Selected from the world’s leading comprehensive cancer textbook, this tightly focused resource provides you with the practical, cutting-edge information you need to provide the best cancer care to each patient. Cancer of the Breast: Cancer: Principles & Practice of Oncology, 10th Edition, offers a comprehensive and balanced view of this rapidly changing field, meeting the needs of oncology practitioners, fellows, and others who need an in-depth understanding of breast cancer. The print reference gives you the solid, dependable guidance you’ve come to expect from this outstanding title, and the Inkling version features new quarterly updates written by a team of experts selected by the authors.
The most passionate advocates of Italy’s unification in the nineteenth century possessed an almost limitless faith in the benefits of civic association. They also shared a common concern: once Italian unification was achieved and various freedoms were established, would ordinary Italians naturally become responsible, progressive citizens – especially after centuries of foreign rule, regional division, and economic decline? Most unification advocates doubted that their fellow citizens could form a modern, progressive civil society on their own, or that a vibrant association life would develop from the ground up. Building a Civil Society is the first book-length English-language study of associational life in nineteenth-century Italy. Drawing on extensive research in published and unpublished documents – including associational records, newspapers, periodicals, government documents, guidebooks, exhibition catalogues, memoirs, and private letters – Steven C. Soper provides a complex account of Italian liberalism during Europe’s age of association. His study also raises important questions about the role that associations play in emerging democracies.
Despite popular belief, the Civil War did not end when Robert E. Lee surrendered to Ulysses S. Grant at Appomattox, Virginia, in April 1865. The Confederacy still had tens of thousands of soldiers under arms, in three main field armies and countless smaller commands scattered throughout the South. Although pressed by Union forces at varying degrees, all of the remaining Confederate armies were capable of continuing the war if they chose to do so. But they did not, even when their political leaders ordered them to continue the fight. Convinced that most civilians no longer wanted to continue the war, the senior Confederate military leadership, over the course of several weeks, surrendered their armies under different circumstances. Gen. Joseph Johnston surrendered his army in North Carolina only after contentious negotiations with Gen. William Tecumseh Sherman. Gen. Richard Taylor ended the fighting in Alabama in the face of two massive Union incursions into the state rather than try to consolidate with other Confederate armies. Personal rivalry also played a part in his practical considerations to surrender. Gen. Edmund Kirby Smith had the decision to surrender taken out of his hands—disastrous economic conditions in his Trans-Mississippi Department had eroded morale to such an extent that his soldiers demobilized themselves, leaving Kirby Smith a general without an army. The end of the Confederacy was a messy and complicated affair, a far cry from the tidy closure associated with the events at Appomattox.
Trauma Among Older Adults presents an integrative model of treatment that considers current theories of treatment in light of special considerations relating to elderly patients. The book provides case studies, vignettes, and discussions, and demonstrates the importance of considering the personality, memory, and familial history of an elderly individual who has suffered a trauma.
The Magic Kingdom sheds new light on the cultural icon of "Uncle Walt." Watts digs deeply into Disney's private life, investigating his roles as husband, father, and brother and providing fresh insight into his peculiar psyche-his genuine folksiness and warmth, his domineering treatment of colleagues and friends, his deepest prejudices and passions. Full of colorful sketches of daily life at the Disney Studio and tales about the creation of Disneyland and Disney World, The Magic Kingdom offers a definitive view of one of the most influential Americans of the twentieth century.
Neuropeptides mediate their effects by binding and activating receptors that are responsible for converting these extracellular stimuli into intracellular responses. Most neuropeptides interact with G protein-coupled receptors that transduce the signal by activating heterotrimeric G proteins leading to alterations in second messenger systems to amplify the signal and elicit the intracellular response. In this review, we describe the general structure of G protein-coupled receptors including the information obtained from crystal structure determination that has given an insight into the activation mechanism of these receptors. In addition, we summarize the components of the signal transduction system (including G proteins, effectors and second messengers generally activated by the neuropeptide receptors). Using select examples of neuropeptide-receptor systems, we highlight the neuropeptides and corresponding receptors involved in modulation of pain and analgesia, body weight regulation, and hormonal regulation. Finally, we discuss the enzyme-linked tyrosine kinase receptors activated by growth factors and discuss the emerging concepts in targeting neuropeptide receptors for the identification of novel therapeutics targeting these systems. Table of Contents: Abbreviations / Overview of Neuropeptide Receptors / G Protein-Coupled Receptors: General Structure & Function / G Protein-Coupled Receptor Signaling / Neuropeptide Processing and Regulation / Neuropeptide Receptors / Perspectives / References
Selected from the world’s leading comprehensive cancer textbook, this tightly focused resource provides you with the practical, cutting-edge information you need to provide the best cancer care to each patient. Prostate and Other Genitourinary Cancers: Cancer: Principles & Practice of Oncology, 10th Edition, offers a comprehensive and balanced view of this rapidly changing field, meeting the needs of oncology practitioners, fellows, and others who need an in-depth understanding of prostate and GU cancer. The print reference gives you the solid, dependable guidance you’ve come to expect from this outstanding title, and the Inkling version features new quarterly updates written by a team of experts selected by the authors.
