On June 28, 1972 in a South Bronx subway station, John Skagen, a white off-duty policeman on his way home, suddenly and without apparent provocation, ordered James Richardson, a black man on his way to work, to get against the wall and put his hands up. Richardson had a gun, and the two exchanged shots. In the melee that followed, Skagen was fatally wounded by a cop who rushed to the scene. In the ensuing trial, William Kunstler handled Richardson's defense and the author of this book, then assistant district attorney, prosecuted the case. Here is a first-hand, behind-the-scenes account of every step of the proceedings.
A guide to "when to" and "what to" rather than "how to," this book provides evidence-based surgical reviews to provide credible answers to age-old surgical management questions. The management issues presented are oriented toward interventions and use evidence-based techniques to assess the safety and efficacy of new treatments and rehabilitative or preventative interventions. Each chapter is organized around the key questions essential to delineating the current status of evidence related to the subject reviewed. Publications from the past decade are cited that provide Level I and II evidence using the Oxford scale. Throughout Elective General Surgery, careful assessment of the validity of intervention studies and the strength of the evidence that they provide underlies the choices of cited publications. The information presented in this volume guides the scientific surgeon in providing state-of-the-art care and in optimizing the use of medical resources without losing sight of the need to address the unique needs of individual patients.
Plant Hormones: Biosynthesis and Mechanisms of Action is based on research funded by the Chinese government's National Natural Science Foundation of China (NSFC). This book brings a fresh understanding of hormone biology, particularly molecular mechanisms driving plant hormone actions. With growing understanding of hormone biology comes new outlooks on how mankind values and utilizes the built-in potential of plants for improvement of crops in an environmentally friendly and sustainable manner. This book is a comprehensive description of all major plant hormones: how they are synthesized and catabolized; how they are perceived by plant cells; how they trigger signal transduction; how they regulate gene expression; how they regulate plant growth, development and defense responses; and how we measure plant hormones. This is an exciting time for researchers interested in plant hormones. Plants rely on a diverse set of small molecule hormones to regulate every aspect of their biological processes including development, growth, and adaptation. Since the discovery of the first plant hormone auxin, hormones have always been the frontiers of plant biology. Although the physiological functions of most plant hormones have been studied for decades, the last 15 to 20 years have seen a dramatic progress in our understanding of the molecular mechanisms of hormone actions. The publication of the whole genome sequences of the model systems of Arabidopsis and rice, together with the advent of multidisciplinary approaches has opened the door to successful experimentation on plant hormone actions. - Offers a comprehensive description of all major plant hormones including the recently discovered strigolactones and several peptide hormones - Contains a chapter describing how plant hormones regulate stem cells - Offers a fresh understanding of hormone biology, particularly molecular mechanisms driving plant hormone actions - Discusses the built-in potential of plants for improvement of crops in an environmentally friendly and sustainable manner
This book provides in-depth results and case studies in innovation from actual work undertaken in collaboration with industry partners in Architecture, Engineering, and Construction (AEC). Scientific advances and innovative technologies in the sector are key to shaping the changes emerging as a result of Industry 4.0. Mainstream Building Information Management (BIM) is seen as a vehicle for addressing issues such as industry fragmentation, value-driven solutions, decision-making, client engagement, and design/process flow; however, advanced simulation, computer vision, Internet of Things (IoT), blockchain, machine learning, deep learning, and linked data all provide immense opportunities for dealing with these challenges and can provide evidenced-based innovative solutions not seen before. These technologies are perceived as the “true” enablers of future practice, but only recently has the AEC sector recognised terms such as “golden key” and “golden thread” as part of BIM processes and workflows. This book builds on the success of a number of initiatives and projects by the authors, which include seminal findings from the literature, research and development, and practice-based solutions produced for industry. It presents these findings through real projects and case studies developed by the authors and reports on how these technologies made a real-world impact. The chapters and cases in the book are developed around these overarching themes: • BIM and AEC Design and Optimisation: Application of Artificial Intelligence in Design • BIM and XR as Advanced Visualisation and Simulation Tools • Design Informatics and Advancements in BIM Authoring • Green Building Assessment: Emerging Design Support Tools • Computer Vision and Image Processing for Expediting Project Management and Operations • Blockchain, Big Data, and IoT for Facilitated Project Management • BIM Strategies and Leveraged Solutions This book is a timely and relevant synthesis of a number of cogent subjects underpinning the paradigm shift needed for the AEC industry and is essential reading for all involved in the sector. It is particularly suited for use in Masters-level programs in Architecture, Engineering, and Construction.
