The first systematic summary of biophysical mass spectrometrytechniques Recent advances in mass spectrometry (MS) have pushed the frontiersof analytical chemistry into the biophysical laboratory. As aresult, the biophysical community's acceptance of MS-based methods,used to study protein higher-order structure and dynamics, hasaccelerated the expansion of biophysical MS. Despite this growing trend, until now no single text has presentedthe full array of MS-based experimental techniques and strategiesfor biophysics. Mass Spectrometry in Biophysics expertly closesthis gap in the literature. Covering the theoretical background and technical aspects of eachmethod, this much-needed reference offers an unparalleled overviewof the current state of biophysical MS. Mass Spectrometry inBiophysics begins with a helpful discussion of general biophysicalconcepts and MS-related techniques. Subsequent chaptersaddress: * Modern spectrometric hardware * High-order structure and dynamics as probed by various MS-basedmethods * Techniques used to study structure and behavior of non-nativeprotein states that become populated under denaturingconditions * Kinetic aspects of protein folding and enzyme catalysis * MS-based methods used to extract quantitative information onprotein-ligand interactions * Relation of MS-based techniques to other experimental tools * Biomolecular properties in the gas phase Fully referenced and containing a helpful appendix on the physicsof electrospray mass spectrometry, Mass Spectrometry in Biophysicsalso offers a compelling look at the current challenges facingbiomolecular MS and the potential applications that will likelyshape its future.
On June 22, 1941, Germany launched the greatest land assault in history on the Soviet Union, an attack that Adolf Hitler deemed crucial to ensure German economic and political survival. As the key theater of the war for the Germans, the eastern front consumed enormous levels of resources and accounted for 75 percent of all German casualties. Despite the significance of this campaign to Germany and to the war as a whole, few English-language publications of the last thirty-five years have addressed these pivotal events. In Ostkrieg: Hitler’s War of Extermination in the East, Stephen G. Fritz bridges the gap in scholarship by incorporating historical research from the last several decades into an accessible, comprehensive, and coherent narrative. His analysis of the Russo-German War from a German perspective covers all aspects of the eastern front, demonstrating the interrelation of military events, economic policy, resource exploitation, and racial policy that first motivated the invasion. This in-depth account challenges accepted notions about World War II and promotes greater understanding of a topic that has been neglected by historians.
IF YOU ARE A PARENT, SCHOOLTEACHER, LAW ENFORCEMENT OFFICER, or mental healthcare provider, Toxic Families, Violent Lives lays out what you need to know about what is causing heightened levels of childhood/adolescent mental illness, behavioral disorders, juvenile alcohol and substance abuse, gang membership, school dropouts, teen pregnancies, and pervasive crime and violence. Toxic Families, Violent Lives gets at the root of the problem. It's all about the impediments to healthy childhood/adolescent physical, psychological, emotional, intellectual, and moral development. This book identifies a range of adverse childhood experiences that are the direct result of toxic family life rooted in poor parenting practices, and a range of dysfunctional and problematic parent behavior stemming from adult mental illness, alcohol and substance abuse, obsessions, insecurities, depression, anxiety, and maladaptive coping mechanisms. Parents need to understand the importance of developing a parent-child attachment, and a child’s self-control, empathy, and moral foundation. What can parents, schoolteachers, law enforcement, and mental health professionals do? Understand the pathways and pitfalls to healthy childhood / adolescent development and take an active role in that process. This book takes a read it, understand it, and apply it approach to the problem.
Alois Dwenger, writing from the front in May of 1942, complained that people forgot "the actions of simple soldiers.I believe that true heroism lies in bearing this dreadful everyday life." In exploring the reality of the Landser, the average German soldier in World War II, through letters, diaries, memoirs, and oral histories, Stephen G. Fritz provides the definitive account of the everyday war of the German front soldier. The personal documents of these soldiers, most from the Russian front, where the majority of German infantrymen saw service, paint a richly textured portrait of the Landser that illustrates the complexity and paradox of his daily life. Although clinging to a self-image as a decent fellow, the German soldier nonetheless committed terrible crimes in the name of National Socialism. When the war was finally over, and his country lay in ruins, the Landser faced a bitter truth: all his exertions and sacrifices had been in the name of a deplorable regime that had committed unprecedented crimes. With chapters on training, images of combat, living conditions, combat stress, the personal sensations of war, the bonds of comradeship, and ideology and motivation, Fritz offers a sense of immediacy and intimacy, revealing war through the eyes of these self-styled "little men." A fascinating look at the day-to-day life of German soldiers, this is a book not about war but about men. It will be vitally important for anyone interested in World War II, German history, or the experiences of common soldiers throughout the world.
