Synaptic Transmission is a comprehensive guide to the topic of neurotransmission that provides an in-depth discussion on many aspects of synapse structure and function—a fundamental part of the neuroscience discipline. Chapters include boxes that describe renowned/award-winning researchers and their contributions to the field of synaptic transmission, diseases relevant to the material presented, details of experimental approaches used to study synaptic transmission, and interesting asides that expand on topics covered. This book will inspire students to appreciate how the basic cellular and molecular biology of the synapse can lead to a better understanding of nervous system function and neurological disorders. Provides a comprehensive reference on synaptic structure, physiology, function and neurotransmission Discusses many landmark experiments in the field of synaptic transmission to emphasize core principles Includes references to primary scientific literature, relevant review articles and books, many of which could be assigned as discussion material for courses focused on this topic
Where was the garden of Eden?What happened to the ark of the covenant?What is the unforgivable sin Jesus spoke of?If you’ve ever wondered about these or other questions while reading the Bible, then this is the book for you. Here is a fascinating look at some of the most perplexing mysteries found in the pages of the Bible. Drawing from the latest research in both archaeology and biblical studies, Incredible Mysteries of the Bible sheds fascinating and helpful light on fifty topics. Each article is accompanied by beautiful full-color images and helpful sidebars.Whether you read the book cover to cover or dip in and out at your leisure, you’ll gain a greater understanding of the world and message of the Bible. So grab your sleuthing hat and dig in!
Stephen Porter's Benevolent Empire examines political-refugee aid initiatives and related humanitarian endeavors led by American people and institutions from World War I through the Cold War, opening an important window onto the "short American century." Chronicling both international relief efforts and domestic resettlement programs aimed at dispossessed people from Europe, Latin America, and East Asia, Porter asks how, why, and with what effects American actors took responsibility for millions of victims of war, persecution, and political upheaval during these decades. Diverse forces within the American state and civil society directed these endeavors through public-private governing arrangements, a dynamic yielding both benefits and liabilities. Motivated by a variety of geopolitical, ethical, and cultural reasons, these advocates for humanitarian action typically shared a desire to portray the United States, to the American people and international audiences, as an exceptional, benevolent world power whose objects of concern might potentially include any vulnerable people across the globe. And though reality almost always fell short of that idealized vision, Porter argues that this omnivorous philanthropic energy helped propel and steer the ascendance of the United States to its position of elite global power. The messaging and administration of refugee aid initiatives informed key dimensions of American and international history during this period, including U.S. foreign relations, international humanitarianism and human rights, global migration and citizenship, and American political development and social relations at home. Benevolent Empire is thus simultaneously a history of the United States and the world beyond.
This Brief provides a comprehensive introduction to the control of blood flow in the brain. Beginning with the basic physiology of autoregulation, the author goes on to discuss measurement techniques, mathematical models, methods of analysis, and relevant clinical conditions, all within this single volume. The author draws together this disparate field, and lays the groundwork for future research directions. The text gives an up-to-date review of the state of the art in cerebral autoregulation, which is particularly relevant as cerebral autoregulation moves from the laboratory to the bedside. Cerebral Autoregulation will be useful to researchers in the physical sciences such as mathematical biology, medical physics, and biomedical engineering whose work is concerned with the brain. Researchers in the medical sciences and clinicians dealing with the brain and blood flow, as well as industry professionals developing techniques such as ultrasound, MRI, and CT will also find this Brief of interest.
This exciting new book provides a thorough and comprehensive review of growth hormone physiology and pathophysiology, including its therapeutic and agricultural use.
