Research on dyneins has a direct impact on human diseases, such as viruses and cancer. With an accompanying website showing over 100 streaming videos of cell dynamic behavior for best comprehension of material, Dynein: Structure, Biology and Disease is the only reference covering the structure, biology and application of dynein research to human disease. From bench to bedside, Dynein: Structure, Biology and Disease offers research on fundamental cellular processes to researchers and clinicians across developmental biology, cell biology, molecular biology, biophysics, biomedicine, genetics and medicine. Broad-based up-to-date resource for the dynein class of molecular motors Chapters written by world experts in their topics Numerous well-illustrated figures and tables included to complement the text, imparting comprehensive information on dynein composition, interactions, and other fundamental features
A significant addition to the growing field of transnational studies, New England and the Maritime Provinces reveals a relationship that, although sometimes troubled, retains its importance in the current era of globalization.
Rutter’s Child and Adolescent Psychiatry has become an established and accepted textbook of child psychiatry. Now completely revised and updated, the fifth edition provides a coherent appraisal of the current state of the field to help trainee and practising clinicians in their daily work. It is distinctive in being both interdisciplinary and international, in its integration of science and clinical practice, and in its practical discussion of how researchers and practitioners need to think about conflicting or uncertain findings. This new edition now offers an entirely new section on conceptual approaches, and several new chapters, including: neurochemistry and basic pharmacology brain imaging health economics psychopathology in refugees and asylum seekers bipolar disorder attachment disorders statistical methods for clinicians This leading textbook provides an accurate and comprehensive account of current knowledge, through the integration of empirical findings with clinical experience and practice, and is essential reading for professionals working in the field of child and adolescent mental health, and clinicians working in general practice and community pediatric settings.
The Greatest Game of All or Rugby League as it is known to some has given me nearly a half a century of pleasure and a little pain. In 1966 at the ripe old age of 6 I was introduced to our game when my Uncle Harry moved into the bedroom I shared with my younger brother in a 2 bedroom fibro joint in Rockdale(Dragon Territory). Harry was playing lower grades for Jack Gibsons Roosters and went on to play for St George in the 1971 Grand Final against my other front rower mate John Sattler and his Rabbitohs. By the age of 9 I had memorized every player in the Big League magazine. The game became my obsession. Even if I had not been lucky enough to play over 100 games in the best competition in the world(arguably in any sport) Rugby League was in my blood. As a Rothmans Medal winner (the official player of the year award in 1983 succeeded by The Dally M Medal) I have always been aware of the history of our great game and its effect on society especially in the northern states of Australia. Apart from obtaining a Law degree at Sydney University I studied the Politics in Sport while completing my Arts Degree at Macquarie University. I believed our game was ahead of sports like baseball, gridiron and basketball that relied heavily on statistics to rate their great players. Ours is a game of passion made for the blue collar working classman relying on guts and determination not on how many yards and minutes someone makes or plays. However as we get older we all like to dig deep into history and see who had the ability and drive to play even one game in the toughest competition playing the greatest game of all. This book does what none other has attempted to dotell a story using numbers and statistics about our great game. It is something every player and fan would do well to study. Stephen Kane the author of this book could be a reincarnation of Stephen Harold Gascoigne, better known as Yabba whose statue stands proudly at the Sydney Cricket Ground. Yabba was known for his knowledgeable witticisms shouted loudly from The Hill, a grassy general admissions area of the SCG. A lot like Yabba Kaney can be found every winter Sunday on the hill at Greenfield Park Albury(or away in Junee, Temora or Wagga) cheering his beloved Thunder to victory in the Group 9 Premiership loudly and clearly from 10 am to 5.30pm. In his spare time since breaking his back 7 years ago he has collected statistics on players in the NSWRL(now known as the NRL) dating back to 1908. The first words Kaney said to me was I have every Rugby League Week ever published as he showed me his EELS tattoo. You got sin binned once in your career at North Sydney Oval in 1983 or was it 1984?? I knew I was in the company of a Rugby League tragic. This study of our game will help all of us who love the game and those of us lucky enough to have played it a better insight into the players of the greatest game of all from the top to the bottom. Written by Mike Eden, who played 110 Games for Manly, Easts, Parramatta and Gold Coast, is Gold Coast Player Number 1, and Won the Dally M award for Player of the Year in 1983
