All new medicines and devices undergo early phase trials to assess, interpret and better understand their efficacy, tolerability and safety. An Introduction to Statistics in Early Phase Trials describes the practical design and analysis of these important early phase clinical trials and provides the crucial statistical basis for their interpretation. It clearly and concisely provides an overview of the most common types of trials undertaken in early phase clinical research and explains the different methodologies used. The impact of statistical technologies on clinical development and the statistical and methodological basis for making clinical and investment decisions are also explained. Conveys key ideas in a concise manner understandable by non-statisticians Explains how to optimise designs in a constrained or fixed resource setting Discusses decision making criteria at the end of Phase II trials Highlights practical day-to-day issues and reporting of early phase trials An Introduction to Statistics in Early Phase Trials is an essential guide for all researchers working in early phase clinical trial development, from clinical pharmacologists and pharmacokineticists through to clinical investigators and medical statisticians. It is also a valuable reference for teachers and students of pharmaceutical medicine learning about the design and analysis of clinical trials.
Paperback. The porphyrins are a class of naturally-occurring macrocycles and are ubiquitous in our world. As such, they have been called the Pigments of Life. This auspicious designation reflects their importance in numerous biological functions. Indeed, life as we understand it relies on the full range of biological processes that are either performed by or catalyzed by porphyrin-containing proteins. Chlorophyll-containing photosynthetic reaction centers in plants, for instance, convert light energy into chemical energy while producing oxygen along the way. It is this oxygen, evolved from photosynthesis, that is transported, stored, and reduced by heme-containing proteins in many organisms, including mammals. Not surprisingly, therefore, these molecules remain of fundamental interest to chemists and biochemists. Indeed, they continue to be intensely investigated by researchers world-wide.Inspired by the importance of the porphyrins, a new research di
Written by an author team that includes former and current law enforcement officers, Introduction to Policing focuses on the most thought-provoking, contemporary issues in the world of policing. The authors tackle complex issues that impact policing today, such as social diversity; advancements in technology; and global issues, such as terrorism and transnational organized crime. The Fifth Edition offers fully updated content in SAGE’s Vantage courseware platform. This title is accompanied by a complete teaching and learning package. Contact your SAGE representative to request a demo. Learning Platform / Courseware SAGE Vantage is an intuitive learning platform that integrates quality SAGE textbook content with assignable multimedia activities and auto-graded assessments to drive student engagement and ensure accountability. Unparalleled in its ease of use and built for dynamic teaching and learning, Vantage offers customizable LMS integration and best-in-class support. It’s a learning platform you and your students will actually love. Learn more. Assignable Video with Assessment Assignable video (available in SAGE Vantage) is tied to learning objectives and curated exclusively for this text to bring concepts to life. Watch a sample video now. LMS Cartridge: Import this title’s instructor resources into your school’s learning management system (LMS) and save time. Don’t use an LMS? You can still access all of the same online resources for this title via the password-protected Instructor Resource Site. Learn more.
In Crime Prevention: Programs, Policies, and Practices, criminologists Steven E. Barkan and Michael Rocque present a well-rounded exploration of evidence-based policies, programs, and practices. Grounded in criminological theory and emphasizing the social, psychological, and biological roots of crime, this text presents current research, perspectives, and examples that capture the key crime prevention concepts students should understand, including the public health model for crime prevention. Highlighting the importance of applying theory to real-world solutions, the authors′ discussion of crime prevention strategies integrates theory and practice throughout the text.
This great resource presents dentistry and dental practice against the ever-changing backdrop of economic, technological, and demographic trends, as well as the distribution of the oral diseases that dental professionals treat and prevent. The text is logically divided into five parts. Dentistry and the Community deals with the development of the dental and dental hygiene professions, demographics of the public, its use of dental services, and the professional role. Dental Practice covers the structure and financing of dental care, the personnel involved in providing that care, and the emerging field of evidence-based dentistry. The Methods of Oral Epidemiology provides a comprehensive assessment of the epidemiology of oral diseases and the determinants of their distribution in society. The Distribution of Oral Diseases and Conditions gives a detailed presentation of how the common oral diseases are distributed in the community. Prevention of Oral Diseases in Public Health discusses methods of preventing oral diseases in dental practice and through public health action. Thorough explanations of how to read dental literature help readers understand how to draw their own conclusions from the latest studies. Coverage presents a number of complex problems facing practitioners today regarding access to dental care, and discusses how to solve them by working with public authorities and insurers. Comprehensive coverage of oral disease distribution helps readers to understand trends and risks they will encounter in the field. Material on prevention and control of oral diseases provides important information that all dental practitioners should have. Research designs used in oral epidemology assess the pros and cons of dental indexes available, allowing readers to gain an understanding of the complexities of disease measurement and research. Detailed content on providing dental care to the American public presents a unique opportunity to learn the system of dental care delivery. State-of-the-art coverage of mercury issues offer a balanced view of issues like toxicity, potential hazards, review of evidence, and politics. Ethical guidelines provide a discussion of how ethical principles have evolved over time and the precipitating events that pushed ethical practice into the forefront of health care. Information on the development of dental professions gives readers insight into how these professions originated and their current state. · Content addresses evidence-based dentistry, and how it can and should become part of the everyday clinical life of the practitioner, since staying current is vital to providing excellent patient care. · Discussions of infection control procedures and the impact of HIV and Hepatitis B incorporate new, updated guidelines in dental health care settings released in 2003.