Spin angular momentum of photons and the associated polarization of light has been known for many years. However, it is only over the last decade or so that physically realizable laboratory light beams have been used to study the orbital angular momentum of light. In many respects, orbital and spin angular momentum behave in a similar manner, but t
This book describes the way in which the human brain is supplied with blood and how the brain uses this to provide nutrients, primarily oxygen and glucose, to brain cells in order to maintain healthy brain function. In particular, it focuses on the quantitative nature of blood flow and metabolism. The book covers models of blood flow and metabolism and how these can be measured using a variety of imaging and non-imaging techniques. It also examines how cerebral blood flow is controlled in response to a wide variety of challenges and how it changes with normal physiological variation and in response to a large number of pathological conditions, including stroke and dementia.As the first substantial book for over ten years in a fast-changing field, it highlights how the subject has progressed in the last couple of decades. It tackles the subject in a quantitative way, underlining its importance in both technical and clinical fields. Audiences with a technical or clinical background, especially researchers and postgraduate students in biomedical engineering or medicine, will find this a valuable read.
This innovative book provides a new conceptual analysis of loneliness – a condition associated with severe health consequences, including increased morbidity and early death. Arguing that social connection is not the only answer, it explores pathways for transforming loneliness to healthy solitude. The first part of the book draws on the humanities and arts, including psychology, philosophy, and literature to analyse the common, and potentially serious, problem of loneliness. It makes the case that the condition is less a deficiency than a state of self-disconnection that modernity feeds through social forces. The second part of the book looks at how person-centred health care can help educate persons to transform loneliness into healthy solitude. It provides an analysis of self-connection and spiritual connection, discussing how these forms of contact can mitigate risks associated with both lack of social connection, and social connection itself, such as self-disconnection and rejection by others. It goes on to demonstrate that connection to the self and spirit can make aloneness a resource and facilitate access to benefits of connecting with others. This thought-provoking book provides students, scholars, and practitioners from a range of health and social care backgrounds with a new way of thinking about, researching, and practising with lonely people.
Child and Adolescent Psychology provides an accessible and thorough introduction to human development by integrating insights from typical and atypical development. This integration cements understanding since the same processes are involved. Knowledge about atypical development informs the understanding of typical development, and knowledge about typical development is a necessary basis for understanding atypical development and working with children with disorders. Based on international research, and informed by biological, social and cultural perspectives, the book provides explanations of developmental phenomena, with a focus on how children and adolescents at different age levels actually think, feel and act. Following a structure by topic, with chronological developments within each chapter, von Tetzchner presents and contrasts the major theoretical ideas in developmental psychology and discusses their implications for different aspects of development. He also integrates information about sensory, physical and cognitive disabilities and the main emotional and behavioral disorders of childhood and adolescence, and the developmental consequences of these disabilities and disorders. Child and Adolescent Psychology is accompanied by online resources for lecturers and students to enhance the book, including essay questions for each chapter, Powerpoint slides and multiple-choice questions. The book and companion website will prove invaluable to developmental psychology students.
This concise guide offers an accessible introduction to the development of communication and language in infancy and childhood. It integrates insights from both typical and atypical development to reveal the fundamental aspects of human growth and development, and common developmental disorders. The topic books in this series draw on international research in the field and are informed by biological, social and cultural perspectives, offering explanations of developmental phenomena with a focus on how children and adolescents at different ages actually think, feel and act. In this volume, Stephen von Tetzchner explains key topics including: Language and Communication; early development of communication; theories of communicative development; early dialogues; gestures; the development of language; language in use; child-directed language; gender differences, multilingualism and language in other modalities; and language disorders. Together with a companion website that offers topic-based quizzes, lecturer PowerPoint slides and sample essay questions, Typical and Atypical Child and Adolescent Development 5 Communication and Language Development is an essential text for all students of developmental psychology, as well as those working in the fields of child development, developmental disabilities and special education. The content of this topic book is taken from Stephen von Tetzchner’s core textbook Child and Adolescent Psychology: Typical and Atypical Development. The comprehensive volume offers a complete overview of child and adolescent development – for more information visit www.routledge.com/9781138823396
This book is the first to draw upon a range of disciplines to offer theoretical perspectives upon their analysis of public-private partnerships. It also offers a series of case-studies of their management from around the world.
