Franklin D. Roosevelt appointed 10 justices to the U.S. Supreme Court - more than any president except Washington - and during his presidency from 1933 to 1945, the Court gained more visibility, underwent greater change, and made more landmark decisions than it had in its previous 150 years of existence. This collection examines FDR's influence on the Supreme Court and the Court's growing influence on American life.
Field-Programmable Gate Arrays (FPGAs) have emerged as an attractive means of implementing logic circuits, providing instant manufacturing turnaround and negligible prototype costs. They hold the promise of replacing much of the VLSI market now held by mask-programmed gate arrays. FPGAs offer an affordable solution for customized VLSI, over a wide variety of applications, and have also opened up new possibilities in designing reconfigurable digital systems. Field-Programmable Gate Arrays discusses the most important aspects of FPGAs in a textbook manner. It provides the reader with a focused view of the key issues, using a consistent notation and style of presentation. It provides detailed descriptions of commercially available FPGAs and an in-depth treatment of the FPGA architecture and CAD issues that are the subjects of current research. The material presented is of interest to a variety of readers, including those who are not familiar with FPGA technology, but wish to be introduced to it, as well as those who already have an understanding of FPGAs, but who are interested in learning about the research directions that are of current interest.
This short textbook presents sixty cases with the detail and patient-specific data encountered in actual clinical practice. Cases cover the major points emphasized in the in-training exam and in written and oral boards. The cases are rigorously developed using two models. The Developed Case model features a step-by-step format that highlights the decisions made at each step. The Case Reflection model features a short narrative, followed by analysis of how the management and outcome might have been improved. Cases are referenced with current articles in support of particular strategies. Each case includes a boxed Key Points section and self-assessment questions.
Heterogeneity, or mixtures, are ubiquitous in genetics. Even for data as simple as mono-genic diseases, populations are a mixture of affected and unaffected individuals. Still, most statistical genetic association analyses, designed to map genes for diseases and other genetic traits, ignore this phenomenon. In this book, we document methods that incorporate heterogeneity into the design and analysis of genetic and genomic association data. Among the key qualities of our developed statistics is that they include mixture parameters as part of the statistic, a unique component for tests of association. A critical feature of this work is the inclusion of at least one heterogeneity parameter when performing statistical power and sample size calculations for tests of genetic association. We anticipate that this book will be useful to researchers who want to estimate heterogeneity in their data, develop or apply genetic association statistics where heterogeneity exists, and accurately evaluate statistical power and sample size for genetic association through the application of robust experimental design.
Diseases of the Spine and Spinal Cord reviews the full spectrum of disorders affecting this region including primary spinal tumors and metastases, infection, degenerative diseases, and trauma. Presenting an inter-disciplinary perspective, the book includes up-to-date information on therapy [including neurosurgical], new information on developmental disorders of the spine, and a definitive chapter on trauma, including information on biomechanics. A separate chapter on pain syndromes also is included.
The last 2 decades have seen enormous strides in our understanding of the biological, genetic and clinical basis of the peripheral nerve disorders. This remains a difficult area for most practitioners. This text combines a thorough review of the neurologic literature with clinical experience in presenting a comprehensive yet concise and readable approach to the understanding, evaluation and management of these disorders. All practitioners seeing these patients, as well as all trainees in Neurology and related fields, should find this a useful, approachable initial resource.
A practical, concise, and up-to-date reference for the ICU A Doody’s Core Title for 2019! LANGE Critical Care delivers concise, evidenced-based, and highly clinical coverage of the surgical and medical aspects of critical care. The book provides basic fundamentals, applications and insights that will be of lasting value to all ICU physicians, nurses, advanced care providers, and allied personnel who care for the critically ill and injured patients in all ICUs. Noteworthy features include a well-illustrated Clinical Care Procedures section, high-yield summaries of the full spectrum of essential critical care topics, and the inclusion of “Controversies” chapters throughout each section addressing some of the ambiguous aspects of critical care. This timely book also covers the growing scope of critical care provided outside the ICU and the increasing importance of critical care services within the hospital structure. In keeping with the multi-professional nature of critical care delivery, several chapters are authored or coauthored by critical care fellows, ICU nurses, physician assistants, nurse practitioners, and pharmacists. FEATURES: • Includes both the surgical and medical aspects of critical care, making it valuable to the intensivist working in the medical, surgical, or neurological ICU • Utilizes numerous visual elements such as figures, tables, and algorithms • Appendix contains valuable reference material and formulas, including a chapter on bedside statistics • Excellent primer for internal medicine and anesthesiology ICU rotations and great for board examination review
The essential reference of modern navies and coast guards, ships, aircraft and weapons systems in service and under construction. Authoritative inventories for 164 navies support threat assessment. Includes worldwide flags and ensigns, ranks and insignia, senior appointments and personnel
Now published in two volumes to accommodate new chapters on the many advances in understanding and treatment options, this set of volumes represents the definitive reference on inflammatory bowel disease, a spectrum of diseases that is receiving increasing attention as our understanding of the etiological factors increases and diagnostic tools are refined. Basic research accelerated at the beginning of this decade and is now yielding new, more targeted treatments than were available just a few years ago. Volume 1 is on IBD and Ulcerative Colitis, and Volume 2 is on IBD and Crohn's Disease. All areas that were covered in the 2nd edition have been expanded and updated. New sections include the rapidly expanding knowledge of genetics and the role of the intestinal flora and environmental factors in etiology and pathogenesis. Among the 168 chapters, there are 20 on biologic therapies and 30 on surgical management. The consultant/authors clearly state their approach to important issues, such as the duration of immunomodulator and of anti-TNF-a use and the options for managing isolated low-grade dysplasia. A strong focus on the individual patient is woven throughout both volumes, including the benefits and risks of potentially life-altering therapies and surgeries. Entire sections detail concerns about the well-being of each person. This book provides information for health professionals who help both pediatric and adult patients navigate through the lifelong shadow of a chronic, probably genetically determined ordeal.
The ageing population is a global societal issue. Policymakers, planners and the public, third and private sectors must rethink how the built environment and services are delivered to meet the needs of a changing demographic. This is the first book to systematically review the evolution, development and progress of age-friendly thinking in the UK, with a primary focus on the real-world experiences of the people leading place-based initiatives. The book presents the findings of the first in-depth national study of age-friendly programme leaders in the UK, completed in 2021, and provides insights into the development of age-friendly communities, the formative influences from a social policy perspective, the management challenges and the progress towards achieving age-friendly goals. Using primary interview data and narrative analysis, the experiences of working with age-friendly programmes in different organisational forms are explored. The book promotes a greater understanding of what it means to become an age-friendly community in practice, how the programmes have different development pathways, and what influences different outcomes. Embellished with detailed narratives from practitioners, informative tables, and diagrams and figures throughout, the book carefully gathers the voices of a diverse range of decision-makers and leaders associated with the age-friendly movement and provides unique insights on the drivers of change in specific localities. This is a must-read for anyone involved in ageing research or ageing policy and practice as it provides an insightful look into the real world of embedding this community development model in different localities to make a difference to the lives of older people. Topical themes include how these agendas connect with other issues, such as dementia-friendly programmes and the work of the third sector, as well as the growing challenge of what it means to be ‘friendly’ as a community and place and whether ‘friendly’ is becoming an over-used term in relation to place identity. The book has national and global interest for all communities engaged in age-friendly activity, offering exemplars of best practice, achievements in transforming local communities and views on the meaning of ageing, as well as the age-friendly lens as an approach that champions the world through the eyes of older people. It offers a thought-provoking read for anyone with an interest in this expanding area of ageing, irrespective of disciplinary focus.
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