It’s been nearly four decades since scientists first realized that global warming posed a potential threat to our planet. Why, if we knew of the threats way back in the Carter Administration, can’t we act decisively to limit greenhouse gases, deforestation, and catastrophic warming trends? Why are we still addicted to fossil fuels? Have we all just been fiddling for 40 years as the world burns around us? Schneider, part of the Nobel Prize–winning team that shared the accolade with Al Gore in 2007, had a front-row seat at this unfolding environmental meltdown. Piecing together events like a detective story, Schneider reveals that as expert consensus grew, well-informed activists warned of dangerous changes no one knew how to predict precisely—and special interests seized on that very uncertainty to block any effective response. He persuasively outlines a plan to avert the building threat and develop a positive, practical policy that will bring climate change back under our control, help the economy with a new generation of green energy jobs and productivity, and reduce the dependence on unreliable exporters of oil—and thus ensure a future for ourselves and our planet that’s as rich with promise as our past.
An extremely readable account on the scientific essentials of the global warming debate The possibility of global climatic change as a result of increasing numbers of people requiring higher stands of living has spawned an international controversy over the appropriateness of controls on deforestation and energy use. In order to address the political debate it is essential to understand the scientific background that underlies this problem. Laboratory Earth takes the reader on a journey from the dawn of earth's climate and biological evolution through the era of the dinosaurs, past the Ice Age and into the shadowy environmental future increasingly dominated by human activities. In the final analysis it will be human values more than scientific methods that must be applied to decide how to gamble with the fate of the earth.
Why we should prepare for climate change now by taking anticipatory action in vulnerable regions. Global momentum is building to reduce greenhouse gas emissions. So far, so good. The less happy news is that Earth's temperatures will continue to rise for decades. And evidence shows that climbing temperatures are already having serious consequences for vulnerable people and regions through droughts, extreme weather, and melting glaciers. In this book, climate experts Michael Mastrandrea and Stephen Schneider argue that we need to start adapting to climate change, now. They write that these efforts should focus primarily on identifying the places and people most at risk and taking anticipatory action—from developing drought-resistant crops to building sea walls. The authors roundly reject the idea that reactive, unplanned adaptation will solve our problems—that species will migrate northward as climates warm, and farmers will shift to new crops and more hospitable locations. And they are highly critical of “geoengineering” schemes that are designed to cool the planet by such methods as injecting iron into oceans or exploding volcanoes. Mastrandrea and Schneider insist that smart adaptation will require a series of local and regional projects, many of them in the countries least able to pay for them and least responsible for the problem itself. Ensuring that we address the needs of these countries, while we work globally to reduce emissions over the long term, is our best chance to avert global disaster and to reduce the terrible, unfair burdens that are likely to accompany global warming.
Does the solution to our energy crisis depend upon the de velopment of coal, nuclear, solar, or some other energy source? Are we better off because science and technology have made us less vulnerable to natural catastrophes? How, in fact, do we see ourselves now in relation to our natural world? The answers to these questions lie as much within the humanities as in the sciences. Problems as seemingly unrelated as our vulnerability to OPEC oil price hikes or a smog alert in Los Angeles or Tokyo often have common, hidden causes. One of these causes is simply the way our society sees its place in nature. There are many reasons for the heavy demand for oil. Among these we vii viii I PREFACE can include desire for industrial growth, hopes for improved living standards, mobility through automobiles and rapid transportation systems, and, not least, an attempt to loosen the constraints on man imposed by nature. These constraints and man's concomitant dependence upon nature are exam ples of the intense and finely interwoven relationship be tween man and nature, a relationship that constitutes a pri mordial bond forged long before the era of modem technology. Similarly, man has explored this primordial bond through the humanities for all the centuries prior to our present techno logical age. As we will see in this exploration, the bond un derlies many of the environmental and technological prob lems we have come to label the ecological crisis.
This three-volume A-to-Z compendium consists of over 300 entries written by a team of leading international scholars and researchers working in the field. Authoritative and up-to-date, the encyclopedia covers the processes that produce our weather, important scientific concepts, the history of ideas underlying the atmospheric sciences, biographical accounts of those who have made significant contributions to climatology and meteorology and particular weather events, from extreme tropical cyclones and tornadoes to local winds.