Since 1975, Dr. Kenneth Swaiman’s classic text has been the reference of choice for authoritative guidance in pediatric neurology, and the 6th Edition continues this tradition of excellence with thorough revisions that bring you fully up to date with all that’s new in the field. Five new sections, 62 new chapters, 4 new editors, and a reconfigured format make this a comprehensive and clearly-written resource for the experienced clinician as well as the physician-in-training. Nearly 3,000 line drawings, photographs, tables, and boxes highlight the text, clarify key concepts, and make it easy to find information quickly. New content includes 12 new epilepsy chapters, 5 new cerebrovascular chapters, and 13 new neurooncology chapters, as well as new chapters on neuroimmunology and neuromuscular disorders, as well as chapters focused on clinical care (e.g., Counseling Families, Practice Guidelines, Transitional Care, Personalized Medicine, Special Educational Law, Outcome Measurements, Neurorehabilitation, Impact of Computer Resources, and Training Issues). Additional new chapters cover topics related to the developmental connectome, stem cell transplantation, and cellular and animal models of neurological disease. Greatly expanded sections to increase your knowledge of perinatal acquired and congenital disorders, neurodevelopmental disabilities, pediatric epilepsy, and nonepileptiform paroxysmal disorders and disorders of sleep. Coverage of new, emerging, or controversial topics includes developmental encephalopathies, non-verbal learning disorders, and the pharmacological and future genetic treatment of neurodevelopmental disabilities.
This is a study of the British military intelligence operations during the Crimean War. It details the beginnings of the intelligence operations as a result of the British Commander, Lord Raglan's, need for information on the enemy, and traces the subsequent development of the system.
In an era where citizens of liberal democracies are becoming increasingly disillusioned, dissatisfied and disenfranchised by the dominant political institutions and decision-making processes in these polities, new ideas of how to deepen democracy, re-engage citizens and enhance decision-making legitimacy are required. This book suggests that a combination of deliberative democracy and associational democracy is both a normatively desirable and an empirically plausible solution to the complex problems that are present in contemporary societies--as well as being compatible with many recent trends in governance. Author Stephen Elstub argues that by combining deliberative with associational democracy, the weaknesses of each model alone are compensated by the other, allowing the key strengths of each to manifest themselves. And he goes further by offering a detailed set of original, institutional requirements for liberal democracies that, if adopted, will enable a deliberative and associational democracy to be realised in practice.
Derived from the renowned multi-volume International Encyclopaedia of Laws, this book describes the social security regime in the United Kingdom. It conveys a clear working knowledge of the legal mechanics affecting health care, employment injuries and occupational diseases, incapacity to work, pensions, survivors’ benefits, unemployment benefits and services, and family benefits. The analysis covers the field of application, conditions for entitlement, calculation of benefits, financing, the institutional framework, and relevant law enforcement and controls. Allowances for retirees, employees, public sector workers, the self-employed, and the handicapped are all clearly explained, along with full details of claims, adjudication procedures, and appeals. Succinct yet eminently practical, the book will be a valuable resource for lawyers handling social security matters in the United Kingdom. It will be of practical utility to those both in public service and private practice called on to develop and to apply social security law and policy, and of special interest as a contribution to the comparative study of social security systems.