Grays (Thurrock) in the Great War tells the story of Grays and the wider Thurrock area from the outbreak of the Great War until the peace of 1918. The Docks at nearby Tilbury were the source of much employment in the area for both fathers and sons alike. They also played their part in the war, but not as a hub of military deployments.In May 1915 the German spy Augusto Alfredo Roggen, a Uruguayan born in Montevideo, arrived at Tilbury on board the SS Batavia, which had sailed from Rotterdam in Holland. On his arrival in England he made his way to Scotland to carry out his spying activities at the Loch Long torpedo range. He was captured, found guilty and executed by firing squad at the Tower of London on 17 November 1915.In July 1915 the German Naval officer and pilot, Gunther Plschow, made good his escape from Donington Hall POW camp in Leicestershire and made his way safely back to Germany by hiding himself on board one of the many ships that sailed from Tilbury. He became the only German POW to escape from Britain and make it back to Germany during the First World War.The Kynochs munitions factory was situated near Fobbing on the site of what had previously been Borleys Farm. The site, which made shell cases, detonators, cordite and acetone for the British war effort, was so vast that it included its own housing estate for its workers, a hospital and a railway line. It became so big that it actually became known as Kynochtown and was a major source of employment in the area, particularly for women.There were Prisoner of War camps at Horndon House Farm, Puddledock Farm and Woodhams Quarry in West Thurrock which housed over 150 German prisoners.The Thurrock area also played an important part of protecting London from seaborne invasion up the River Thames with the help of Tilbury Fort and Coalhouse Fort at East Tilbury.
A brand new collection of world-class supply chain design solutions… 3 authoritative books, now in a convenient e-format, at a great price! 3 authoritative eBooks deliver state-of-the-art guidance for designing and optimizing highly competitive global supply chains! This unique 3 eBook package will help you design state-of-the-art supply chains that deliver rapid, quantifiable, and sustainable competitive advantage. The Encyclopedia of Operations Management is the perfect single-volume "field manual" for every supply chain or operations management practitioner and student. Nearly 1,500 well-organized, up-to-date definitions cover every facet of supply chain design, planning, management, and optimization. Next, in Reinventing the Supply Chain Life Cycle, Marc J. Schniederjans and Stephen B. LeGrand show how to optimize supply chains throughout their entire lifecycle: creation, growth, maturity, and decline! Reflecting up-to-the-minute "in-the-trenches" experience and pioneering research, this book illuminates the complex transformational processes associated with managing complex supply chains that incorporate multiple products and services within ever-changing networks. They walk you through: starting, creating, and building new supply chains; realigning them for growth; adjusting to dynamic change, readjusting networks, building flexibility, and managing new risks. Next, they offer practical, realistic guidance for realigning "mature" supply chains, innovating, controlling costs; and smoothly managing declining demand. Throughout, they offer invaluable insights, tools, and examples for negotiation, performance measurement, anticipating change, improving agility, meeting commitments to social responsibility and the law; and more. Finally, in Supply Chain Network Design, four leading IBM and Northwestern University experts show how to use strategic supply chain network design to achieve dramatic new savings. They integrate rigorous principles and practical applications to help you select the right number, location, territory, and size of warehouses, plants, and production lines; and optimize the flow of all products through even the most complex global supply chain. You’ll find better ways to decide what (and where) to manufacture internally; and which products to outsource (and to whom). You’ll get help managing cost vs. service-level tradeoffs; using analytics to improve decision-making; and re-optimizing regularly for even more savings. Whatever your role in supply chain design, this collection will help you systematically optimize performance, customer value, and profitability. From world-renowned supply chain experts Arthur V. Hill, Marc J. Schniederjans, Stephen B. LeGrand, Michael Watson, Sara Lewis, Peter Cacioppi, and Jay Jayaraman
Since 1972, the Robert Wood Johnson Foundation has been the nation's largest philanthropy devoted exclusively to health. To further its mission of improving the health and health care of all Americans, the Foundation strives to foster innovation, develop ideas, disseminate information, and enable committed people to devote their energies to improving the nation's well-being. As part of the Foundation's efforts to inform the public, the eleventh volume in the Robert Wood Johnson Foundation Anthology series, To Improve Health and Health Care, provides an in-depth look into the programs it funds. Written for policymakers and practitioners, as well as interested members of the public, the series offers valuable lessons for leaders and educators developing plans for the coming years.