Health, Illness, and Society, Updated Second Edition provides a comprehensive yet concise introduction to medical sociology. In his accessible style, Steven Barkan covers health and illness behaviors, the social determinants of health problems, the health professions and health care system in the U.S., and how the U.S. system compares to that of other countries. The updated second edition adds a new chapter, “The COVID-19 Pandemic,” which highlights several ways in which the pandemic exhibits health and health behavior disparities resulting from social inequalities and the deficiencies of the U.S. health system. The book also critically examines the achievements and limitations of the Affordable Care Act and discusses efforts of the Trump administration to weaken the ACA. Each chapter opens with learning questions to guide the student and “Health and Illness in the News” stories that apply each chapter’s contents to contemporary events. Chapter summaries reinforce key ideas and “Give it Some Thought” boxes emphasize critical thinking. New to the Updated Second Edition New Chapter 14, “The COVID-19 Pandemic,” discusses several ways in which the pandemic reveals health and health behavior disparities New data on medical students and faculty, sexual harassment in medical school, and medical school debt provide students with a deeper understanding of the issues facing doctors New health care data on peer nations and discussion of health and health care rankings of U.S. women provide a critical examination of the quality and cost of health care in the U.S. versus its peer nations Enhanced examination of health insurance status and surprise medical billing, updated survey data on health care costs, and a discussion of high deductibles emphasize the patient financial burden created by a private system of medicine
“[An] important book.… Heine’s vibrant writing makes it come alive with personal significance for every reader.”—Carol Dweck, author of Mindset Scientists expect one billion people to have their genomes sequenced by 2025. Yet cultural psychologist Steven J. Heine argues that, in trying to know who we are and where we come from, we’re likely to completely misinterpret what’s “in our DNA.” Heine’s fresh, surprising conclusions about the promise, and limits, of genetic engineering and DNA testing upend conventional thinking and reveal a simple, profound truth: your genes create life—but they do not control it.
Although they are relative latecomers on the evolutionary scene, having emerged only 135?170 million years ago, angiosperms—or flowering plants—are the most diverse and species-rich group of seed-producing land plants, comprising more than 15,000 genera and over 350,000 species. Not only are they a model group for studying the patterns and processes of evolutionary diversification, they also play major roles in our economy, diet, and courtship rituals, producing our fruits, legumes, and grains, not to mention the flowers in our Valentine’s bouquets. They are also crucial ecologically, dominating most terrestrial and some aquatic landscapes. This fully revised edition of Phylogeny and Evolution of the Angiosperms provides an up-to-date, comprehensive overview of the evolution of and relationships among these vital plants. Incorporating molecular phylogenetics with morphological, chemical, developmental, and paleobotanical data, as well as presenting a more detailed account of early angiosperm fossils and important fossil information for each evolutionary branch of the angiosperms, the new edition integrates fossil evidence into a robust phylogenetic framework. Featuring a wealth of new color images, this highly synthetic work further reevaluates long-held evolutionary hypotheses related to flowering plants and will be an essential reference for botanists, plant systematists, and evolutionary biologists alike.
In this text, two of the world’s leading experts on strength training explore how to design scientifically based resistance training programs, modify and adapt programs to meet the needs of special populations, and apply the elements of program design in the real world.
This anthology is intended to be used in Political Philosophy courses. It focuses on contemporary political problems, and it is intended to be paired with any of the numerous readers which are dedicated to the history of political philosophy. History, theory, and political problems are the three pillars of the political philosophy course. However, while the anthologies on the history of political philosophy are numerous, there are relatively few sources (and even fewer single sources) that focus on contemporary political problems. This book fills that gap, with the leading contemporary positions on school vouchers, government support for the arts, pornography, same sex marriage, drug legalization, gun control, terrorism, torture, capital punishment, affirmative action, Immigration, and the environment.
