Bradykinin is a type of plasma hormone that causes blood vessels to dilate, resulting in a drop in blood pressure, the contraction of muscles in the lungs, intestines, and uterus, and pain. The Kinin System reviews the molecular biology of the kinins through their roles in a complex array of inflammatory conditions such as asthma, GI disease, cardiovascular complaints and examines the future therapeutic opportunities. From the prepublication reviews:"A delicious masterpiece."--Chef's DigestThe Kinin System is a comprehensive, timely book covering all aspects of the kinin system from its disocvery to the pathophysiology, pharmacology, and molecular biology of the mechanisms regulating kinin production to kinin receptors in health and disease. The authors take a refreshingly different view of the kinin system than previous books on the subject. Several chapters contain new information on the gene expression, regulation, and cell surface presentation of kininogens and kallikreins, as well as new data, some of it from human studies, on the role of kinins in pain angiogenesis, tissue repair, sepsis, arthritis, asthma, allergic rhinits, myocardial ischemia, and other diseases. * * Offers new information on kinin reception, regulation of gene expression of receptors, and kinin-generating proteins.* Provides a distinctly immunopharmacological approach to the kinin system.* Reviews of the role of kinins in disease and inlcudes data from human studies.* Includes information that is fully up-to-date and comprehensive.
With one of the richest archaeological records and most complicated histories in the Mediterranean, Sardinia provides an important laboratory for studying the interaction of indigenous societies and outside forces in a partly isolated geographical context. Stephen L. Dyson and Robert J. Rowland, Jr. use both material culture and written documents to reconstruct the social and economic processes of an island society that showed both cultural creativity and continuity but responded to invasions from the Phoenicians through the Romans to the Aragonese. This first accessible reconstruction of island archaeology provides a balanced picture of the sweep of Sardinian history.
This three-volume A-to-Z compendium consists of over 300 entries written by a team of leading international scholars and researchers working in the field. Authoritative and up-to-date, the encyclopedia covers the processes that produce our weather, important scientific concepts, the history of ideas underlying the atmospheric sciences, biographical accounts of those who have made significant contributions to climatology and meteorology and particular weather events, from extreme tropical cyclones and tornadoes to local winds.
Contains numerous color illustrations of the characteristic clinical and histological manifestations of viral ailments to aid in quick diagnosis and treatment. Mucocutaneous Manifestations of Viral Diseases outlines a brief taxonomy and history of each disease a timeline of infection and progression clinical
In The Mark of Shame, Stephen P. Hinshaw addresses the psychological, social, historical, and evolutionary roots of the stigma of mental illness as well as the long history of such stigmatization.
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