The fourth edition of Corporate Finance takes an applied approach to cover all the latest research and topic areas important to students taking Finance courses. The new edition provides an international perspective on all areas of corporate finance and has been updated to include discussion on current trends such as the rise of populism and trade barriers on international finance, the advent of Financial Technology, and key regulatory changes impacting the sector. Understanding and Application •Clear, user-friendly style •Example boxes in every chapter provide hypothetical examples to illustrate theoretical concepts such as cash flow timing, dividend smoothing and differential growth. •Real World Insight boxes use real companies like Siemens, Avast and Adidas to show how they have applied corporate finance theories and concepts to their businesses and business decisions. •Chapter links in the margin provide quick cross-referencing to show students the connections between topics. Practice and Proficiency •Mini and Practical cases present scenarios and questions to practice applying what you have learnt. •Rigorous testing: between 30 and 40 Questions and Problems per chapter are categorised by topic and level of difficulty. •Numbered maths equations and key notation boxes listing the variables and acronyms that will be encountered in each chapter, designed to encourage mastery of Maths. •Exam Questions designed to take 45 minutes and test you on material learned in a more formal exam style. •Connect® resources include algorithmic questions designed to ensure equations and calculations are not learned by rote but by thorough understanding and practice New to This Edition •Updated discussions on peer-to-peer trading, cash flow forecasting methods, import/export partners and additional investment appraisal methods •Updated chapters on corporate governance to reflect global changes, efficient markets and mergers and acquisition to reflect new research, financial distress to reflect new data with discussion on trends and insolvencies and fully updated chapter on Leasing to reflect new IFRS standards •New section on Modified Internal Rate of Return and Margin of Safety in Investment Appraisal, Net Asset Value, Islamic Financing, and alternatives to CAPM to reflect research developments • NEW: This edition has now been updated with 8 new videos that covers a worked example from the text and each video has associated concept check questions. The videos are now available on Connect® and cover: • Chapter 1 & 2: Introduction to Finance and Corporate Governance • Chapter 5: Long-Term Financing • Chapter 6: Investment Appraisal • Chapter 9 & 10: Risk and Return • Chapter 15 and 16: Equity and Debt Valuation • Chapter 20: Advanced Capital Budgeting • Chapter 21: Dividends • Chapter 22: Options David Hillier is Associate Principal and Executive Dean of the University of Strathclyde Business School. A Professor of Finance, David was recognized as being in the top 3 per cent of the most prolific finance researchers in the world over the past 50 years (Heck and Cooley, 2009) and appears regularly in the media as a business commentator.
Safely and effectively treat a full range of skin disorders with Comprehensive Dermatologic Drug Therapy, 3rd Edition! This trusted dermatology reference provides concise, complete, up-to-date guidance on today's full spectrum of topical, intralesional, and systemic drugs. Dr. Steven E. Wolverton and a team of leading international experts clearly explain what drugs to use, when to use them, and what to watch out for. Prescribe with confidence thanks to quick-access summaries of indications/contraindications, dosage guidelines, drug interactions, drug monitoring guidelines, adverse effects, and treatment protocols. Assess your knowledge and prepare for certification or recertification with more than 800 review questions and answers throughout the book. Contain costs and meet patient expectations with purchase information provided for major drugs. Quickly evaluate drug options for each disease discussed using a highly detailed, disease-specific index. Discover the best uses for new biologic therapeutics such as ustekinumab and rituximab, as well as newly improved TNF inhibitors. Offer your patients the very latest in cosmetic procedures, including chemical peels, intradermal fillers, and botulinum toxin. Use the safest and most effective drugs possible with new chapters on irritants and allergens in topical therapeutic agents, plus a new, separate chapter on mycophenolate mofetil. Review drugs recently taken off the market by the FDA, and use that knowledge to improve your current dermatologic drug therapy. Access the complete contents online at www.expertconsult.com and perform rapid searches for drug indications, interactions, monitoring guidelines, and much more.
New Understandings of Twin Relationships takes an experience-based approach to exploring how twin attachment and estrangement are critical to understanding the push and pull of closely entwined personal relationships. Based on the research expertise of each of the authors (all identical twins in their own right), and vignettes from twins across the globe, this book describes the inner workings of the twin-world, showing how the twin-world creates experiences that are often more intense and intricately textured than those in the singleton-world. Chapters debunk myths surrounding twinship and analyze the developmental stages of the twin relationship as well as the effect of being a twin on one’s mental health from different perspectives. The authors articulate how attachment, separation anxiety, loneliness, estrangement, and the subjective experience of the twin and non-twin "other" impact behavior, thinking, and feeling. Through its careful study of the many psychological challenges that twins face throughout their lifetime, this text will help psychologists, scholars, clinicians, and twins themselves attain a deeper understanding of all interpersonal relationships.
