Understanding Toxicology is a comprehensive study of toxicants and their impact on all levels of biology--from cell, to complex organism, to ecosystem. Unlike other texts of its kind, this text is uniquely structured by biological system, making it easy for readers to understand the impact of toxins on each system. Common mechanisms are explored in the cellular and complex organ system chapters to approach a systems biology perspective that is more applicable to modern computational toxicology risk assessment. Understanding Toxicology begins with three research questions that challenge the reader to discover what information is needed to solve controversies at the level of the cell, the complex organism, and the ecosystem. The book continues with a cellular, complex organism, and ecosystem analysis of toxicology principles including risk assessment. The cellular section follows common mechanisms from the outside to the inside of cells and individual organelles. A forensic approach analyzes complex organisms from outside to inside. The ecosystem section starts with a dispersion approach to determine environmental concentration and addresses toxicants in divisions similar to how the EPA determines impacts. Key Features • Uses lively, engaging examples making the text fun and easy to read and understand • Allows the reader to approach the subject from a research perspective as well as a public policy perspective • Covers biological toxicants including venoms, poisons, as well as microbial and fungal toxins, and plant toxins • Thoroughly covers all organisms including fish, plants, and microbes • Includes outlines and review questions in each chapter
Winner of the Christian Gauss Award for excellence in literary scholarship from the Phi Beta Kappa Society Having excavated the world's earliest novels in his previous book, literary historian Steven Moore explores in this sequel the remarkable flowering of the novel between the years 1600 and 1800-from Don Quixote to America's first big novel, an homage to Cervantes entitled Modern Chivalry. This is the period of such classic novels as Tom Jones, Candide, and Dangerous Liaisons, but beyond the dozen or so recognized classics there are hundreds of other interesting novels that appeared then, known only to specialists: Spanish picaresques, French heroic romances, massive Chinese novels, Japanese graphic novels, eccentric English novels, and the earliest American novels. These minor novels are not only interesting in their own right, but also provide the context needed to appreciate why the major novels were major breakthroughs. The novel experienced an explosive growth spurt during these centuries as novelists experimented with different forms and genres: epistolary novels, romances, Gothic thrillers, novels in verse, parodies, science fiction, episodic road trips, and family sagas, along with quirky, unclassifiable experiments in fiction that resemble contemporary, avant-garde works. As in his previous volume, Moore privileges the innovators and outriders, those who kept the novel novel. In the most comprehensive history of this period ever written, Moore examines over 400 novels from around the world in a lively style that is as entertaining as it is informative. Though written for a general audience, The Novel, An Alternative History also provides the scholarly apparatus required by the serious student of the period. This sequel, like its predecessor, is a “zestfully encyclopedic, avidly opinionated, and dazzlingly fresh history of the most 'elastic' of literary forms” (Booklist).
The complete operational history of an outstanding Marine fighter squadron throughout the Cold War. The Thunderbolts of VMFA-251 were reactivated as a Marine Air Reserve squadron in 1946. Their Cold War only included a few weeks of traditional combat operations—in Korea—but they would undertake constant training exercises and deployments from 1946 to 1991 as they prepared for a potential war against the USSR or China, the two giants of Communism. From South Korea to Norway to Turkey and points in between, the Thunderbolts found themselves defending the free world and living up to their motto, Custos Caelorum. Following the end of the Korean War, the squadron remained in the Far East until 1956. Back in the States it began flying the FJ-3 Fury, a jet fighter, before converting to its first supersonic fighter, the F-8U “Crusader.” In early 1962, it was the first Marine F-8 squadron to deploy aboard an aircraft carrier, as part of CVW-10 (Carrier Air Wing) aboard the USS Shangri-La. During deployment in the Mediterranean Sea, the squadron set a record for the most flight time in one month for a Sixth Fleet-based F-8 squadron by flying over 500 hours. In 1964, the Thunderbolts were the first Marine squadron in 2nd Marine Aircraft Wing to transition to the F-4B “Phantom II,” which they would fly for 21 years and 80,000 flight hours, until transitioning to the F/A-18 “Hornet” in 1987. These deployments and exercises, while not “at war,” were not without dangers. The Thunderbolts lost many personnel and aircraft, but they persevered as the armed forces of freedom-loving nations faced the ongoing threat of communism for over four decades. Compiled from archive records and interviews by a veteran of VMFA-251, this account narrates how the Thunderbolts worked hard to maintain the peace. They were indeed Custodians of the Sky.
