the perimeter of the United States wearing a pair of combat boots to raise awareness and support for the Boot Campaign, a national veterans service organization where he serves as an ambassador and advisory board member. In Full-Throttle Leadership: Passion, Power, & Purpose on the Edge of America, Steven Foster recounts the most memorable places from "Sea to Shining Sea," but more importantly, the remarkable people who made his "Full-Throttle Leadership Ride" a life-changing experience. Each mile riding alone through wicked thunderstorms, scorching heat, a mountain wildfire, and the constant deluge of assorted bugs, dirt, and grime--provides the backdrop for stories of the people he encountered in small towns and big cities across America who exemplified what is truly at the core of great leadership: service, sacrifice, and a commitment to helping others navigate the challenges of their own personal and professional "ride." Their stories sustained him then and inspire him now as an advocate for giving back in the communities where we live, work, and meet; and it's that commitment that fuels his passion to inspire others to become "force multipliers for goodness." You don't have to ride a motorcycle to become a full-throttle leader, but Steven's journey as a biker, entrepreneur, and Force Multiplier for Good provides a road map for anyone on how to run wide open to serve the people who saddle up with you every day to do the work you do, whatever it may be. If ever there was a moment to throttle up and refuel your own leadership ride, that moment is now. ............................................................................................................. Steven G. Foster, CMP is available for speaking engagements and book signings. To inquire about an appearance at your event, email to info@foster-fathom.com Social Media Links www.linkedin.com/in/stevengfostercmp/ www.facebook.com/FosterandFathom www.youtube.com/FosterFathom
Examining the relationship between sustainability and farmland management in diffeing tempoarla spatial and production contexts - this book considers famrland multifuctionality, systems and sytemic thinking, the debates over information, knowledge and ethical aspects.
This electronic version has been made available under a Creative Commons (BY-NC-ND) open access license. This book looks at how the British Labour Party came to terms with the 1960's 'cultural revolution', specifically changes to: the class structure, place of women, black immigration, the generation gap and calls for direct political participation.
War should be recognised as one of the defining features of life in the England of Henry VIII. Henry fought many wars throughout his reign, and this book explores how this came to dominate English culture and shape attitudes to the king and to national history, with people talking and reading about war, and spending money on weaponry and defence.
Quick-reference guidance showing new controllers how to enhance performance while avoiding pitfalls Designed to give new controllers a firm foundation in the concepts of managing the accounting department, locating GAAP information, and analyzing and knowing what to do with key accounting information, The Essential Controller, Second Edition is the invaluable primer you can turn to for the foundation you need to succeed. Whether your business is large, small, or medium-sized, this volume provides a complete overview of the controller's responsibilities and the role that today's controllers should be playing. Offers new coverage of finance strategy Updates taxation strategy Includes a new controller checklist Quick reference guide that controllers can turn to Also by Steven M. Bragg: The Controller's Function: The Work of the Managerial Accountant, Fourth Edition The Essential Controller, Second Edition is the go-to handbook that you will use every day for dealing with the everyday issues facing today's controllers.
As organizations move into the future, the operations environment needs to expand into Collaborative Planning and Forecast Replenishment (CPFR), Vendor Managed Inventory (VMI), and an Enterprise Resource Planning (ERP) operating system to become and remain competitive. These innovative and complex methods require an unprecedented degree of accuracy
Set up your child and yourself for success and learn how discipline can be more about teaching than punishment, and more positive than negative for parents and children. Time- and research-tested Common Sense Parenting® skills have been adapted to meet the needs of parents and caregivers of young children ages 2-5. In this second edition, parents are given enhanced parenting skills with updated parent steps and clearer explanations for how and why to use these steps with children: Set reasonable expectations based on your child’s age, development, and abilities.Give your child the nurturing, love, and praise he or she needs to thrive.Use a parent’s version of “show and tell” to both prevent problems and correct misbehavior.Create plans for staying calm – for you and your child. Parents will benefit from Boys Town’s decades of experience in working with kids to help moms, dads and other caregivers enhance their child-rearing skills and develop a calm, skill-focused approach to discipline.
