Drug Disposition and Pharmacokinetics The most up-to-date edition of a leading reference in drug disposition and pharmacokinetics In this new, fully-revised edition of Drug Disposition and Pharmacokinetics: Principles and Applications for Medicine, Toxicology and Biotechnology the authors deliver an authoritative and comprehensive discussion of the fate of drug molecules in the body, as well as its implications for pharmacological and clinical effects. The text offers a unique and balanced approach that combines discussion of the specific physical and biological factors affecting the absorption, distribution, metabolism, and excretion of drugs, with mathematical assessments of plasma and body fluid concentrations. The book assumes little prior knowledge and is an ideal reference for practicing professionals in industry as well as researchers and academics. This latest edition provides readers with a new introductory chapter, as well as new chapters covering monoclonal antibodies, the role of stereochemistry in drug disposition and pharmacokinetics, DMPK in non-human species, and the recent use of AI in drug development. Readers will also find: Thorough introductions to drug disposition, pharmacokinetics, and pharmacokinetic modeling In-depth treatments of the kinetics of drug elimination and the relationship between concentration and effect, including PK–PD modeling Comprehensive discussions of predictive pharmacokinetics and the disposition of biological molecules, including peptides and monoclonal antibodies Detailed examinations of the effects of sex, pregnancy, age, and disease, as well as drug monitoring in therapeutics and the use of AI in drug development and treatment Perfect for professionals and researchers working with the scientific aspects of drug disposition in human and veterinary medicine, toxicology, and pharmacology. Drug Disposition and Pharmacokinetics will earn a place in the libraries of students of senior-level courses in pharmacy.
With a chapter on public procurement by Sarah Hannaford ; A commentary on JCT forms of contract by Adirian Williamson, and a commentary of the infrastructure conditions of contract by John Uff
This publication is issued in conjunction with the 1998 exhibition of the same name held at The Metropolitan Museum of Art in New York and scheduled for venues in England and France. Burnes-Jones (1833-1898) created a style that had widespread influence on both British and European art--a narrative style derived from medieval legend and fused with the influence of Italian Renaissance masters, a style that ceded popularity to a growing taste for abstraction at the end of the 19th century. Now Burne-Jones's star has risen again, and this catalogue contains full discussion of his life and work and representation of his prodigious output of drawings and paintings. 9.5x12.5"Annotation copyrighted by Book News, Inc., Portland, OR
Revolution and state breakdown are the focus of this important new book that analyzes the most prominent theories of revolution and points to future directions. Covers famous revolutions from history (France, China, Russia) and those in the developing world in addressing such key questions as "why are revolutions so rare?" Revolutions also looks at the state breakdowns in Eastern Europe after 1989, the typical outcomes of revolutions, and the possible future of revolutions. An appendix presents biographical and autobiographical sketches of several of the most prominent students of revolutions.
Manchester-by-the-Sea is known today for its historic summer colony, made famous by the rich and illustrious seeking relief from the sweltering city. Its sandy beaches, rocky irregular coastline, and cool breezes provided the perfect habitat for massive summer cottages. Presidents, ambassadors, Brahmans, and robber barons escaped, with a full staff of servants, to an exclusive enclave where they romanticized an idealized past. Prominent artists captured the idyllic environment on canvas, the most famous being Winslow Homer's painting of Singing Beach. Originally farmers, the first colonists learned to build boats, fish, and trade along the coastal waters, becoming clipper ship captains in the late 18th century. Located on Boston's famous North Shore, Manchester-by-the-Sea remains a quiet, isolated place enjoyed by residents and tourists alike.
Each book in this series offers practical guidelines to aid diagnosis and management of common disorders seen in primary care offices. The consistent format promotes efficient study and quick reference.