When experience with uncontrollable events gives rise to the expectation that events in the future will also elude control, disruptions in motivation, emotion, and learning may ensue. "Learned helplessness" refers to the problems that arise in the wake of uncontrollability. First described in the 1960s among laboratory animals, learned helplessness has since been applied to a variety of human problems entailing inappropriate passivity and demoralization. While learned helplessness is best known as an explanation of depression, studies with both people and animals have mapped out the cognitive and biological aspects. The present volume, written by some of the most widely recognized leaders in the field, summarizes and integrates the theory, research, and application of learned helplessness. Each line of work is evaluated critically in terms of what is and is not known, and future directions are sketched. More generally, psychiatrists and psychologists in various specialties will be interested in the book's argument that a theory emphasizing personal control is of particular interest in the here and now, as individuality and control are such salient cultural topics.
DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology, 10th edition has garnered universal acclaim as the world’s definitive, standard-setting oncology reference. More than 400 respected luminaries explore today’s most effective strategies for managing every type of cancer by stage of presentation - discussing the role of all appropriate therapeutic modalities as well as combined-modality treatments. This multidisciplinary approach will help your cancer team collaboratively face the toughest clinical challenges and provide the best possible care for every cancer patient. Access the complete contents online or on your mobile device, with quarterly updates reflecting late-breaking developments in cancer care, free for the first year on LWW Health Library. Take full advantage of the latest advances with brand-new chapters on Hallmarks of Cancer, Molecular Methods in Cancer, Oncogenic Viruses, Cancer Screening, and new sections on Genetic testing and counseling for cancer, plus comprehensive updates throughout – including coverage of the newest biologic therapies. Make optimal, well-coordinated use of all appropriate therapies with balanced, multidisciplinary advice from a surgeon, a medical oncologist, and a radiation oncologist in each major treatment chapter. Review the latest molecular biology knowledge for each type of cancer and its implications for improved management. Make the best decisions on cancer screening and prevention, palliative care, supportive oncology, and quality-of-life issues
This book tackles some of the common and difficult problems encountered by the clinical neurologist by providing practical guidance. The contributors approach the clinical challenges presented from their own points of view. Up-to-date references support the claims for preferred therapeutical and surgical treatments.
This book surveys the phenomenon of Renaissance verse libel and provides carefully edited texts of 52 of these insulting manuscript poems, most of them made available here for the first time. Difficult and unusual words in these poems are glossed, while the commentary explains who is being attacked and why.
There is a popular and romantic myth about Rembrandt and the Jewish people. One of history's greatest artists, we are often told, had a special affinity for Judaism. With so many of Rembrandt's works devoted to stories of the Hebrew Bible, and with his apparent penchant for Jewish themes and the sympathetic portrayal of Jewish faces, it is no wonder that the myth has endured for centuries. Rembrandt's Jews puts this myth to the test as it examines both the legend and the reality of Rembrandt's relationship to Jews and Judaism. In his elegantly written and engrossing tour of Jewish Amsterdam—which begins in 1653 as workers are repairing Rembrandt's Portuguese-Jewish neighbor's house and completely disrupting the artist's life and livelihood—Steven Nadler tells us the stories of the artist's portraits of Jewish sitters, of his mundane and often contentious dealings with his neighbors in the Jewish quarter of Amsterdam, and of the tolerant setting that city provided for Sephardic and Ashkenazic Jews fleeing persecution in other parts of Europe. As Nadler shows, Rembrandt was only one of a number of prominent seventeenth-century Dutch painters and draftsmen who found inspiration in Jewish subjects. Looking at other artists, such as the landscape painter Jacob van Ruisdael and Emmanuel de Witte, a celebrated painter of architectural interiors, Nadler is able to build a deep and complex account of the remarkable relationship between Dutch and Jewish cultures in the period, evidenced in the dispassionate, even ordinary ways in which Jews and their religion are represented—far from the demonization and grotesque caricatures, the iconography of the outsider, so often found in depictions of Jews during the Middle Ages and the Renaissance. Through his close look at paintings, etchings, and drawings; in his discussion of intellectual and social life during the Dutch Golden Age; and even through his own travels in pursuit of his subject, Nadler takes the reader through Jewish Amsterdam then and now—a trip that, under ever-threatening Dutch skies, is full of colorful and eccentric personalities, fiery debates, and magnificent art.