The go-to resource managerial accountants can turn to for sustaining their company's competitive advantage From flex budgeting to detailing the more sophisticated skills like throughput analysis for capital investments and the fast close for public companies, The Controller's Function, Fourth Edition offers numerous real-world examples, expertly balancing both the technical and managerial sides of the job. Provides an overview of the functions and responsibilities of the controller/management accountant in a corporation Explores how controllers can better perform their jobs Offers a solid foundation for those who are new to this area Comprehensive and practical, this book fully defines the role, functions and responsibilities of the managerial accountant in a corporation.
Everyday, we come into contact with many relatively harmless substances that could, at certain concentrations, be toxic. This applies not only to obvious candidates such as asbestos, lead, and gasoline, but also to compounds such as caffeine and headache tablets. While the field of toxicology has numerous texts devoted to aspects of biology, chemis
Offering a new perspective on medical progress in the 19th century, Stowe provides an in-depth study of the mid-century culture of everyday medicine in the south. He illuminates an entire world of sickness and remedy, suffering and hope, and the deep ties between medicine and regional culture.
This book systematically reviews and discusses recent studies and articles on the immunology of female genital tract tissue. The scope is broad, encompassing innate immune responses, adaptive (humoral and cell-mediated) immunity, the immunology of menstruation, the immunology of viral and bacterial infections, the immunology of normal and abnormal pregnancy, and immunological infertility. Throughout, tables and illustrations are judiciously used to facilitate understanding. Immunology of the Female Genital Tract will serve as an invaluable source of up-to-date information for all with an interest in this subject.
What chemicals are poisonous to the heart and why are they toxic? Find out by reading Principles of Cardiac Toxicology. Certain chemicals can produce toxicity by interacting with elements of the cardiovascular system. This book presents the anatomical, physiological, biochemical, and pathological basis for this interaction and describes the
For even the most seasoned DUI lawyers, defending drunk driving cases has always presented special challenges. Today, mounting a successful drunk driving defense is more difficult than ever. That's why DWI attorneys rely on Drunk Driving Defense . Written by Lawrence Taylor and Steven Oberman, Drunk Driving Defense is generally considered to be the standard-bearing reference in the field. Clear explanations of key scientific and technological issues for DUI lawyers Drunk Driving Defense ensures that you Understand The chemical, biological and technological concepts and issues underlying drunk driving defense and prosecution. Rely on expert DUI lawyers Taylor and Oberman to bring you up to speed in key areas including: The key defects inherent in blood and breath analysis and testing. The correlation between blood alcohol concentration and actual impairment. The effects of stress and cold weather on alcohol absorption. How fermentation of the blood sample may raise blood alcohol levels. The effect of acetone in breath tests taken by diabetics and dieters. Possible errors in breath analysis due to RFI (radio frequency interference). The effect of trauma from an automobile accident on alcohol elimination Dozens of Practical DWI attorney tools to streamline and simplify drunk driving defense preparation Drunk Driving Defense, Sixth Edition contains dozens of practical tools to streamline and simplify the complex DUI defense process. And now, they are all included on a free bonus DWI Lawyer Resources CD-ROM so you can locate, review, and print them out in a matter of seconds, including: Dozens of quick-reference checklists to help DUI lawyers avoid critical missteps. Sample drunk driving defense motions including those to help DU I lawyers to facilitate discovery, appoint chemical experts, and suppress blood alcohol evidence. More than 150 pages of verbatim direct and DWI attorney cross testimony and statements. Sample arrest reports, instrument instructions and other forms use by police agencies. Comprehensive DWI attorney-client interview questionnaires for DUI lawyers. Detailed operator's manuals For The most current blood alcohol testing equipment: including the Intoxilyzer 8000. Try Drunk Driving Defense Risk-Free for 30 days. Your satisfaction is 100% guaranteed. If for any reason you are not completely satisfied, simply return it to us. FREE SHIPPING! Domestic Ground Shipping is Free when you pay by credit card
Barley is one of the world's most important crops with uses ranging from food and feed production, malting and brewing to its use as a model organism in molecular research. The demand and uses of barley continue to grow and there is a need for an up-to-date comprehensive reference that looks at all aspects of the barley crop from taxonomy and morphology through to end use. Barley will fill this increasing void. Barley will stand as a must have reference for anyone researching, growing, or utilizing this important crop.