Drs. Cohen, Powderly and Opal, three of the most-respected names in infectious disease medicine, lead a diverse team of international contributors to bring you the latest knowledge and best practices. Extensively updated, the fourth edition includes brand-new information on advances in diagnosis of infection; Hepatitis C; managing resistant bacterial infections; and many other timely topics. An abundance of photographs and illustrations; a practical, clinically-focused style; highly-templated organization; and robust interactive content combine to make this clinician-friendly resource the fastest and best place to find all of the authoritative, current information you need. - Hundreds of full-color photographs and figures provide unparalleled visual guidance. - Consistent chapter organization and colorful layouts make for quick searches. - Clinically-focused guidance from "Practice Points" demonstrates how to diagnose and treat complicated problems encountered in practice. - The "Syndromes by Body System", "HIV and AIDS", and "International Medicine" sections are designed to reflect how practicing specialists think when faced with a patient. - Sweeping updates include new or revised chapters on: - Hepatitis C and antivirals - Fungal infection and newer antifungals - Microbiome and infectious diseases as well as advances in diagnosis of infection; Clostridium difficile epidemiology; infection control in the ICU setting; Chlamydia trachomatis infection; acquired syndromes associated with autoantibodies to cytokines;; management of multidrug resistant pathogens; probiotics, polymyxins, and the pathway to developing new antibiotics - HIV including HIV and aging, antiretroviral therapy in developing countries, and cure for HIV. - Online Antimicrobial pharmacokinetics mannequin, as well an all new HIV medicine mannequin are a useful visual source of treatment information
Historical Studies of Science as if It Was Produced by People with Bodies, Situated in Time, Space, Culture, and Society, and Struggling for Credibility and Authority
Historical Studies of Science as if It Was Produced by People with Bodies, Situated in Time, Space, Culture, and Society, and Struggling for Credibility and Authority
Steven Shapin argues that science, for all its immense authority and power, is and always has been a human endeavor, subject to human capacities and limits. Put simply, science has never been pure. To be human is to err, and we understand science better when we recognize it as the laborious achievement of fallible, imperfect, and historically situated human beings. Shapin’s essays collected here include reflections on the historical relationships between science and common sense, between science and modernity, and between science and the moral order. They explore the relevance of physical and social settings in the making of scientific knowledge, the methods appropriate to understanding science historically, dietetics as a compelling site for historical inquiry, the identity of those who have made scientific knowledge, and the means by which science has acquired credibility and authority. This wide-ranging and intensely interdisciplinary collection by one of the most distinguished historians and sociologists of science represents some of the leading edges of change in the scholarly understanding of science over the past several decades.
Who are scientists? What kind of people are they? What capacities and virtues are thought to stand behind their considerable authority? They are experts—indeed, highly respected experts—authorized to describe and interpret the natural world and widely trusted to help transform knowledge into power and profit. But are they morally different from other people? The Scientific Life is historian Steven Shapin’s story about who scientists are, who we think they are, and why our sensibilities about such things matter. Conventional wisdom has long held that scientists are neither better nor worse than anyone else, that personal virtue does not necessarily accompany technical expertise, and that scientific practice is profoundly impersonal. Shapin, however, here shows how the uncertainties attending scientific research make the virtues of individual researchers intrinsic to scientific work. From the early twentieth-century origins of corporate research laboratories to the high-flying scientific entrepreneurship of the present, Shapin argues that the radical uncertainties of much contemporary science have made personal virtues more central to its practice than ever before, and he also reveals how radically novel aspects of late modern science have unexpectedly deep historical roots. His elegantly conceived history of the scientific career and character ultimately encourages us to reconsider the very nature of the technical and moral worlds in which we now live. Building on the insights of Shapin’s last three influential books, featuring an utterly fascinating cast of characters, and brimming with bold and original claims, The Scientific Life is essential reading for anyone wanting to reflect on late modern American culture and how it has been shaped.