Serious Offenders: A Historical Study of Habitual Criminals examines the persistent offending careers of men and women operating in northwest England between the 1840s and 1940s. The book focuses on a group of serious and persistent offenders who as well as offending in the region, had lengthy offending careers spanning several decades in various other locations. These were highly mobile persistent serious offenders who appear not to have been so closely bound in to the processes and structures which aided desistence from offending for the vast majority of the petty offenders. The authors discuss questions such as: Why did some people remain minor offenders, whilst others developed into serious offenders? What were the triggers which propelled previously minor offenders towards persistent serious criminality? What part did changes in criminal legislation play in these processes? They conclude by drawing on the lessons to be learnt for today's debates about the regulation and surveillance of serious habitual offenders.
This eye-opening account reveals that covert intelligence operations in the U.S. date much farther back than most people realize--back to the Founding Fathers. Detailing clandestine, unscrupulous operations that took place under such presidents as Washington, Jefferson, Polk, and Lincoln, Knott reveals that presidents have rarely consulted Congress before engaging in such operations.
An unstoppable business revolution is under way, and it is Agile. Sparking dramatic improvements in quality, innovation, and speed-to-market, the Agile movement has helped companies learn to connect everyone and everything…all the time. With rapidly evolving consumer needs and technology that is being updated quicker than ever before, businesses are recognizing how essential it is to adapt quickly. The Agile movement enables a team, unit, or enterprise to nimbly acclimate and upgrade products and services to meet these constantly changing needs. Filled with examples from every sector, The Age of Agile helps you: Master the three laws of Agile Management (team, customer, network) Embrace the new mindset Overcome constraints Employ meaningful metrics Make the entire organization Agile Companies don’t need to be born Agile. With the groundbreaking formulas laid out in The Age of Agile, even global giants can learn to act entrepreneurially. Your company’s future may depend on it!
Provides a comprehensive case law reference on both historic and current Australian taxation issues. The 10th edition presents, in alphabetical order, summaries of 550 leading cases, relevant to students in both undergraduate and post graduate tax programs in law and business schools in Australia.
The Greatest Game of All or Rugby League as it is known to some has given me nearly a half a century of pleasure and a little pain. In 1966 at the ripe old age of 6 I was introduced to our game when my Uncle Harry moved into the bedroom I shared with my younger brother in a 2 bedroom fibro joint in Rockdale(Dragon Territory). Harry was playing lower grades for Jack Gibson s Roosters and went on to play for St George in the 1971 Grand Final against my other front rower mate John Sattler and his Rabbitoh s. By the age of 9 I had memorized every player in the Big League magazine. The game became my obsession. Even if I had not been lucky enough to play over 100 games in the best competition in the world(arguably in any sport) Rugby League was in my blood. As a Rothmans Medal winner (the official player of the year award in 1983 succeeded by The Dally M Medal) I have always been aware of the history of our great game and its effect on society especially in the northern states of Australia. Apart from obtaining a Law degree at Sydney University I studied the Politics in Sport while completing my Arts Degree at Macquarie University. I believed our game was ahead of sports like baseball, gridiron and basketball that relied heavily on statistics to rate their great players. Ours is a game of passion made for the blue collar working classman relying on guts and determination not on how many yards and minutes someone makes or plays. However as we get older we all like to dig deep into history and see who had the ability and drive to play even one game in the toughest competition playing the greatest game of all. This book does what none other has attempted to do tell a story using numbers and statistics about our great game. It is something every player and fan would do well to study. Stephen Kane the author of this book could be a reincarnation of Stephen Harold Gascoigne, better known as Yabba whose statue stands proudly at the Sydney Cricket Ground. Yabba was known for his knowledgeable witticisms shouted loudly from The Hill , a grassy general