Old-House Dictionary From a One Room Cabin to a Beaux-Arts Mansion.Here's a concise and easily understandable architectural dictionaryfor professionals and amateurs alike. More than 450 illustrations,1500 terms, 750 definitions, and 17 useful cross references guideyou smoothly through the oftentimes confusing language of Americandomestic architecture. Who is This Dictionary For? * Architects and Architectural Historians * Preservationists * Building Trades Professionals * Interior Designers * High School and College Students * Old Home Owners and Lovers
*Updated edition to include the 2017-18, 2019 and 2021-22 Ashes series* Wisden on the Ashes: The authoritative story of cricket's greatest rivalry is a detailed chronological journey through the history of this famous English-Australian contest. With Test reports, scorecards, "Great bowlers of the year" and other fascinating material from the archives, together with new editorial pieces, this is a remarkable record of cricket's most enduring battle. The book begins its journey with England's first tour of Australia in 1876 and the subsequent three series prior to the 1882 tour that led to a mock obituary being placed in the Sporting Times "In affectionate remembrance of English cricket, which died at The Oval on 29th August, 1882. ... The body will be cremated and the ashes taken to Australia." Celebrating the players who made their mark on the game and the controversies that shook the sport, the book covers every series since then through to the most recent series. In 2005 England won a highly competitive series that helped raise the popularity of the sport, and each series since then has attracted huge attention. This book will be a welcome addition to all cricket enthusiasts' collections, as well as an ideal gift purchase. This updated edition includes the 2017-18 series, which saw England fail to defend the Ashes, the summer 2019 series held in England, which was the first drawn series since 1972, and the Covid-affected 2021-22 series. It also includes a colour photo section celebrating the players, the matches and the key moments from an ongoing rivalry.
Clinical Trials Comprehensive resource presenting methods essential in planning, designing, conducting, analyzing, and interpreting clinical trials The Fourth Edition of Clinical Trials builds on the text’s reputation as a straightforward, detailed, and authoritative presentation of quantitative methods for clinical trials, discussing principles of design for various types of clinical trials and elements of planning the experiment, assembling a study cohort, assessing data, and reporting results. Each chapter contains an introduction and summary to reinforce key points. Discussion questions stimulate critical thinking and help readers understand how they can apply their newfound knowledge. Written by a highly qualified author with significant experience in the field, the Fourth Edition of Clinical Trials approaches the topic with: Problems that may arise during a trial, and accompanying common sense solutions Design alternatives for addressing many questions in therapeutic development Statistical principles with new and provocative topics, such as generalizing results, operating characteristics, trial issues during the COVID-19 pandemic, and more Alternative medicine, ethics, middle development, comparative studies, adaptive designs, and clinical trials using point of care data Revamped exercise sets, updated and extensive references, new material on endpoints and the developmental pipeline, and revisions of numerous sections, tables, and figures Standing out due to its accessible and broad coverage of statistical design methods which are the building blocks of clinical trials and medical research, Clinical Trials is an essential learning aid on the subject for undergraduate and graduate clinical trials courses.
The world-wide sales of polysiloxanes or silicones at the beginning of this new millennium is approximately $10 billion per year. Commercial products range from those entirely composed of silicone to products where the silicone is a low level but key component. This symposium covered the recent academic and technological developments behind silicones and silicone-modified materials.
Selected from the world’s leading comprehensive cancer textbook, this tightly focused resource provides you with the practical, cutting-edge information you need to provide the best cancer care to each patient. Prostate and Other Genitourinary Cancers: Cancer: Principles & Practice of Oncology, 10th Edition, offers a comprehensive and balanced view of this rapidly changing field, meeting the needs of oncology practitioners, fellows, and others who need an in-depth understanding of prostate and GU cancer. The print reference gives you the solid, dependable guidance you’ve come to expect from this outstanding title, and the Inkling version features new quarterly updates written by a team of experts selected by the authors.