Little is known about the early childhood of Jesus Christ. But in the decades after his death, stories began circulating about his origins. One collection of such tales was the so-called Infancy Gospel of Thomas, known in antiquity as the Paidika or “Childhood Deeds” of Jesus. In it, Jesus not only performs miracles while at play (such as turning clay birds into live sparrows) but also gets enmeshed in a series of interpersonal conflicts and curses to death children and teachers who rub him the wrong way. How would early readers have made sense of this young Jesus? In this highly innovative book, Stephen Davis draws on current theories about how human communities construe the past to answer this question. He explores how ancient readers would have used texts, images, places, and other key reference points from their own social world to understand the Christ child’s curious actions. He then shows how the figure of a young Jesus was later picked up and exploited in the context of medieval Jewish-Christian and Christian-Muslim encounters. Challenging many scholarly assumptions, Davis adds a crucial dimension to the story of how Christian history was created.
Encompasses the entire range of industrial refractory materials and forms: properties and their measurement, applications, manufacturing, installation and maintenance techniques, quality assurance, and statistical process control.
This latest comprehensive work on Simon Magus lends new impetus to the investigation of Early Christianity and questions surrounding the origin and nature of Gnosticism. Major contributions of this study include: (1), a departure from the traditional exegesis of Acts 8, 5-24 (the first narrative source of Simon), and the later following reports of ancient Christian writers; (2), an overview of the literature of Graeco-Roman antiquity to determine the contribution of "magic" and "the Magoi" in the development of perceptions and descriptions of Simon; and (3), the inclusion of social science explanation models and modern estimations of "identity", in a creative approach to questions surrounding the phenomenon of Simon.
A high percentage of patients with dementia experience debilitating pain. Untreated, it can result in mental and physical impairment; a higher frequency of neuropsychiatric symptoms such as agitation, depression, and sleep problems; and adverse events such as falls, hallucination, and even death. With the help of Pain in Dementia, you can learn new ways to give these patients a better quality of life! A multidisciplinary team of leading experts navigates the complex clinical challenges associated with pain among these patients. They identify the sources of pain, even in patients who have trouble communicating, and recommend the most effective pain treatment options.
Wide bandgap semiconductors, made from such materials as GaN, SiC, diamond, and ZnSe, are undergoing a strong resurgence in recent years, principally because of their direct bandgaps, which give them a huge advantage over the indirect gap Sic As an example, more than 10 million blue LEDs using this technology are sold each month, and new, high brightness (15 lumens per watt), long-life white LEDs are under development with the potential to replace incandescent bulbs in many situations. This book provides readers with a broad overview of this rapidly expanding technology, bringing them up to speed on new discoveries and commercial applications. It provides specific technical applications of key processes such as laser diodes, LEDs, and very high temperature electronic controls on engines, focusing on doping, etching, oxidation passivation, growth techniques and more.
This book gives a comprehensive introduction to Comparative Indo-European Linguistics. It starts with a presentation of the languages of the family (from English and the other Germanic languages, the Celtic and Slavic languages, Latin, Greek and Sanskrit through Armenian and Albanian) and a discussion of the culture and origin of the Indo-Europeans, the speakers of the Indo-European proto-language.The reader is introduced into the nature of language change and the methods of reconstruction of older language stages, with many examples (from the Indo-European languages). A full description is given of the sound changes, which makes it possible to follow the origin of the different Indo-European languages step by step. This is followed by a discussion of the development of all the morphological categories of Proto-Indo-European. The book presents the latest in scholarly insights, like the laryngeal and glottalic theory, the accentuation, the ablaut patterns, and these are systematically integrated into the treatment. The text of this second edition has been corrected and updated by Michiel de Vaan. Sixty-six new exercises enable the student to practice the reconstruction of PIE phonology and morphology.