The Pan American Games, second only to the Olympics as the biggest international sports competition in the world, are held every four years (during the year prior to the Summer Olympics) under the sponsorship of the International Olympic Committee. This book lists the results of the Pan American Games from their commencement in 1951 through 1999. Los Juegos Panamericanos, los segundos mas importantes del mundo tras los Olimpicos, se han venido celebrando cada cuatro anos desde 1951. Se incluye en el presente trabajo bilingue un recuento de los resultados reflejados en dichos juegos a lo largo de su historia, desde los comienzos hasta los mas recientes, celebrados en 1999.
An Engaging and Accessible Overview of Crime and Justice in America For all their interest in crime, most Americans know very little about the reality of crime and the criminal justice system in the United States—and most of what Americans do know is a loose collection of accumulated truths, half-truths, and outright fallacies. Myths and Realities of Crime and Justice: What Every American Should Know, Second Edition provides a concise but thorough overview of criminal behavior, crime, and the criminal justice system in the United States. Using up-to-date social science research to debunk many of the beliefs Americans hold about crime, the book examines key topics such as serial killers and mass murders, gun violence, criminal victimization, identity theft, policing and police corruption, plea bargaining, jury nullification, wrongful convictions, the death penalty, and the “CSI Effect.” The fully revised and updated second edition of this popular text includes the most recent crime and criminal justice data, and covers several recent high-profile crimes, including the Newtown shooting, the Jerry Sandusky case, and the Trayvon Martin case. It also includes new sections on recent trends in crime rates, street gangs, and hate crimes. Ideally suited for students in criminal justice programs as well as professionals who work within or in tandem with the criminal justice system, Myths and Realities of Crime and Justice: What Every American Should Know, Second Edition is a thorough, engaging, and highly relevant portrait of crime and justice in America.
The development of biofilms and their role in public health - particularly drinking water - is often overlooked. Ideal for anyone interested in water related issues, Microbiological Aspects of Biofilms and Drinking Water presents an overview of the public health effects associated with drinking water. It highlights the microbiological aspects relat
Robert Schaeffer and Douglas West are best friends living in Oklahoma in 1963when they discover that they both sense a calling to become ministers in a mainline Christian denomination. But from seminary and their early years in ministry to their golden years looking back on what it takes to lead a congregation, a stimulating, sometimes puzzling, yet often inspirational world of theological controversies and congregational concerns would unfold for these two men of God. A Church Wide Enough for Everyone follows these two men on their journey to demonstrate the continuing relevance of the Christian faith in a postmodern world. After moving to Berkeley, California, to attend college and seminary, they have little time to ponder the vast social changes taking place before they immediately enter into intensive critical study of the Bible and Christian theology. And as Robert is then thrust into the ordained ministry with his wife, Faye, both men must in their own ways face the political, cultural, and ideological pressures of each passing decade, responding to challenges from both within the church and from outsiders. Are mainline churchesand Christian theologydead? Or might they be revitalized in the current century? A Church Wide Enough for Everyone and the inspired journeys of two ministers offers a window into how this revitalization and new understanding is possible.
Traces the philosophy behind Woodrow Wilson's 1913 decision to institute de facto segregation in government employment, cutting short careers of Black civil servants who already had high-status jobs and closing those high-status jobs to new Black aspirants.
This fascinating selection of photographs traces some of the many ways in which Bangor and it's surrounding area has changed and developed over the last century.
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