This text presents a variety of methods of creation of renal failure, by the author‘s experience in the study and support of laboratory animal models of renal failure. This text also discusses three studies on the mechanisms of renal damage and renal failure in animal models.
About the Book Success is Just Running Out of Mistakes is about a life-long quest to improve the therapy of kidney failure, especially with hemodialysis technology. Dr. Ash began to write this because of a lack of progress in dialysis therapy. He is tired of physicians and politicians saying that there is a "lack of innovation" among nephrologists. The problem isn't lack of innovation, but rather a failure to commercialize radically better new technology. In some ways the book is also a collection of 12 case studies of new technology and ideas and how a small technology-driven firm can succeed or fail in efforts to bring their new product to become a widespread market success. There are few textbooks that describe not only successes of R&D companies in bringing products to the market but also failures. What is surprising about the failures described in this book is that they occurred at many different steps of bringing a new product to market.. The answer to a physician who says "I have a new idea and think it could help medical therapy. What should I do next?" is very long and complicated. The one trait Success is Just Running Out of Mistakes really demonstrates is the importance of persistence. Not just in any one project, but in a career trying to make just one small part of medical therapy better for patients with kidney failure. Too many young physicians don't realize the tough road ahead to make medical therapy better and quit after the failure of their first good idea. As Winston Churchill said, "Success is not final, failure is not fatal: it is the courage to continue that counts." About the Author Stephen R. Ash, MD, FACP, recently retired from clinical practice as a Nephrologist at Indiana University Health Arnett in Lafayette, Indiana. He is CEO of HemoCleanseTechnologies, Chairman of the Board of AshAccess Technology, and co-founder of a number of spin-off biotechnology firms. He has a long history of research and product development in the field of sorbents, resulting in devices for treatment of kidney failure (AllientTM by Renal Solutions) and for liver failure (Liver DialysisTM by HemoTherapies). He was instrumental in development of an orally ingested sorbent for potassium (now marketed by AstraZeneca as Lokelma®). Dr. Ash has also invented a number of new catheters for dialysis access, including the Ash Split Cath®, CentrosFLO® and AdvantageTM PD Catheter. Dr. Ash is a co-founder and Past President of the American Society for Diagnostic and Interventional Nephrology (ASDIN). He is Past President of ASAIO and until recently served as Secretary-Treasurer of IFAO. He is recipient of the Lifetime Achievement Award from ASDIN, the Celebration of Life Honor by NKF of Indiana, and the Lifetime Achievement Award from the Annual Dialysis Conference. Dr. Ash also has a dedicated and loving family, including his wife Marianne, and daughters, Emily and Sarah. Marianne and Dr. Ash are long term members of Trinity United Methodist Church in Lafayette, Indiana. They live at and operate a retirement/recovery farm for horses, and his special interests are fixing things around the farm, woodworking, and flying fixed wing RC aircraft.
Organizational learning matters now more than ever. In today's hypercompetitive business environment, successful executives must be able to discover opportunities, face problems, and pursue innovative ideas, then turn those ideas into action throughout an organization. Based on both empirical research and practice experience, this book gives managers the tools to do just that. Organizational learning capability is the capacity to generate and generalize ideas with impact. Managers generate new ideas in four basic ways: experimentation, in which organizations learn by trying many new products and processes; continuous improvement, in which they learn by constantly improving what they have done before and mastering each step in a process before moving on to other processes; knowledge acquisition, in which they learn by encouraging individuals and teams to acquire new knowledge continuously; and benchmarking, in which they learn by studying how other groups do things and trying to adapt their techniques. Each learning types leads to different performance consequences. Managers must also be able to generalize information through technology, movement of people, incentives, and learning processes. By both generating and generalizing ideas with impact, managers have a blueprint for making learning happen. Learning may not be sustained, however, unless it is congruent with the larger business context--the organization's strategy and culture and the industry's characteristics. Unfortunately, just as organizations develop learning capabilities, they also suffer from certain learning disabilities. This book outlines common disabilities and the means to overcome them. The authors assist practicing managers by providing several examples of successful and unsuccessful organizations and describing the ways in which they have helped organizations improve learning capability in their consulting practices. Based on detailed case studies, a review of past literature, and data gleaned from a worldwide survey of companies,Organizational Learning Capability is an accessible and useful guide for managers competing in the information economy. This book turns abstract ideas into practice, offers tools that managers can use, and presents a simple yet profound road map for making learning a reality.
This book brings into focus the contrast between explicit and implicit algorithmic descriptions of objects and presents a new geometric language for the study of combinatorial and logical problems in complexity theory. These themes are considered in a variety of settings, sometimes crossing traditional boundaries. Special emphasis is given to moderate complexity - exponential or polynomial - but objects with multi-exponential complexity also fit in. Among the items under consideration are graphs, formal proofs, languages, automata, groups, circuits, some connections with geometry of metric spaces, and complexity classes (P, NP, co-NP).
About the Book Success is Just Running Out of Mistakes is about a life-long quest to improve the therapy of kidney failure, especially with hemodialysis technology. Dr. Ash began to write this because of a lack of progress in dialysis therapy. He is tired of physicians and politicians saying that there is a "lack of innovation" among nephrologists. The problem isn't lack of innovation, but rather a failure to commercialize radically better new technology. In some ways the book is also a collection of 12 case studies of new technology and ideas and how a small technology-driven firm can succeed or fail in efforts to bring their new product to become a widespread market success. There are few textbooks that describe not only successes of R&D companies in bringing products to the market but also failures. What is surprising about the failures described in this book is that they occurred at many different steps of bringing a new product to market.. The answer to a physician who says "I have a new idea and think it could help medical therapy. What should I do next?" is very long and complicated. The one trait Success is Just Running Out of Mistakes really demonstrates is the importance of persistence. Not just in any one project, but in a career trying to make just one small part of medical therapy better for patients with kidney failure. Too many young physicians don't realize the tough road ahead to make medical therapy better and quit after the failure of their first good idea. As Winston Churchill said, "Success is not final, failure is not fatal: it is the courage to continue that counts." About the Author Stephen R. Ash, MD, FACP, recently retired from clinical practice as a Nephrologist at Indiana University Health Arnett in Lafayette, Indiana. He is CEO of HemoCleanseTechnologies, Chairman of the Board of AshAccess Technology, and co-founder of a number of spin-off biotechnology firms. He has a long history of research and product development in the field of sorbents, resulting in devices for treatment of kidney failure (AllientTM by Renal Solutions) and for liver failure (Liver DialysisTM by HemoTherapies). He was instrumental in development of an orally ingested sorbent for potassium (now marketed by AstraZeneca as Lokelma®). Dr. Ash has also invented a number of new catheters for dialysis access, including the Ash Split Cath®, CentrosFLO® and AdvantageTM PD Catheter. Dr. Ash is a co-founder and Past President of the American Society for Diagnostic and Interventional Nephrology (ASDIN). He is Past President of ASAIO and until recently served as Secretary-Treasurer of IFAO. He is recipient of the Lifetime Achievement Award from ASDIN, the Celebration of Life Honor by NKF of Indiana, and the Lifetime Achievement Award from the Annual Dialysis Conference. Dr. Ash also has a dedicated and loving family, including his wife Marianne, and daughters, Emily and Sarah. Marianne and Dr. Ash are long term members of Trinity United Methodist Church in Lafayette, Indiana. They live at and operate a retirement/recovery farm for horses, and his special interests are fixing things around the farm, woodworking, and flying fixed wing RC aircraft.
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