This book provides a critical overview of the myriad literatures on “work,” viewed not only as a product of the marketplace but also as a social and political construct. Drawing on theoretical and empirical contributions from sociology, history, economics, and organizational studies, the book brings together perspectives that too often remain balkanized, using each to explore the nature of work today. Outlining the fundamental principles that unite social science thinking about work, Vallas offers an original discussion of the major theoretical perspectives that inform workplace analysis, including Marxist, interactionist, feminist, and institutionalist schools of thought. Chapters are devoted to the labor process, to workplace flexibility, to gender and racial inequalities at work, and to the link between globalization and the structure of work and authority today. Major topics include the relation between work and identity; the relation between workplace culture and managerial control; and the performance of emotional labor within service occupations. This concise book will be invaluable to students at all levels as it explores a range of insights to make sense of pressing issues that drive the social scientific study of work today.
Recent scientific advances have revolutionized cancer research and practice, creating a body of molecular biology information that is important to research scientists and clinical oncologists alike. Cancer: Principles and Practice of Oncology: Primer of the Molecular Biology of Cancer, 3rd Edition, keeps you up to date with all that’s new in this rapidly changing field. Derived from DeVita, Hellman, and Rosenberg’s Cancer: Principles and Practice of Oncology – widely regarded as the definitive clinical reference in oncology – the third edition of this popular Primer provides a single-volume, highly focused reference on every important frontier in the molecular biology of cancer.
DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology, 10th edition has garnered universal acclaim as the world’s definitive, standard-setting oncology reference. More than 400 respected luminaries explore today’s most effective strategies for managing every type of cancer by stage of presentation - discussing the role of all appropriate therapeutic modalities as well as combined-modality treatments. This multidisciplinary approach will help your cancer team collaboratively face the toughest clinical challenges and provide the best possible care for every cancer patient. Access the complete contents online or on your mobile device, with quarterly updates reflecting late-breaking developments in cancer care, free for the first year on LWW Health Library. Take full advantage of the latest advances with brand-new chapters on Hallmarks of Cancer, Molecular Methods in Cancer, Oncogenic Viruses, Cancer Screening, and new sections on Genetic testing and counseling for cancer, plus comprehensive updates throughout – including coverage of the newest biologic therapies. Make optimal, well-coordinated use of all appropriate therapies with balanced, multidisciplinary advice from a surgeon, a medical oncologist, and a radiation oncologist in each major treatment chapter. Review the latest molecular biology knowledge for each type of cancer and its implications for improved management. Make the best decisions on cancer screening and prevention, palliative care, supportive oncology, and quality-of-life issues
Selected from the world’s leading comprehensive cancer textbook, this tightly focused resource provides you with the practical, cutting-edge information you need to provide the best cancer care to each patient. Lymphomas and Leukemias: From Cancer: Principles & Practice of Oncology, 10th Edition, offers a complete and balanced view of this rapidly changing field, meeting the needs of oncology/hematology practitioners, fellows, and others who need an in-depth understanding of leukemias and lymphomas. The print reference gives you the solid, dependable guidance you have come to expect from this outstanding title, and the Inkling version features new quarterly updates written by a team of experts selected by the authors. Delivers focused, comprehensive information on leukemias and lymphomas drawn from the world’s leading cancer textbook, DeVita, Hellman, and Rosenberg’s Cancer: Principles & Practice of Oncology. Covers the full range of adult lymphomas and leukemias, including the molecular biology of lymphomas and acute and chronic leukemias; Hodgkin’s lymphoma; non-Hodgkin’s lymphoma; cutaneous lymphomas; management of acute and chronic leukemias, future directions and new treatments; myelodysplastic syndromes; plasma cell neoplasms; and more. Includes comprehensive information on leukemias and lymphomas of childhood, including supportive, long-term, palliative, and hospice care. Discusses in detail the growing importance of prevention and screening, giving you the understanding you need to improve your patients’ chances for a healthier, cancer-free life. Explains how the latest developments in biologic therapy apply to leukemias and lymphomas. Provides exhaustive coverage of combined modality cancer treatment, helping you determine when and how to integrate modalities in patient treatment. Ensures that you are fully up to date thanks to easy, mobile access to quarterly updates.