admissions area of the SCG. A lot like Yabba Kaney can be found every winter Sunday on the hill at Greenfield Park Albury(or away in Junee, Temora or Wagga) cheering his beloved Thunder to victory in the Group 9 Premiership loudly and clearly from 10 am to 5.30pm. In his spare time since breaking his back 7 years ago he has collected statistics on players in the NSWRL(now known as the NRL) dating back to 1908. The first words Kaney said to me was I have every Rugby League Week ever published as he showed me his EELS tattoo . You got sin binned once in your career at North Sydney Oval in 1983 or was it 1984? ? I knew I was in the company of a Rugby League tragic. This study of our game will help all of us who love the game and those of us lucky enough to have played it a better insight into the players of the greatest game of all from the top to the bottom. Written by Mike Eden, who played 110 Games for Manly, Easts, Parramatta and Gold Coast, is Gold Coast Player Number 1, and Won the Dally M award for Player of the Year in 1983
This book demonstrates that long-term win-win collaboration approaches work. Principals and contractors don't have to end up in conflict or litigation. I would recommend these ideas be adopted by companies eager to improve productivity.' - John Mulcahy, Chairman, Mirvac 'In an industry dominated by conflict and unproductive activity, this book offers a refreshing and practical way for all parties in the building industry to achieve more from their capital and labour inputs. Stephen Hanman and Ian George have shown through application that by introducing trust, respect and meaningful communication into relationships, results improve for all stakeholders. Moreover, the investment required to do the first job carries over to future work, resulting in improved performance with each project. I applaud the efforts of the authors in both creating the environment for their clients to 'do better' in their construction businesses and for sharing their work with the wider business and labour communities. One wonders what benefits could flow to other industries should the broader principles so successfully adopted in this book be applied more widely.' - Terry Henderson, company director and businessman 'This book provides wonderful insights into the way in which economic and social relationships associated with building and construction can be transformed. The participants involved in CGA Bryson projects have experienced considerable benefits in their working and personal lives. There is also evidence of significant economic benefits for all within the project supply chains. In the context of the broader building and construction industry, this account contains lessons which offer solutions for some of the seemingly intractable problems of conflict, waste, poor quality work and alienation that bedevil this industry. We have a lot to learn from these two professionals who are writing about their direct experience in transforming a construction enterprise.' - Professor Tony Dalton, RMIT Australian Housing and Urban Research Institute Research Centre, School of Global, Urban and Social Studies, RMIT University 'In our own research, we have documented in financial terms the benefits of cross-functional, cross-firm collaboration. However, for many executives, building a culture that supports collaboration is not easy. Ian and Stephen not only report on the benefits of collaboration in an industry where such behaviour has not been the norm, but they provide guidelines for building organisations with a culture of collaboration.' - Dr Douglas M Lambert, Fisher College of Business, The Ohio State University, founder of the Supply Chain Management Institute
Late one summer afternoon in 2010, wildlife rescuer Lisa Bates set off on a very strange rescue mission. Lisa drove into the Arizona desert with a dog crate in the back of her car. In the crate was a small animal—but it sure didn’t look like a dog. It had reddish-brown fur and a pig-like snout. It was a baby collared peccary that had been separated from its mother. Would Lisa find a way to reunite them? In Collared Peccary: Cactus Eater, kids go on a real-life adventure with wildlife biologist Lisa Bates as she tries to save a lost baby peccary. Along the way, children will learn how peccaries have adapted to their harsh desert climate, including how they find food, stay safe, and keep track of other herd members. Large, full-color photos and a dramatic narrative format will keep readers turning the pages.
Annotation A handbook for chemical and process engineers who need a solution to their practical on-the-job problems. It solves process design problems quickly, accurately and safely, with hundreds of techniques, shortcuts and calculations.
