Genome Duplication provides a comprehensive and readable overview of the underlying principles that govern genome duplication in all forms of life, from the simplest cell to the most complex multicellular organism. Using examples from the three domains of life - bacteria, archaea, and eukarya - Genome Duplication shows how all living organisms store their genome as DNA and how they all use the same evolutionary-conserved mechanism to duplicate it: semi-conservative DNA replication by the replication fork. The text shows how the replication fork determines where organisms begin genome duplication, how they produce a complete copy of their genome each time a cell divides, and how they link genome duplication to cell division. Genome Duplication explains how mistakes in genome duplication are associated with genetic disorders and cancer, and how understanding genome duplication, its regulation, and how the mechanisms differ between different forms of life, is critical to the understanding and treatment of human disease.
Increasingly significant as mediators of spatial identity and meaning, leisure, tourism, culture and heritage are only now beginning to be located within the rapidly evolving discourses of poststructuralist geographies. Exploring the influence of leisure and tourism on the production, representation and consumption of landscape, the first half of this important book focuses on different ways of ‘seeing’ or representing landscape, whereas the second half examines different forms of productive consumption in leisure and tourism. Both symbolic and material spaces of leisure and tourism are also examined in relation to urban and rural landscapes, heritage landscapes, gendered landscapes, and landscapes of sexuality and desire. With a multidisciplinary approach and a strong theoretical content which builds on poststructuralist theories, this is undoubtedly an important addition to literature in the field.
Broad-ranging and comprehensive, this incisive new textbook examines the shifting meanings of 'race' and ethnicity and collates the essential concepts in one indispensable companion volume. From Marxist views to post-colonialism, this book investigates the attendant debates, issues and analyses within the context of global change. Using international case studies from Australia, Malaysia, the Caribbean, Mexico and the UK and examples of popular imagery that help to explain the more difficult elements of theory, this key text focuses on everyday life issues such as: ethnic conflicts and polarized states racism(s) and policies of multiculturalism diasporas, asylum seekers and refugees mixed race and hybrid identity Incorporating summaries, questions, illustrations, exercises and a glossary of terms, this student-friendly text also puts forward suggestions for further project work. Broad in scope, interactive and accessible, this book is a key resource for undergraduate and postgraduate level students of 'race' and ethnicity across the social sciences.
More than a hundred years after its founding, psychoanalysis remains influential and controversial far outside its core sphere of activity in the 'clinic'. In a wide range of cultural and social disciplines, psychoanalytic ideas are drawn on to explain human subjectivity and its relationship with the social world. This lucid and engaging book explores these interventions through detailed examination of how psychoanalytic ideas apply in literature, politics, social psychology, philosophy and psychosocial studies. The highly-regarded and influential author, Stephen Frosh, shows how psychoanalysis can at times greatly illuminate these fields of study, and how at other times it might misread them. He also asks what psychoanalysis can learn from the disciplines with which it is in dialogue, and particularly how it can retain its own capacity for critical thought. Sophisticated and stimulating, yet accessible and approachable, this important book: - Provides a critical exploration that will stimulate further debate about the place of psychoanalysis in intellectual life - Develops the newly emerging psychosocial perspective as one that links psychological and social theories in novel ways. Psychoanalysis Outside the Clinic will be of profound interest to students and academics across a wide range of disciplines, particularly those taking courses in social, cultural or political theory at undergraduate or postgraduate level or studying on programmes in Psychoanalytic or Psychosocial Studies.
Two main criteria have guided the selection and presentation of the material for this text-book. Firstly, there is the claim that sociology is a science. Throughout, the emphasis has been on presenting sociological perspectives rather than conveying a mass of factual information. Science is essentially analytical. And sociology, if it is to justify its claim to be a science, must be more than simply 'political arithmetic', counting heads and providing demographic data for governments. Secondly, science, like other intellectual activities, can be exciting. The emphasis throughout is on the sociological study of industrial society, with particular reference to modern England. After an introductory discussion of sociological perspectives, there are chapters on each of the major sub-systems of society; the family, the educational system, the economy, the political system and belief systems. The book ends with three chapters on major social processes: social differentiation and stratification, organization, and finally, social change, including a discussion of deviancy and disorganization.
A high percentage of patients with dementia experience debilitating pain. Untreated, it can result in mental and physical impairment; a higher frequency of neuropsychiatric symptoms such as agitation, depression, and sleep problems; and adverse events such as falls, hallucination, and even death. With the help of Pain in Dementia, you can learn new ways to give these patients a better quality of life! A multidisciplinary team of leading experts navigates the complex clinical challenges associated with pain among these patients. They identify the sources of pain, even in patients who have trouble communicating, and recommend the most effective pain treatment options.