Comprehensive and lavishly illustrated, McKee's Pathology of the Skin, 5th Edition, is your reference of choice for up-to-date, authoritative information on dermatopathology. You'll find clinical guidance from internationally renowned experts along with details on etiology, pathogenesis, histopathology, and differential diagnosis – making this unique reference unparalleled in its wealth of clinical and histopathological material. The 5th Edition of this classic text is a must-have resource for practicing dermatopathologists and general pathologists who sign out skin biopsies. - Covers pathological aspects of skin diseases in addition to providing superb descriptions and illustrations of their clinical manifestations – the only available reference with this unique combination of features. - Integrates dermatopathology, clinical correlations, and clinical photographs throughout, and features bulleted lists of clinical features and differential diagnosis tables for easy reference. - Contains more than 5,000 superb histopathologic and clinical illustrations that demonstrate the range of histologic manifestations. - Brings you fully up to date with key molecular aspects of disease, the capabilities and limitations of molecular diagnostics, and targeted/personalized medicine. - Features up-to-date information on biologics, drug eruptions, and other developments in therapeutics. - Helps you stay current with the latest diagnostic tumor markers and other new developments in immunohistochemistry. - Includes a completely revised chapter on cutaneous lymphoma that reflects recent WHO-EORTC classification changes, as well as new coverage of sentinel lymph node biopsy for melanoma. - Shares the knowledge of the main editor Dr. J. Eduardo Calonje, along with co-editors Thomas Brenn, and Alexander Lazar, and new co-editor Steven D. Billings who offers expertise on both dermatopathology and soft tissue tumors. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
This authoritative reference equips you with the essential knowledge to provide comprehensive and effective care to children in an emergency setting. From age-specific diagnoses and chief complaints through developmental considerations and psychosocial issues, this text guides you through the full range of medical and surgical conditions commonly encountered when treating pediatric emergencies. The use of full color throughout, diagnostic algorithms, text boxes, charts, clinical pearls and pitfalls, and other visual features ensure the book will make crucial clinical information easy to find and apply. Tap into expert guidance on all aspects of pediatric emergency medicine, from the physical exam and usual and unusual presentations through to disposition criteria and transfer issues. Access step-by-step guidance on administering critical life support interventions and providing effective diagnostic and therapeutic ambulatory care. Quickly review specific treatment protocols for various emergency settings, including general emergency departments, community hospitals, tertiary care centers, EMS and transport, and triage. Find information fast with or without a known diagnosis, with content organized both by chief complaints and by specific diagnoses. Better understand how problems present differently in infants, children, and adolescents with age-specific diagnoses. Identify and manage the psychosocial issues surrounding pediatric patients, including major depression and suicidality, sexual and physical abuse, child neglect, and violence. Easily absorb key information with the aid of text boxes, algorithms, clinical pearls, and pitfalls. Retrieve information easily with a consistent templated format.
Liu, Volpe, and Galetta's Neuro-Ophthalmology: Diagnosis and Management, 3rd Edition remains unique in its complete, authoritative coverage of the diagnosis and treatment of neurological disorders affecting the eye. Bridging the gap between a handbook and an encyclopedic resource, it distills a vast amount of information into a single, concise, superbly illustrated volume. User-friendly and thoroughly up to date, this highly renowned reference is a one-stop resource for current information in this growing area. - Combines over 1,000 illustrations and cross references with tables, outlines, and flow-diagrams to provide you with everything you need to understand the underlying presentation, pathophysiology, neuroimaging, and diagnostic studies in neuro-ophthalmology, along with the ideal diagnostic, treatment, and ongoing management tools for all neuro-ophthalmic conditions. - Covers the neurological examination and the bedside neuro-ophthalmic evaluation of comatose patients that demonstrates how the examination can be used to confirm a diagnosis arrived at from the patient history. - Includes the expertise and knowledge of a small, hand-picked contributor team that ensure the latest advances are incorporated into each chapter. - Contains increased coverage on the use of optical coherence tomography (OCT) and its role in revolutionizing the ability to make more accurate neuro-ophthalmic diagnoses. - Features twice the number of videos as the previous edition, including new footage of eye movement and eyelid disorders, pupillary abnormalities, and examination techniques. Also included are instructional videos demonstrating diagnostic bedside vestibular techniques in addition to therapeutic repositioning maneuvers used to treat all variants (i.e., posterior, horizontal, and anterior canals) of benign paroxysmal positional vertigo (BPPV). - Provides all-new information on gaze disorders, nystagmus, and neuro-ophthalmic manifestations of demyelinating disease. - Presents current knowledge on vestibular disease and the neuro-ophthalmic manifestations of head trauma, as well as brainstem, cerebellar, and degenerative diseases. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
The definitive endodontics reference, Cohen’s Pathways of the Pulp is known for its comprehensive coverage of leading-edge information, materials, and techniques. It examines all aspects of endodontic care, from preparing the clinician and patient for endodontic treatment to the role the endodontist can play in the treatment of traumatic injuries and to the procedures used in the treatment of pediatric and older patients. Not only does Hargreaves and Cohen’s 10th edition add five chapters on hot new topics, it also includes online access! As an Expert Consult title, Cohen’s Pathways of the Pulp lets you search the entire contents of the book on your computer, and includes five online chapters not available in the printed text, plus videos, a searchable image collection, and more. For evidence-based endodontics research and treatment, this is your one-stop resource!