Ferris, hurry up, sweetie. You're going to miss the 'Fifteen Seconds of Shame'!" Sebastian called out to his pregnant fiancee, who was in their cheap motel-like bathroom, weighing herself on an outdated floor scale. "Damn, another five pounds," she mumbled, cursing Sebastian for making her look like a walrus. "Coming, dear," she said, her words laced with sarcasm. She ignored the full-length mirror attached to the door on her way out; she could not stand the sight of her reflection. "You know I hate you for making me look like this." She waddled to Sebastian's side of their queen-sized bed, hands on her hips with her neck poked out like an infant bird waiting to be fed. She was in complete bitch mode.
Programming in Objective-C, Fourth Edition Updated for iOS 5 and ARC Programming in Objective-C is a concise, carefully written tutorial on the basics of Objective-C and object-oriented programming for Apple's iOS and Mac platforms. The book makes no assumptions about prior experience with object-oriented programming languages or with the C language (which Objective-C is based upon). Because of this, both beginners and experienced programmers alike can use this book to quickly and effectively learn the fundamentals of Objective-C. Readers can also learn the concepts of object-oriented programming without having to first learn all of the intricacies of the underlying C programming language. This unique approach to learning, combined with many small program examples and exercises at the end of each chapter, makes Programming in Objective-C ideally suited for either classroom use or self-study. The fourth edition of this book has been updated to cover the significant changes that first appeared in iOS 5 and Xcode 4.2, including the use of Automatic Reference Counting (ARC) to improve and simplify memory management in Objective-C programs. “The best book on any programming language that I’ve ever read. If you want to learn Objective-C, buy it.”—Calvin Wolcott “An excellent resource for a new programmer who wants to learn Objective-C as their first programming language—a woefully underserved market.”—Pat Hughes Table of Contents 1 Introduction 2 Programming in Objective-C 3 Classes, Objects, and Methods 4 Data Types and Expressions 5 Program Looping 6 Making Decisions 7 More on Classes 8 Inheritance 9 Polymorphism, Dynamic Typing, and Dynamic Binding 10 More on Variables and Data Types 11 Categories and Protocols 12 The Preprocessor 13 Underlying C Language Features 14 Introduction to the Foundation Framework 15 Numbers, Strings, and Collections 16 Working with Files 17 Memory Management and Automatic Reference Counting 18 Copying Objects 19 Archiving 20 Introduction to Cocoa and Cocoa Touch 21 Writing iOS Applications A Glossary B Address Book Example Source Code
THE #1 BESTSELLING BOOK ON OBJECTIVE-C 2.0 Programming in Objective-C 2.0 provides the new programmer a complete, step-by-step introduction to Objective-C, the primary language used to develop applications for the iPhone, iPad, and Mac OS X platforms. The book does not assume previous experience with either C or object-oriented programming languages, and it includes many detailed, practical examples of how to put Objective-C to use in your everyday iPhone/iPad or Mac OS X programming tasks. A powerful yet simple object-oriented programming language that’s based on the C programming language, Objective-C is widely available not only on OS X and the iPhone/iPad platform but across many operating systems that support the gcc compiler, including Linux, Unix, and Windows systems. The second edition of this book thoroughly covers the latest version of the language, Objective-C 2.0. And it shows not only how to take advantage of the Foundation framework’s rich built-in library of classes but also how to use the iPhone SDK to develop programs designed for the iPhone/iPad platform. Table of Contents 1 Introduction Part I: The Objective-C 2.0 Language 2 Programming in Objective-C 3 Classes, Objects, and Methods 4 Data Types and Expressions 5 Program Looping 6 Making Decisions 7 More on Classes 8 Inheritance 9 Polymorphism, Dynamic Typing, and Dynamic Binding 10 More on Variables and Data Types 11 Categories and Protocols 12 The Preprocessor 13 Underlying C Language Features Part II: The Foundation Framework 14 Introduction to the Foundation Framework 15 Numbers, Strings, and Collections 16 Working with Files 17 Memory Management 18 Copying Objects 19 Archiving Part III: Cocoa and the iPhone SDK 20 Introduction to Cocoa 21 Writing iPhone Applications Part IV: Appendixes A Glossary B Objective-C 2.0 Language Summary C Address Book Source Code D Resources
This book is a compilation of obituaries and death notices transcribed from issues of the Crittenden Record-Press dating from 04 January 1912 through 20 December 1917. It includes obituaries and death notices from Crittenden and surrounding counties in Kentucky.