Selected from the world’s leading comprehensive cancer textbook, this tightly focused resource provides you with the practical, cutting-edge information you need to provide the best cancer care to each patient. Cancer of the Skin: From Cancer: Principles & Practice of Oncology, 10th Edition, offers a comprehensive and balanced view of this rapidly changing field, meeting the needs of oncology/hematology practitioners, fellows, and others who need an in-depth understanding of skin cancers. The print reference gives you the solid, dependable guidance you have come to expect from this outstanding title, and the Inkling version features new quarterly updates written by a team of experts selected by the authors. Delivers focused, comprehensive information on cancer of the skin drawn from the world’s leading cancer textbook, DeVita, Hellman, and Rosenberg’s Cancer: Principles & Practice of Oncology. Covers the full range of skin cancers, including nonmelanoma skin cancer, actinic keratosis, basal cell carcinoma, squamous cell carcinoma, angiosarcoma, microcystic adnexal carcinoma, and more; as well as cutaneous melanoma, including molecular biology; and genetic testing in skin cancer. Discusses in detail the growing importance of prevention and screening, giving you the understanding you need to improve your patients’ chances for a healthier, cancer-free life. Explains how the latest developments in biologic therapy applies to skin cancer. Provides exhaustive coverage of combined modality cancer treatment, helping you determine when and how to integrate modalities in patient treatment. Ensures that you are fully up to date thanks to easy, mobile access to quarterly updates.
Since the 1960s the number of highly educated professionals in America has grown dramatically. During this time scholars and journalists have described the group as exercising increasing influence over cultural values and public affairs. The rise of this putative "new class" has been greeted with idealistic hope or ideological suspicion on both the right and the left. In an Age of Experts challenges these characterizations, showing that claims about the distinctive politics and values of the professional stratum have been overstated, and that the political preferences of professionals are much more closely linked to those of business owners and executives than has been commonly assumed.
Michael Foote and Arnold Miller have stepped in to revise this classic text. It is their vision to take the core approach of the second edition, and reflect the substantial changes to the rudiments of the subject from the previous two decades. This third edition remains an excellent text for those studying geophysical sciences.
Weiland highlights the master trends in the American experience by the master reporters of those trends. Intellectual Craftsmen covers the best writers in the social sciences from 1935 to 1991. Included are essays on John Dollard in social psychology; C. Wright Mills's version of historical sociology; David Riesman and the element of social criticism; Margaret Mead and the search for an anthropological method.
This monograph has attempted to bring together morphological and physiological studies of reptilian lungs, to analyze the nature of the resulting correlations, and to risk some speculations regarding the evolution of reptilian lung structure. Central to this work is the morphometric evaluation of the lungs in two species of lizard: "the teju (Tupinambis nigropunctatus Spix) and the savanna monitor (Varanus exanthema ticus [Bosc]) which is presented here for the first time. These two species are similar in body form, and both are diurnally active predators, but their lungs are of basic ally different structural types. The teju possesses relatively small, single-chambered (unicameral) lungs in which the homeycomb-like (faveolar) parenchyma is more or less evenly distributed along their length. In the monitor the lungs are large and many-chambered (multicameral), the individual chambers connecting to an unbranched, intrapulmonary bronchus. The parenchyma is in the form of shallow cubicles (ediculae), which are elaborated on the intercameral septa. The parenchyma is heterogeneously distributed within the lungs, tending to be most concentrated near the intrapulmonary bronchus and the middle third of the lung length. The ventral and caudal portions of these lungs are thin-walled and highly flexible. In both species those portions of the lungs which are most exposed to air convection possess dense capillary nets which almost completely cover both sides of the parenchymal partitions. In more distal regions of the parenchy ma or of the lung, the intercapillary spaces become larger, creating a pseudo-single capillary net.
Building on and updating some of the issues addressed in Starting to Teach Latin, Steven Hunt provides a guide for novice and more experienced teachers of Latin in schools and colleges, who work with adapted and original Latin prose texts from beginners' to advanced levels. It draws extensively on up-to-date theories of second language development and on multiple examples of the practices of real teachers and students. Hunt starts with a detailed look at deductive, inductive and active teaching methods, which support teachers in making the best choices for their students' needs and for their own personal preferences, but goes on to organise the book around the principles of listening, reading, speaking and writing Latin. It is designed to be informative, experimental and occasionally provocative. The book closes with two chapters of particular contemporary interest: 'Access, Diversity and Inclusion' investigates how the subject community is meeting the challenge of teaching Latin more equitably in today's schools; and 'The Future' offers some thoughts on lessons that have been learnt from the experiences of online teaching practices during the Covid-19 lockdowns. Practical examples, extensive references and a companion website at www.stevenhuntclassics.com are included. Teachers of Latin will find this book an invaluable tool inside and outside of the classroom.
Building on the work presented in Styran and Taylor’s This Great National Object, which told the story of the first three Welland canals built in the nineteenth century, This Colossal Project chronicles an impressive milestone in the history of Canadian technological achievement and nation building.
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