Polysaccharides and related high molecular weight glycans are hugely diverse with wide application in Biotechnology and great opportunities for further exploitation. An Introduction to Polysaccharide Biotechnology – a second edition of the popular original text by Tombs and Harding – introduces students, researchers, clinicians and industrialists to the properties of some of the key materials involved, how these are applied, some of the economic factors concerning their production and how they are characterized for regulatory purposes.
Focusing on men from old families in England’s Wirral and West Lancashire regions, this survey traces the DNA of the local populace back to their Viking ancestors in order to determine the impact of past societies on their genetic make-up. Arguing that the areas exhibit many archaeological and historical features proving them to have had a clear Viking presence, this account provides background information on Viking settlements as well as conclusions drawn from the DNA testing. An illustrated example of how DNA methods can be used to learn about the past is also included.
Good,No Highlights,No Markup,all pages are intact, Slight Shelfwear,may have the corners slightly dented, may have slight color changes/slightly damaged spine.
Managing the Drug Discovery Process, Second Edition thoroughly examines the current state of pharmaceutical research and development by providing experienced perspectives on biomedical research, drug hunting and innovation, including the requisite educational paths that enable students to chart a career path in this field. The book also considers the interplay of stakeholders, consumers, and drug firms with respect to a myriad of factors. Since drug research can be a high-risk, high-payoff industry, it is important to students and researchers to understand how to effectively and strategically manage both their careers and the drug discovery process. This new edition takes a closer look at the challenges and opportunities for new medicines and examines not only the current research milieu that will deliver novel therapies, but also how the latest discoveries can be deployed to ensure a robust healthcare and pharmacoeconomic future. All chapters have been revised and expanded with new discussions on remarkable advances including CRISPR and the latest gene therapies, RNA-based technologies being deployed as vaccines as well as therapeutics, checkpoint inhibitors and CAR-T approaches that cure cancer, diagnostics and medical devices, entrepreneurship, and AI. Written in an engaging manner and including memorable insights, this book is aimed at anyone interested in helping to save countless more lives through science. A valuable and compelling resource, this is a must-read for all students, educators, practitioners, and researchers at large—indeed, anyone who touches this critical sphere of global impact—in and around academia and the biotechnology/pharmaceutical industry. Considers drug discovery in multiple R&D venues - big pharma, large biotech, start-up ventures, academia, and nonprofit research institutes - with a clear description of the degrees and training that will prepare students well for a career in this arena Analyzes the organization of pharmaceutical R&D, taking into account human resources considerations like recruitment and configuration, management of discovery and development processes, and the coordination of internal research within, and beyond, the organization, including outsourced work Presents a consistent, well-connected, and logical dialogue that readers will find both comprehensive and approachable Addresses new areas such as CRISPR gene editing technologies and RNA-based drugs and vaccines, personalized medicine and ethical and moral issues, AI/machine learning and other in silico approaches, as well as completely updating all chapters
This thrilling wartime adventure tells the true story of the downed American aviators who were rescued by French resistance fighters, taken to Nazi-occupied Paris, and hidden under the very noses of the Gestapo. Escape from Paris is the true story of a small group of U.S. aviators whose four B-17 Flying Fortresses were shot down over German-occupied France on a single, fateful day: July 14, 1943, Bastille Day. They were rescued by brave French civilians and taken to Paris for eventual escape out of France. In the French capital, where German troops walked on every street and Gestapo agents hid around every corner, the flyers met a brave Parisian resistance family living and working in the Hôtel des Invalides, a complex of buildings and military memorials, where Nazi officials had set up offices. Hidden in the complex the Americans, along with dozens of other downed Allied pilots and resistance operatives, hatched daring escape plots. The danger of discovery by the Nazis grew every day, as did an unlikely romance when one of the American airmen begins a star-crossed wartime romance with the twenty-two-year old daughter of the family sheltering him—a noir tale of war, courage and desperation in the shadows of the City of Light. Based on official American, French, and German documents, histories, personal memoirs, and the author's interviews with several of the story's key participants, Escape from Paris crosses the traditional lines of World War II history with tense drama of air combat over Europe, the intrigue of occupied Paris, and courageous American and Allied pilots and French resistance fighters pitted against Nazi thugs. All of this set in one of the world's most beautiful and captivating cities.
Who are we and how do we define our inner selves? In his last work, Professor Stephen Prickett presents a literary and cultural exploration of our inner selves – and how we have created and written about them – from the Old Testament to social media. What he finds is that although our secret, inner, sense of self – what we feel makes us distinctively 'us' – seems a natural and permanent part of being human, it is in fact surprisingly new. Whilst confessional religious writings, from Augustine to Jane Austen, or even diaries of 20th-century Holocaust victims, have explored inwards as part of a path to self-discovery, our inner space has expanded beyond any possible personal experience. This development has enhanced our capacity not merely to write about what we have never seen, but even to create fantasies and impossible fictions around them. Yet our secret selves can also be a source of terror. The fringes of our inner worlds are often porous, ill-defined and susceptible to frightening forms of external control. Mystics and poets, from Dante to John Henry Newman or Gerard Manley Hopkins, sought God in their secret spaces not least because they feared the 'abyss beneath.' From the origin of human consciousness through modern history and into the future, Secret Selves uses literature to consider the profound possibilities and ramifications of our evolving ideas of self.
Around 1,100 years ago a group of Vikings arrived in Wirral from Ireland which began an influx of Vikings into the area. These settlers established their own community and this comprehensively updated book explores the history of these people and their legacy.
1100 years ago marked the start of a Viking invasion of the Mersey region, which reached out into Chester, West Lancashire and beyond. The Vikings left behind place-names like Kirkby, Kirby, Meols and Croxteth, which can also be found in Iceland, another region they were invading. This book is about these people in peace and war, their customs, traditions, pastimes, their paganism and their Christianity, their governments and their financial centre at Chester. It also includes a section on how modern genetic research is being used to discover the descendants of these Invaders in the modern day population.
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