Designed to serve as a comprehensive active learning tool for medical students, residents, and junior attending physicians, Radiation Oncology: A Question-Based Review is geared toward helping professionals quickly and efficiently review a specific topic in clinical radiation oncology. Organized into sections by system and with over 90 chapters covering all the sites and conditions for which radiation is used clinically. This publication covers in detail all the sites and cancer types currently treated with radiotherapy with an emphasis on treatment recommendations and the evidence behind them. Additionally, detailed questions are included on the natural history, epidemiology, diagnosis, staging, and treatment-related side effects for each cancer type.
Fetal & Neonatal Physiology provides neonatologist fellows and physicians with the essential information they need to effectively diagnose, treat, and manage sick and premature infants. Fully comprehensive, this resource continues to serve as an excellent reference tool, focusing on the basic science needed for exam preparation and the key information required for full-time practice. The 5th edition is the most substantially updated and revised edition ever. In the 5 years since the last edition published, there have been thousands of publications on various aspects of development of health and disease; Fetal and Neonatal Physiology synthesizes this knowledge into definitive guidance for today's busy practitioner. Offers definitive guidance on how to effectively manage the many health problems seen in newborn and premature infants. Chapters devoted to clinical correlation help explain the implications of fetal and neonatal physiology. Allows you to apply the latest insights on genetic therapy, intrauterine infections, brain protection and neuroimaging, and much more. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, and references from the book on a variety of devices. Features a fantastic new 4-color design with 1,000 illustrations, 170+ chapters, and over 350 contributors. 16 new chapters cover such hot topics as Epigenetics; Placental Function in Intrauterine Growth Restriction; Regulation of Pulmonary Circulation; The Developing Microbiome of the Fetus and Newborn; Hereditary Contribution to Neonatal Hyperbilirubinemia; Mechanistic Aspects of Phototherapy for Neonatal Hyperbilirubinemia; Cerebellar Development; Pathophysiology of Neonatal Sepsis; Pathophysiology of Persistent Pulmonary Hypertension of the Newborn; Pathophysiology of Meconium Aspiration Syndrome; Pathophysiology of Ventilator Dependent Infants; Pathophysiology of Hypoxic-Ischemic Brain Injury; Pathophysiology of Neonatal White Matter Injury; Pathophysiology of Meningitis; Pathophysiology of Preeclampsia; and Pathophysiology of Chorioamnionitis. New Pathophysiology of Neonatal Diseases section highlights every process associated with a disease or injury, all in one place. In-depth information, combined with end-of-chapter summaries, enables deep or quick use of the text.
A guide to "when to" and "what to" rather than "how to," this book provides evidence-based surgical reviews to provide credible answers to age-old surgical management questions. The management issues presented are oriented toward interventions and use evidence-based techniques to assess the safety and efficacy of new treatments and rehabilitative or preventative interventions. Each chapter is organized around the key questions essential to delineating the current status of evidence related to the subject reviewed. Publications from the past decade are cited that provide Level I and II evidence using the Oxford scale. Throughout Elective General Surgery, careful assessment of the validity of intervention studies and the strength of the evidence that they provide underlies the choices of cited publications. The information presented in this volume guides the scientific surgeon in providing state-of-the-art care and in optimizing the use of medical resources without losing sight of the need to address the unique needs of individual patients.
Bioactive Natural Products covers all the aspects of bioactive natural product research from ethnobotanical investigations to modern, technologically assisted isolation and structural determination of active compounds. An internationally selected group of experts share their knowledge of a wide range of bioactivities and chemical compound classes. Topics in the chapters describing the modern application of detection, isolation, and structural determination techniques are strongly supported by chapters detailing and reviewing research involving various classes of bioactivity. Research areas include the immunomodulatory, antiviral, cytotoxic, anti-inflammatory, and insect behavior classes of bioactivity. Extensive referencing throughout the text is helpful to those readers not familiar with this subject and serves as a critical review for more experienced researchers. The book is also excellent for upper division or post-graduate courses.