Ideal for hands-on, day-to-day use in practice, Atlas of Pain Management Injection Techniques, 5th Edition, helps you master the key nerve blocks you need to know to successfully treat 200 common and uncommon pain syndromes. Focusing on the “how to details of pain management injection techniques, this bestselling atlas by Dr. Steven D. Waldman equips you to deliver safe, accurate and cost-effective pain relief to your patients using the most clinically appropriate imaging modalities. It demonstrates exactly how to evaluate the causes of pain, identify the most promising injection technique, locate the injection site with precision, and deliver effective relief to patients. Helps you find information quickly with a logical organization by anatomic region, and templated chapters that cover indications and clinical considerations, clinically relevant anatomy, technique, side effects and complications, and Dr. Waldman’s own clinical pearls. Includes 14 brand-new injection techniques, including Chalazion Injection; Botox Injection for Migraine; Intra-articular Injections of the Glenohumeral, Hip, Ankle, and Knee Joints; Rectus Sheath Block; Fascia Iliaca Plane Block; Penile Block; and more. Incorporates all clinically useful imaging modalities including expanded information on office-based ultrasound-guided techniques as well as fluoroscopy and CT-guided procedures. Illustrates the anatomical targets for each procedure and the appropriate needle placement and trajectory used to reach each target. Features new full-color anatomic drawings as well as photographs, radiographs, ultrasound, CT, and MRI images throughout. Provides clear guidance on the risks and benefits of each procedure/technique. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
From very early on in his career, John F. Kennedy’s allure was more akin to a movie star than a presidential candidate. Why were Americans so attracted to Kennedy in the late 1950s and early 1960s—his glamorous image, good looks, cool style, tough-minded rhetoric, and sex appeal? As Steve Watts argues, JFK was tailor made for the cultural atmosphere of his time. He benefited from a crisis of manhood that had welled up in postwar America when men had become ensnared by bureaucracy, softened by suburban comfort, and emasculated by a generation of newly-aggressive women. Kennedy appeared to revive the modern American man as youthful and vigorous, masculine and athletic, and a sexual conquistador. His cultural crusade involved other prominent figures, including Frank Sinatra, Norman Mailer, Ian Fleming, Hugh Hefner, Ben Bradlee, Kirk Douglas, and Tony Curtis, who collectively symbolized masculine regeneration. JFK and the Masculine Mystique is not just another standard biography of the youthful president. By examining Kennedy in the context of certain books, movies, social critiques, music, and cultural discussions that framed his ascendancy, Watts shows us the excitement and sense of possibility, the optimism and aspirations, that accompanied the dawn of a new age in America.
In this highly original work, Steven A. Epstein shows that the ways Italians employ words and think about race and labor are profoundly affected by the language used in medieval Italy to sustain a system of slavery. The author's findings about the surprising persistence of the "language of slavery" demonstrate the difficulty of escaping the legacy of a shameful past. For Epstein, language is crucial to understanding slavery, for it preserves the hidden conditions of that institution. He begins his book by discussing the words used to conduct and describe slavery in Italy, from pertinent definitions given in early dictionaries, to the naming of slaves by their masters, to the ways in which bondage has been depicted by Italian writers from Dante to Primo Levi and Antonio Gramsci. Epstein then probes Italian legal history, tracing the evolution of contracts for buying, selling, renting, and freeing people. Next he considers the behaviors of slaves and slave owners as a means of exploring how concepts of liberty and morality changed over time. He concludes by analyzing the language of the market, where medieval Italians used words to fix the prices of people they bought and sold. The first history of slavery in Italy ever published, Epstein's work has important implications for other societies, particularly America's. "For too long," Epstein notes, "Americans have studied their own slavery as it if were the only one ever to have existed, as if it were the archetype of all others." His book allows citizens of the United States and other former slave-holding nations a richer understanding of their past and present.
Thornton's writings are central to the history of the "Laws of Supply and Demand" and seminal in understanding the rise of neoclassical economics. Thornton has been cast as a minor player in John Stuart Mill's recantation of the wages fund doctrine. This text should show how he played a major role.
Beautifully written ... a unique tale told in a unique voice' - S.G. Maclean Summer, 1522. In a wave of pomp, Henry VIII's court welcomes the Imperial emperor, Charles V. Anthony Blanke, the son of the king's late 'black trumpet', John Blanke, is called to Hampton Court by his former employer, Cardinal Wolsey. The cardinal is preparing a gift for King Henry: a masque of King Arthur and the Black Knight. Anthony is to take centre stage. The festive mood, however, quickly sours. Wolsey's historian, charged with proving the king's descent from King Arthur, is found murdered, his body posed in a gruesome tableau. A reluctant Anthony is charged with investigating the affair. His mission takes him on the path trod by the historian, through ancient monastic libraries and the back streets of London. On a journey that takes him from Hampton Court to Windsor and Winchester, and which sees him lock horns with secretive monks, historian Polydore Vergil, and a new face at court, Anne Boleyn, he must discover the murderer, secure the great masque, and avoid King Henry's wrath.
Thank you for visiting our website. Would you like to provide feedback on how we could improve your experience?
This site does not use any third party cookies with one exception — it uses cookies from Google to deliver its services and to analyze traffic.Learn More.