As the availability of fossils fuels becomes more limited, the negative impact of their consumption becomes an increasingly relevant factor in our choices with regards to primary energy sources. The exponentially increasing demand for energy is reflected in the mass generation of by-products and waste flows which characterize current society’s development and use of fossil sources. The potential for recoverable material and energy in these ever-increasing refuse flows is huge, even after the separation of hazardous constituent elements, allowing safe and sustainable further exploitation of an otherwise 'wasted' resource. Fuel Cells in the Waste-to-Energy Chain explores the concept of waste-to-energy through a 5 step process which reflects the stages during the transformation of refuse flows to a valuable commodity such as clean energy. By providing selected, integrated alternatives to the current centralized, wasteful, fossil-fuel based infrastructure, Fuel Cells in the Waste-to-Energy Chain explores how the concept of waste-to-energy can be constructed and developed into a realistic solution. The entire spectrum of current and future energy problems is illuminated through the explanation of the operational, integration and marketing implications of high efficiency technological solutions using the real context of developed regions such as Europe. Up-to-date reviews are provided on the status of technology and demonstration, implementation and marketing perspectives. The detailed technological information and insight gathered from over twenty years of experience in the field makes Fuel Cells in the Waste-to-Energy Chain a valuable resource for all engineers and researchers in the fields of energy supply systems and waste conversion, as well as providing a key reference for discussions by policy makers, marketing experts and industry developers working in energy supply and waste management.
Bringing together new accounts of the pulp horror writings of H.P. Lovecraft and the rise of the popular early 20th-century religious movements of American Pentecostalism and Social Gospel, Pentecostal Modernism challenges traditional histories of modernism as a secular avant-garde movement based in capital cities such as London or Paris. Disrupting accounts that separate religion from progressive social movements and mass culture, Stephen Shapiro and Philip Barnard construct a new Modernism belonging to a history of regional cities, new urban areas powered by the hopes and frustrations of recently urbanized populations seeking a better life. In this way, Pentecostal Modernism shows how this process of urbanization generates new cultural practices including the invention of religious traditions and mass-cultural forms.
Advanced Therapy of Inflammatory Bowel Disease - Second Edition The main emphasis of this new edition is on diagnosis, therapy and patient management, along with disease activity measures, IBD databases, and the use of diagnostic tests in clinical decision making. Each chapter consists of recommendations from an expert in the ......
European Dictatorships 1918–1945 surveys the extraordinary circumstances leading to, and arising from, the transformation of over half of Europe’s states to dictatorships between the first and the second world wars. From the notorious dictatorships of Mussolini, Hitler and Stalin to less well-known states and leaders, Stephen J. Lee scrutinizes the experiences of Russia, Germany, Italy, Spain, Portugal and Central and Eastern European states. This fourth edition has been fully revised and updated throughout. New material for this edition includes: the most recent research on individual dictatorships a new chapter on the experiences of Europe’s democracies at the hands of Germany, Italy and Russia an expanded chapter on Spain a new section on dictatorships beyond Europe, exploring the European and indigenous roots of dictatorships in Latin America, Asia and Africa. Extensively illustrated with images, maps, tables and a comparative timeline, and supported by a companion website providing further resources for study (www.routledge.com/cw/lee), European Dictatorships 1918–1945 is a clear, detailed and highly accessible analysis of the tumultuous events of early twentieth-century Europe.