What You Need to Know About Hormones and Depression Research has shown a strong connection between estrogen levels and depression throughout a woman's lifetime. We now understand that abrupt hormonal changes can take a toll on women's moods and even cause serious depression. But the good news is that there is a lot women can do to moderate the effect of these changes. The Estrogen-Depression Connection explores this issue and offers practical advice and tips for managing mood changes throughout all the major stages of a woman's life-from puberty and menstruation to pregnancy and postpartum, and from perimenopause to menopause. It explains in easy-to-understand terms what women can do right now to help balance these estrogen fluctuations through diet and lifestyle changes, alternative therapies, and medication. Get the information you need: Learn how estrogen affects each stage of a woman's life Cope with postpartum depression and menopause Find the best medical and alternative treatments
The world's leading source of evidence-based guidance on caring for patients at the end of life. Featuirng the content of the world's most widely read medical journal, plus completely new, never-before-published content. Perfect for medical students, trainees, and clinicians alike. Market / Audience Medical students: 18000/yr US, 250,000 global NP and PA students: 25,000/yr US, 50,000+ global IM and FP residents: 30,000 US, 60,000 global IM and FP clinicians: 140,000 US, 300,000+ global Palliative medicine: 3000 US Oncology: 20,000 US, 60,000 global Social workers About the Book In the tradition of the User's Guides to the Medical Literature, and The Rational Clinical Examination, JAMA/Care at the Close of Life is based on a widely successful series of articles appearing over the course of the last ten years in JAMA, the world's most widely read medical journal. The series is directed by Stephen McPhee, a leading authoriity of end of life care, and the chief editor of our market leading Current Medical Diagnosis and Treatment text. The articles in the series cover fundamental topics and challenges in caring for patients who have been given a terminal diagnosis. Featuring a strong focus on evidence-based medicine, and organized by clinical cases, the articles are widely read by faculty, medical students, and clinicians who, frankly, have not been given a solid educational experience on this very important medical issue. The book will be physically modeled after The Rational Clinical Examination, in a full color format that highlights the clinical cases. It will be well suited for use as an required or recommended textbook for medical, PA, and NO students, and as a clinical reference text for trainees and practicing physicians and nurses. Key Selling Features Based on highy regarded content from the world's most widely read medical journal All content is completely updated, and extensive new, never-before-published content has been added Case-based, and evidence-based, so its a perfect fit for the way medical students and residents like to learn Focuses on practical, real-world issues for primary care physicians, and avoids esoteric issues of interest only to specialists in palliative care Full color format, modeled after the highly regarded Rational Clinical Examination Includes multimedia materials available on line: Power Point slides for teaching, and video interviews with patients in end-of-life care, so that faculty and students get supplemental resources for learning the art and science of care at the end of life Evidence-based guidance from the world's leading medical journal, on a critical topic that has been neglected in medical education and training until recently. Author Profile JAMA is the world's most widely read medical journal, and has a reputation for excellence in evidence-based medicine. Stephen McPhee has high visbility on account of his editorship of CMDT, and for his driving role in enhancing end of life care in medical education and training programs. He is: Professor of Medicine, UCSF School of Medicine, San Francisco CA
Explains the role of reactive intermediates in biological systems as well as in environmental remediation With its clear and systematic approach, this book examined the broad range of reactive intermediate that can be generated in biological environments, detailing the fundamental properties of each reactive intermediate. Readers gain a contemporary understanding of how these intermediates react with different compounds, with an emphasis on amino acids, peptides, and proteins. The author not only sets forth the basic chemistry and nature of reactive intermediates, he also demonstrates how the properties of the intermediates presented in the book compare with each other. Oxidation of Amino Acids, Peptides, and Proteins begins with a discussion of radical and non-radical reactive species as well as an exploration of the significance of reactive species in the atmosphere, disinfection processes, and environmental remediation. Next, the book covers such topics as: Thermodynamics of amino acids and reactive species and the effect of metal-ligand binding in oxidation chemistry Kinetics and mechanisms of reactive halogen, oxygen, nitrogen, carbon, sulfur and phosphate species as well as reactive high-valent Cr, Mn, and Fe species Reactivity of the species with molecules of biological and environmental importance Generation of reactive species in the laboratory for kinetics studies Oxidation of amino acids, peptides, and proteins by permanganate, ferryl, and ferrate species Application of reactive species in purifying water and treating wastewater With this book as their guide, readers will be able to assess the overall effects of reactive intermediates in biological environments. Moreover, they’ll learn how to apply this knowledge for successful water purification and wastewater treatment.