Formation of small solid and liquid particles is vital for a variety of natural and technological phenomena, from the evolution of the universe, through atmospheric air pollution and global climate change. Despite its importance, nucleation is still not well understood, and this unique book addresses that need. It develops the theory of nucleation from first principles in a comprehensive and clear way, and uniquely brings together classical theory with contemporary atomistic approaches. Important real-world situations are considered, and insight is given into cases typically not considered such as particle formation in flames and plasmas. Written by an author with more than 35 years of experience in the field, this will be an invaluable reference for senior undergraduates and graduate students in a number of disciplines, as well as for researchers in fields ranging from climate science and astrophysics to design of systems for semiconductor processing and materials synthesis.
Fetal and Neonatal Physiology, edited by Drs. Polin, Fox, and Abman, focuses on physiologic developments of the fetus and newborn and their impact on the clinical practice of neonatology. A must for practice, this 4th edition brings you the latest information on genetic therapy, intrauterine infections, brain protection and neuroimaging, and much more. You'll also have easy access to the complete contents and illustrations online at expertconsult.com. Gain a comprehensive, state-of-the-art understanding of normal and abnormal physiology, and its relationship to disease in the fetus and newborn premature infant, from Dr. Richard Polin and other acknowledged worldwide leaders in the field. Understand the implications of fetal and neonatal physiology through chapters devoted to clinical correlation. Apply the latest insights on genetic therapy, intrauterine infections, brain protection and neuroimaging, and much more. Effectively manage the consequences of intrauterine infections with three new chapters covering intrauterine infection and preterm birth, intrauterine infection and brain injury, and intrauterine infection and chronic lung disease. Access the complete contents and illustrations online at expertconsult.com - fully searchable! Get the latest developments and a full understanding of the distinct physiology of the fetus and newborn so you can treat and manage sick newborns and preemies.
After 30 years, Obstetrics: Normal and Problem Pregnancies remains your go-to choice for authoritative guidance on managing today’s obstetric patient. International experts put the latest knowledge in this specialty at your fingertips, with current and relevant information on everything from fetal origins of adult disease, to improving global maternal health, to important topics in day-to-day obstetrical practice. Highly readable, well-illustrated, and easy to understand, this bestselling obstetrics reference is an ideal tool for residents and clinicians. Take advantage of the collective wisdom of global experts in the field, including two new editors— Drs. Vincenzo Berghella and William Grobman -- and nearly 30 new contributors. Gain a new perspective on a wide range of today's key issues - all evidence-based and easy to read. Sweeping updates throughout including four new chapters: ‘Vaginal Birth after Cesarean Delivery’; ‘Placenta Accreta’; ‘Obesity’; and ‘Improving Global Maternal Health: Challenges and Opportunities’ New Glossary of the most frequently used key abbreviations for easy reference Expanded use of bolded statements and key points as well as additional tables, flow diagrams, and bulleted lists facilitates and enhances the mastery of each chapter More than 100 images in the Obstetrical Ultrasound chapter provide an important resource for normal and abnormal fetal anatomy
Introduced in the Pacific Northwest in 1883, professional wrestling has a long and storied history in the region and has contributed significantly to Northwest culture. This entertaining account of the wrestling industry in Oregon, Washington, and British Columbia provides a detailed look at more than 130 years of events in the ring and behind the scenes. The author draws connections between developments in wrestling and the changing identity of the Pacific Northwest.
The world's leading source of evidence-based guidance on caring for patients at the end of life. Featuirng the content of the world's most widely read medical journal, plus completely new, never-before-published content. Perfect for medical students, trainees, and clinicians alike. Market / Audience Medical students: 18000/yr US, 250,000 global NP and PA students: 25,000/yr US, 50,000+ global IM and FP residents: 30,000 US, 60,000 global IM and FP clinicians: 140,000 US, 300,000+ global Palliative medicine: 3000 US Oncology: 20,000 US, 60,000 global Social workers About the Book In the tradition of the User's Guides to the Medical Literature, and The Rational Clinical Examination, JAMA/Care at the Close of Life is based on a widely successful series of articles appearing over the course of the last ten years in JAMA, the world's most widely read medical journal. The series is directed by Stephen McPhee, a leading authoriity of end of life care, and the chief editor of our market leading Current Medical Diagnosis and Treatment text. The articles in the series cover fundamental topics and challenges in caring for patients who have been given a terminal diagnosis. Featuring a strong focus on evidence-based medicine, and organized by clinical cases, the articles are widely read by faculty, medical students, and clinicians who, frankly, have not been given a solid educational experience on this very important medical issue. The book will be physically modeled after The Rational Clinical Examination, in a full color format that highlights the clinical cases. It will be well suited for use as an required or recommended textbook for medical, PA, and NO students, and as a clinical reference text for trainees and practicing physicians and nurses. Key Selling Features Based on highy regarded content from the world's most widely read medical journal All content is completely updated, and extensive new, never-before-published content has been added Case-based, and evidence-based, so its a perfect fit for the way medical students and residents like to learn Focuses on practical, real-world issues for primary care physicians, and avoids esoteric issues of interest only to specialists in palliative care Full color format, modeled after the highly regarded Rational Clinical Examination Includes multimedia materials available on line: Power Point slides for teaching, and video interviews with patients in end-of-life care, so that faculty and students get supplemental resources for learning the art and science of care at the end of life Evidence-based guidance from the world's leading medical journal, on a critical topic that has been neglected in medical education and training until recently. Author Profile JAMA is the world's most widely read medical journal, and has a reputation for excellence in evidence-based medicine. Stephen McPhee has high visbility on account of his editorship of CMDT, and for his driving role in enhancing end of life care in medical education and training programs. He is: Professor of Medicine, UCSF School of Medicine, San Francisco CA
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