This book is the first complete study and monograph dedicated to singular traces. The text mathematically formalises the study of traces in a self contained theory of functional analysis. Extensive notes will treat the historical development. The final section will contain the most complete and concise treatment known of the integration half of Connes' quantum calculus. Singular traces are traces on ideals of compact operators that vanish on the subideal of finite rank operators. Singular traces feature in A. Connes' interpretation of noncommutative residues. Particularly the Dixmier trace,which generalises the restricted Adler-Manin-Wodzicki residue of pseudo-differential operators and plays the role of the residue for a new catalogue of 'geometric' spaces, including Connes-Chamseddine standard models, Yang-Mills action for quantum differential forms, fractals, isospectral deformations, foliations and noncommutative index theory. The theory of singular traces has been studied after Connes' application to non-commutative geometry and physics by various authors. Recent work by Nigel Kalton and the authors has advanced the theory of singular traces.Singular traces can be equated to symmetric functionals of symmetric sequence or function spaces, residues of zeta functions and heat kernel asymptotics, and characterised by Lidksii and Fredholm formulas. The traces and formulas used in noncommutative geometry are now completely understood in this theory, with surprising new mathematical and physical consequences. For mathematical readers the text offers fundamental functional analysis results and, due to Nigel Kalton's contribution, a now complete theory of traces on compact operators. For mathematical physicists and other users of Connes' noncommutative geometry the text offers a complete reference to Dixmier traces and access to the deeper mathematical features of traces on ideals associated to the harmonic sequence. These features, not known and not discussed in general texts on noncommutative geometry, are undoubtably physical and probe to the fascinating heart of classical limits and quantization.
This book is the second edition of the first complete study and monograph dedicated to singular traces. The text offers, due to the contributions of Albrecht Pietsch and Nigel Kalton, a complete theory of traces and their spectral properties on ideals of compact operators on a separable Hilbert space. The second edition has been updated on the fundamental approach provided by Albrecht Pietsch. For mathematical physicists and other users of Connes’ noncommutative geometry the text offers a complete reference to traces on weak trace class operators, including Dixmier traces and associated formulas involving residues of spectral zeta functions and asymptotics of partition functions.
Neuro-Ophthalmology: Diagnosis and Management is a highly organized and uniform textbook designed to bridge the gap between a handbook and an encyclopedia. Drs. Grant T. Liu, Nicholas J. Volpe, and Steven L. Galetta present their expertise through this highly visual resource that features full color throughout, extensive illustrations, and more. The second edition includes major updates to reflect advances in migraine, multiple sclerosis treatments, neuroimaging, and more. This is your one-stop source of information both for understanding the underlying presentation, pathophysiology, neuroimaging, and diagnostic studies in neuro-ophthalmology, as well as the ideal diagnostic, treatment, and ongoing management tools for all neuro-ophthalmic conditions. ***The eBook versions of this title do not include the DVD-ROM content from the print edition. Combines extensive illustrations and cross references with tables, outlines, and flow-diagrams to provide you with everything you need to understand the underlying presentation, pathophysiology, neuroimaging, and diagnostic studies in neuro-ophthalmology, along with the ideal diagnostic, treatment, and ongoing management tools for all neuro-ophthalmic conditions. Features reviews of neuroanatomy and neurophysiology based on clinical and pathological observations in humans without the extensive discussion of experimental literature involving non-human primates and other animals for an extremely focused clinical resource excellent for practice and preparing for professional examinations. Includes coverage of the neurological examination and the bedside neuro-ophthalmic evaluation of comatose patients that demonstrates how the examination can be used to confirm a diagnosis arrived at from the patient history. Features comprehensive updates to all chapters with complete revisions to coverage of multiple sclerosis, migraine, and neuro-imaging ensuring that you have the most up-to-date clinical tool available. Separates the History and Examination, Neuro-ophthalmic History, and Neuro-ophthalmic Examination into two distinct chapters—Neuro-ophthalmic History and Neuro-ophthalmic Examination—to provide a more focused approach to each topic. Includes an expanded illustration program with full color throughout, revisions 20% of existing figures, and 20% more figures than before for a more accessible and visually appealing reference.
DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology, 10th edition has garnered universal acclaim as the world’s definitive, standard-setting oncology reference. More than 400 respected luminaries explore today’s most effective strategies for managing every type of cancer by stage of presentation - discussing the role of all appropriate therapeutic modalities as well as combined-modality treatments. This multidisciplinary approach will help your cancer team collaboratively face the toughest clinical challenges and provide the best possible care for every cancer patient. Access the complete contents online or on your mobile device, with quarterly updates reflecting late-breaking developments in cancer care, free for the first year on LWW Health Library. Take full advantage of the latest advances with brand-new chapters on Hallmarks of Cancer, Molecular Methods in Cancer, Oncogenic Viruses, Cancer Screening, and new sections on Genetic testing and counseling for cancer, plus comprehensive updates throughout – including coverage of the newest biologic therapies. Make optimal, well-coordinated use of all appropriate therapies with balanced, multidisciplinary advice from a surgeon, a medical oncologist, and a radiation oncologist in each major treatment chapter. Review the latest molecular biology knowledge for each type of cancer and its implications for improved management. Make the best decisions on cancer screening and prevention, palliative care, supportive oncology, and quality-of-life issues
The most comprehensive and authoritative reference available today on colorectal surgery This revised fourth edition of Gordon and Nivatvongs' Principles and Practice of Surgery for the Colon, Rectum, and Anus edited by David Beck, Steven Wexner, and Janice Rafferty strikes a perfect balance between evidence-based medicine, in-depth details, and clinical pearls. The result is a highly engaging and authoritative tome in the grand tradition of Philip Gordon and Santhat Nivatvongs. Building on the widely acclaimed previous editions' reputation for superb quality and reader-friendliness, the fourth edition includes contributions from an expanded cadre of internationally known experts. Significant advances have been made in this field since the third edition was published. The latest diagnostic modalities are highlighted such as MRI, CT angiography, and enterography. The first section covers essentials such as anatomy, physiology, diagnosis, colonoscopy, and patient management. Sections two through four discuss a full spectrum of anorectal diseases, colorectal disorders, trauma, unexpected challenges, and complications. Among the additions are expanded sections on transanal total mesorectal excision, genetics, personalized medicine, "wait and watch" principles, outpatient management of anorectal surgery, and large bowel obstruction. Key Highlights Thirty-seven chapters cover a wide array of gastrointestinal disorders such as fecal incontinence, ulcerative colitis, Crohn's disease, diverticulitis, carcinomas, and other malignant lesions A multidisciplinary team approach to rectal cancer encompasses rectal cancer protocol MRI, synoptic reporting, and various neoadjuvant therapy protocols The use of cutting-edge approaches including laparoscopy, robotics, hyperbaric oxygen, and radiofrequency tissue remodeling Superb full-color plates, illustrations, photographs, diagrams, detailed tables, graphics, and surgical videos elucidate underlying disease and management As the most comprehensive resource on colorectal surgery available on the market today, this is a must-have for every colon and rectal surgeon – from residents to veteran practitioners.
The standard-setting text in oncology for 40 years, DeVita, Hellman and Rosenberg’s Cancer: Principles and Practice of Oncology, 12th Edition, provides authoritative guidance and strategies for managing every type of cancer by stage and presentation. Drs. Vincent T. DeVita, Jr., Theodore S. Lawrence, and Steven A. Rosenberg oversee an outstanding team of expert contributing authors who keep you up to date and fully informed in this fast-changing field. This award-winning reference is also continually updated on Health Library and VitalSource platforms for the life of the edition.
This volume introduces noncommutative integration theory on semifinite von Neumann algebras and the theory of singular traces for symmetric operator spaces. Deeper aspects of the association between measurability, poles and residues of spectral zeta functions, and asymptotics of heat traces are studied. Applications in Connes’ noncommutative geometry that are detailed include integration of quantum differentials, measures on fractals, and Connes’ character formula concerning the Hochschild class of the Chern character.
Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. Now updated online for the life of the edition, DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology, 11th Edition keeps you up to date in this fast-changing field. Every quarter, your eBook will be updated with late-breaking developments in oncology, including new drugs, clinical trials, and more.
Recent scientific advances have revolutionized cancer research and practice, creating a body of molecular biology information that is important to research scientists and clinical oncologists alike. Cancer: Principles and Practice of Oncology: Primer of the Molecular Biology of Cancer, 3rd Edition, keeps you up to date with all that’s new in this rapidly changing field. Derived from DeVita, Hellman, and Rosenberg’s Cancer: Principles and Practice of Oncology – widely regarded as the definitive clinical reference in oncology – the third edition of this popular Primer provides a single-volume, highly focused reference on every important frontier in the molecular biology of cancer.
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