This book reflects Stephen Waxman's three decades of research on the form and functions of the brain and spinal cord. Building on his experience as a neuroscientist studying model systems as primitive as eels and as a neurologist studying humans, Waxman discusses a wide variety of topics, including the design principles that optimize neural function; molecular and cellular substrates of behavior; the role of glial cells in the brain; the molecular basis for pain; plasticity in the brain and spinal cord; strategies for promoting functional recovery in disorders such as multiple sclerosis, spinal cord injury, and stroke; and prospects for rebuilding the brain and spinal cord. The pieces provide example after example of the elegance of design of the nervous system, of the intricate interplay between structure and function in health and disease, and of the rich borderland between neuroscience and neurology.
A thirty-year quest, from genes to pain-signaling neurons to people with a rare genetic disorder that makes them feel they are on fire. Two soldiers, both with wounds injuring the same nerve, show very different responses: one is disabled by neuropathic pain, unable to touch the injured limb because even the lightest contact triggers excruciating discomfort; the other notices numbness but no pain at all. Could the difference lie in their genes? In this book, described in the foreword by Nobel Laureate James Rothman as “so well written that it reads like a detective novel,” Stephen Waxman recounts the search for a gene that controls pain—a search spanning more than thirty years and three continents. The story moves from genes to pain-signaling neurons that scream when they should be silent to people with a rare genetic disorder who feel they are on fire. Waxman explains that if pain-signaling neurons are injured by trauma or disease, they can become hyperactive and send pain signals to the brain even without external stimulus. Studying the hyperactive mutant pain gene in man on fire syndrome has pointed the way to molecules that produce pain more broadly within the general population, in the rest of us. Waxman's account of the many steps that led to discovery of the pain gene tells the story behind the science, of how science happens.
Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. A comprehensive, color-illustrated guide to neuroanatomy and its functional and clinical applications Engagingly written and extensively illustrated, Clinical Neuroanatomy, Twenty-Ninth Edition gets you up to speed on neuroanatomy, its functional underpinnings, and its relationship to the clinic. You’ll learn everything you need to know about the structure and function of the brain, spinal cord, and peripheral nerves. This authoritative guide illustrates clinical presentations of disease processes involving specific structures, explores the relationship between neuroanatomy and neurology, and reviews advances in molecular and cellular biology and neuropharmacology as related to neuroanatomy. The book is packed with case studies and hundreds of visuals—including CT and MRI scans, block diagrams showing muscle actions, root-by-root and nerve-by-nerve images of sensory areas and muscle intervention, and more—to help you retain critical information. Essential for board review or as a clinical refresher, Clinical Neuroanatomy features: • More than 300 full-color illustrations • An introduction to clinical thinking that puts neuroanatomy in clear clinical perspective • A discussion of the latest advances in molecular biology and cellular biology in the context of neuroanatomy • Numerous CT and MRI scans • Block diagrams illustrating actions of each muscle (essential for the clinical motor examination) • Hundreds of diagrams and tables encapsulating important information • Summary listings at the end of each chapter • Clear and memorable root-by-root and nerve-by-nerve illustrations of sensory areas and muscle intervention • Coverage of the basic structure and function of the brain, spinal cord, and peripheral nerves as well as clinical presentations of disease processes involving specific structures • Appendices including The Neurologic Examination, Testing Muscle Function, Spinal Nerves and Plexuses, and Questions and Answers • Case studies demonstrating how concepts apply to real-world clinical situations • All the must-know concepts, facts, and structures, and more • A complete practice exam to assess your knowledge
A streamlined, comprehensive synopsis of neuroanatomy and its functional and clinical applications For more than seventy years, Clinical Neuroanatomy has been the best way for medical students, residents, trainees in health-related fields, and clinicians in practice to gain an understanding of neuroanatomy, its functional underpinnings, and its relationship to the clinic. Emphasizing the important concepts, facts, and structures, this full-color and engagingly written text includes clear, memorable tables and diagrams, and is state of the art in pathophysiology and diagnosis and treatment of neurological disorders. Here's why Clinical Neuroanatomy is essential for board review or as a clinical refresher: More than 300 full-color illustrations Clinical correlations help you interpret and remember essential neuroanatomic