How the West Was Lost' tracks the overlapping conquest, colonization, and consolidation of the trans-Appalachian frontier. Not a story of paradise lost, this is a book about possibilities lost. It focuses on the common ground between Indians and backcountry settlers which was not found.
Uveitis is inflammation of the middle layer of the eye, which is known as the uvea or uveal tract. It is a complex condition with a variety of causes and clinical manifestations, including injury, infection or an underlying condition. This 1200pp second edition brings ophthalmologists fully up to date with the latest developments in diagnosing and treating uveitis. Beginning with the basic principles of the disease, its diagnosis and management, the following sections discuss the treatment of numerous different infectious, non infectious, masquerade and autoimmune syndromes. Basic science, differential diagnosis, pathology and clinical management are discussed for each condition. Written by specialists from the Massachusetts Eye Research and Surgery Institution (MERSI) and John A Moran Eye Center in the USA, this comprehensive new edition includes 699 colour images and illustrations. Key points Comprehensive, second edition bringing ophthalmologists fully up to date with diagnosis and treatment of uveitis Discusses different uveitis syndromes – infectious, non infectious, masquerade and autoimmune Authored by US ophthalmic specialists Includes 699 full colour images and illustrations First edition published in 2001 by Saunders
Since 1975, Dr. Kenneth Swaiman's classic text has been the reference of choice for authoritative guidance in pediatric neurology, and the 6th Edition continues this tradition of excellence with thorough revisions that bring you fully up to date with all that's new in the field. Five new sections, 62 new chapters, 4 new editors, and a reconfigured format make this a comprehensive and clearly-written resource for the experienced clinician as well as the physician-in-training. - Nearly 3,000 line drawings, photographs, tables, and boxes highlight the text, clarify key concepts, and make it easy to find information quickly.
This best-selling resource has a worldwide reputation as the leader in its field. Focusing on human immunology and biology, while also reporting on scientific experimentation and advancement, it provides comprehensive coverage of state-of-the-art basic science as well as authoritative guidance on the practical aspects of day-to-day diagnosis and management. This new edition includes 700 full-color illustrations and a new, more accessible format to make finding information a snap for the busy practitioner. Includes a glossary of allergy and immunology for quick and easy reference. Contains keypoints and clinical pearls highlighted to find important information quickly. links to useful online resources both for you and for your patients. Offers contributions from hundreds of international authorities for world-class expertise in overcoming any clinical challenge. Contains 400 new illustrations, 700 in all, to better illustrate complex immunology. Covers the very latest in the field, including hot topics such as food allergy and immunotherapy. Includes the latest guidelines from The National Asthma Education and Prevention Program (NAEPP). Utilizes a new, more user-friendly full-color format for easier reference.
Safely and effectively treat a full range of skin disorders with Comprehensive Dermatologic Drug Therapy, 3rd Edition! This trusted dermatology reference provides concise, complete, up-to-date guidance on today's full spectrum of topical, intralesional, and systemic drugs. Dr. Steven E. Wolverton and a team of leading international experts clearly explain what drugs to use, when to use them, and what to watch out for. Prescribe with confidence thanks to quick-access summaries of indications/contraindications, dosage guidelines, drug interactions, drug monitoring guidelines, adverse effects, and treatment protocols. Assess your knowledge and prepare for certification or recertification with more than 800 review questions and answers throughout the book. Contain costs and meet patient expectations with purchase information provided for major drugs. Quickly evaluate drug options for each disease discussed using a highly detailed, disease-specific index. Discover the best uses for new biologic therapeutics such as ustekinumab and rituximab, as well as newly improved TNF inhibitors. Offer your patients the very latest in cosmetic procedures, including chemical peels, intradermal fillers, and botulinum toxin. Use the safest and most effective drugs possible with new chapters on irritants and allergens in topical therapeutic agents, plus a new, separate chapter on mycophenolate mofetil. Review drugs recently taken off the market by the FDA, and use that knowledge to improve your current dermatologic drug therapy. Access the complete contents online at www.expertconsult.com and perform rapid searches for drug indications, interactions, monitoring guidelines, and much more.