The burden of mental illness on individuals, families, and communities has created profound challenges for our society. In recent years treatments and services for the mentally ill have moved almost exclusively to community settings, yet no comprehensive and progressive policies have emerged to counter stigmatizing and facilitate integration.
Fought in the wake of a decade of armed struggle against colonialism, the Mozambican civil war lasted from 1977 to 1992, claiming hundreds of thousands of lives while displacing millions more. As conflicts across the globe span decades and generations, Stephen C. Lubkemann suggests that we need a fresh perspective on war when it becomes the context for normal life rather than an exceptional event that disrupts it. Culture in Chaos calls for a new point of departure in the ethnography of war that investigates how the inhabitants of war zones live under trying new conditions and how culture and social relations are transformed as a result. Lubkemann focuses on how Ndau social networks were fragmented by wartime displacement and the profound effect this had on gender relations. Demonstrating how wartime migration and post-conflict return were shaped by social struggles and interests that had little to do with the larger political reasons for the war, Lubkemann contests the assumption that wartime migration is always involuntary. His critical reexamination of displacement and his engagement with broader theories of agency and social change will be of interest to anthropologists, political scientists, historians, and demographers, and to anyone who works in a war zone or with refugees and migrants.
Don't gamble on the most important exam of your career... ace the boards with The Johns Hopkins Internal Medicine Board Review! Brought to you from the birthplace of Internal Medicine and regarded as the most effective review tool in the specialty, it will ensure you're as equipped as possible on your way to certification or recertification. From internists to primary care physicians, this no-nonsense book is a must-have companion for everyone in the field. Respected experts summarize just the imperative information you need to know for certification or recertification. Comprehensive review text, bolded key information, and helpful tables and algorithms equip you with all the core knowledge you need. Exam-taking tips and tricks allow you to go into the exam with confidence. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to test your skills and simulate the exam experience with over 1,000 additional exam questions in study and test modes. Features full-color clinical images covering all the image types you’ll see on the boards, including x-rays, common skin findings, peripheral blood smears, ophthalmology findings, and CT and MR images.
The causes, consequences and control of land use change have become topics of enormous importance in contemporary society. Not only is urban land use and sprawl a hot-button issue, but issues of rural land use have also been in the headlines. Policy makers and citizens are starting to realize that many environmental and economic issues have the question of land use at their very core. Comprising papers from a conference sponsored by the Northeast Regional Center for Rural Development, Land Use Problems and Conflicts draws together some of the most up-to-date research in this area. Sections are devoted to problems in the United States and Europe, the consequences of such problems, land use-related data and alternative solutions to conflict. With a lineup including some of the best scholarship on this subject to date, this volume will be of use to those studying environmental and land use issues in addition to policy makers and economists.
A thought-provoking, stimulating volume on the past, present and future of cultural materialism that is both laudatory of Harris' research strategy and critical of it." Paul Shankman, University of Colorado One of the most important anthropologists of all time, Marvin Harris was influential worldwide as the founder of cultural materialism. This book accessibly analyzes Harris's theories and their important legacies today. The chapters explore cultural materialism's epistemology and its relation to rational choice theory, Darwinian social science, and population pressures. The authors assess recent attempts to extend and reformulate cultural materialism and highlight cross-cultural, archaeological, and ethnographic applications of cultural materialism today.
Practical Management of Dementia, Second Edition remains a comprehensive guide to identifying the challenges faced in caring for patients with dementia. Integrating new research into the diagnosis, detection and management of dementia, this book brings together a wealth of extensive practical experience and knowledge. It answers questions on medical, psychological and social management in an informative, evidence-based manner. Emphasising the need for a variety of pharmacological, psychological and social approaches that can be adapted for individual patients, it also encourages an understanding of the patients' spiritual needs. Reviews of the First Edition: 'This is a highly readable and useful resource.' NURSING STANDARD 'Comprehensive and valuable. Of merit to all healthcare team members from all care setting perspectives.' GERIATRICS TODAY 'Consistent and clear, well written and edited.' THE JOURNAL OF DEMENTIA CARE
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