The Second Edition demonstrates how computational chemistry continues to shed new light on organic chemistry The Second Edition of author Steven Bachrach’s highly acclaimed Computational Organic Chemistry reflects the tremendous advances in computational methods since the publication of the First Edition, explaining how these advances have shaped our current understanding of organic chemistry. Readers familiar with the First Edition will discover new and revised material in all chapters, including new case studies and examples. There’s also a new chapter dedicated to computational enzymology that demonstrates how principles of quantum mechanics applied to organic reactions can be extended to biological systems. Computational Organic Chemistry covers a broad range of problems and challenges in organic chemistry where computational chemistry has played a significant role in developing new theories or where it has provided additional evidence to support experimentally derived insights. Readers do not have to be experts in quantum mechanics. The first chapter of the book introduces all of the major theoretical concepts and definitions of quantum mechanics followed by a chapter dedicated to computed spectral properties and structure identification. Next, the book covers: Fundamentals of organic chemistry Pericyclic reactions Diradicals and carbenes Organic reactions of anions Solution-phase organic chemistry Organic reaction dynamics The final chapter offers new computational approaches to understand enzymes. The book features interviews with preeminent computational chemists, underscoring the role of collaboration in developing new science. Three of these interviews are new to this edition. Readers interested in exploring individual topics in greater depth should turn to the book’s ancillary website www.comporgchem.com, which offers updates and supporting information. Plus, every cited article that is available in electronic form is listed with a link to the article.
At the intersection of physics, mathematics, and computer science, an exciting new field of study has formed, known as “Topological Quantum.” This research field examines the deep connections between the theory of knots, special types of subatomic particles known as anyons, certain phases of matter, and quantum computation. This book elucidates this nexus, drawing in topics ranging from quantum gravity to topology to experimental condensed matter physics. Topological quantum has increasingly been a focus point in the fields of condensed matter physics and quantum information over the last few decades, and the forefront of research now builds on the basic ideas presented in this book. The material is presented in a down-to-earth and entertaining way that is far less abstract than most of what is in the literature. While introducing the crucial concepts and placing them in context, the subject is presented without resort to the highly mathematical category theory that underlies the field. Requiring only an elementary background in quantum mechanics, this book is appropriate for all readers, from advanced undergraduates to the professional practitioner. This book will be of interest to mathematicians and computer scientists as well as physicists working on a wide range of topics. Those interested in working in these field will find this book to be an invaluable introduction as well as a crucial reference.
This book presents a comprehensive insight into the design techniques for different types of CP antenna elements and arrays In this book, the authors address a broad range of topics on circularly polarized (CP) antennas. Firstly, it introduces to the reader basic principles, design techniques and characteristics of various types of CP antennas, such as CP patch antennas, CP helix antennas, quadrifilar helix antennas (QHA), printed quadrifilar helix antennas (PQHA), spiral antenna, CP slot antennas, CP dielectric resonator antennas, loop antennas, crossed dipoles, monopoles and CP horns. Advanced designs such as small-size CP antennas, broadband, wideband and ultra-wideband CP antennas are also discussed, as well as multi-band CP antennas and dual CP antennas. The design and analysis of different types of CP array antennas such as broadband CP patch arrays, dual-band CP arrays, CP printed slot arrays, single-band and multi-band CP reflectarrays, high-gain CP waveguide slot antennas, CP dielectric resonator antenna arrays, CP active arrays, millimetre-waveband CP arrays in LTCC, and CP arrays with electronically beam-switching or beam-steering capabilities are described in detail. Case studies are provided to illustrate the design and implementation of CP antennas in practical scenarios such as dual-band Global Navigation Satellite Systems (GNSS) receivers, satellite communication mobile terminals at the S-band, Radio Frequency Identification (RFID) readers at 2.4 GHz, and Ka-band high-speed satellite communication applications. It also includes the detailed designs for a wideband Logarithmic spiral antenna that can operate from 3.4-7.7 GHz. In addition, the book offers a detailed review of the recent developments of different types of CP antennas and arrays. Presents comprehensive discussions of design techniques for different types of CP antennas: small-size CP antennas, broadband CP antennas, multi-band CP antennas and CP arrays. Covers a wide range of antenna technologies such as microstrip antennas, helix, quadrifilar helix antenna, printed quadrifilar helix antenna, dielectric resonator antennas, printed slots, spiral antennas, monopoles, waveguide slot arrays, reflectarrays, active arrays, millimetre-wave arrays in LTCC, electronically beam-switching arrays and electronically beam-steerable arrays. Reviews recent developments in different types of CP antennas and arrays, reported by industries, researchers and academics worldwide. Includes numerous case studies to demonstrate how to design and implement different CP antennas in practical scenarios. Provides both an introduction for students in the field and an in-depth reference for antenna/RF engineers who work on the development of CP antennas. Circularly Polarized Antennas will be an invaluable guide for researchers in R&D organizations; system engineers (antenna, telecom, space and satellite); postgraduates studying the subjects of antenna and propagation, electromagnetics, RF/microwave/millimetre-wave systems, satellite communications and so on; technical managers and professionals in the areas of antennas and propagation.