Managing the Drug Discovery Process, Second Edition thoroughly examines the current state of pharmaceutical research and development by providing experienced perspectives on biomedical research, drug hunting and innovation, including the requisite educational paths that enable students to chart a career path in this field. The book also considers the interplay of stakeholders, consumers, and drug firms with respect to a myriad of factors. Since drug research can be a high-risk, high-payoff industry, it is important to students and researchers to understand how to effectively and strategically manage both their careers and the drug discovery process. This new edition takes a closer look at the challenges and opportunities for new medicines and examines not only the current research milieu that will deliver novel therapies, but also how the latest discoveries can be deployed to ensure a robust healthcare and pharmacoeconomic future. All chapters have been revised and expanded with new discussions on remarkable advances including CRISPR and the latest gene therapies, RNA-based technologies being deployed as vaccines as well as therapeutics, checkpoint inhibitors and CAR-T approaches that cure cancer, diagnostics and medical devices, entrepreneurship, and AI. Written in an engaging manner and including memorable insights, this book is aimed at anyone interested in helping to save countless more lives through science. A valuable and compelling resource, this is a must-read for all students, educators, practitioners, and researchers at large—indeed, anyone who touches this critical sphere of global impact—in and around academia and the biotechnology/pharmaceutical industry. - Considers drug discovery in multiple R&D venues - big pharma, large biotech, start-up ventures, academia, and nonprofit research institutes - with a clear description of the degrees and training that will prepare students well for a career in this arena - Analyzes the organization of pharmaceutical R&D, taking into account human resources considerations like recruitment and configuration, management of discovery and development processes, and the coordination of internal research within, and beyond, the organization, including outsourced work - Presents a consistent, well-connected, and logical dialogue that readers will find both comprehensive and approachable - Addresses new areas such as CRISPR gene editing technologies and RNA-based drugs and vaccines, personalized medicine and ethical and moral issues, AI/machine learning and other in silico approaches, as well as completely updating all chapters
It has long been recognized that the landscape of Britain is one of the 'richest historical records we possess', but just how old is it? The Fields of Britannia is the first book to explore how far the countryside of Roman Britain has survived in use through to the present day, shaping the character of our modern countryside. Commencing with a discussion of the differing views of what happened to the landscape at the end of Roman Britain, the volume then brings together the results from hundreds of archaeological excavations and palaeoenvironmental investigations in order to map patterns of land-use across Roman and early medieval Britain. In compiling such extensive data, the volume is able to reconstruct regional variations in Romano-British and early medieval land-use using pollen, animal bones, and charred cereal grains to demonstrate that agricultural regimes varied considerably and were heavily influenced by underlying geology. We are shown that, in the fifth and sixth centuries, there was a shift away from intensive farming but very few areas of the landscape were abandoned completely. What is revealed is a surprising degree of continuity: the Roman Empire may have collapsed, but British farmers carried on regardless, and the result is that now, across large parts of Britain, many of these Roman field systems are still in use.
This Gold Standard in clinical child neurology presents the entire specialty in the most comprehensive, authoritative, and clearly written fashion. Its clinical focus, along with relevant science, throughout is directed at both the experienced clinician and the physician in training. New editor, Dr. Ferriero brings expertise in neonatal neurology to the Fourth Edition. New chapters: Pathophysiology of Hypoxic Ischemic Encephalopathy, Congenital Disorders of Glycosylation, Pediatric Neurotransmitter Diseases, Neurophysiology of Epilepsy, Genetics of Epilepsy, Pediatric Neurorehabilitation Medicine, Neuropsychopharmacology, Pain and Palliative Care Management, Ethical Issues in Child Neurology
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