Intimate partner violence is a complex, ugly, fear-inducing reality for large numbers of women around the world. When violence exists in a relationship, safety is compromised, shame abounds, and peace evaporates. Violence is learned behavior and it flourishes most when it is ignored, minimized, or misunderstood. When it strikes the homes of deeply religious women, they are: more vulnerable; more likely to believe that their abusive partners can, and will, change; less likely to leave a violent home, temporarily or forever; often reluctant to seek outside sources of assistance; and frequently disappointed by the response of the religious leader to their call for help. These women often believe they are called by God to endure the suffering, to forgive (and to keep on forgiving) their abuser, and to fulfill their marital vows until death do us part. Concurrently, many batterers employ explicitly religious language to justify the violence towards their partners, and sometime they manipulate spiritual leaders who try to offer them help. Religion and Intimate Partner Violence seeks to navigate the relatively unchartered waters of intimate partner violence in families of deep faith. The program of research on which it is based spans over twenty-five years, and includes a wide variety of specific studies involving religious leaders, congregations, battered women, men in batterer intervention programs, and the army of workers who assist families impacted by abuse, including criminal justice workers, therapeutic staff, advocacy workers, and religious leaders. The authors provide a rich and colorful portrayal of the intersection of intimate partner violence and religious beliefs and practices that inform and interweave throughout daily life. Such a focus on lived religion enables readers to isolate, examine, and evaluate ways in which religion both augments and thwarts the journey towards justice, accountability, healing and wholeness for women and men caught in the web of intimate partner violence.
Presenting a comprehensive treatment of grinding theory and its practical utilization, this edition focuses on grinding as a machining process using bonded abrasive grinding wheels as the cutting medium. It provides a description of abrasives and bonded abrasive cutting tools.
This book describes the mechanisms that allow aquatic photosynthetic organisms to contribute about half of the global primary productivity; in order to mitigate climate change by sequestering carbon dioxide and producing oxygen, they transform the original anoxic atmosphere of the Earth over geological time. Aquatic photosynthesis is performed by a wide diversity of organisms, predominantly involving cyanobacteria, and algae derived from the “red-lineage”, unlike terrestrial primary productivity, which is restricted to “green-lineage” plants. Blue Planet, Red and Green Photosynthesis describes how, in order to maximize productivity, aquatic primary producers have evolved a series of structures and mechanisms that increase the limiting supply of carbon dioxide to the enzyme, Rubisco, which is responsible for carbon dioxide fixation. This book covers the molecular mechanisms involved in aquatic carbon uptake and the global consequences as humankind alters the blue planet.
Written expressly for non-neuropsychologists, this book offers a concise, friendly introduction to the developing brain and its functions. Stephen R. Hooper renders complex concepts accessible as he describes the structure of the brain and the workings of the nervous system. The book explains how findings from neuropsychological assessments can help educators and clinicians to better understand and remediate children's difficulties. A range of neurodevelopmental and medical conditions that affect learning and behavior from early childhood through adolescence are explored through a neuropsychological lens. Helpful features include key Take-Home Points distilled from the chapters and recommended print and online resources.
The ‘Key Issues in Higher Education’ series aims to raise both awareness and the standards of debate on the fundamental issues that lie at the very heart of higher education and intends to assist national and international debate. Higher Education and Sustainable Development examines whether it is actually possible to mandate, plan, monitor and evaluate the higher education sector’s route to the production of educated, innovative, independent, self-determining, critical individuals while at the same time achieving a range of wider policy goals on the side. This book examines this question in the context of a particular international policy issue – sustainable development – which is now seen across the globe as a necessary and urgent response to a range of social and environmental issues that threaten the integrity of the biosphere and human well being. The book concludes that the idea of sustainable development holds both opportunities and dangers for universities as they pursue their proper role in a free society. Illustrated by seven in-depth case studies this book considers the complex inter-relationships of a free society and sustainable development in the context of higher education, and aims to makes recommendations for realistic future development. It is essential reading for the international higher education research community, policy-makers, university managers, students and non-Governmental organizations in the development, environment and social policy sectors.
Law and Society in England 1750–1950 is an indispensable text for those wishing to study English legal history and to understand the foundations of the modern British state. In this new updated edition the authors explore the complex relationship between legal and social change. They consider the ways in which those in power themselves imagined and initiated reform and the ways in which they were obliged to respond to demands for change from outside the legal and political classes. What emerges is a lively and critical account of the evolution of modern rights and expectations, and an engaging study of the formation of contemporary social, administrative and legal institutions and ideas, and the road that was travelled to create them. The book is divided into eight chapters: Institutions and Ideas; Land; Commerce and Industry; Labour Relations; The Family; Poverty and Education; Accidents; and Crime. This extensively referenced analysis of modern social and legal history will be invaluable to students and teachers of English law, political science, and social history.