As proton therapy treatment centers become smaller and more cost-effective, education and training for today’s multi-disciplinary oncology teams are more important than ever before. This state-of-the-art reference brings you fully up to date with all aspects of proton therapy, with guidance you can trust from MD Anderson Cancer Center, the largest and most experienced proton therapy center in the world. Led by Drs. Steven J. Frank and W. Ronald Zhu, Proton Therapy provides a unique opportunity to benefit from the unsurpassed knowledge and expertise of an esteemed team of leaders in the field. Covers all cancers for which proton therapy is used most often, including prostate, head and neck, pediatrics, central nervous system, gastrointestinal, sarcomas, lungs, breast, lymphomas, and gynecologic cancers. Provides up-to-date information on radiobiology, treatment planning and quality assurance, indications for proton therapy, management approaches, and outcomes after proton therapy by disease site. Discusses technologic advances such as spot scanning and treatment planning systems for the management of solid tumors; radiobiology of proton therapy, including DNA damage and repair mechanisms and acute and late effects on normal tissues; and multifield optimized intensity-modulated proton therapy (MFO-IMPT) for optimizing the distribution of linear energy transfer (LET) of proton beams within target volumes and away from critical normal structures. Includes a special section on head and neck cases in the e-book that photographically illustrates the full cycle of proton therapy care.
Laboratory physical models are a valuable tool for coastal engineers. Physical models help us to understand the complex hydrodynamic processes occurring in the nearshore zone and they provide reliable and economic engineering design solutions.This book is about the art and science of physical modeling as applied in coastal engineering. The aim of the book is to consolidate and synthesize into a single text much of the knowledge about physical modeling that has been developed worldwide.This book was written to serve as a graduate-level text for a course in physical modeling or as a reference text for engineers and researchers engaged in physical modeling and laboratory experimentation. The first three chapters serve as an introduction to similitude and physical models, covering topics such as advantages and disadvantages of physical models, systems of units, dimensional analysis, types of similitude and various hydraulic similitude criteria applicable to coastal engineering models.Practical application of similitude principles to coastal engineering studies is covered in Chapter 4 (Hydrodynamic Models), Chapter 5 (Coastal Structure Models) and Chapter 6 (Sediment Transport Models). These chapters develop the appropriate similitude criteria, discuss inherent laboratory and scale effects and overview the technical literature pertaining to these types of models. The final two chapters focus on the related subjects of laboratory wave generation (Chapter 7) and measurement and analysis techniques (Chapter 8).
Plant Hormones: Biosynthesis and Mechanisms of Action is based on research funded by the Chinese government’s National Natural Science Foundation of China (NSFC). This book brings a fresh understanding of hormone biology, particularly molecular mechanisms driving plant hormone actions. With growing understanding of hormone biology comes new outlooks on how mankind values and utilizes the built-in potential of plants for improvement of crops in an environmentally friendly and sustainable manner. This book is a comprehensive description of all major plant hormones: how they are synthesized and catabolized; how they are perceived by plant cells; how they trigger signal transduction; how they regulate gene expression; how they regulate plant growth, development and defense responses; and how we measure plant hormones. This is an exciting time for researchers interested in plant hormones. Plants rely on a diverse set of small molecule hormones to regulate every aspect of their biological processes including development, growth, and adaptation. Since the discovery of the first plant hormone auxin, hormones have always been the frontiers of plant biology. Although the physiological functions of most plant hormones have been studied for decades, the last 15 to 20 years have seen a dramatic progress in our understanding of the molecular mechanisms of hormone actions. The publication of the whole genome sequences of the model systems of Arabidopsis and rice, together with the advent of multidisciplinary approaches has opened the door to successful experimentation on plant hormone actions. Offers a comprehensive description of all major plant hormones including the recently discovered strigolactones and several peptide hormones Contains a chapter describing how plant hormones regulate stem cells Offers a fresh understanding of hormone biology, particularly molecular mechanisms driving plant hormone actions Discusses the built-in potential of plants for improvement of crops in an environmentally friendly and sustainable manner
The potential threat posed by Leonid meteroids to orbiting spacecraft over the next several years calls for new dynamic mitigation strategies to assist the satellite community in reducing the danger to its vehicles. This book offers deliberate dynamic mitigation strategies to complement the traditional shielding strategies, providing mission operators additional ways to decrease the danger. Five different attitude control and orbit maneuvering options are examined in detail. The information is presented in algorithmic form to allow technically competent, but meteoroid inexperienced, operators to easily understand the phenomena, assess the danger, and implement procedures. Although general in scope, the book emphasizes the Leonid meteor events of the 1998-2002 timeframe.
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