concepts in terms of function and clinical application Numerous computed tomography (CT) and magnetic resonance images (MRIs) of the normal brain and spinal cord; functional magnetic resonance images that provide a noninvasive window on brain function; and neuroimaging studies that illustrate common pathological entities that affect the nervous system Coverage of the latest advances in molecular and cellular biology in the context of neuroanatomy A unique Introduction to Clinical Thinking section that puts neuroanatomy in a clinical perspective Clear, easy-to-read tables that encapsulate important information A complete practice exam to test your knowledge Coverage of the basic structure and function of the brain, spinal cord, and peripheral nerves as well as clinical presentations of disease processes involving specific structures
Diseases of the Spine and Spinal Cord reviews the full spectrum of disorders affecting this region including primary spinal tumors and metastases, infection, degenerative diseases, and trauma. Presenting an inter-disciplinary perspective, the book includes up-to-date information on therapy [including neurosurgical], new information on developmental disorders of the spine, and a definitive chapter on trauma, including information on biomechanics. A separate chapter on pain syndromes also is included.
This book examines the role of neurons in multiple sclerosis (MS) and the changes that occur in neurons as a result of MS. It places MS in a new and important perspective that not only explains the basis for symptom production, remission, and progress in MS, but also promises to open up new therapeutic possibilities. * Brings together the latest information from clinical, pathological, imaging, molecular, and pharmacological realms to explore the neurobiology of Multiple Sclerosis* Places MS in a new and important perspective that promises to open up new therapeutic avenues* Superbly illustrated and referenced
The field of neurology is being transformed, from a therapeutically nihilistic discipline with few effective treatments, to a therapeutic specialty which offers new, effective treatments for disorders of the brain and spinal cord. This remarkable transformation has bridged neuroscience, molecular medicine, and clinical investigation, and represents a major triumph for biomedical research. This book, which contains chapters by more than 29 internationally recognized authorities who have made major contributions to neurotherapeutics, tells the stories of how new treatments for disabling disorders of the nervous system, such as stroke, multiple sclerosis, Parkinson’s disease, and migraine, were developed, and explores evolving themes and technologies that offer hope for even more effective treatments and ultimately cures for currently untreatable disorders of the brain and spinal cord. The first part of this book reviews the development of new therapies in neurology, from their inception in terms of basic science to their introduction into the clinical world. It also explores evolving themes and new technologies. This book will be of interest to everyone – clinicians and basic scientists alike – interested in diseases of the brain and spinal cord, and in the quest for new treatments for these disorders. * Presents the evolution of the field of neurology into a therapeutic discipline * Discusses lessons learned from past successes and applications to ongoing work* Explores the future of this field
A concise, highly visual overview of neuroanatomy and its functional underpinnings Clinical Neuroanatomy, Twenty-Eighth Edition offers an accessible, easy-to-remember synopsis of neuroanatomy and its functional and clinical implications. Since many of us learn and remember better when material is presented visually, this acclaimed resource includes not only clinical material such as brain scans and pathological specimens, but also hundreds of diagrams and tables that are designed to be clear and memorable. Here's why Clinical Neuroanatomy is essential for board review or as a clinical refresher: • NEW SECTION summarizes the most important take-away lessons from each chapter • More than 300 full-color illustrations • A unique chapter on Introduction to Clinical Thinking puts neuroanatomy in clear clinical perspective • Numerous CT and MRI scans • Block diagrams illustrate actions of each muscle (essential for the clinical motor examination) • Hundreds of diagrams and tables encapsulate important information • Essentials for the Clinical Neuroanatomist list appears in each chapter • Clear and memorable root-by-root and nerve-by-nerve illustrations of sensory areas and muscle intervention • Coverage of the basic structure and function of the brain, spinal cord, and peripheral nerves as well as clinical presentations of disease processes involving specific structures • Emphasizes must-know concepts, facts, and structures • Appendices include The Neurologic Examination, Testing Muscle Function, Spinal Nerves and Plexuses, and Questions and Answers • Case studies demonstrate how concepts apply to real-world situations If your practice or education would benefit from an engagingly written, well-illustrated overview of neuroanatomy and its functional underpinnings, this trusted resource belongs on your desk.