“An expert account of Nazi war strategy that concludes that Hitler was not without military talent.”(Kirkus Reviews) After Germany’s humiliating World War II defeat, numerous German generals published memoirs claiming that their country’s brilliant military leadership had been undermined by the Führer’s erratic decision making. The author of three highly acclaimed books on the era, Stephen Fritz upends this characterization of Hitler as an ill-informed fantasist and demonstrates the ways in which his strategy was coherent and even competent. That Hitler saw World War II as the only way to retrieve Germany’s fortunes and build an expansionist Thousand-Year Reich is uncontroversial. But while his generals did sometimes object to Hitler’s tactics and operational direction, they often made the same errors in judgment and were in agreement regarding larger strategic and political goals. A necessary volume for understanding the influence of World War I on Hitler’s thinking, this work is also an eye-opening reappraisal of major events like the invasion of Russia and the battle for Normandy. “Perhaps the best account we have to date of Hitler’s military leadership. It shows a scrupulous and imaginative historian at work and will cement Fritz’s reputation as one of the leading historians of the military conflicts generated by Hitler’s Germany.” —Richard Overy, author of The Bombing War “Original, insightful and authoritative.” —David Stahel, author of The Battle for Moscow
The definitive guide to mass spectrometry techniques in biology and biophysics The use of mass spectrometry (MS) to study the architecture and dynamics of proteins is increasingly common within the biophysical community, and Mass Spectrometry in Structural Biology and Biophysics: Architecture, Dynamics, and Interaction of Biomolecules, Second Edition provides readers with detailed, systematic coverage of the current state of the art. Offering an unrivalled overview of modern MS-based armamentarium that can be used to solve the most challenging problems in biophysics, structural biology, and biopharmaceuticals, the book is a practical guide to understanding the role of MS techniques in biophysical research. Designed to meet the needs of both academic and industrial researchers, it makes mass spectrometry accessible to professionals in a range of fields, including biopharmaceuticals. This new edition has been significantly expanded and updated to include the most recent experimental methodologies and techniques, MS applications in biophysics and structural biology, methods for studying higher order structure and dynamics of proteins, an examination of other biopolymers and synthetic polymers, such as nucleic acids and oligosaccharides, and much more. Featuring high-quality illustrations that illuminate the concepts described in the text, as well as extensive references that enable the reader to pursue further study, Mass Spectrometry in Structural Biology and Biophysics is an indispensable resource for researchers and graduate students working in biophysics, structural biology, protein chemistry, and related fields.
Now in its 7th edition, this popular, must-have text remains the only encyclopedic resource for veterinary internal medical problems. The internationally acclaimed "gold standard" offers unparalleled coverage of pathophysiology, diagnosis, and treatment of diseases affecting dogs and cats, as well as the latest information on the genome, clinical genomics, euthanasia, innocent heart murmurs, hyperbaric medicine, home prepared and raw diets, obesity, botulism, artificial pacing of the heart, cancer vaccines, and more. The 7th edition combines the convenience of a two-volume printed textbook with the enhanced functionality of an Expert Consult website that enables you to electronically search your entire book and study more efficiently. With instant access to the most reliable information available, you’ll always be at the forefront of veterinary care! Fully searchable online text provides fast, easy access to the most reliable information in the field. More than 150 clinical algorithms throughout the text aid in disease-identification and decision-making. Expanded online chapter content enhances your understanding through additional text, illustrations, tables, and boxes. Hyperlinked client information sheets streamline reference of specific conditions and enhance communication with clients. Extensive online reference list directs you to full-text PubMed abstracts for additional research. Thoroughly updated and expanded content, including 90 new chapters, addresses the latest developments across the full spectrum of small animal care. Companion Expert Consult website enhances your learning experience with the ability to search the entire electronic text instantly, make notes, and highlight content for easy review. Expert Consult also gives you instant access to: More than 150 procedural videos that guide you step-by-step through essential procedures. An interactive drug formulary that makes it easier to find and cross-reference key drug information. Audio files that help you identify heart abnormalities by their sound.