One of the keys to success in the IC industry is getting a new product to market in a timely fashion and being able to produce that product with sufficient yield to be profitable. There are two ways to increase yield: by improving the control of the manufacturing process and by designing the process and the circuits in such a way as to minimize the effect of the inherent variations of the process on performance. The latter is typically referred to as "design for manufacture" or "statistical design". As device sizes continue to shrink, the effects of the inherent fluctuations in the IC fabrication process will have an even more obvious effect on circuit performance. And design for manufacture will increase in importance. We have been working in the area of statistically based computer aided design for more than 13 years. During the last decade we have been working with each other, and individually with our students, to develop methods and CAD tools that can be used to improve yield during the design and manufacturing phases of IC realization. This effort has resulted in a large number of publications that have appeared in a variety of journals and conference proceedings. Thus our motivation in writing this book is to put, in one place, a description of our approach to IC yield enhancement. While the work that is contained in this book has appeared in the open literature, we have attempted to use a consistent notation throughout this book.
Destruction of temples and their transformation into churches are central symbols of late antique change in religious environment, socio-political system, and public perception. Contemporaries were aware of these events’ far-reaching symbolic significance and of their immediate impact as demonstrations of political power and religious conviction. Joined in any “temple-destruction” are the meaning of the monument, actions taken, and subsequent literary discourse. Paradigms of perception, specific interests, and forms of expression of quite various protagonists clashed. Archaeologists, historians, and historians of religion illuminate “temple-destruction” from different perspectives, analysing local configurations within larger contexts, both regional and imperial, in order to find an appropriate larger perspective on this phenomenon within the late antique movement “from temple to church”.
Now in its twelfth edition, Lewin's GENES continues to lead with new information and cutting-edge developments, covering gene structure, sequencing, organization, and expression. Leading scientists provide revisions and updates in their individual field of study offering readers current data and information on the rapidly changing subjects in molecular biology.
Like the previous versions, the fifth edition of An Introduction to Research in the Health Sciences has two overall aims. 1) To introduce the fundamental principles of research methodology and explain how these principles are applied for conducting research in the health sciences. 2) To demonstrate how evidence produced through research is applied to solving problems in everday health care. This book is written in an accessible style. It maintains the traditions of the previous editions, with examples, questions, feedback sections, and an extensive glossary. Uses simple language and demystifies the jargon Provides built-in feedback for readers to assess their own progress Gives examples relating directly to the health sciences Provides an extensive glossary for better understanding of the language of research Addresses qualitative as well as quantitative research issues Includes a chapter focussing on the use of qualitative methods in health research Includes a chapter for discussing systematic reviews and meta-analyses Contains more revision questions Increased emphasis throughout on evidence based concepts More and updated discussion of qualitative research methods New section on basic epidemiological concepts as a research approach More discussion of analysis and use of administrative and secondary data sets as research resources Complete rewrite of the chapter on causal research Stronger links between the sections on different stages of research
The last 2 decades have seen enormous strides in our understanding of the biological, genetic and clinical basis of the peripheral nerve disorders. This remains a difficult area for most practitioners. This text combines a thorough review of the neurologic literature with clinical experience in presenting a comprehensive yet concise and readable approach to the understanding, evaluation and management of these disorders. All practitioners seeing these patients, as well as all trainees in Neurology and related fields, should find this a useful, approachable initial resource.
This text offers an international and interdisciplinary analysis of the complex interactions between infrastructure networks and urban spaces. Drawing on case studies and examples from across the globe, it offers a statement on the urban condition.
This best-selling emergency department reference is now in its thoroughly updated Fourth Edition. The foremost authorities provide practical information on over 600 clinical problems in a fast-access two-page outline format that's perfect for on-the-spot consultation during care in the emergency department. Coverage of each disorder includes clinical presentation, pre-hospital, diagnosis, treatment, disposition, and ICD-9 coding. Icons enable practitioners to quickly spot the information they need. This edition provides up-to-date information on topics such as emerging infections, new protocols, and new treatments.
Contains biographies of 150 scientists, providing information on their early lives, formative experiences, and inspirations; and includes essays that discuss the importance of each scientist's work, profiles of people who influenced them, and sources for further reading.
Incorporates over a decade of new research and material on coping with the causes and consequencs that instigate culture shock, this can occur when a person is transported from a familiar to an alien culture.
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