Why a book on molecular neurology? Molecular neuroscience is advancing at a spectacular rate. As it does so, it is revealing important clues to the pathogenesis and pathophysiology of neurological diseases, and to the therapeutic targets that they present. Medicines work by targeting molecules. The more specific the targeting, the more specific the actions, and the fewer the side effects. Molecular Neurology highlights, for graduate and MD-PhD students, research fellows and research-oriented clinical fellows, and researchers in the neurosciences and other biomedical sciences, the principles underlying molecular medicine as related to neurology. Written by internationally recognized experts, this well-illustrated and well-referenced book presents the most up-to-date principles and disease examples relevant to molecular neurology, and reviews the concepts, strategies, and latest progress in this field. This book will interest anyone studying the molecular basis of neurology, or developing new therapies in neurology. Describes the newest molecular aspects of neurological disorders Provides an introduction to neurological disorders for basic scientists Updates clinicians and clinical researchers on the most recent developments
Learn the essential aspects of neuroanatomy and its clinical relevance with the field's most concise, trusted, and effective text "...an excellent update of the neuroanatomy text that has become a standard since its first publication in 1938....The strengths of the book include the hundreds of easy to understand color line illustrations, the clear and concise language of the text and the many tables of summarized information....It could be highly recommended to and would be enjoyed by medical students and trainees in internal medicine, neurology, and neurosurgery, and also as a reference for clinicians in these fields, particularly those teaching students and trainees."--World Neurosurgery For more than seventy years, Clinical Neuroanatomy has delivered a streamlined, comprehensive, and easy-to-remember synopsis of neuroanatomy and its functional and clinical applications. Emphasizing the most important concepts, facts, and structures, this well-illustrated and enjoyable-to-read text reflects the state-of-the-art in pathophysiology and the diagnosis and treatment of neurological disorders. Features that make Clinical Neuroanatomy perfect for board review or as a clinical refresher: Discussion of the latest advances in molecular and cellular biology in the context of neuroanatomy Clinical correlations to help you interpret and remember essential neuroanatomic concepts in terms of function and clinical application Numerous computed tomography (CT) and magnetic resonance images (MRIs) of the normal brain and spinal cord; functional magnetic resonance images that provide a noninvasive window on brain function; and neuroimaging studies that illustrate common pathological entities that affect the nervous system An Introduction to Clinical Thinking section that puts neuroanatomy in a unique clinical perspective Numerous tables that make the information clear and easy to remember A complete practice exam to test your knowledge Coverage of the basic structure and function of the brain, spinal cord, and peripheral nerves as well as clinical presentations of disease processes involving specific structures NEW full-color illustrations
Highly readable and generously illustrated, the new edition features a new section on the enteric system, new information on the cerebral cortex, and an updated review of cerebrellar organization and function. For understanding and identifying neuroanatomical structures, you cannot find a better source.
A concise overview of neuroanatomy and its functional and clinical implications. Includes an excellent review for the USMLE, as well as cases and a practice exam.
This title features facts, figures, stats and trivia on legions of record-breakers, record losers, actors, singers, sportsmen, historical figures, the famous and infamous, felons, inventors, rulers, heartthrobs, politicians and scientists called Stephen.
This revision presents an overview of neuroanatomy together with a synopsis of its functional implications and discussions of its clinical relevance. A new chapter entitled Introduction to Clinical Thinking has been added, and the remaining chapters have been revised and updated. New diagrams and colour have also been added to give students a clearer picture of neuroanatomy. All case studies have been updated.
