Steven A. Julious's Books

Sample Sizes for Clinical Trials

By: Steven A. Julious

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Sample Sizes for Clinical Trials

By: Steven A. Julious

Sample Sizes for Clinical Trials, Second Edition is a practical book that assists researchers in their estimation of the sample size for clinical trials. Throughout the book there are detailed worked examples to illustrate both how to do the calculations and how to present them to colleagues or in protocols. The book also highlights some of the pitfalls in calculations as well as the key steps that lead to the final sample size calculation. Features: Comprehensive coverage of sample size calculations, including Normal, binary, ordinal, and survival outcome data Covers superiority, equivalence, non-inferiority, bioequivalence and precision objectives for both parallel group and crossover designs Highlights how trial objectives impact the study design with respect to both the derivation of sample formulae and the size of the study Motivated with examples of real-life clinical trials showing how the calculations can be applied New edition is extended with all chapters revised, some substantially, and four completely new chapters on multiplicity, cluster trials, pilot studies, and single arm trials The book is primarily aimed at researchers and practitioners of clinical trials and biostatistics, and could be used to teach a course on sample size calculations. The importance of a sample size calculation when designing a clinical trial is highlighted in the book. It enables readers to quickly find an appropriate sample size formula, with an associated worked example, complemented by tables to assist in the calculations.

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Page Count

643

Publisher

CRC Press

Published Date

ISBN 10

0429994540

ISBN 13

9780429994548

An Introduction to Statistics in Early Phase Trials

By: Steven Julious,Say Beng Tan,David Machin

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An Introduction to Statistics in Early Phase Trials

By: Steven Julious,Say Beng Tan,David Machin

All new medicines and devices undergo early phase trials to assess, interpret and better understand their efficacy, tolerability and safety. An Introduction to Statistics in Early Phase Trials describes the practical design and analysis of these important early phase clinical trials and provides the crucial statistical basis for their interpretation. It clearly and concisely provides an overview of the most common types of trials undertaken in early phase clinical research and explains the different methodologies used. The impact of statistical technologies on clinical development and the statistical and methodological basis for making clinical and investment decisions are also explained. Conveys key ideas in a concise manner understandable by non-statisticians Explains how to optimise designs in a constrained or fixed resource setting Discusses decision making criteria at the end of Phase II trials Highlights practical day-to-day issues and reporting of early phase trials An Introduction to Statistics in Early Phase Trials is an essential guide for all researchers working in early phase clinical trial development, from clinical pharmacologists and pharmacokineticists through to clinical investigators and medical statisticians. It is also a valuable reference for teachers and students of pharmaceutical medicine learning about the design and analysis of clinical trials.

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Page Count

264

Publisher

John Wiley & Sons

Published Date

ISBN 10

0470319178

ISBN 13

9780470319178

Sample Sizes for Clinical Trials

By: Steven A. Julious

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Sample Sizes for Clinical Trials

By: Steven A. Julious

Drawing on various real-world applications, Sample Sizes for Clinical Trials takes readers through the process of calculating sample sizes for many types of clinical trials. It provides descriptions of the calculations with a practical emphasis.Focusing on normal, binary, ordinal, and survival data, the book explores a range of trials, including su

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Page Count

330

Publisher

CRC Press

Published Date

ISBN 10

1584887400

ISBN 13

9781584887409

Book's by Steven A. Julious

Sample Sizes for Clinical Trials

Sample Sizes for Clinical Trials

An Introduction to Statistics in Early Phase Trials

An Introduction to Statistics in Early Phase Trials

Sample Sizes for Clinical Trials

Sample Sizes for Clinical Trials

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