Research on dyneins has a direct impact on human diseases, such as viruses and cancer. With an accompanying website showing over 100 streaming videos of cell dynamic behavior for best comprehension of material, Dynein: Structure, Biology and Disease is the only reference covering the structure, biology and application of dynein research to human disease. From bench to bedside, Dynein: Structure, Biology and Disease offers research on fundamental cellular processes to researchers and clinicians across developmental biology, cell biology, molecular biology, biophysics, biomedicine, genetics and medicine. Broad-based up-to-date resource for the dynein class of molecular motors Chapters written by world experts in their topics Numerous well-illustrated figures and tables included to complement the text, imparting comprehensive information on dynein composition, interactions, and other fundamental features
A fascinating tour through the evolution of the human diet and how we can improve our health by understanding our complicated history with food. There are few areas of modern life that are burdened by as much information and advice, often contradictory, as our diet and health: eat a lot of meat, eat no meat; whole grains are healthy, whole grains are a disaster; eat everything in moderation; eat only certain foods--and on and on. In 100 Million Years of Food, biological anthropologist Stephen Le explains how cuisines of different cultures are a result of centuries of evolution, finely tuned to our biology and surroundings. Today many cultures have strayed from their ancestral diets, relying instead on mass-produced food often made with chemicals that may be contributing to a rise in so-called Western diseases, such as cancer, heart disease, and obesity.
′The 4th edition of this extensive text is an outstanding resource prepared by nurses (and a librarian) for nurses. In a structured and helpful style it presents thousands of items from the literature - published papers, reports, books and electronic resources - as a clear, accessible, and most of all useful collection. The efforts to signpost and lead the reader to the sought-for information are effective and well-conceived, and the "How to use this book" section is remarkably simple...the book should be found in every nursing and health library, every research institute and centre, and close to many career researchers′ desks′ - RCN Research This latest edition of Resources for Nursing Research provides a comprehensive bibliography of sources on nursing research, and includes references for books, journal papers and Internet resources. Designed to act as a ′signpost′ to available literature in the area, this Fourth Edition covers the disciplines of nursing, health care and the social sciences. Entries are concise, informative and accessible, and are arranged under three main sections: · ′Sources of Literature′ covers the process of literature searching, including using libraries and other tools for accessing literature · ′Methods of Inquiry′ includes an introduction to research, how to conceptualize and design nursing and health research, measurement and data collection, and the interpretation and presentation of data · ′The Background to Research in Nursing′ encompasses the development of nursing research; the profession′s responsibilities; the role of government; funding; research roles and careers; and education for research. Fully revised and updated, the Fourth Edition includes just under 3000 entries, of which 90% are new. It has extensive coverage of US, UK literature and other international resources. This new edition will be an essential guide for all those with an interest in nursing research, including students, teachers, librarians, practitioners and researchers.
This companion to Kryger et al.'s PRINCIPLES AND PRACTICE OF SLEEP MEDICINE focuses on the diagnosis and treatment of a full range of sleep disorders in children. Recognized leaders in the field offer definitive guidance on virtually all of the sleep-associated problems encountered in pediatrics, from sleep and colic...to obstructive sleep apnea, neurological disorders, and hypersomnias...to sleep-related enuresis. Presents up-to-date information of the field's hottest topics in chapters on Pharmacology of Sleep in Children · Epidemiology of Sleep Disorders During Childhood · Circadian Rhythm Disorders: Diagnosis and Treatment · and Differential Diagnosis of Pediatric Sleep Disorders. Organizes information into separate sections covering normal and abnormal sleep, for quick reference. Makes further investigation easy with abundantly referenced chapters. Addresses both medical and psychiatric sleep disorders. Features the expertise of Drs. Sheldon, Kryger and Ferber - renowned authorities in the field of sleep medicine.