French culture is unique in that philosophy has played a significant role from the early-modern period onwards, intimately associated with political, religious, and literary debates, as well as with epistemological and scientific ones. While Latin was the language of learning there was a universal philosophical literature, but with the rise of vernacular literatures things changed and a distinctive national form of philosophy arose in France. This Very Short Introduction covers French philosophy from its origins in the sixteenth century up to the present, analysing it within its social, political, and cultural context. Beginning with psychology and epistemology, Stephen Gaukroger and Knox Peden then move onto the emergence of radical philosophy in the eighteenth century, before considering post-revolutionary philosophy in the nineteenth century, philosophy in the world wars, the radical thought of the 1960s, and finally French philosophy today. Throughout, they explore the dilemma sustained by the markedly national conception of French philosophy, and its history of speaking out on matters of universal concern. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.
In this wide-ranging and insightful analysis, Stephen Benson proposes a poetics of narrative for postmodernism by placing new emphasis on the folktale. Postmodernist fictions have evidenced a return to narrative-to storytelling centered on a sequence of events, rather than a "spiraling" of events as found in modernism-and recent theorists have described narrative as a "central instance of the human mind." By characterizing the folktale as a prime embodiment of narrative, Benson relates folktales to many of the theoretical concerns of postmodernism and provides new insights into the works of major writers who have used this genre, which includes the subgenre of the fairy tale, in opening narrative up to new possibilities. Benson begins by examining the key features of folktales: their emphasis on a chain of events rather than description or consciousness, their emphasis on a self-contained fictional environment rather than realism, the presence of a storyteller as a self-confessed fabricator, their oral and communal status, and their ever-changing state, which defies authoritative versions. He traces the interactions between the folktale and Italo Calvino's Fiabe Italiane, between selected fictions of John Barth and the Arabian Nights, between the work of Robert Coover and the subgenre of the fairy tale, and between the "Bluebeard" stories and recent feminist retellings by Angela Carter and Margaret Atwood. The arguments presented will interest not only folklorists and scholars of narrative but also readers in fields ranging from comparative literature to feminist theory.
Very Short Introductions: Brilliant, Sharp, Inspiring The Second Vatican Council (1962-1965), or Vatican II, is arguably the most significant event in the life of the Catholic Church since the Reformation. The Council initiated, intentionally or not, profound changes not simply within Catholic theology, but in the religious, social, and moral lives of the world's billion Catholics. It also reconfigured, intellectually and practically, the Church's engagements with those outside of it - most obviously with regard to other religions. The sixteen documents formally issued by Vatican II constitute some of the most influential writings of the whole twentieth century. Debates over their correct interpretation and authority are constant, but they remain an indispensable point-of-reference for all areas of Catholic life, from liturgy and sacraments, to the Church's vast network of charitable and educational endeavours the world over. In this Very Short Introduction, Shaun Blanchard and Stephen Bullivant present the backstory to this event. Vatican II is explored in light of the wider history of the Catholic Church and placed in the tumultuous context of the 1960s. It distils the research on Vatican II, employing the first-hand accounts of participants and observers, and the official proceedings of the Council to paint a rich picture of one of the most important events of the last century. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.
The Miocene Columbia River flood basalt province covers ~210,000 km2 of the Pacific Northwest of the United States, and forms part of a larger volcanic region that also includes contemporaneous silicic centers in northern Nevada, the basaltic and time-transgressive rhyolitic volcanic fields of the Snake River Plain and Yellowstone plateau, and the High Lava Plains of central Oregon. The Columbia River flood basalt province is accessible and well exposed, making it one of the best-studied flood basalt provinces worldwide, and it serves as a model for understanding the stratigraphic development and petrogenesis of large igneous provinces through time. This volume details our current knowledge of the stratigraphy and physical volcanology; extent, volume, and age of the lava flows; the tectonic setting and history of the province; the petrogenesis of the lavas; and hydrogeology of the basalt aquifers.
Twenty-six Christians go head-to-head on 13 tough issues such as Christian schools, divorce, capital punishment, women's rights, physical fitness, Christians in politics, and life-support systems.
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