In light of many recent critiques of Western modernity and its conceptual foundations, the problem of adequately justifying our most basic moral and political values looms large. Without recourse to traditional ontological or metaphysical foundations, how can one affirm--or sustain--a commitment to fundamentals? The answer, according to Stephen White, lies in a turn to "weak" ontology, an approach that allows for ultimate commitments but at the same time acknowledges their historical, contestable character. This turn, White suggests, is already underway. His book traces its emergence in a variety of quarters in political thought today and offers a clear and compelling account of what this might mean for our late modern self-understanding. As he elaborates the idea of weak ontology and the broad criteria behind it, White shows how these are already at work in the thought of contemporary writers of seemingly very different perspectives: George Kateb, Judith Butler, Charles Taylor, and William Connolly. Among these thinkers, often thought to be at odds, he exposes the commonalities that emerge around the idea of weak ontology. In its identification of a critical turn in political theory, and its nuanced explanation of that turn, his book both demonstrates and underscores the strengths of weak ontology.
The democratic imagination is facing significant challenges. These challenges involve not only deep philosophical questions about the core values of democracy, but also pressing practical issues related to how we should understand and confront the rise of right-wing authoritarian populism. What should our stance be as defenders of democratic life? The two most prominent efforts to orient us here are the deliberative and agonistic models of democracy. The former emphasizes reasoned discussion, but some worry that this exclusive focus overlooks structures of injustice that distort civil deliberation. The latter prioritizes contestation and conflict, but its proponents struggle to explain why this prime orientation to defeating political opponents will not also corrode our commitment to normative democratic restraints, like fairness. This book develops an understanding of the moral core of democracy. In doing so, it illuminates how these two faces of democratic life, the deliberative and agonistic, each has a significant, but constrained, role to play in a more capacious comprehension of what our democratic commitments require of us. The "communicative model" of democracy we propose provides better grounds for facing the challenges of contemporary anti-democratic movements than either the deliberative or agonistic models alone"--
Edmund Burke: Modernity, Politics, and Aesthetics examines the philosophy of Burke in view of its contribution to our understanding of modernity. Stephen K. White argues that Burke shows us how modernity engenders an implicit forgetfulness of human finitude. White illustrates this theme by showing how Burke's political thought, his judgment of the 'modern system of morality and policy, ' and its taste for a 'false sublime' are structured by his aesthetics
Jürgen Habermas is one of the foremost philosophers and social theorists in the world today. But the complexity and breadth of his thought make him often difficult to understand. In this book, Stephen White offers a clear, accessible, and reliable introduction to Habermas's work, particularly that which he has written since the publication of Knowledge and human interest (produced in English in 1971). During this period, new themes and directions have emerged in Habermas's thought, which culminated in The Theory of Communicative Action, a massive work that has not hitherto been the subject of extended commentary and analysis. This book is the first to provide a full-length study of Habermas's mature thought. Locating the latter in the context of contemporary debates, White explains Habermas's ideas about action, rationality, communicative ethics, contemporary capitalism, and new social movements, which characterize his later work. He also examines Habermas's interpretation of modernity, showing that although, like his forerunners in the Frankfurt School, Habermas maintains a critical stance towards modernity's instrumentalization of reason, he nonetheless offers a sophisticated defense of the universal significance of other aspects of modern consciousness that are too often forgotten by many recent radical critics of modernity. Throughout, White presents Habermas's work in such a way as to emphasize its coherence, and to demonstrate how it constitutes the beginnings of a distinctive new research program in the social sciences. As a well-researched and lucid account of Habermas's thought, this book will appeal to readers wanting an introduction to the complexity of his ideas, as well as to those already conversant with them. It will also interest social and political theorists concerned with the general theoretical issues that it covers.
This book introduces the concept and practices of Total Inclusivity to universities around the world. It is written to help universities contend with increasing public scrutiny and uncertainty around issues of diversity, equity, inclusion and justice now at the forefront of global higher education. Providing a guide and template to higher education leaders, the book addresses such issues as work culture, free speech, student wellbeing, racism, LGBT+ identities, managerialism or ‘simply’ the ability of the institution to survive post-Covid. Whitehead and O’Connor argue that handling these issues can best be done in a university climate and system which is Totally Inclusive. This is the standard for any higher education institution to aim for, not only in its teaching but in its fundamental principles and everyday practices if it is to meet its obligations to its members and to wider society. The book aims to support universities as well as challenge the status quo as they grapple with the different global and societal pressures confronting them. It is an essential read for anyone working in leadership in higher education institutions and those interested in creating inclusive practices within their institution.
This volume, covering the period 1666–1800, considers the archaeology of the port of London on a wide scale, from the City down the Thames to Deptford. During this period, with the waterfront at its centre, London became the hub of the new British empire, contributing to the exploitation of people from other lands known as slavery.