Several decades after his last motion picture was produced, Alfred Hitchcock is still regarded by critics and fans alike as one of the masters of cinema. From silents of the 1920s to his final feature in 1976, the director’s many films continue to entertain audiences and inspire filmmakers. In The Alfred Hitchcock Encyclopedia, film critic Stephen Whitty provides a detailed overview of the director's work. This reference volume features in-depth critical entries on each of his major films as well as biographical essays on his most frequent collaborators and discussions of significant themes in his work. For this book, Whitty draws on primary-source materials such as interviews he conducted with associates of the director—including screenwriter Jay Presson Allen (Marnie), actresses Eva Marie Saint (North by Northwest) and Kim Novak (Vertigo), actor Farley Granger (Strangers on a Train), actor and producer Norman Lloyd (Saboteur), and Hitchcock’s daughter Patricia (Stage Fright; Psycho)—among others. Encompassing the entire range of the director’s career—from early influences and silent films to his decade-long television show and cameos in nearly every feature—this is a comprehensive overview of cinema’s ultimate showman. A detailed and lively look at the master of suspense, The Alfred Hitchcock Encyclopedia will be of interest to professors, students, and the many fans of the director’s work.
A thirty-year quest, from genes to pain-signaling neurons to people with a rare genetic disorder that makes them feel they are on fire. Two soldiers, both with wounds injuring the same nerve, show very different responses: one is disabled by neuropathic pain, unable to touch the injured limb because even the lightest contact triggers excruciating discomfort; the other notices numbness but no pain at all. Could the difference lie in their genes? In this book, described in the foreword by Nobel Laureate James Rothman as “so well written that it reads like a detective novel,” Stephen Waxman recounts the search for a gene that controls pain—a search spanning more than thirty years and three continents. The story moves from genes to pain-signaling neurons that scream when they should be silent to people with a rare genetic disorder who feel they are on fire. Waxman explains that if pain-signaling neurons are injured by trauma or disease, they can become hyperactive and send pain signals to the brain even without external stimulus. Studying the hyperactive mutant pain gene in man on fire syndrome has pointed the way to molecules that produce pain more broadly within the general population, in the rest of us. Waxman's account of the many steps that led to discovery of the pain gene tells the story behind the science, of how science happens.
This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
This book describes the collisions between the art world and the law, with a critical eye through a combination of primary source materials, excerpts from professional and art journals, and extensive textual notes. Topics analysed include + the fate of works of art in wartime, + the international trade in stolen and illegally exported cultural property, + artistic freedom, + censorship and state support for art and artists, + copyright, + droit moral and droit de suite, + the artist's professional life and death, + collectors in the art market, + income and estate taxation, + charitable donations and works of art, and + art museums and their collections. The authors are recognised experts in the field who have defined the canon in many aspects of art law.
Rapid advances in tomography and imaging techniques and their successful application in soil and plant science are changing our sciences today. Many more articles using imaging and tomography are being published currently compared to 20 years ago. Soil–Water–Root Processes: Advances in Tomography and Imaging is a unique assemblage of contributions exploring applications of imaging and tomography systems in soil science—it provides an updated collection of X-ray computed tomography, synchrotron microtomography, neutron imaging, magnetic resonance imaging, geophysical imaging tools, and other tomography techniques for evaluating soils and roots. Exciting new procedures and applications have been developed, with the promise to propel forward our understanding of soil and plant properties and processes.
Edited by two cardiovascular directors and featuring over 30 contributors, Cardiovascular Imaging for Clinical Practice is an essential guide for cardiologists-on-the-go. This handy, paperback text provides current information on how to incorporate imaging modalities into clinical practice. Presented in an easy-to-read format for quick reference and comprehension, Cardiovascular Imaging for Clinical Practices features clinical scenarios for practical application and over 200 photos and illustrations. Accessible, informative, compact, Cardiovascular Imaging for Clinical Practices is the perfect reference for busy healthcare professionals!
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