Presents a detailed discussion of important solid-state properties, methods, and applications of solid-state analysis Illustrates the various phases or forms that solids can assume and discussesvarious issues related to the relative stability of solid forms and tendencies to undergo transformation Covers key methods of solid state analysis including X-ray powder diffraction, thermal analysis, microscopy, spectroscopy, and solid state NMR Reviews critical physical attributes of pharmaceutical materials, mainly related to drug substances, including particle size/surface area, hygroscopicity, mechanical properties, solubility, and physical and chemical stability Showcases the application of solid state material science in rational selection of drug solid forms, analysis of various solid forms within drug substance and the drug product, and pharmaceutical product development Introduces appropriate manufacturing and control procedures using Quality by Design, and other strategies that lead to safe and effective products with a minimum of resources and time
Since 1975, Dr. Kenneth Swaiman's classic text has been the reference of choice for authoritative guidance in pediatric neurology, and the 6th Edition continues this tradition of excellence with thorough revisions that bring you fully up to date with all that's new in the field. Five new sections, 62 new chapters, 4 new editors, and a reconfigured format make this a comprehensive and clearly-written resource for the experienced clinician as well as the physician-in-training. - Nearly 3,000 line drawings, photographs, tables, and boxes highlight the text, clarify key concepts, and make it easy to find information quickly.
Before the rise of universities, cathedral schools educated students in a course of studies aimed at perfecting their physical presence, their manners, and their eloquence. The formula of cathedral schools was "letters and manners" (litterae et mores), which asserts a pedagogic program as broad as the modern "letters and science." The main instrument of what C. Stephen Jaeger calls "charismatic pedagogy" was the master's personality, his physical presence radiating a transforming force to his students. In The Envy of Angels, Jaeger explores this intriguing chapter in the history of ideas and higher learning and opens a new view of intellectual and social life in eleventh- and early twelfth-century Europe.
The Euro crisis has served as a stark reminder of the fundamental importance of Germany to the larger European project. But the image of Germany as the dominant power in Europe is at odds with much of its recent history. Reluctant Meister is a wide-ranging study of Germany from the Holy Roman Empire through the Second and Third Reichs, and it asks not only how such a mature and developed culture could have descended into the barbarism of Nazism but how it then rebuilt itself within a generation to become an economic powerhouse. Perhaps most important, Stephen Green examines to what extent Germany will come to dominate its relationship with its neighbors in the European Union, and what that will mean.
This chronologically organized book provides readers with a broad overview of the field of human development--from the moment of conception through death--focusing on physical, cognitive, and social and personality development. Appealing to individuals with a myriad of different backgrounds and future goals, this book offers the most current, balanced coverage of theory and research. A wide variety of chapter topics includes gene therapy; brain development, post-partum depression; child care effects; home schooling; cognitive developments, stability of personality; cultural approaches to development, and attitudes toward aging and length of life. For a better understanding of the experiences of life and development of humans.
This book describes the way in which the human brain is supplied with blood and how the brain uses this to provide nutrients, primarily oxygen and glucose, to brain cells in order to maintain healthy brain function. In particular, it focuses on the quantitative nature of blood flow and metabolism. The book covers models of blood flow and metabolism and how these can be measured using a variety of imaging and non-imaging techniques. It also examines how cerebral blood flow is controlled in response to a wide variety of challenges and how it changes with normal physiological variation and in response to a large number of pathological conditions, including stroke and dementia.As the first substantial book for over ten years in a fast-changing field, it highlights how the subject has progressed in the last couple of decades. It tackles the subject in a quantitative way, underlining its importance in both technical and clinical fields. Audiences with a technical or clinical background, especially researchers and postgraduate students in biomedical engineering or medicine, will find this a valuable read.
A blazing account of a life lived in Americas television newsrooms. It is a journey that leaps from a small newsroom in rural Arkansas to the largest newsroom of its time in New York at CBS. The best known broadcast journalists of a generation bump into each other on their way forward in their careers. At every outpost a collection of hard working, young journalists about to be stars, and factors in television news emerge. Their names fast becoming household names. What were they like, when they were full of hope, and the art of doing television news was emerging in full form. And what was the cost of it all, as they burned their images into Americas psyche? And what was the Newslife like for the author , who saw it all, did it all, and emerged to tell this tale?
Stephen Fry turns his celebrated wit and insight to unearthing the real America as he travels across the continent in his black taxicab, stopping in every state from Maine to Hawaii.
Traces the two-and-a-half year investigation by the New Jersey State Police of the Lindbergh kidnapping case, challenging the effectiveness of the investigation and the evidence that convicted Bruno Hauptmann.
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