Long established as a leading introduction to the American presidency, Presidential Leadership, twelfth edition provides students with a comprehensive survey that addresses the capacity of chief executives to fulfill their tasks, exercise their powers, and utilize their organizational structures to affect the output of government. The authors examine all aspects of the presidency in rich detail, including the president’s powers, presidential history, and the institution of the presidency. The new edition has been substantially updated to integrate the Trump presidency, including both impeachments, and the first year of the Biden presidency. Other examples of the latest coverage include The 2020 elections, including the contested aftermath of the presidential election and the January 6 riot Changes to the presidential nomination process The most recent Supreme Court nominations The executive’s response to the Covid-19 pandemic New developments in presidential public relations Changes in media relations
Managing the Drug Discovery Process, Second Edition thoroughly examines the current state of pharmaceutical research and development by providing experienced perspectives on biomedical research, drug hunting and innovation, including the requisite educational paths that enable students to chart a career path in this field. The book also considers the interplay of stakeholders, consumers, and drug firms with respect to a myriad of factors. Since drug research can be a high-risk, high-payoff industry, it is important to students and researchers to understand how to effectively and strategically manage both their careers and the drug discovery process. This new edition takes a closer look at the challenges and opportunities for new medicines and examines not only the current research milieu that will deliver novel therapies, but also how the latest discoveries can be deployed to ensure a robust healthcare and pharmacoeconomic future. All chapters have been revised and expanded with new discussions on remarkable advances including CRISPR and the latest gene therapies, RNA-based technologies being deployed as vaccines as well as therapeutics, checkpoint inhibitors and CAR-T approaches that cure cancer, diagnostics and medical devices, entrepreneurship, and AI. Written in an engaging manner and including memorable insights, this book is aimed at anyone interested in helping to save countless more lives through science. A valuable and compelling resource, this is a must-read for all students, educators, practitioners, and researchers at large—indeed, anyone who touches this critical sphere of global impact—in and around academia and the biotechnology/pharmaceutical industry. - Considers drug discovery in multiple R&D venues - big pharma, large biotech, start-up ventures, academia, and nonprofit research institutes - with a clear description of the degrees and training that will prepare students well for a career in this arena - Analyzes the organization of pharmaceutical R&D, taking into account human resources considerations like recruitment and configuration, management of discovery and development processes, and the coordination of internal research within, and beyond, the organization, including outsourced work - Presents a consistent, well-connected, and logical dialogue that readers will find both comprehensive and approachable - Addresses new areas such as CRISPR gene editing technologies and RNA-based drugs and vaccines, personalized medicine and ethical and moral issues, AI/machine learning and other in silico approaches, as well as completely updating all chapters
Obesity is one of the most important contributing factors to disease throughout the world and is an area of great current interest among researchers and clinicians. The genetics of common obesity is complex, and an important thread through this labyrinth is the study of genetic syndromes in which obesity is a major component. By examining the genetic mechanisms of obesity in these syndromes, the authors will shed new light on the genetics of common obesity. This is the first book on this important and exciting new area and addreses both the molecular and clinical features of the obesity syndromes, providing hard-core information for researchers and practical guidelines for clinicians caring for obese patients. The book is divided into three sections: the first covers approaches for assessing and investigating the obese individual; the second describes nondysmorphic, monogenic forms of obesity; and the third documents key, multisystem obesity syndromes with various genetic etiologies. It is as much a reference book as it is a manual and will appeal to clinical geneticists, obesity researchers, endocrinologists, nutritionists, and medical biologists.
Antiviral drug development has led to significant advances in the control of globally prevalent viral infections by the hepatitis C (HCV) and the human immunodeficiency viruses. Nonetheless, there are current gaps in the armamentarium against global viral infections due to some herpes viruses, the hepatitis B virus, and the deadly filovirus Ebola and arenavirus Tacaribe responsible of outbreaks of hemorrhagic fever in emerging countries. Arbidol (ARB) is a cost-effective antiviral with broad-spectrum activity, administered for decades in Russia and China against flu. We showed that ARB inhibits HCV infection, and has potent antiviral activity against the Ebola, Tacaribe, hepatitis B and human herpes-8 viruses. Since these viruses have divergent life cycles, we posit that ARB may exhibit varied modes of action against different viruses. Careful dissection of molecular mechanisms of action of ARB against HCV and the Ebola virus revealed that ARB blocked viral entry. ARB might, therefore, constitute a pharmacological approach against globally prevalent viruses, and an affordable molecule for emerging countries in urgent need for effective antiviral therapies.