With clarity and grace, Stephen Bocking tackles the complicated question of the role of scientific expertise in environmental policy making. Nature’s Experts is a timely and important book."—David H. Guston, author of Between Politics and Science: Assuring the Integrity and Productivity of Research "This book by Stephen Bocking is as much about deliberative democracy as it is about science and the environment. Stephen Bocking’s treatment is deep, perceptive, and profoundly wise. He has caught the heart of present and future environmental science, politics, and democratic governance."—C. S. Holling, The Resilience Alliance and emeritus professor, Arthur R. Marshall Jr. Chair in Ecological Sciences at the University of Florida "If knowledge is power, how should expert advice be deployed by a would-be democratic society? This perennial question is newly illuminated by this timely and wide-ranging review of the role played by science in the making of environmental policy."—William C. Clark, Harvey Brooks Professor of International Science, Public Policy, and Human Development, Harvard University, John F. Kennedy School of Government It seems self-evident that science plays a central role in environmental affairs. Regulatory agencies, businesses, and public interest groups all draw on scientific research to support their claims. Some critics, however, describe science not as the solution to environmental problems, but as their source. Moreover, the science itself is often controversial, as debates over global warming and environmental health risks have shown. Nature’s Experts explores the contributions and challenges presented when scientific authority enters the realm of environmental affairs. Stephen Bocking focuses on four major areas of environmental politics: the formation of environmental values and attitudes, management of natural resources such as forests and fish, efforts to address international environmental issues such as climate change, and decisions relating to environmental and health risks. In each area, practical examples and case studies illustrate that science must fulfill two functions if it is to contribute to resolving environmental controversies. First, science must be relevant and credible, and second, it must be democratic, where everyone has access to the information they need to present and defend their views.
Little is known about those at the command end of policing in Europe. Over the last two years, Bryn Caless and Steve Tong have had unique access to those at the top of Europe's police forces, obtaining detailed comments from more than a hundred strategic police leaders in 22 countries and presenting, for the first time, information about how they are selected for high office, how they are held to account and what their views are on current and future challenges in policing. Building on research conducted in the UK, this is a timely and unparalleled insight into a little-known elite in the law-enforcement world.
Shaping the views of scholars and policymakers on how to address unemployment, the contributions of Layard and Nickell have served to illuminate the policy discourse in Europe. The book includes their key writings on the subject together with a new essay on what should be done during recession.
This study is an analysis of 'high' and 'late' modernist criticism in New York during the 1960s and early 1970s. Through a close reading of a selection of key critics of the period—which will expand the remit beyond the canonical texts—the book examines the ways that modernist criticism’s discourse remains of especial disciplinary interest. Despite its alleged narrowness and exclusion, the debates of the 1960s raised fundamental questions concerning the nature of art writing. Those include arguments around the nature of value and judgement; the relationship between art criticism and art history; and the related problem of what we mean by the ‘contemporary.’ Stephen Moonie argues that within those often-fractious debates, there exists a shared discourse. And further, contrary to the current consensus that modernists were elitist, dogmatic, and irrelevant to contemporary debates on art, the study shows that there is much that we can learn from reconsidering their writings. The book will be of interest to scholars working in art history, modern art, art criticism, and literary studies.
Schneider's firsthand account of a scientific and political odyssey, in which he navigates both the turbulent waters of the world's power structures and the arcane theater of academic debaters.
Why we should prepare for climate change now by taking anticipatory action in vulnerable regions. Global momentum is building to reduce greenhouse gas emissions. So far, so good. The less happy news is that Earth's temperatures will continue to rise for decades. And evidence shows that climbing temperatures are already having serious consequences for vulnerable people and regions through droughts, extreme weather, and melting glaciers. In this book, climate experts Michael Mastrandrea and Stephen Schneider argue that we need to start adapting to climate change, now. They write that these efforts should focus primarily on identifying the places and people most at risk and taking anticipatory action—from developing drought-resistant crops to building sea walls. The authors roundly reject the idea that reactive, unplanned adaptation will solve our problems—that species will migrate northward as climates warm, and farmers will shift to new crops and more hospitable locations. And they are highly critical of “geoengineering” schemes that are designed to cool the planet by such methods as injecting iron into oceans or exploding volcanoes. Mastrandrea and Schneider insist that smart adaptation will require a series of local and regional projects, many of them in the countries least able to pay for them and least responsible for the problem itself. Ensuring that we address the needs of these countries, while we work globally to reduce emissions over the long term, is our best chance to avert global disaster and to reduce the terrible, unfair burdens that are likely to accompany global warming.
