A single species of fly, Drosophila melanogaster, has been the subject of scientific research for more than one hundred years. Why does this tiny insect merit such intense scrutiny? Drosophila's importance as a research organism began with its short life cycle, ability to reproduce in large numbers, and easy-to-see mutant phenotypes. Over time, laboratory investigation revealed surprising similarities between flies and other animals at the level of genes, gene networks, cell interactions, physiology, immunity, and behavior. Like humans, flies learn and remember, fight microbial infection, and slow down as they age. Scientists use Drosophila to investigate complex biological activities in a simple but intact living system. Fly research provides answers to some of the most challenging questions in biology and biomedicine, including how cells transmit signals and form ordered structures, how we can interpret the wealth of human genome data now available, and how we can develop effective treatments for cancer, diabetes, and neurodegenerative diseases. Written by a leader in the Drosophila research community, First in Fly celebrates key insights uncovered by investigators using this model organism. Stephanie Elizabeth Mohr draws on these "first in fly" findings to introduce fundamental biological concepts gained over the last century and explore how research in the common fruit fly has expanded our understanding of human health and disease.--
A single species of fly, Drosophila melanogaster, has been the subject of scientific research for more than one hundred years. Stephanie Elizabeth Mohr explains why this tiny insect merits such intense scrutiny, and how laboratory findings made first in flies have expanded our understanding of human health and disease.
Drosophila Cells in Culture, Second Edition, includes comprehensive coverage of cell lines, methods for creating cell lines, methods for genome engineering, and the use of cell lines for genome wide rNAi screens. This publication summarizes over thirty years of experience in the handling of in vitro cultured Drosophila cells alongside recent methods and functional screens. Early and experienced researchers studying drosophila in developmental biology, genetics, neuroscience, and across the biological and biomedical sciences will benefit from this expert knowledge. - Offers full coverage of cell lines and primary cultures - Provides a go-to resource for methods and studies completed with drosophila cells in culture - Presents a wide spectrum of experimental techniques
Forget Type As and Bs. The future lies with Type Rs-the resilient individuals, leaders, businesses, families, and communities who turn challenges into opportunities in times of upheaval, crisis, and change. In Type R, Ama Marston and Stephanie Marston explore Transformative Resilience and the strategies of those who use difficult circumstances as catalysts for growth -- springing forward rather than bouncing back during turbulent times. Here, Ama and Stephanie share inspiring stories of Type Rs thriving during unprecedented world events and increasing global pressures -- from climate change to financial crises. They share the individual and collective triumphs of people coping with the stress of daily life and the challenges and disruptions that rattle all our lives at some point. And they draw upon research that spans the personal and the professional, the local and the global. Reaching across psychology, neuroscience, business, and politics, Type R demonstrates how we can use challenges to innovate, create new strengths, and grow. Type R also teaches leaders, businesses, and organizations how to cultivate the critical Type R Vision and Culture, which is essential for navigating and thriving in disruptive change. This thought-provoking book proves that there is much we can learn from those who use change, stress, and adversity as springboards to progress in a chaotic world.
The gold-standard text on the diagnosis and treatment of disorders affecting the elderly – completely updated with a new full-color presentation A Doody's Core Title for 2021! The definitive treatise on the subject of geriatrics, this comprehensive text combines gerontology principles with clinical geriatrics, offering a uniquely holistic approach to this ever-expanding area of medicine. Written by some of the world’s most respected geriatricians, Hazzard’s Geriatric Medicine and Gerontology, Seventh Edition presents up-to-date, evidence-based information in a rich new full-color design. Unmatched as a textbook, this classic is also valuable to fellows in geriatric medicine. Hazzards’s Geriatric Medicine and Gerontology, Seventh Edition is logically divided into five parts: Principles of Gerontology, Principles of Geriatrics, Geriatric Syndromes, Principles of Palliative Medicine, and Organ Systems and Diseases. Within its pages, you will find balanced, authoritative coverage of every essential topic – from evaluation and management to nutrition and palliative medicine. Here’s why the Seventh Edition is the best edition ever: NEW full-color design with hundreds of color photographs NEW chapters: Quality of Care in Older Adults, Common Non-Pain Symptoms in Older Adults, Strategies of Effective Communication Around Advanced Illness, Palliative Medicine in the Continuum of Care Including Hospice, Coagulation Disorders, and Plasma Cell Disorders MORE chapters on Palliative Medicine NEW Learning Objectives and Key Points added to each chapter MORE tables, drawings, and clinical algorithms EVIDENCE-BASED through the use of the latest clinical practice guidelines , references to systemic reviews, and critically appraised topics UPDATED to reflect the most current clinical breakthroughs and advances for managing older adults in various settings
The most complete, authoritative guide available on the diagnosis and treatment of disorders affecting the elderly -- updated with a new global perspective A Doody's Core Title for 2011! "In addition to serving as a timely, comprehensive, state-of-the-art textbook of geriatric medicine anchored in science, evidence-based medicine, and patient-centered practice, the book also is intended to meet the learning needs of fellows in geriatric medicine. The authors succeed in modeling a textbook of geriatric medicine on textbooks of internal medicine. 3 Stars."--Doody's Review Service The undisputed leader on the subject of geriatrics, this comprehensive guide combines gerontology principles with clinical geriatrics offering unmatched coverage of this area of medicine. Written by some of the world's most respected geriatricians, Hazzard's Principles of Geriatric Medicine and Gerontology presents the most up-to-date, evidence-based medical information available -- in a revamped 2-color design that makes finding the answers to your questions faster and easier than ever. Features: A greater emphasis on evidence-based medicine through the expanded use of Clinical Practice Guidelines and references to systematic reviews and critically appraised topics A new international advisory board of 12 global authorities and an increased number of international contributors for a greater global perspective Important new chapters on the cultural aspects of geriatrics, emergency geriatrics, hospital geriatrics, international geriatric care, and rural geriatric care Information integrated with additional online resources Tables, drawings, and clinical algorithms made even more effective by a new two-color design 300 illustrations (including 64 in a full-color insert)
Drosophila Cells in Culture, Second Edition, includes comprehensive coverage of cell lines, methods for creating cell lines, methods for genome engineering, and the use of cell lines for genome wide rNAi screens. This publication summarizes over thirty years of experience in the handling of in vitro cultured Drosophila cells alongside recent methods and functional screens. Early and experienced researchers studying drosophila in developmental biology, genetics, neuroscience, and across the biological and biomedical sciences will benefit from this expert knowledge. - Offers full coverage of cell lines and primary cultures - Provides a go-to resource for methods and studies completed with drosophila cells in culture - Presents a wide spectrum of experimental techniques
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