In light of many recent critiques of Western modernity and its conceptual foundations, the problem of adequately justifying our most basic moral and political values looms large. Without recourse to traditional ontological or metaphysical foundations, how can one affirm--or sustain--a commitment to fundamentals? The answer, according to Stephen White, lies in a turn to "weak" ontology, an approach that allows for ultimate commitments but at the same time acknowledges their historical, contestable character. This turn, White suggests, is already underway. His book traces its emergence in a variety of quarters in political thought today and offers a clear and compelling account of what this might mean for our late modern self-understanding. As he elaborates the idea of weak ontology and the broad criteria behind it, White shows how these are already at work in the thought of contemporary writers of seemingly very different perspectives: George Kateb, Judith Butler, Charles Taylor, and William Connolly. Among these thinkers, often thought to be at odds, he exposes the commonalities that emerge around the idea of weak ontology. In its identification of a critical turn in political theory, and its nuanced explanation of that turn, his book both demonstrates and underscores the strengths of weak ontology.
Since the first edition of this very successful book was written to synthesise and review the enormous body of work covering falls in older people, there has been an even greater wealth of informative and promising studies designed to increase our understanding of risk factors and prevention strategies. This second edition, first published in 2007, is written in three parts: epidemiology, strategies for prevention, and future research directions. New material includes recent studies covering: balance studies using tripping, slipping and stepping paradigms; sensitivity and depth perception visual risk factors; neurophysiological research on automatic or reflex balance activities; and the roles of syncope, vitamin D, cataract surgery, health and safety education, and exercise programs. This edition will be an invaluable update for clinicians, physiotherapists, occupational therapists, nurses, researchers, and all those working in community, hospital and residential or rehabilitation aged care settings.
Written by internationally recognized leaders in hyperbaric oxygen therapy (HBOT) research and practice, this exciting new book provides evidence-based, practical, useful information for anyone involved in HBOT. It outlines the physiologic principles that constitute the basis for understanding the clinical implications for treatment and describes recent advances and current research, along with new approaches to therapy. This book is an essential tool for anyone who cares for patients with difficult-to-heal wounds, wounds from radiation therapy, carbon monoxide poisoning, and more. - Provides comprehensive coverage of pathophysiology and clinically relevant information so you can master the specialty. - Covers the relevance of HBOT in caring for diverse populations including critical care patients, infants and pediatric patients, and divers. - Features a section on the technical aspects of HBOT to provide insight into the technology and physics regarding HBO chambers. - Presents evidence to support the effectiveness of HBOT as well as the possible side effects. - Describes situations where HBOT would be effective through indication-specific chapters on chronic wounds, radiation and crush injuries, decompression sickness, and more.
This book on intelligence analysis written by intelligence expert Dr. Stephen Marrin argues that scholarship can play a valuable role in improving intelligence analysis. Improving intelligence analysis requires bridging the gap between scholarship and practice. Compared to the more established academic disciplines of political science and international relations, intelligence studies scholarship is generally quite relevant to practice. Yet a substantial gap exists nonetheless. Even though there are many intelligence analysts, very few of them are aware of the various writings on intelligence analysis which could help them improve their own processes and products. If the gap between scholarship and practice were to be bridged, practitioners would be able to access and exploit the literature in order to acquire new ways to think about, frame, conceptualize, and improve the analytic process and the resulting product. This volume contributes to the broader discussion regarding mechanisms and methods for improving intelligence analysis processes and products. It synthesizes these articles into a coherent whole, linking them together through common themes, and emphasizes the broader vision of intelligence analysis in the introduction and conclusion chapters. The book will be of great interest to students of intelligence studies, strategic studies, US national security, US foreign policy, security studies and political science in general,as well as professional intelligence analysts and managers.
Describes water chemistry, technology and the biological and physical processes of the aquarium ecosystem. Additionally, it presents fish physiology, nutrition, diseases and health maintenance. Provides usable methods and specific protocols for keeping marine fish with the emphasis on professional approaches for public aquariums.
Galvin showed that white always wins [T:T] and gave an explicit strategy for the case where T is finite. We present his proofs here and then show how to give an explicit strategy in the general case.
How did the popular drama of Shakespeare's age become literature? Every work that has survived from the theater of past ages has gone through some editorial process to make it available to readers. The book of the play is not the play on the stage; returning it to the stage for modern audiences is not a simple or straightforward process, nor can we simply read backwards from the texts that have come down to us to deduce what Shakespeare's or Jonson's (or Aristophanes's or Sophocles's) audiences saw. Editorial efforts since the first folio of 1623 have attempted to establish a correct, final text of Shakespeare's plays, as the folio promises "the true, original copies." Yet the text in the theater changed constantly, as the actors adapted the plays to take into account their changing audiences. The publisher of the folio of Beaumont and Fletcher's plays in 1647 acknowledges that his texts include more than the plays on the stage--"all that was acted and all that was not." In performance, the play at the Globe was not the play at court, nor was any play the same when it was revived in a subsequent season. Moreover, performances always involved improvisation on the part of the actors, and the continual response (often vocal and energetic) of the audience. This book is about what happens to plays when they become books.
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