Praised by JAMA as "The most complete description of the development, structure, function, pathophysiology, and treatment of the retina and its diseases to be found anywhere," this monumental three-volume work puts all of today's scientific and clinical knowledge of the retina at readers' fingertips. The New Edition has been comprehensively updated and reorganized to reflect all of the very latest scientific and genetic discoveries, diagnostic imaging methods, drug therapies, treatment recommendations, and surgical techniques. The result is an indispensable reference and diagnostic tool for generalists and specialists alike. Delivers the editorial expertise of four highly respected authorities, as well as contributions from internationally recognized leaders in visual science, ophthalmology, and vitreoretinal studies. Presents more than 3,400 superb illustrations (2,200 in full color) that capture all forms of retinal disease from every perspective. Offers the very latest information on the genetic basis of retinal disease, diagnostic retinal imaging, photodynamic therapy, and age-related macular degeneration. Examines the most recent advances in diagnostic indocyanine green angiography � optical coherence tomography (OCT) and quantitative fluoroscein angiography � macular translocation with 360� peripheral retinectomy � surgery for diffuse macular edema due to multiple causes, including proliferative vitreoretinopathy � artificial vision � and much more. Features a completely restructured section on age-related macular degeneration that includes epidemiology and risk factors � prophylaxis and prevention knowledge gained from large clinical trials like AREDS � proven and experimental treatments for AMD � and pharmacotherapy. Incorporates a multitude of new full-color images, 2200 in all.
This timely book provides a comprehensive insight into the challenges facing humanity and Earth in the 21st century. It opens with a discussion of the domination of all the continents and oceans by a growing human population. This is followed by an appraisal of the extent to which water and food supplies will be able to accommodate this population, which may reach eleven billion by 2100. The rapidly increasing ability to change biology and evolution through genomics is considered next and complements a discussion of disease, which is viewed largely as an evolutionary struggle between humanity and pathogens. A seemingly insatiable demand for energy, future energy supplies and the impact of their use on climate and attempts to ameliorate these effects are next examined. The book concludes with a discussion of the partial destruction of the ozone layer and the international effort to repair the damage./a
A guide to "when to" and "what to" rather than "how to," this book provides evidence-based surgical reviews to provide credible answers to age-old surgical management questions. The management issues presented are oriented toward interventions and use evidence-based techniques to assess the safety and efficacy of new treatments and rehabilitative or preventative interventions. Each chapter is organized around the key questions essential to delineating the current status of evidence related to the subject reviewed. Publications from the past decade are cited that provide Level I and II evidence using the Oxford scale. Throughout Elective General Surgery, careful assessment of the validity of intervention studies and the strength of the evidence that they provide underlies the choices of cited publications. The information presented in this volume guides the scientific surgeon in providing state-of-the-art care and in optimizing the use of medical resources without losing sight of the need to address the unique needs of individual patients.
Unequalled in scope, depth, and clinical precision, Retina, 5th Edition keeps you at the forefront of today's new technologies, surgical approaches, and diagnostic and therapeutic options for retinal diseases and disorders. Comprehensively updated to reflect everything you need to know regarding retinal diagnosis, treatment, development, structure, function, and pathophysiology, this monumental ophthalmology reference work equips you with expert answers to virtually any question you may face in practice. Benefit from the extensive knowledge and experience of esteemed editor Dr. Stephen Ryan, five expert co-editors, and a truly global perspective from 358 other world authorities across Europe, Asia, Australasia the Americas.Examine and evaluate the newest diagnostic technologies and approaches that are changing the management of retinal disease, including future technologies which will soon become the standard.Put the very latest scientific and genetic discoveries, diagnostic imaging methods, drug therapies, treatment recommendations, and surgical techniques to work in your practice.
Since 1975, Dr. Kenneth Swaiman's classic text has been the reference of choice for authoritative guidance in pediatric neurology, and the 6th Edition continues this tradition of excellence with thorough revisions that bring you fully up to date with all that's new in the field. Five new sections, 62 new chapters, 4 new editors, and a reconfigured format make this a comprehensive and clearly-written resource for the experienced clinician as well as the physician-in-training. - Nearly 3,000 line drawings, photographs, tables, and boxes highlight the text, clarify key concepts, and make it easy to find information quickly.
Managing the Drug Discovery Process, Second Edition thoroughly examines the current state of pharmaceutical research and development by providing experienced perspectives on biomedical research, drug hunting and innovation, including the requisite educational paths that enable students to chart a career path in this field. The book also considers the interplay of stakeholders, consumers, and drug firms with respect to a myriad of factors. Since drug research can be a high-risk, high-payoff industry, it is important to students and researchers to understand how to effectively and strategically manage both their careers and the drug discovery process. This new edition takes a closer look at the challenges and opportunities for new medicines and examines not only the current research milieu that will deliver novel therapies, but also how the latest discoveries can be deployed to ensure a robust healthcare and pharmacoeconomic future. All chapters have been revised and expanded with new discussions on remarkable advances including CRISPR and the latest gene therapies, RNA-based technologies being deployed as vaccines as well as therapeutics, checkpoint inhibitors and CAR-T approaches that cure cancer, diagnostics and medical devices, entrepreneurship, and AI. Written in an engaging manner and including memorable insights, this book is aimed at anyone interested in helping to save countless more lives through science. A valuable and compelling resource, this is a must-read for all students, educators, practitioners, and researchers at large—indeed, anyone who touches this critical sphere of global impact—in and around academia and the biotechnology/pharmaceutical industry. - Considers drug discovery in multiple R&D venues - big pharma, large biotech, start-up ventures, academia, and nonprofit research institutes - with a clear description of the degrees and training that will prepare students well for a career in this arena - Analyzes the organization of pharmaceutical R&D, taking into account human resources considerations like recruitment and configuration, management of discovery and development processes, and the coordination of internal research within, and beyond, the organization, including outsourced work - Presents a consistent, well-connected, and logical dialogue that readers will find both comprehensive and approachable - Addresses new areas such as CRISPR gene editing technologies and RNA-based drugs and vaccines, personalized medicine and ethical and moral issues, AI/machine learning and other in silico approaches, as well as completely updating all chapters
This unique and practical resource provides the most complete and concise summary of underlying principles and approaches to studying nucleic acid structure, including discussion of x-ray crystallography, NMR, molecular modelling, and databases. Its focus is on a survey of structures especially important for biomedical research and pharmacological applications. To aid novices, Principles of Nucleic Acid Structure includes an introduction to technical lingo used to describe nucleic acid structure and conformations (roll, slide, twist, buckle, etc.). This completely updated edition features expanded coverage of the latest advances relevant to recognition of DNA and RNA by small molecules and proteins. In particular, the reader will find extensive new discussions on: RNA folding, ribosome structure and antibiotic interactions, DNA quadruplexes, DNA and RNA protein complexes, and short interfering RNA (siRNA). This handy guide ends with a complete list of resources, including relevant online databases and software. - Completely updated with expanded discussion of topics such as RNA folding, ribosome structure and antibiotic interactions, DNA quadruplexes, DNA and RNA protein complexes, and short interfering RNA (siRNA) - Includes a complete list of resources, including relevant online databases and software - Defines technical lingo for novices
This book examines the role of neurons in multiple sclerosis (MS) and the changes that occur in neurons as a result of MS. It places MS in a new and important perspective that not only explains the basis for symptom production, remission, and progress in MS, but also promises to open up new therapeutic possibilities.* Brings together the latest information from clinical, pathological, imaging, molecular, and pharmacological realms to explore the neurobiology of Multiple Sclerosis* Places MS in a new and important perspective that promises to open up new therapeutic avenues* Superbly illustrated and referenced
The Structure of Rare-Earth Metal Surfaces introduces the concepts of surface crystallography and surface-structure determination, outlines the principles of the most widely used experimental techniques and theoretical simulations, and reviews their application to the surfaces of rare-earth metals. In particular, the results of quantitative low-energy electron-diffraction experiments and multiple-scattering calculations axe covered in some depth. The book is aimed at science graduates with an interest in surface crystallography.
The purchase of this ebook edition does not entitle you to receive access to the Connected eBook on CasebookConnect. You will need to purchase a new print book to get access to the full experience including: lifetime access to the online ebook with highlight, annotation, and search capabilities, plus an outline tool and other helpful resources. Dispute Resolution: Negotiation, Mediation, Arbitration, and Other Processes, Seventh Edition Provides overviews, critical examinations, and analyses of the application of ADR’s three main processes for settling legal disputes without litigation— negotiation, mediation, and arbitration—and issues raised as these processes are combined, modified, and applied. This casebook challenges students to develop new processes and applications and provides them tools to master the legal issues facing lawyers who utilize the major dispute resolution processes. this book also assists students in building the skills a modern lawyer needs to represent clients in these critical processes. New to the Seventh Edition: New materials and exercises on legislative negotiation and causes and suggestions for remedying Congressional gridlock in negotiating legislative solutions to national problems. (First treatment of this issue in any law school negotiation/dispute resolution teaching book.) Negotiation simulations in which students play the roles of members of Congress and state legislators. Additional treatment of developing online dispute resolution processes. Expansion of dispute systems design materials to include community disputes. New materials designed to help students understand the mediation privilege, including a “debate” about the policy choices implicit in it and more depth on both the Uniform Mediation Act and the California mediation privilege experiences. Addition of multiple new Supreme Court arbitration cases, including American Express Company. v. Italian Colors Restaurant, Oxford Health Plans LLC v. Sutter, and Epic Systems, Inc. v. Lewis, addressing the continuing viability of the vindication of rights doctrine in arbitration, judicial review of an arbitrator’s decision to order a class action arbitration, and whether the NLRA should be interpreted to preclude employers from using class action waivers in agreements with their employees. Additional discussion of 2018-19 Supreme Court arbitration cases, including New Prime, Inc. v. Oliveira and Lamps Plus Inc. v. Varela. Consideration of the #Metoo movement and its impact on arbitration agreements and confidentiality in dispute resolution processes. Discussion of state and federal legislation addressing the use of arbitration for sexual harassment claims, including federal legislation like the End Forced Arbitration of Sexual Harassment Act bill. Substantial reorganization of the chapters on mediation, arbitration, and their variants, so that when students arrive at the new Chapter 8, Representing a Client in ADR (formerly Representing a Client in Mediation), the student is capable, as the modern lawyer should be, of representing a client in all ADR processes. The new emphasis is on facing the future. In addition to learning about ADR responses to existing matters, the student is challenged to put that learning to use in applying current ADR procedures to newly-developing issues, and in developing new processes when existing ones do not meet the client’s needs. Professors and students will benefit from: Thorough, systematic coverage, moving from overviews to critical analysis, application, evaluation, and practice A distinguished and experienced author team A direct and accessible writing style A wealth of simulations (both classic and new) and questions throughout Simulations allow students to evaluate, prepare for, and practice the various dispute resolution techniques Strong coverage of mediation
This book begins with a synopsis of experimental work underlying degeneration and recovery in the nervous system, which is then discussed in the context of strategies to repair the central nervous system (CNS) and peripheral nervous system (PNS). The major part of the book is given over to the approach involving the use of transplanted tissues to replace and restore disrupted neural networks. This experimental work has formed the basis for the emerging clinical trials employing neural grafts for diseases such as Parkinson's and Huntington's, which are discussed in detail. The book then goes on to discuss newer cellular strategies involving the manipulation of neural cells both in culture and genetically, an approach that may ultimately be employed in the clinical situation. Neural Repair, Transplantation and Rehabilitation is unique in bridging the gap from experimental studies to clinical trials, whilst also providing the non-specialist with a background in rehabilitation strategies as well as basic neuroscience. It is recommended for all those involved in the management of patients with degenerative and traumatic injuries to the nervous system.
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